SG11201803145RA - Methods and compositions for inducing hematopoietic cell differentiation - Google Patents
Methods and compositions for inducing hematopoietic cell differentiationInfo
- Publication number
- SG11201803145RA SG11201803145RA SG11201803145RA SG11201803145RA SG11201803145RA SG 11201803145R A SG11201803145R A SG 11201803145RA SG 11201803145R A SG11201803145R A SG 11201803145RA SG 11201803145R A SG11201803145R A SG 11201803145RA SG 11201803145R A SG11201803145R A SG 11201803145RA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- methods
- cell differentiation
- hematopoietic cell
- inducing hematopoietic
- Prior art date
Links
- 230000024245 cell differentiation Effects 0.000 title 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
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Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016211671B2 (en) | 2015-01-26 | 2022-05-26 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
SG10201913767VA (en) | 2015-05-04 | 2020-03-30 | Cytomx Therapeutics Inc | Anti-cd166 antibodies, activatable anti-cd166 antibodies, and methods of use thereof |
WO2017015320A1 (en) | 2015-07-21 | 2017-01-26 | Children's Medical Center Corporation | Pd-l1 expressing hematopoietic stem cells and uses |
CA3003150A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
CN108473961B (en) * | 2015-11-04 | 2022-11-29 | 菲特治疗公司 | Methods and compositions for inducing hematopoietic cell differentiation |
EP3405568A4 (en) | 2016-01-20 | 2019-12-04 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
CA3013357A1 (en) | 2016-02-01 | 2017-08-10 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
JP7058223B2 (en) * | 2016-04-15 | 2022-04-21 | メモリアル スローン ケタリング キャンサー センター | Transgenic T cells and chimeric antigen receptor T cell compositions and related methods |
US11525119B2 (en) | 2016-09-06 | 2022-12-13 | The Children's Medical Center Corporation | Immune cells derived from induced pluripotent stem cell |
JP7098615B2 (en) | 2016-12-05 | 2022-07-11 | フェイト セラピューティクス,インコーポレイテッド | Compositions and Methods for Immune Cell Regulation in Adoptive Cell Transfer |
US11913022B2 (en) | 2017-01-25 | 2024-02-27 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
CN110691844B (en) * | 2017-02-07 | 2023-09-08 | 新加坡科技研究局 | Methods and kits for generating simulated innate immune cells from pluripotent stem cells |
JP2020507349A (en) | 2017-02-09 | 2020-03-12 | インダプタ セラピューティクス インコーポレイテッド | Engineered natural killer (NK) cells and compositions and methods thereof |
US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
AU2018234827B2 (en) | 2017-03-15 | 2024-04-04 | Orca Biosystems Inc. | Compositions and methods for hematopoietic stem cell transplants |
US11414648B2 (en) | 2017-03-24 | 2022-08-16 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
SG11201909795RA (en) * | 2017-04-26 | 2019-11-28 | Univ Kyoto | Hematopoietic progenitor cell marker |
EA202090247A1 (en) | 2017-07-14 | 2020-05-12 | Цитомкс Терапьютикс, Инк. | ANTIBODIES AGAINST CD166 AND THEIR APPLICATION |
CN111194349A (en) * | 2017-08-08 | 2020-05-22 | 桑格摩生物治疗股份有限公司 | Chimeric antigen receptor mediated cell targeting |
KR102167548B1 (en) * | 2017-09-21 | 2020-10-19 | 한국생명공학연구원 | A method for producing natural killer cells and uses thereof |
WO2019060708A1 (en) | 2017-09-22 | 2019-03-28 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
CA3077344A1 (en) * | 2017-09-29 | 2019-04-04 | Regents Of The University Of Minnesota | Methods of making, expanding, and using a human progenitor t cell |
EP3728563A4 (en) | 2017-12-22 | 2021-11-10 | Fate Therapeutics, Inc. | Enhanced immune effector cells and use thereof |
EP3740566A4 (en) * | 2018-01-18 | 2021-10-27 | Agency for Science, Technology and Research | Method for differentiation of human pluripotent stem cell lines in suspension culture |
WO2019195800A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Novel differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
