PT3345615T - Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi) - Google Patents

Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi)

Info

Publication number
PT3345615T
PT3345615T PT171721996T PT17172199T PT3345615T PT 3345615 T PT3345615 T PT 3345615T PT 171721996 T PT171721996 T PT 171721996T PT 17172199 T PT17172199 T PT 17172199T PT 3345615 T PT3345615 T PT 3345615T
Authority
PT
Portugal
Prior art keywords
tfpi
monoclonal antibodies
antibodies against
tissue factor
pathway inhibitor
Prior art date
Application number
PT171721996T
Other languages
English (en)
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44542552&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3345615(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of PT3345615T publication Critical patent/PT3345615T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
PT171721996T 2010-03-01 2011-03-01 Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi) PT3345615T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30929010P 2010-03-01 2010-03-01

Publications (1)

Publication Number Publication Date
PT3345615T true PT3345615T (pt) 2020-01-17

Family

ID=44542552

Family Applications (2)

Application Number Title Priority Date Filing Date
PT171721996T PT3345615T (pt) 2010-03-01 2011-03-01 Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi)
PT117512442T PT2542257T (pt) 2010-03-01 2011-03-01 Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi)

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT117512442T PT2542257T (pt) 2010-03-01 2011-03-01 Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi)

Country Status (36)

Country Link
US (3) USRE47150E1 (pt)
EP (2) EP2542257B1 (pt)
JP (4) JP6025570B2 (pt)
KR (4) KR101903931B1 (pt)
CN (5) CN110835373A (pt)
AU (1) AU2011223710B2 (pt)
BR (1) BR112012022258A2 (pt)
CA (3) CA2976671C (pt)
CL (2) CL2012002415A1 (pt)
CO (1) CO6620068A2 (pt)
CR (1) CR20120453A (pt)
CU (1) CU23982B1 (pt)
CY (2) CY1119410T1 (pt)
DK (2) DK3345615T3 (pt)
DO (1) DOP2012000239A (pt)
EA (2) EA032189B9 (pt)
EC (2) ECSP12012134A (pt)
ES (2) ES2765418T3 (pt)
GT (1) GT201200252A (pt)
HK (2) HK1232232A1 (pt)
HR (2) HRP20171472T1 (pt)
HU (2) HUE047173T2 (pt)
IL (3) IL221551B (pt)
LT (2) LT3345615T (pt)
ME (2) ME03578B (pt)
MX (2) MX2012010198A (pt)
MY (1) MY174760A (pt)
NZ (2) NZ702494A (pt)
PE (1) PE20160538A1 (pt)
PH (3) PH12018500639A1 (pt)
PL (2) PL3345615T3 (pt)
PT (2) PT3345615T (pt)
RS (2) RS59830B1 (pt)
SG (3) SG183443A1 (pt)
SI (2) SI2542257T1 (pt)
WO (1) WO2011109452A1 (pt)

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UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
JP5714505B2 (ja) 2008-12-22 2015-05-07 ノヴォ ノルディスク アー／エス 組織因子経路阻害因子に対する抗体
SI2542257T1 (en) 2010-03-01 2018-01-31 Bayer Healthcare Llc Optimized monoclonal antibodies against Tissue Factor Pathway Inhibitor (TFPI)
CN103080135B (zh) * 2010-06-30 2017-06-13 诺沃—诺迪斯克有限公司 能够特异性结合组织因子途径抑制剂的抗体
UA113623C2 (uk) * 2011-04-01 2017-02-27 Байєр Хелскеа Ллс Моноклональне антитіло проти інгібітору шляху тканинного фактора (tfpi)
CA2868789A1 (en) 2012-03-30 2013-10-03 Bayer Healthcare Llc Protease-regulated antibodies
US9592297B2 (en) * 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
TW201522368A (zh) * 2013-03-15 2015-06-16 Bayer Healthcare Llc 抗組織因子路徑抑制劑之前藥抗體
US20160009818A1 (en) * 2013-03-15 2016-01-14 Bayer Healthcare Llc Anti-TFPI Antibody Variants with Differential Binding Across pH Range For Improved Pharmacokinetics
MY178445A (en) * 2015-02-25 2020-10-13 Mogam Inst Biomedical Res Novel antibody binding to tfpi and composition comprising the same
IL302353A (en) * 2015-08-19 2023-06-01 Pfizer TFPI inhibitory antibodies and their uses
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
AU2019359540A1 (en) * 2018-10-11 2021-04-29 Pfizer Inc. Dosage regimen for TFPI antagonists
CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体
CN117285632A (zh) * 2022-06-17 2023-12-26 安源医药科技（上海）有限公司 针对tfpi的单克隆抗体及其用途

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