DK0994728T3 - Rekombinante antistoffer, som er specifikke for beta-amyloide ender, DNA, der koder derfor, samt fremgangsmåder til anvendelse heraf - Google Patents
Rekombinante antistoffer, som er specifikke for beta-amyloide ender, DNA, der koder derfor, samt fremgangsmåder til anvendelse herafInfo
- Publication number
- DK0994728T3 DK0994728T3 DK98918035T DK98918035T DK0994728T3 DK 0994728 T3 DK0994728 T3 DK 0994728T3 DK 98918035 T DK98918035 T DK 98918035T DK 98918035 T DK98918035 T DK 98918035T DK 0994728 T3 DK0994728 T3 DK 0994728T3
- Authority
- DK
- Denmark
- Prior art keywords
- amyloid
- dna encoding
- beta
- methods
- antibodies specific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4185097P | 1997-04-09 | 1997-04-09 | |
PCT/US1998/006900 WO1998044955A1 (en) | 1997-04-09 | 1998-04-09 | Recombinant antibodies specific for beta-amyloid ends, dna encoding and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0994728T3 true DK0994728T3 (da) | 2008-12-01 |
Family
ID=21918670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98918035T DK0994728T3 (da) | 1997-04-09 | 1998-04-09 | Rekombinante antistoffer, som er specifikke for beta-amyloide ender, DNA, der koder derfor, samt fremgangsmåder til anvendelse heraf |
Country Status (16)
Country | Link |
---|---|
US (2) | US20090069258A1 (da) |
EP (3) | EP2305709A1 (da) |
JP (3) | JP3816111B2 (da) |
CN (1) | CN1177616C (da) |
AT (1) | ATE402717T1 (da) |
AU (1) | AU743827B2 (da) |
CA (1) | CA2286305A1 (da) |
CY (1) | CY1110371T1 (da) |
DE (1) | DE69839808D1 (da) |
DK (1) | DK0994728T3 (da) |
ES (1) | ES2312185T3 (da) |
IL (1) | IL132262A (da) |
NZ (1) | NZ337765A (da) |
PT (1) | PT994728E (da) |
SI (1) | SI0994728T1 (da) |
WO (1) | WO1998044955A1 (da) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8173127B2 (en) | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
AU2008203784B2 (en) * | 1999-05-28 | 2012-01-19 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
AUPQ180499A0 (en) * | 1999-07-23 | 1999-08-19 | Biomolecular Research Institute Limited | Beta-amyloid peptide inhibitors |
EP1307219A4 (en) * | 1999-08-13 | 2005-04-06 | Univ Columbia | PROCESS FOR INHIBITING THE BINDING OF BETA FOLDED FIBRILLES TO RAGE (ADVANCED GLYCATION ENDPRODUCT RECEPTOR) |
IL149976A0 (en) * | 1999-12-08 | 2002-12-01 | Mindset Biopharmaceuticals Usa | Chimeric peptides as immunogens, antibodies thereto, and methods for immunization using chimeric peptides or antibodies |
CZ306683B6 (cs) | 2000-02-24 | 2017-05-03 | Washington University | Léčivo pro prevenci nebo léčení preklinické nebo klinické Alzheimerovy nemoci |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US6815175B2 (en) | 2001-03-16 | 2004-11-09 | Cornell Research Foundation, Inc. | Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder |
WO2002088307A2 (en) | 2001-04-30 | 2002-11-07 | Eli Lilly And Company | Humanized antibodies |
EP1385545B1 (en) | 2001-04-30 | 2009-01-07 | Eli Lilly And Company | Humanized antibodies recognizing the beta-amyloid peptide |
US7771722B2 (en) | 2001-08-17 | 2010-08-10 | Eli Lilly And Company | Assay method for alzheimer's disease |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
WO2004013172A2 (en) * | 2002-07-24 | 2004-02-12 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
WO2004029629A1 (en) * | 2002-09-27 | 2004-04-08 | Janssen Pharmaceutica N.V. | N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses |
US20040146512A1 (en) * | 2002-10-09 | 2004-07-29 | Arnon Rosenthal | Methods of treating Alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof |
ES2344645T3 (es) | 2003-02-10 | 2010-09-02 | Applied Molecular Evolution, Inc. | Moleculas de union al abeta. |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
TWI306458B (en) | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
ZA200703561B (en) * | 2004-10-05 | 2009-09-30 | Wyeth Corp | Methods and compositions for improving recombinant protein production |
GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
AR052051A1 (es) | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
CA2589860A1 (en) | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
EP1940466B1 (en) * | 2005-10-21 | 2012-11-28 | Merck Sharp & Dohme Corp. | Anti-addl monoclonal antibodies and use thereof |
CN1329413C (zh) * | 2006-01-23 | 2007-08-01 | 南京医科大学 | 一种治疗或预防老年性痴呆的抗体及其表达载体和在制药中的应用 |
EA015654B9 (ru) * | 2006-03-30 | 2012-01-30 | Глаксо Груп Лимитед | Антитела против бета-амилоидного пептида |
WO2009017467A1 (en) | 2007-07-27 | 2009-02-05 | Elan Pharma International Limited | Treatment of amyloidogenic diseases |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
KR101735257B1 (ko) | 2007-01-05 | 2017-05-12 | 유니버시티 오브 취리히 | 질환 특이적 결합 분자 및 표적을 제공하는 방법 |
IL199534A (en) | 2007-01-05 | 2013-01-31 | Univ Zuerich | An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses. |
DK2104682T3 (da) | 2007-01-11 | 2017-01-16 | Michael Bacher | Diagnose og behandling af alzheimers og andre demenssygdomme |
EP1944315A1 (en) * | 2007-01-11 | 2008-07-16 | Philipps-Universität Marburg | Prophylaxis and therapy of alzheimer's disease and other neurodementing diseases |
ES2535641T3 (es) | 2007-01-18 | 2015-05-13 | Eli Lilly & Company | Amiloide beta Fab pegilado |
NZ579310A (en) | 2007-03-01 | 2012-03-30 | Probiodrug Ag | Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof |
EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
US8323654B2 (en) | 2007-05-14 | 2012-12-04 | Medtronic, Inc. | Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules |
WO2008141321A1 (en) | 2007-05-14 | 2008-11-20 | Medtronic, Inc. | Methods and device to neutralize soluble toxic agents in the brain |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
EP2949666B1 (en) | 2008-12-19 | 2018-12-19 | Biogen International Neuroscience GmbH | Human anti-alpha-synuclein antibodies |
EP2258398A1 (en) | 2009-05-26 | 2010-12-08 | Araclón Biotech, S. L. | Albumin-amyloid peptide conjugates and uses thereof |
CA2772488C (en) | 2009-09-11 | 2018-04-17 | Probiodrug Ag | Heterocyclic derivatives as inhibitors of glutaminyl cyclase |
US9181233B2 (en) | 2010-03-03 | 2015-11-10 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
US8269019B2 (en) | 2010-03-10 | 2012-09-18 | Probiodrug Ag | Inhibitors |
EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
EP2598236A2 (en) * | 2010-07-30 | 2013-06-05 | Technische Universität Dortmund | Polymeric complements to b-amyloid peptides |
CN107828820B (zh) * | 2010-10-27 | 2022-06-07 | 学校法人自治医科大学 | 用于向神经系统细胞导入基因的腺相关病毒粒子 |
JP6050264B2 (ja) | 2011-03-16 | 2016-12-21 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
EP2691393B1 (en) | 2011-03-31 | 2016-09-14 | Pfizer Inc | Novel bicyclic pyridinones |
WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
PT2723379T (pt) | 2011-06-23 | 2018-11-14 | Univ Of Zuerich | Moléculas de ligação anti-alfa-sinucleína |