WO2019212691A1 (en) * | 2018-04-30 | 2019-11-07 | Cedars-Sinai Medical Center | Diagnostic and drug screening for molecular signatures of early onset sporadic parkinson's disease |
WO2020027094A1 (en) * | 2018-07-31 | 2020-02-06 | サイアス株式会社 | METHOD FOR PRODUCING REGENERATED T CELL POPULATION VIA iPS CELLS |
US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
CN109266618B (en) * | 2018-10-18 | 2021-04-23 | 赛元生物科技(杭州)有限公司 | Macrophage capable of targeting tumor cells and preparation method thereof |
US20220143084A1 (en) | 2019-02-15 | 2022-05-12 | Editas Medicine, Inc. | Modified natural killer (nk) cells for immunotherapy |
KR20220004126A (en) * | 2019-04-26 | 2022-01-11 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | Generation of functional and patient-specific thymic tissue in vivo from induced pluripotent stem cells |
CA3139836A1 (en) * | 2019-05-09 | 2020-11-12 | Figene, Llc | Fibroblast generated patient-specific vaccines |
CN110106144B (en) * | 2019-05-17 | 2021-10-08 | 苏州大学 | Method and kit for inducing hematopoietic stem cells to differentiate into pre-T-lineage cells |
WO2021024170A1 (en) * | 2019-08-05 | 2021-02-11 | Voloshin Sela Tali | Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity |
CN114341349A (en) * | 2019-08-20 | 2022-04-12 | 艾达普特免疫有限公司 | Hematopoietic induction medium |
GB201911953D0 (en) * | 2019-08-20 | 2019-10-02 | Adaptimmune Ltd | T cell production fram RAG inacivated iPSCs |
GB201911957D0 (en) * | 2019-08-20 | 2019-10-02 | Adaptimmune Ltd | Methods of producing haemogenic progenitor cells from pluripotent stem cells |
MX2022004080A (en) * | 2019-10-07 | 2022-07-27 | Fate Therapeutics Inc | Enhanced chimeric antigen receptor for immune effector cell engineering and use thereof. |
US20240131156A1 (en) * | 2019-10-17 | 2024-04-25 | Fate Therapeutics, Inc. | Enhanced chimeric antigen receptor for immune effector cell engineering and use thereof |
AU2020382287A1 (en) * | 2019-11-13 | 2022-06-02 | Karis Bio Inc. | Method of isolation of pure culture of vascular endothelial cells, medium for maintaining characteristics of vascular endothelial cells, and culture method including same |
MX2022005892A (en) * | 2019-11-14 | 2022-06-14 | Amgen Inc | Hematopoietic precursor cell production. |
CN115135754A (en) * | 2020-02-28 | 2022-09-30 | 普渡研究基金会 | Generation of aortal-gonadal-mesonephroid hematopoietic cells from human pluripotent stem cells under defined conditions |
JP2023516632A (en) * | 2020-02-28 | 2023-04-20 | 武田薬品工業株式会社 | Method for producing natural killer cells from pluripotent stem cells |
CA3173124A1 (en) * | 2020-04-06 | 2021-10-14 | Kyle M. LOH | Generating populations of human blood and blood vessel progenitors from pluripotent stem cells |
JP2023522715A (en) * | 2020-04-21 | 2023-05-31 | インティマ バイオサイエンス, インコーポレイテッド | Cell vaccine platform and usage |
CN111808812B (en) * | 2020-08-31 | 2020-12-15 | 首都医科大学附属北京友谊医院 | Material and method for differentiation of pluripotent stem cells into hematopoietic stem cells |
JP2023543248A (en) * | 2020-09-24 | 2023-10-13 | ▲広▼州▲輯▼因医▲療▼科技有限公司 | Use of compounds to improve human hematopoietic stem cell transplantation efficiency |
CN112119977B (en) * | 2020-10-15 | 2021-10-19 | 中国人民解放军军事科学院军事医学研究院 | Construction method and application of mouse model of depression and memory impairment induced by CD317 |
EP4232567A1 (en) | 2020-10-26 | 2023-08-30 | Shoreline Biosciences, Inc. | Methods of inducing antibody-dependent cellular cytotoxicity (adcc) using modified natural killer (nk) cells |
CN114525257A (en) * | 2020-10-30 | 2022-05-24 | 未来智人再生医学研究院(广州)有限公司 | Pluripotent stem cell expressing Tim-3 blocker or derivative thereof and application |
TW202237826A (en) | 2020-11-30 | 2022-10-01 | 瑞士商克里斯珀醫療股份公司 | Gene-edited natural killer cells |
US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
CN116635064A (en) | 2020-12-18 | 2023-08-22 | 世纪治疗股份有限公司 | Chimeric antigen receptor systems with adaptive receptor specificity |
WO2022144632A1 (en) * | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
