PT1015585E - Homologos de ligandos de tie - Google Patents

Homologos de ligandos de tie

Info

Publication number
PT1015585E
PT1015585E PT98946987T PT98946987T PT1015585E PT 1015585 E PT1015585 E PT 1015585E PT 98946987 T PT98946987 T PT 98946987T PT 98946987 T PT98946987 T PT 98946987T PT 1015585 E PT1015585 E PT 1015585E
Authority
PT
Portugal
Prior art keywords
tie
ligandos
homes
nucleic acid
acid molecules
Prior art date
Application number
PT98946987T
Other languages
English (en)
Inventor
Paul J Godowski
Austin L Gurney
Hillan Kenneth
Botstein David
Audrey Goddard
Roy Margaret
Ferrara Napoleone
Tumas Daniel
Schwall Ralph
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/933,821 external-priority patent/US5972338A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT1015585E publication Critical patent/PT1015585E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
PT98946987T 1997-09-19 1998-09-14 Homologos de ligandos de tie PT1015585E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/933,821 US5972338A (en) 1997-09-19 1997-09-19 Tie ligands homologues
US08/960,507 US6057435A (en) 1997-09-19 1997-10-29 Tie ligand homologues

Publications (1)

Publication Number Publication Date
PT1015585E true PT1015585E (pt) 2006-10-31

Family

ID=27130048

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98946987T PT1015585E (pt) 1997-09-19 1998-09-14 Homologos de ligandos de tie

Country Status (15)

Country Link
US (3) US6057435A (pt)
EP (4) EP1696030A1 (pt)
JP (4) JP2001517437A (pt)
KR (4) KR100692334B1 (pt)
AT (1) ATE327329T1 (pt)
AU (1) AU756449B2 (pt)
CA (1) CA2304129A1 (pt)
CY (1) CY1105161T1 (pt)
DE (1) DE69834649T2 (pt)
DK (1) DK1015585T3 (pt)
ES (1) ES2268790T3 (pt)
IL (2) IL134648A0 (pt)
NZ (1) NZ502946A (pt)
PT (1) PT1015585E (pt)
WO (1) WO1999015653A2 (pt)