EP2751116B1 (en) | 2011-08-31 | 2016-10-12 | Pfizer Inc | Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds |
ES2585262T3 (es) | 2012-05-04 | 2016-10-04 | Pfizer Inc | Compuestos heterocíclicos de hexahidropiran[3,4-d][1,3]tiazin-2-amina sustituidos como inhibidores de PPA, BACE1 y BACE2 |
ES2637245T3 (es) | 2012-06-29 | 2017-10-11 | Pfizer Inc. | Nuevas 4-(amino sustituido)-7H-pirrolo[2,3-d]pirimidinas como inhibidores de LRRK2 |
EP2897964A1 (en) | 2012-09-20 | 2015-07-29 | Pfizer Inc. | Alkyl-substituted hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds |
UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
EP2931731A1 (en) | 2012-12-11 | 2015-10-21 | Pfizer Inc. | Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1 |
WO2014097038A1 (en) | 2012-12-19 | 2014-06-26 | Pfizer Inc. | CARBOCYCLIC- AND HETEROCYCLIC-SUBSTITUTED HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS |
EP2956458B1 (en) | 2013-02-13 | 2017-08-09 | Pfizer Inc | Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
US9233981B1 (en) | 2013-02-15 | 2016-01-12 | Pfizer Inc. | Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
PE20151332A1 (es) | 2013-02-19 | 2015-09-20 | Pfizer | Compuestos de azabencimidazol |
WO2015049616A1 (en) | 2013-10-04 | 2015-04-09 | Pfizer Inc. | Novel bicyclic pyridinones as gamma-secretase modulators |
WO2015092592A1 (en) | 2013-12-17 | 2015-06-25 | Pfizer Inc. | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
BR112016022519A8 (pt) | 2014-04-01 | 2018-03-06 | Pfizer | cromeno e 1,1a,2,7b-tetra-hidrociclopropa[c]cromeno piridopirazinadionas como moduladores de gama-secretase |
CR20160455A (es) | 2014-04-10 | 2016-12-16 | Pfizer | 2-AMINO-6-METIL-4,4a,5,6-TETRAHIDROPIRANO[3,4-d][1,3]TIAZIN-8a(8H)-IL-1,3-TIAZOL-4-ILA |
JP6713982B2 (ja) | 2014-07-24 | 2020-06-24 | ファイザー・インク | ピラゾロピリミジン化合物 |
KR102061952B1 (ko) | 2014-08-06 | 2020-01-02 | 화이자 인코포레이티드 | 이미다조피리다진 화합물 |
PL3221349T3 (pl) | 2014-11-19 | 2021-05-17 | Axon Neuroscience Se | Humanizowane przeciwciała tau w chorobie Alzheimera |
MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
KR102000382B1 (ko) | 2015-02-03 | 2019-07-15 | 화이자 인코포레이티드 | 신규 시클로프로파벤조푸라닐 피리도피라진디온 |
CA2989456C (en) | 2015-06-17 | 2022-01-04 | Pfizer Inc. | Tricyclic compounds and their use as phosphodiesterase inhibitors |
CN108137586B (zh) | 2015-09-14 | 2021-04-13 | 辉瑞大药厂 | 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物 |
EP3353174A1 (en) | 2015-09-24 | 2018-08-01 | Pfizer Inc | N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl]amides useful as bace inhibitors |
BR112018003489A2 (pt) | 2015-09-24 | 2018-09-25 | Pfizer | n-[2-(2-amino-6,6-dissubstituído-4,4a,5,6-tetra-hidropirano[3,4-d][1,3]tiazin-8a(8h)-il)-1,3-tiazol-4-il]amidas |
WO2017051303A1 (en) | 2015-09-24 | 2017-03-30 | Pfizer Inc. | Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors |
RU2719599C2 (ru) | 2016-02-23 | 2020-04-21 | Пфайзер Инк. | Соединения 6, 7-дигидро-5H-пиразоло[5,1-b][1,3]оксазин-2-карбоксамида |
JP7046018B2 (ja) | 2016-07-01 | 2022-04-01 | ファイザー・インク | 神経性疾患および神経変性疾患を処置するための5,7-ジヒドロピロロピリジン誘導体 |
JP7219223B2 (ja) | 2017-03-10 | 2023-02-07 | ファイザー・インク | LRRK2阻害剤としての新規のイミダゾ[4,5-c]キノリン誘導体 |
ES2910083T3 (es) | 2017-03-10 | 2022-05-11 | Pfizer | Derivados de imidazo[4,5-c]quinolina cíclicos sustituidos |
WO2018226992A1 (en) | 2017-06-07 | 2018-12-13 | Adrx, Inc. | Tau aggregation inhibitors |
KR20200013783A (ko) | 2017-06-22 | 2020-02-07 | 화이자 인코포레이티드 | 디히드로-피롤로-피리딘 유도체 |
US11453701B2 (en) | 2017-08-18 | 2022-09-27 | Adrx, Inc. | Tau aggregation peptide inhibitors |
CA3073066A1 (en) | 2017-08-22 | 2019-02-28 | Biogen Ma Inc. | Pharmaceutical compositions containing anti-beta amyloid antibodies |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
EP4219464A1 (en) | 2018-03-23 | 2023-08-02 | Pfizer Inc. | Piperazine azaspiro derivaves |
CA3098807A1 (en) | 2018-05-08 | 2019-11-14 | Neuracle Science Co., Ltd. | Adeno-associated virus (aav) delivery of anti-fam19a5 antibodies |
AU2019304384A1 (en) | 2018-07-17 | 2021-01-28 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-abeta antibody, antigen-binding fragment thereof and application thereof |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4185097A (en) | 1978-01-09 | 1980-01-22 | A. H. Robins Company, Inc. | Method of combating Herpes simplex viruses with lignosulfonates |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
GB8719963D0 (en) | 1987-08-24 | 1987-09-30 | Cattaneo A | Recombinant dna products |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
EP0683234B2 (en) * | 1993-01-25 | 2007-06-06 | Takeda Chemical Industries, Ltd. | Antibody against beta-amyloid or their derivative and use thereof |
US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
US5688651A (en) * | 1994-12-16 | 1997-11-18 | Ramot University Authority For Applied Research And Development Ltd. | Prevention of protein aggregation |
US5786180A (en) * | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
US5965614A (en) * | 1996-11-22 | 1999-10-12 | Athena Neurosciences, Inc. | N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US8173127B2 (en) * | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
-
1998
- 1998-04-09 WO PCT/US1998/006900 patent/WO1998044955A1/en active IP Right Grant
- 1998-04-09 AU AU71034/98A patent/AU743827B2/en not_active Ceased
- 1998-04-09 ES ES98918035T patent/ES2312185T3/es not_active Expired - Lifetime
- 1998-04-09 DK DK98918035T patent/DK0994728T3/da active
- 1998-04-09 SI SI9830913T patent/SI0994728T1/sl unknown
- 1998-04-09 EP EP10011650A patent/EP2305709A1/en not_active Withdrawn
- 1998-04-09 EP EP08011798A patent/EP2006303A1/en not_active Withdrawn
- 1998-04-09 DE DE69839808T patent/DE69839808D1/de not_active Expired - Lifetime
- 1998-04-09 EP EP98918035A patent/EP0994728B1/en not_active Revoked
- 1998-04-09 CA CA002286305A patent/CA2286305A1/en not_active Abandoned
- 1998-04-09 AT AT98918035T patent/ATE402717T1/de active
- 1998-04-09 NZ NZ337765A patent/NZ337765A/en not_active IP Right Cessation
- 1998-04-09 CN CNB988035464A patent/CN1177616C/zh not_active Expired - Fee Related
- 1998-04-09 PT PT98918035T patent/PT994728E/pt unknown
- 1998-04-09 JP JP54304398A patent/JP3816111B2/ja not_active Expired - Fee Related
-
1999
- 1999-10-07 IL IL132262A patent/IL132262A/en not_active IP Right Cessation
-
2005
- 2005-07-20 JP JP2005210196A patent/JP2005320349A/ja active Pending
-
2007
- 2007-05-08 US US11/745,759 patent/US20090069258A1/en not_active Abandoned
-
2008
- 2008-10-30 CY CY20081101230T patent/CY1110371T1/el unknown
-
2009
- 2009-05-07 JP JP2009113001A patent/JP2009173680A/ja active Pending
-
2010
- 2010-01-21 US US12/691,046 patent/US20110027279A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1254294A (zh) | 2000-05-24 |
CN1177616C (zh) | 2004-12-01 |