EP4293107A1 (en) * | 2021-02-05 | 2023-12-20 | Sungkwang Medical Foundation | Method for differentiating pluripotent stem cell-derived hemogenic endothelial cells into lymphoid lineage cells |
KR20220113586A (en) * | 2021-02-05 | 2022-08-16 | 의료법인 성광의료재단 | Method for producing gene-edited cells using pluripotent stem cell-derived hemogenic endothelial cells |
GB202102297D0 (en) * | 2021-02-18 | 2021-04-07 | Adaptimmune Ltd | Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells |
CN112831461B (en) * | 2021-02-26 | 2023-08-08 | 澳门大学 | Method and medicine for inducing stem cells to differentiate into mesoderm lineage or trophoblast lineage |
EP4326852A1 (en) * | 2021-04-22 | 2024-02-28 | Artec Biotech, Inc. | Method for producing hematopoietic cells from stem cells using vascular organoids |
EP4351599A1 (en) * | 2021-05-14 | 2024-04-17 | Appia Bio, Inc. | Production of engineered t cells from stem cells |
EP4355861A1 (en) * | 2021-06-15 | 2024-04-24 | Takeda Pharmaceutical Company Limited | Method for producing natural killer cells from pluripotent stem cells |
CN117836405A (en) * | 2021-08-13 | 2024-04-05 | 先声创新公司 | Three-dimensional culture of pluripotent stem cells to produce hematopoietic stem cells |
CA3227202A1 (en) * | 2021-08-19 | 2023-02-23 | Cedars-Sinai Medical Center | Ipsc-derived immune cells in prophylaxis and treatment of age-associated and neurodegenerative diseases |
KR20230038628A (en) * | 2021-09-10 | 2023-03-21 | 의료법인 성광의료재단 | A method for producing pluripotent stem cell-derived hematopoietic stem cells and a method for producing a humanized mouse model using the prepared hematopoietic stem cells |
WO2023138680A1 (en) * | 2022-01-20 | 2023-07-27 | 科济生物医药(上海)有限公司 | Method for inducing cell differentiation |
CN114350608B (en) * | 2022-01-27 | 2024-05-28 | 昭泰英基生物医药(香港)有限公司 | Composition for inducing T cells to be reprogrammed into NK-like cells and application thereof |
CN114702591B (en) * | 2022-05-17 | 2022-09-23 | 诺赛联合(北京)生物医学科技有限公司 | Preparation technology of adult cell-derived organoid |
CN114774365B (en) * | 2022-06-16 | 2022-08-23 | 呈诺再生医学科技(北京)有限公司 | Method for obtaining CD34+ cells and NK cells by inducing iPSC differentiation and application thereof |
KR20230173249A (en) | 2022-06-16 | 2023-12-27 | 대한민국(질병관리청 국립보건연구원장) | DUSP6 deficient stem cells and their use |
WO2023246820A1 (en) * | 2022-06-20 | 2023-12-28 | 上海优替济生生物医药有限公司 | Compound for inducing stem cell-like memory cell in vitro, and application thereof |
WO2023247722A1 (en) * | 2022-06-22 | 2023-12-28 | Fondazione Telethon Ets | Method for isolating hemogenic endothelial cells |
CN114958771B (en) * | 2022-06-27 | 2023-12-05 | 广东康盾创新产业集团股份公司 | Preparation method of IPSC-CAR-NK cells |
WO2024020587A2 (en) | 2022-07-22 | 2024-01-25 | Tome Biosciences, Inc. | Pleiopluripotent stem cell programmable gene insertion |
WO2024036105A2 (en) * | 2022-08-11 | 2024-02-15 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Method for generating cells of the t cell lineage with engineering broadly reactive human notch ligand |
WO2024059070A1 (en) * | 2022-09-13 | 2024-03-21 | R.P. Scherer Technologies, Llc | Method of differentiation of pluripotent stem cells to hematopoietic precursor and stem cells |
WO2024059584A1 (en) * | 2022-09-14 | 2024-03-21 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
WO2024101919A1 (en) * | 2022-11-10 | 2024-05-16 | 의료법인 성광의료재단 | Medium composition for inducing differentiation from pluripotent stem cells into natural killer cells and differentiation method using same |
CN116445408B (en) * | 2023-05-22 | 2024-02-02 | 呈诺再生医学科技(北京)有限公司 | Use of LSD1 inhibitors to promote iPSC differentiation to HSCs and maintenance of HSC dryness |
CN116574672B (en) * | 2023-07-11 | 2023-10-20 | 北京北启生物医药有限公司 | Culture medium and method for inducing differentiation of chemically induced pluripotent stem cells into hematogenic endothelial cells |
CN117050941B (en) * | 2023-10-11 | 2024-01-26 | 苏州艾凯利元生物科技有限公司 | Method for preparing natural killer cells |
CN117050940B (en) * | 2023-10-11 | 2024-01-26 | 苏州艾凯利元生物科技有限公司 | Method for preparing natural killer cells |
CN117106714B (en) * | 2023-10-11 | 2024-01-26 | 苏州艾凯利元生物科技有限公司 | Method for preparing B cells |
Family Cites Families (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
WO1998056913A1 (en) | 1997-06-13 | 1998-12-17 | Ludwig Institute For Cancer Research | Smad6 and uses thereof |
ATE277895T1 (en) | 1997-07-01 | 2004-10-15 | Warner Lambert Co | 4-BROMINE OR 4-IODINE-PHENYLAMINO-BENZHYDROXAMIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS |
US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
MXPA02008265A (en) | 2000-02-24 | 2004-09-10 | Xcyte Therapies Inc | Simultaneous stimulation and concentration of cells. |
US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
US6960614B2 (en) | 2000-07-19 | 2005-11-01 | Warner-Lambert Company | Oxygenated esters of 4-lodo phenylamino benzhydroxamic acids |
JP2002060786A (en) | 2000-08-23 | 2002-02-26 | Kao Corp | Germicidal stainproofing agent for hard surface |
US6689744B2 (en) | 2000-09-22 | 2004-02-10 | Genentech, Inc. | Notch receptor agonists and uses |
WO2002059285A1 (en) | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
US20040224385A1 (en) | 2001-08-20 | 2004-11-11 | Barbas Carlos F | Zinc finger binding domains for cnn |
US7700572B2 (en) | 2001-11-02 | 2010-04-20 | Giuliani International, Ltd. | SMAD7 inhibitors for the treatment of CNS diseases |
US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
ES2407849T3 (en) | 2002-03-13 | 2013-06-14 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US7575925B2 (en) | 2002-12-10 | 2009-08-18 | Sunnybrook Health Sciences Centre | Cell preparations comprising cells of the T cell lineage and methods of making and using them |
US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
DE602004031037D1 (en) | 2003-11-19 | 2011-02-24 | Array Biopharma Inc | HETEROCYCLIC INHIBITORS OF MEK |
US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
EP3363907A1 (en) | 2004-05-27 | 2018-08-22 | The Trustees of the University of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
US20070036769A9 (en) | 2004-06-03 | 2007-02-15 | Linheng Li | BMP pathway methods and compositions |
MY149960A (en) | 2005-05-18 | 2013-11-15 | Array Biopharma Inc | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases |
JPWO2007088651A1 (en) | 2006-02-01 | 2009-06-25 | 国立大学法人 東京大学 | Combination use of TGF-β signal inhibitor and antitumor agent |
CN101495623B (en) | 2006-03-24 | 2013-09-11 | 儿童医疗中心有限公司 | Method to modulate hematopoietic stem cell growth |
AU2007271964B2 (en) | 2006-07-14 | 2012-01-19 | Novartis Ag | Pyrimidine derivatives as ALK-5 inhibitors |
WO2008094597A2 (en) | 2007-01-30 | 2008-08-07 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc) |
WO2008121420A1 (en) | 2007-03-30 | 2008-10-09 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes |
WO2009091826A2 (en) | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
WO2009097140A1 (en) | 2008-01-30 | 2009-08-06 | Memorial Sloan-Kettering Cancer Center | Methods for off -the -shelf tumor immunotherapy using allogeneic t-cell precursors |
WO2009104825A1 (en) * | 2008-02-18 | 2009-08-27 | Kaist | Method for inducing the defferentiation of embryonic stem cells into hemangioblast |
AU2009322346B2 (en) | 2008-12-03 | 2015-07-02 | The Scripps Research Institute | Stem cell cultures |
WO2010087594A2 (en) | 2009-01-28 | 2010-08-05 | 한국생명공학연구원 | Cd93 or use of soluble fragment thereof |
CA2753208C (en) * | 2009-02-20 | 2018-08-21 | Cellular Dynamics International, Inc. | Methods and compositions for the differentiation of stem cells |
CA2753679C (en) | 2009-02-27 | 2021-03-02 | Cellular Dynamics International, Inc. | Differentiation of pluripotent cells |
EP2419511B1 (en) | 2009-04-09 | 2018-01-17 | Sangamo Therapeutics, Inc. | Targeted integration into stem cells |
EP3235901B1 (en) | 2009-10-16 | 2022-12-21 | The Scripps Research Institute | Induction of pluripotent cells |
