CU23982B1 - Anticuerpos monoclonales optimizados contra el inhibidor de la vía del factor tisular (tfpi) - Google Patents

Anticuerpos monoclonales optimizados contra el inhibidor de la vía del factor tisular (tfpi)

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Publication number
CU23982B1
CU23982B1 CU20120126A CU20120126A CU23982B1 CU 23982 B1 CU23982 B1 CU 23982B1 CU 20120126 A CU20120126 A CU 20120126A CU 20120126 A CU20120126 A CU 20120126A CU 23982 B1 CU23982 B1 CU 23982B1
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CU
Cuba
Prior art keywords
tfpi
inhibitor
monoclonal antibodies
antibodies against
optimized monoclonal
Prior art date
Application number
CU20120126A
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English (en)
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CU20120126A7 (es
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed filed Critical
Publication of CU20120126A7 publication Critical patent/CU20120126A7/es
Publication of CU23982B1 publication Critical patent/CU23982B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Filtering Materials (AREA)
CU20120126A 2010-03-01 2012-08-30 Anticuerpos monoclonales optimizados contra el inhibidor de la vía del factor tisular (tfpi) CU23982B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30929010P 2010-03-01 2010-03-01
PCT/US2011/026766 WO2011109452A1 (en) 2010-03-01 2011-03-01 Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)

Publications (2)

Publication Number Publication Date
CU20120126A7 CU20120126A7 (es) 2013-01-30
CU23982B1 true CU23982B1 (es) 2014-03-26

Family

ID=44542552

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20120126A CU23982B1 (es) 2010-03-01 2012-08-30 Anticuerpos monoclonales optimizados contra el inhibidor de la vía del factor tisular (tfpi)

Country Status (36)

Country Link
US (3) US9309324B2 (es)
EP (2) EP2542257B1 (es)
JP (4) JP6025570B2 (es)
KR (4) KR20190047135A (es)
CN (5) CN107987166A (es)
AU (1) AU2011223710B2 (es)
BR (1) BR112012022258A2 (es)
CA (3) CA3101298A1 (es)
CL (2) CL2012002415A1 (es)
CO (1) CO6620068A2 (es)
CR (1) CR20120453A (es)
CU (1) CU23982B1 (es)
CY (2) CY1119410T1 (es)
DK (2) DK3345615T3 (es)
DO (1) DOP2012000239A (es)
EA (2) EA201892184A1 (es)
EC (2) ECSP12012134A (es)
ES (2) ES2642512T3 (es)
GT (1) GT201200252A (es)
HK (2) HK1232232A1 (es)
HR (2) HRP20171472T1 (es)
HU (2) HUE047173T2 (es)
IL (3) IL221551B (es)
LT (2) LT2542257T (es)
ME (2) ME03578B (es)
MX (2) MX2012010198A (es)
MY (1) MY174760A (es)
NZ (2) NZ602115A (es)
PE (1) PE20160538A1 (es)
PH (3) PH12018500641A1 (es)
PL (2) PL3345615T3 (es)
PT (2) PT3345615T (es)
RS (2) RS59830B1 (es)
SG (3) SG10201903166PA (es)
SI (2) SI3345615T1 (es)
WO (1) WO2011109452A1 (es)

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Publication number Priority date Publication date Assignee Title
UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
CA2745317C (en) † 2008-12-22 2019-03-05 Ida Hilden Antibodies against tissue factor pathway inhibitor
DK3345615T3 (da) 2010-03-01 2020-01-20 Bayer Healthcare Llc Optimerede monoklonale antistoffer mod inhibitor af vævsfaktoraktiveringsvejen (tfpi)
EP2588499B1 (en) * 2010-06-30 2020-04-08 Novo Nordisk A/S Antibodies that are capable of specifically binding tissue factor pathway inhibitor
DK2694544T3 (en) * 2011-04-01 2019-04-15 Bayer Healthcare Llc MONOCLONAL ANTIBODIES AGAINST TIBI FACTOR ACTIVITY INHIBITOR (TFPI)
KR20150030639A (ko) 2012-03-30 2015-03-20 바이엘 헬스케어 엘엘씨 프로테아제로 조절된 항체
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
US9556280B2 (en) * 2013-03-15 2017-01-31 Bayer Healthcare Llc Anti-TFPI antibody variants with differential binding across PH range for improved pharmacokinetics
AR095502A1 (es) * 2013-03-15 2015-10-21 Bayer Healthcare Llc Anticuerpos profármaco contra el inhibidor de la vía del factor tisular
CN112225812B (zh) * 2015-02-25 2024-08-13 财团法人牧岩生命科学研究所 结合tfpi的新型抗体以及包含所述抗体的组合物
IL302353A (en) 2015-08-19 2023-06-01 Pfizer TFPI inhibitory antibodies and their uses
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
MX2021004120A (es) * 2018-10-11 2021-09-10 Pfizer Regimen de dosificacion para antagonistas de tfpi.
KR102692277B1 (ko) * 2019-03-11 2024-08-05 현대자동차주식회사 상용 전기차용 모터 마운트
CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体
CN117285632A (zh) * 2022-06-17 2023-12-26 安源医药科技（上海）有限公司 针对tfpi的单克隆抗体及其用途

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