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WO2001034800A1 (en) * 1999-11-12 2001-05-17 Human Genome Sciences, Inc. 19 human secreted proteins
US6057435A (en) 1997-09-19 2000-05-02 Genentech, Inc. Tie ligand homologues
US5972338A (en) * 1997-09-19 1999-10-26 Genentech, Inc. Tie ligands homologues
US6350450B1 (en) * 1997-09-19 2002-02-26 Genentech, Inc. TIE ligand homologue antibody
CA2313804A1 (en) * 1997-12-19 1999-07-01 Regeneron Pharmaceuticals, Inc. Receptor tyrosine kinase, ar-1, is a regulator of angiogenesis
AU2493699A (en) * 1998-02-04 1999-08-23 Zymogenetics Inc. Angiopoietin homolog zapo3, dna encoding it, and method of making it
AU3661199A (en) * 1998-04-27 1999-11-16 Zymogenetics Inc. Novel polypeptide growth factors and materials and methods for making them
AU4320499A (en) * 1998-06-02 1999-12-20 Eli Lilly And Company Angiopoietin related gene sequence scarface 1
SV1999000069A (es) * 1998-06-02 2000-04-11 Lilly Co Eli Angiopoyetina relacionada con secuencia del gen 3 en la cicatrizacion de la cara ref. x-12261
AU4643699A (en) * 1998-06-24 2000-01-10 Compugen Ltd. Angiopoietin-like growth factor sequences
DE69920462T2 (de) 1998-07-13 2005-10-13 Board of Regents, The University of Texas System, Austin Verwendung von antikörper gegen aminophospholipide zur krebsbehandlung
US6406693B1 (en) 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
CA2331789C (en) * 1998-07-13 2013-09-10 Board Of Regents, The University Of Texas System Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
JP2002522019A (ja) * 1998-07-20 2002-07-23 キュラジェン コーポレイション 新脈管形成に関与する分泌タンパク質のヌクレオチド配列およびアミノ酸配列
AU5210899A (en) * 1998-07-24 2000-02-14 Eli Lilly And Company Angiopoietin related gene sequence scarface 2
AU5472899A (en) * 1998-08-20 2000-03-14 Incyte Pharmaceuticals, Inc. Human angiopoietin-3
US6537554B1 (en) 1998-09-10 2003-03-25 Curagen Corporation Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis
US20050148101A1 (en) * 1999-01-23 2005-07-07 Bamdad Cynthia C. Interaction of colloid-immobilized species with species on non-colloidal structures
IL144849A0 (en) * 1999-03-02 2002-06-30 Regeneron Pharma Angiopoietin-related protein and nucleic acids
EP1159419A1 (en) * 1999-03-08 2001-12-05 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
ES2223705T3 (es) 1999-04-28 2005-03-01 Board Of Regents, The University Of Texas System Composiciones y metodos para el tratamiento de cancer mediante inhibi cion selectiva del vegf.
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
EP1208195A2 (en) * 1999-06-15 2002-05-29 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6835381B1 (en) 1999-07-02 2004-12-28 Bayer Ag Methods for modulating angiogenesis by using the anti-angiogenic angiotensin-7 and polynucleotides encoding therefor
ES2252032T3 (es) * 1999-07-02 2006-05-16 Bayer Ag Modulacion de angiogenesis usando angiotensina-7 antiangiogenica y polinucleotidos codificantes para dicha sustancia para el tratamiento de tumores.
WO2001003735A1 (en) * 1999-07-12 2001-01-18 Maine Medical Center Research Institute Cancer treatment using angiopoietins targeted to aminophospholipids
JP2003505350A (ja) * 1999-07-20 2003-02-12 ジェネンテック・インコーポレーテッド 免疫関連疾患の治療のための組成物と方法
WO2001029085A2 (en) * 1999-10-21 2001-04-26 Royal Netherlands Academy Of Arts And Sciences Cdt6 can inhibit angiogenesis and tumor growth, and can induce or enhance the formation of structures containing collagen v
CA2423630C (en) * 2000-10-03 2011-12-06 Minerva Biotechnologies Corporation Magnetic in situ dilution
AU2002365261A1 (en) * 2001-10-18 2003-09-02 The Children's Hospital Of Philadelphia Methods and materials for the recruitment of endothelial cells
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
JPWO2003083114A1 (ja) * 2002-03-28 2005-08-04 アステラス製薬株式会社 アンジオポエチン関連増殖因子
CA2518627A1 (en) * 2003-06-06 2004-12-16 Astellas Pharma Inc. Method of screening antiobesity agents and animal model of obesity
CA2535171A1 (en) * 2003-08-12 2005-03-03 Dyax Corp. Tie1-binding ligands
US7485297B2 (en) * 2003-08-12 2009-02-03 Dyax Corp. Method of inhibition of vascular development using an antibody
US7871610B2 (en) * 2003-08-12 2011-01-18 Dyax Corp. Antibodies to Tie1 ectodomain
JP2008510488A (ja) * 2004-08-25 2008-04-10 ジェネンテック・インコーポレーテッド 新規な遺伝子破壊、これに関する組成物と方法
WO2006059691A1 (ja) * 2004-12-03 2006-06-08 Astellas Pharma Inc. 抗肥満薬のスクリーニング方法
WO2006066071A2 (en) * 2004-12-17 2006-06-22 Mayo Foundation For Medical Education And Research Prognosis of renal cell carcinoma
US20080213253A1 (en) * 2007-01-12 2008-09-04 Dyax Corp. Combination therapy for the treatment of cancer
US20090104210A1 (en) * 2007-10-17 2009-04-23 Tota Michael R Peptide compounds for treating obesity and insulin resistance
WO2009158432A2 (en) 2008-06-27 2009-12-30 Amgen Inc. Ang-2 inhibition to treat multiple sclerosis
US10288617B2 (en) 2009-10-26 2019-05-14 Externautics Spa Ovary tumor markers and methods of use thereof
US8921058B2 (en) 2009-10-26 2014-12-30 Externautics Spa Prostate tumor markers and methods of use thereof
EP2494351B1 (en) * 2009-10-26 2016-06-08 Externautics S.p.A. Colon and rectal tumor markers and methods of use thereof
KR101109486B1 (ko) * 2009-10-29 2012-01-31 현대제철 주식회사 크레인 그래브용 체결장치

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Publication number Priority date Publication date Assignee Title
US5955291A (en) * 1992-01-09 1999-09-21 Alitalo; Kari Antibodies recognizing tie receptor tyrosine kinase and uses thereof
AU3353293A (en) * 1992-01-09 1993-08-03 Helsinki University Holding, Ltd. Tie, a novel endothelial cell receptor tyrosine kinase
AU4651893A (en) * 1992-06-26 1994-01-24 Immunex Corporation Novel tyrosine kinase
WO1995013387A1 (en) * 1993-11-12 1995-05-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Tie-2, a novel receptor tyrosine kinase
US5643755A (en) * 1994-10-07 1997-07-01 Regeneron Pharmaceuticals Inc. Nucleic acid encoding tie-2 ligand
AUPM379494A0 (en) * 1994-02-10 1994-03-03 Ludwig Institute For Cancer Research Immunointeractive molecules - ii
JPH10506011A (ja) * 1994-09-22 1998-06-16 ヘルシンキ、ユニバーシティ、ライセンシング、リミテッド、オサケ、ユキチュア レセプターチロシンキナーゼ、ｔｉｅのプロモーター
US5650490A (en) * 1994-10-07 1997-07-22 Regeneron Pharmaceuticals, Inc. Tie-2 ligand 2
US5814464A (en) 1994-10-07 1998-09-29 Regeneron Pharma Nucleic acids encoding TIE-2 ligand-2
WO1996012269A1 (en) * 1994-10-13 1996-04-25 The Boeing Company Jet engine fan noise reduction system utilizing electro pneumatic transducers
ATE273384T1 (de) * 1995-04-06 2004-08-15 Regeneron Pharma Tie-2 liganden, herstellungsverfahren und verwendung
DE69720241T2 (de) * 1996-06-19 2003-12-11 Regeneron Pharma Ligand (tie ligand-4) vom tie-2 rezeptor und dessen verwendungen
US5851797A (en) * 1996-06-19 1998-12-22 Regeneron Pharmaceuticals, Inc. Tie ligand-3, methods of making and uses thereof
US5972338A (en) 1997-09-19 1999-10-26 Genentech, Inc. Tie ligands homologues
US6057435A (en) 1997-09-19 2000-05-02 Genentech, Inc. Tie ligand homologues
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues

Also Published As

Publication number Publication date
JP2004113239A (ja) 2004-04-15
US6057435A (en) 2000-05-02
US6413770B1 (en) 2002-07-02
KR100692336B1 (ko) 2007-03-14
WO1999015653A2 (en) 1999-04-01
CA2304129A1 (en) 1999-04-01
JP2001517437A (ja) 2001-10-09
KR100692335B1 (ko) 2007-03-13
ATE327329T1 (de) 2006-06-15
JP2004097224A (ja) 2004-04-02
IL134648A (en) 2007-08-19
ES2268790T3 (es) 2007-03-16
AU9388098A (en) 1999-04-12
KR100692334B1 (ko) 2007-03-14
KR20060060062A (ko) 2006-06-02
US6551822B1 (en) 2003-04-22
DK1015585T3 (da) 2006-10-02
AU756449B2 (en) 2003-01-16
KR20060060061A (ko) 2006-06-02
DE69834649D1 (de) 2006-06-29
EP1015585B1 (en) 2006-05-24
WO1999015653A3 (en) 1999-05-20
DE69834649T2 (de) 2007-05-03
CY1105161T1 (el) 2009-11-04
EP1724349A1 (en) 2006-11-22
EP1015585A2 (en) 2000-07-05
EP1696029A1 (en) 2006-08-30
NZ502946A (en) 2001-11-30
KR20060060060A (ko) 2006-06-02
IL134648A0 (en) 2001-04-30
JP2004129656A (ja) 2004-04-30
KR20010024146A (ko) 2001-03-26
EP1696030A1 (en) 2006-08-30
KR100692333B1 (ko) 2007-03-14

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