EP2510096B2 (en) | 2009-12-10 | 2018-02-07 | Regents of the University of Minnesota | Tal effector-mediated dna modification |
JPWO2011096482A1 (en) | 2010-02-03 | 2013-06-13 | 国立大学法人 東京大学 | Immune function reconstruction using pluripotent stem cells |
US9206394B2 (en) | 2010-02-03 | 2015-12-08 | The University Of Tokyo | Method for reconstructing immune function using pluripotent stem cells |
JP5777115B2 (en) * | 2010-03-18 | 2015-09-09 | 国立大学法人京都大学 | Differentiation induction method from pluripotent stem cells to mesoderm cells |
EP2580320B1 (en) | 2010-06-14 | 2018-08-01 | The Scripps Research Institute | Reprogramming of cells to a new fate |
CA2802249A1 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
JP6050230B2 (en) | 2010-07-21 | 2016-12-21 | サンガモ バイオサイエンシーズ, インコーポレイテッド | Methods and compositions for modification of HLA loci |
CN108531444A (en) | 2010-08-05 | 2018-09-14 | 威斯康星校友研究基金会 | Simplification basal medium for people's pluripotent cell culture |
ES2654994T3 (en) * | 2010-08-12 | 2018-02-15 | Fate Therapeutics, Inc. | Enhanced therapy with stem cells and hematopoietic precursors |
US9181529B2 (en) | 2010-10-19 | 2015-11-10 | Cellular Dynamics International, Inc. | Titration of differentiation medium components |
AU2011349446C1 (en) | 2010-12-22 | 2016-01-21 | Fate Therapauetics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
US8700106B2 (en) | 2011-03-09 | 2014-04-15 | Universal Electronics Inc. | System and method for provision of infrared signalling in smart phone devices |
CN102732483B (en) * | 2011-03-31 | 2014-12-03 | 北京大学 | Preparation method for hematopoietic progenitor cells and special medium for same |
US20130071414A1 (en) | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
JP2014520551A (en) | 2011-07-11 | 2014-08-25 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | Cell reprogramming method and genome modification method |
JP5872041B2 (en) * | 2011-08-16 | 2016-03-01 | サムスン ライフ パブリック ウェルフェア ファンデーション | Composition for promoting neurogenesis comprising stem cell-derived microvesicles |
WO2013028684A1 (en) * | 2011-08-23 | 2013-02-28 | Wisconsin Alumni Research Foundation | Angiohematopoietic progenitor cells |
CN102329769B (en) * | 2011-09-28 | 2013-07-31 | 浙江大学 | Method for obtaining hematopoietic stem cells |
US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
US9834754B2 (en) * | 2011-11-21 | 2017-12-05 | University Health Network | Populations of hematopoietic progenitors and methods of enriching stem cells therefor |
JP6220791B2 (en) | 2011-12-02 | 2017-10-25 | フェイト セラピューティクス,インコーポレイテッド | Enhanced stem cell composition |
EP2788475A1 (en) * | 2011-12-05 | 2014-10-15 | Primorigen Biosciences Inc. | Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof |
CA2858069C (en) | 2011-12-08 | 2020-02-11 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
EP2606884A1 (en) | 2011-12-21 | 2013-06-26 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Inhibitors of notch signaling pathway and use thereof in treatment of cancers |
ES2641840T3 (en) * | 2012-02-24 | 2017-11-14 | Fred Hutchinson Cancer Research Center | Compositions and methods for the treatment of hemoglobinopathies |
EP4253409A3 (en) | 2012-04-17 | 2023-12-06 | University of Washington through its Center for Commercialization | Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof |
EP3839050A3 (en) | 2012-04-18 | 2021-09-29 | The Board of Trustees of the Leland Stanford Junior University | Non-disruptive gene targeting |
EP3567102A1 (en) | 2012-04-24 | 2019-11-13 | Dan S. Kaufman | Method for developing natural killer cells from stem cells |
JP6164746B2 (en) * | 2012-05-22 | 2017-07-19 | 国立大学法人 東京大学 | Method for producing antigen-specific T cells |
WO2013176916A1 (en) | 2012-05-25 | 2013-11-28 | Roman Galetto | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
US20150148292A1 (en) | 2012-07-09 | 2015-05-28 | Emory University | Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto |
CN112430580A (en) | 2012-10-02 | 2021-03-02 | 纪念斯隆-凯特琳癌症中心 | Compositions and methods for immunotherapy |
JP6494515B2 (en) | 2012-10-19 | 2019-04-03 | エージェンシー フォー サイエンス, テクノロジー アンド リサーチ | Method for differentiating stem cells into one or more cell lineages |
US9382531B2 (en) * | 2012-10-22 | 2016-07-05 | Wisconsin Alumni Research Foundation | Induction of hemogenic endothelium from pluripotent stem cells |
EP2929017A4 (en) | 2012-12-05 | 2016-09-28 | Sangamo Biosciences Inc | Methods and compositions for regulation of metabolic disorders |
ES2896354T3 (en) | 2012-12-21 | 2022-02-24 | Astellas Inst For Regenerative Medicine | Methods for the production of platelets from pluripotent stem cells |
SG11201507275TA (en) * | 2013-03-13 | 2015-10-29 | Wisconsin Alumni Res Found | Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions |
NZ712693A (en) | 2013-03-15 | 2021-07-30 | Memorial Sloan Kettering Cancer Center | Compositions and methods for immunotherapy |
US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
AU2014248119B2 (en) | 2013-04-03 | 2019-06-20 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted T-cells derived from pluripotent stem cells |
WO2014165825A2 (en) * | 2013-04-04 | 2014-10-09 | President And Fellows Of Harvard College | Therapeutic uses of genome editing with crispr/cas systems |
US9381210B2 (en) * | 2013-04-15 | 2016-07-05 | Wisconsin Alumni Research Foundation | Induced pluripotent stem cell model of chronic myeloid leukemia revealed olfactomedin 4 as a novel therapeutic target in leukemia stem cells |
WO2014200030A1 (en) * | 2013-06-12 | 2014-12-18 | 国立大学法人京都大学 | Induced pluripotent stem cell selection method and method for inducing differentiation to blood cells |
CN103361310B (en) * | 2013-06-25 | 2015-09-23 | 中国人民解放军军事医学科学院野战输血研究所 | Substratum, test kit and uses thereof |
WO2015057976A1 (en) | 2013-10-17 | 2015-04-23 | Sangamo Biosciences, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells |
US9932607B2 (en) | 2013-11-15 | 2018-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Site-specific integration of transgenes into human cells |
EP3805369A1 (en) | 2014-03-04 | 2021-04-14 | Fate Therapeutics, Inc. | Improved reprogramming methods and cell culture platforms |
AU2015235852B2 (en) | 2014-03-28 | 2019-08-15 | Regents Of The University Of Minnesota | Polypeptides, cells, and methods involving engineered CD16 |
CN103937743B (en) * | 2014-04-27 | 2017-12-01 | 浙江大学 | A kind of method that candidate stem cell is obtained using three-dimensional inducible system |
EP3770252A1 (en) | 2015-01-26 | 2021-01-27 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
AU2016211671B2 (en) | 2015-01-26 | 2022-05-26 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
CN104745529B (en) * | 2015-03-13 | 2019-03-05 | 华南生物医药研究院 | Leptin is divided into purposes and its application in hematopoietic stem/progenitor in inducing embryo stem cell |
US20170020922A1 (en) * | 2015-07-16 | 2017-01-26 | Batu Biologics Inc. | Gene editing for immunological destruction of neoplasia |
CN108601821B (en) | 2015-10-05 | 2023-09-19 | 精密生物科学公司 | Genetically modified cells comprising modified human T cell receptor alpha constant region genes |
CN108473961B (en) * | 2015-11-04 | 2022-11-29 | 菲特治疗公司 | Methods and compositions for inducing hematopoietic cell differentiation |
CA3003150A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
US11136547B2 (en) | 2016-03-23 | 2021-10-05 | Kyoto University | Mesoderm induction method having high blood cell differentiation capacity |
JP7058223B2 (en) | 2016-04-15 | 2022-04-21 | メモリアル スローン ケタリング キャンサー センター | Transgenic T cells and chimeric antigen receptor T cell compositions and related methods |
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US20210222126A1 (en) | 2021-07-22 |
US10947505B2 (en) | 2021-03-16 |
EP3371301A1 (en) | 2018-09-12 |
CN108473961A (en) | 2018-08-31 |
US20180320137A1 (en) | 2018-11-08 |
AU2016348342B2 (en) | 2023-07-06 |
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