ATE394484T1 - Smad 6 und dessen anwendungen - Google Patents

Smad 6 und dessen anwendungen

Info

Publication number
ATE394484T1
ATE394484T1 AT98926540T AT98926540T ATE394484T1 AT E394484 T1 ATE394484 T1 AT E394484T1 AT 98926540 T AT98926540 T AT 98926540T AT 98926540 T AT98926540 T AT 98926540T AT E394484 T1 ATE394484 T1 AT E394484T1
Authority
AT
Austria
Prior art keywords
nucleic acids
smad
applications
polypeptides
fragments
Prior art date
Application number
AT98926540T
Other languages
English (en)
Inventor
Kohei Miyazono
Masahiro Kawabata
Original Assignee
Ludwig Inst Cancer Res
Japan Found Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Inst Cancer Res, Japan Found Cancer filed Critical Ludwig Inst Cancer Res
Application granted granted Critical
Publication of ATE394484T1 publication Critical patent/ATE394484T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT98926540T 1997-06-13 1998-06-12 Smad 6 und dessen anwendungen ATE394484T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4999097P 1997-06-13 1997-06-13
US5304097P 1997-07-18 1997-07-18
US6617397P 1997-11-18 1997-11-18

Publications (1)

Publication Number Publication Date
ATE394484T1 true ATE394484T1 (de) 2008-05-15

Family

ID=27367651

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98926540T ATE394484T1 (de) 1997-06-13 1998-06-12 Smad 6 und dessen anwendungen

Country Status (8)

Country Link
US (4) US6270994B1 (de)
EP (1) EP0991758B1 (de)
JP (1) JP3626206B2 (de)
AT (1) ATE394484T1 (de)
AU (1) AU749465B2 (de)
CA (1) CA2292339A1 (de)
DE (1) DE69839444D1 (de)
WO (1) WO1998056913A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566131B1 (en) * 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of Smad6 expression
AU7627700A (en) * 1999-08-04 2001-03-05 Uab Research Foundation The interaction of smad6 with hox proteins and uses thereof
US6673570B1 (en) 1999-09-20 2004-01-06 Ludwig Institute For Cancer Research Smad associating polypeptides
WO2001021794A2 (en) * 1999-09-20 2001-03-29 Ludwig Institute For Cancer Research Smad associating polypeptides
JP2001218840A (ja) * 2000-02-14 2001-08-14 Kanegafuchi Chem Ind Co Ltd トランスフォーミング増殖因子βの吸着材、吸着除去方法および吸着器
EP1467624A4 (de) * 2001-12-27 2006-07-26 Yissum Res Dev Co Verfahren zur induktion oder verstärkung der binde gewebs reparatur
AUPS160602A0 (en) * 2002-04-08 2002-05-16 University Of Queensland, The Therapeutic method
AU2002952086A0 (en) * 2002-10-16 2002-11-07 The University Of Queensland Treatment of osteoarthritis
WO2005077403A1 (en) * 2004-02-04 2005-08-25 Stryker Corporation Therapeutic methods using smads
RU2386638C2 (ru) 2004-03-31 2010-04-20 Дженентек, Инк. Гуманизированные анти-тфр-бета-антитела
WO2007050793A2 (en) 2005-10-25 2007-05-03 The Johns Hopkins University Methods and compositions for the treatment of marfan syndrome and associated disorders
EP1998810A4 (de) 2006-03-13 2009-09-02 Univ Johns Hopkins Erhöhung der endothelialen thromboresistenz
JP2009539842A (ja) * 2006-06-05 2009-11-19 ノバルティス アクチエンゲゼルシャフト 副甲状腺関連障害の処置におけるＴＧＦ−βアンタゴニストの使用
WO2009117439A2 (en) 2008-03-17 2009-09-24 The Scripps Research Institute Combined chemical and genetic approaches for generation of induced pluripotent stem cells
EP2488630B1 (de) 2009-10-16 2017-07-05 The Scripps Research Institute Induzierung pluripotenter zellen
JP5909482B2 (ja) 2010-03-31 2016-04-26 ザ スクリプス リサーチ インスティテュート 細胞の再プログラム
EP2580320B1 (de) 2010-06-14 2018-08-01 The Scripps Research Institute Neuprogrammierung von zellen für ein neues zellschicksal
KR102482184B1 (ko) 2010-12-22 2022-12-28 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
KR20130131414A (ko) 2010-12-27 2013-12-03 엘에스아이피 환도 운에이고우도우가이샤 ｉＰＳ 세포와 그 제조법
ES2917222T3 (es) 2011-12-28 2022-07-07 Kyoto Prefectural Public Univ Corp Normalización del cultivo de células endoteliales de la córnea
US20140170158A1 (en) * 2012-12-17 2014-06-19 The Johns Hopkins University Compositions and methods for treating or preventing lung diseases
CA2927898C (en) 2013-10-31 2021-11-16 Kyoto Prefectural Public University Corporation Therapeutic drug for diseases related to endoplasmic reticulum cell death in corneal endothelium
US11268069B2 (en) 2014-03-04 2022-03-08 Fate Therapeutics, Inc. Reprogramming methods and cell culture platforms
US10023879B2 (en) 2014-06-04 2018-07-17 Fate Therapeutics, Inc. Minimal volume reprogramming of mononuclear cells
EP3250680A4 (de) 2015-01-26 2018-12-05 Fate Therapeutics, Inc. Verfahren und zusammensetzungen zur induzierung differenzierung hämatopoietischer zellen
WO2016187312A1 (en) 2015-05-18 2016-11-24 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and compositions for treating an alphavirus infection
CN108291237B (zh) 2015-10-16 2023-11-21 菲特治疗公司 用于诱导和维护基态多能性的平台
SG11201803145RA (en) 2015-11-04 2018-05-30 Fate Therapeutics Inc Methods and compositions for inducing hematopoietic cell differentiation
AU2016349504B2 (en) 2015-11-04 2023-02-09 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
JP6425701B2 (ja) * 2016-10-31 2018-11-21 キヤノン株式会社 インクジェット記録装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968770A (en) * 1995-02-10 1999-10-19 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd523 as a target
CA2247246A1 (en) * 1996-02-16 1997-08-21 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
WO1997039105A1 (en) * 1996-04-18 1997-10-23 The Johns Hopkins University Mad-related genes in the human
JP3431637B2 (ja) * 1997-05-20 2003-07-28 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Ｓｍａｄ７およびその使用