AU743827B2 (en) | 2002-02-07 |
PT994728E (pt) | 2008-11-11 |
EP0994728A1 (en) | 2000-04-26 |
JP2009173680A (ja) | 2009-08-06 |
SI0994728T1 (sl) | 2009-02-28 |
JP2005320349A (ja) | 2005-11-17 |
WO1998044955A1 (en) | 1998-10-15 |
US20090069258A1 (en) | 2009-03-12 |
ES2312185T3 (es) | 2009-02-16 |
EP2305709A1 (en) | 2011-04-06 |
CA2286305A1 (en) | 1998-10-15 |
DE69839808D1 (de) | 2008-09-11 |
AU7103498A (en) | 1998-10-30 |
JP3816111B2 (ja) | 2006-08-30 |
NZ337765A (en) | 2001-09-28 |
IL132262A (en) | 2009-11-18 |
EP0994728A4 (en) | 2001-11-28 |
ATE402717T1 (de) | 2008-08-15 |
JP2002503092A (ja) | 2002-01-29 |
EP0994728B1 (en) | 2008-07-30 |
CY1110371T1 (el) | 2015-04-29 |
US20110027279A1 (en) | 2011-02-03 |
EP2006303A1 (en) | 2008-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0994728T3 (da) | Rekombinante antistoffer, som er specifikke for beta-amyloide ender, DNA, der koder derfor, samt fremgangsmåder til anvendelse heraf | |
ATE329028T1 (de) | Nl3 tie rezeptortyrosinekinase ligandhomologe | |
AR038568A1 (es) | Anticuerpos anti-a beta y su uso | |
DE69841514D1 (de) | Menschliche Toll-Like-Rezeptorproteine, zugehörige Reagenzien und Verfahren | |
NO931889L (no) | Protease og beslektede DNA-forbindelser | |
WO1996009386A3 (en) | Allelic variation of the serotonin 5ht2c receptor | |
DE69839444D1 (de) | Smad 6 und dessen anwendungen | |
ATE301716T1 (de) | Vmp-ähnliche sequenzen von pathogener borrelia | |
BR9912455A (pt) | ácidos nucléicos codificadores de proteìnas envolvidas em transdução sensória | |
FR2706484B1 (fr) | Polypeptide mutant de la protéine kinase C, séquences d'acides nucléiques codant pour ledit polypeptide et leurs utilisations. | |
EP0910396A4 (en) | ISOLATED NUCLEIC ACID MOLECULES ENCODING THE GAGE TUMOR REPELLENT REPELLENTANT, THE TUMOR REPELLENT REPELLENTANT AND ITS USE | |
DK0990703T3 (da) | Nyt polypeptid, DNA, som koder herfor, samt anvendelse heraf | |
DE69626522D1 (de) | Peptide mit pronociceptiveigenschaften | |
WO2001016317A3 (en) | Polycyclic aromatic hydrocarbon induced molecules | |
EP1117682A4 (en) | NEW PEPTIDES | |
DK1129191T3 (da) | Fremgangsmåder til diagnosticering eller behandling af neurologiske sygdomme | |
ATE332916T1 (de) | Farbstoff-markiertes peptid und dessen verwendung zur diagnostik | |
EP0816498A3 (en) | Excitatory amino acid receptor protein and related nucleic acid compounds | |
BR9403572A (pt) | Composto, processo para sua preparação e formulação farmacêutica | |
TW342413B (en) | Novel toxins isolated from Bracon Hebetor | |
BR9611851A (pt) | Molécula de ácido nucléico isolada e purificada, vetor de experessão recombinatória, célula hospedeira contendo um vetor de expressão recombina tório, proteìnas tbpa e tbpb isolada e purificadas, método para preparar uma protéina tbpa e tbpb, anti-corpo policlÈnico ou monoclÈnico, e vacinas assim obtidas | |
ITRM950434A0 (it) | Polipeptide per la riparazione di informazione genetica, sequenza nucleotidica che codifica per esso e procedimento per la sua preparazione. | |
BR9801168A (pt) | Peptìdios de complexo de tlp de carcinoma urogenital e os seus anticorpos. | |
ZA958038B (en) | Isolated truncated nucleic acid molecules which code for gage tumor rejection antigen the tumor rejection antigen and uses thereof | |
BRPI9715268B8 (pt) | preparações farmacêuticas liofilizadas estáveis de anticorpos monoclonais ou policlonais, bem como processo para sua produção |