Also Published As

Publication number Publication date
EP0991758B1 (de) 2008-05-07
WO1998056913A9 (en) 1999-04-08
AU749465B2 (en) 2002-06-27
CA2292339A1 (en) 1998-12-17
US7560532B2 (en) 2009-07-14
WO1998056913A1 (en) 1998-12-17
JP3626206B2 (ja) 2005-03-02
US20060003379A1 (en) 2006-01-05
US6964853B2 (en) 2005-11-15
DE69839444D1 (de) 2008-06-19
EP0991758A1 (de) 2000-04-12
JP2001527421A (ja) 2001-12-25
US20040053278A1 (en) 2004-03-18
US20020106732A1 (en) 2002-08-08
US6270994B1 (en) 2001-08-07
AU7835398A (en) 1998-12-30
US6534476B2 (en) 2003-03-18

Similar Documents

Publication Publication Date Title
DE69839444D1 (de) Smad 6 und dessen anwendungen
BR0012759A (pt) Neurotoxinas recombinantes ativáveis
WO1999053061A3 (en) Tumor associated nucleic acids and uses therefor
IL131016A0 (en) Selection of proteins using rna-protein fusions
IS2835B (is) Taugavaxtarþættir
NO971875D0 (no) Cathepsin 02 protease
DK1015586T3 (da) TIE-receptortyrosinkinaseligandhomologer
PT1015585E (pt) Homologos de ligandos de tie
DE69833014D1 (de) Menschliche toll homologen
DK1093517T3 (da) Neisseria-meningitidis-antigener og præparater
DE69736068D1 (de) Faktor viii vom schwein und hybriden
DE69939553D1 (de) Charakterisierung der proteinfamilie von soc/crac kalziumkanälen
EP0832973A3 (de) GTP-bindende Proteine
ATE476495T1 (de) Bazillus thuringiensis und dessen insektizide proteine
FI885504A0 (fi) Vaskulaera antikoagulerande proteiner, dessa koderande dna, deras framstaellningsfoerfarande och deras anvaendning.
DE69737651D1 (de) Cortistatin: neuropeptide, zusammensetzungen und methoden
ATE253113T1 (de) Für ein fibroblasten-aktivierungsprotein kodierende nukleinsäure und verwendungen dafür
ATE285474T1 (de) Haemophilus adhäsionsproteinen
WO2001053453A3 (en) Novel bone marrow nucleic acids and polypeptides
EP0911409A3 (de) Deformylase
DK1005532T3 (da) Isolerede nukleinsyremolekyler kodende for SSX familiemedlemmer og anvendelser deraf
DE60120187D1 (de) Verkürztes bard1 protein und dessen diagnostische und therapeutische anwendungen
WO2001021794A3 (en) Smad associating polypeptides
WO2002038765A3 (en) Dna encoding bovine immunoglobulin a inducing protein and uses therefor
WO2000037634A3 (en) Novel polypeptides and nucleic acids encoding same

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties