BR9914465A - Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células - Google Patents

Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células

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Publication number
BR9914465A
BR9914465A BR9914465-4A BR9914465A BR9914465A BR 9914465 A BR9914465 A BR 9914465A BR 9914465 A BR9914465 A BR 9914465A BR 9914465 A BR9914465 A BR 9914465A
Authority
BR
Brazil
Prior art keywords
differentiation
cell population
cells
proliferation
pharmaceutical composition
Prior art date
Application number
BR9914465-4A
Other languages
English (en)
Inventor
Tony Peled
Eitan Fibach
Avi Treves
Original Assignee
Gamida Cell Ltd
Hadasit Med Res Service
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1999/002664 external-priority patent/WO1999040783A1/en
Application filed by Gamida Cell Ltd, Hadasit Med Res Service filed Critical Gamida Cell Ltd
Publication of BR9914465A publication Critical patent/BR9914465A/pt

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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Abstract

"MéTODOS PARA CONTROLAR A PROLIFERAçãO E A DIFERENCIAçãO DE CELúLAS-TRONCO E CéLULAS PROGENITORAS E UMA COMPOSIçãO FARMACêUTICA PARA INDUZIR A DIFERENCIAçãO EM UMA POPULAçãO DE CéLULAS", compreendendo um método para expandir a população de células, inibindo ao mesmo tempo a diferenciação das células, o método incluindo o passo de prover as células com condições para proliferação de células e, ao mesmo tempo, de reduzir a capacidade das células em utilizar o cobre. O método pode ser executado tanto in-vivo como ex-vivo. Um método para induzir a diferenciação numa população de células, o método incluindo o passo de prover as células com um quelator metálico de transição que liga o cobre e que é efetivo em induzir a diferenciação das células.
BR9914465-4A 1998-09-29 1999-08-17 Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células BR9914465A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16165998A 1998-09-29 1998-09-29
PCT/US1999/002664 WO1999040783A1 (en) 1998-02-17 1999-02-08 Method of controlling proliferation and differentiation of stem and progenitor cells
PCT/IL1999/000444 WO2000018885A1 (en) 1998-09-29 1999-08-17 Methods of controlling proliferation and differentiation of stem and progenitor cells

Publications (1)

Publication Number Publication Date
BR9914465A true BR9914465A (pt) 2001-10-09

Family

ID=26795414

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914465-4A BR9914465A (pt) 1998-09-29 1999-08-17 Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células

Country Status (8)

Country Link
US (4) US7429489B2 (pt)
EP (1) EP1117762A4 (pt)
JP (1) JP2003523166A (pt)
AU (2) AU770896C (pt)
BR (1) BR9914465A (pt)
CA (1) CA2344653A1 (pt)
IL (2) IL142094A0 (pt)
WO (1) WO2000018885A1 (pt)

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US20120328526A1 (en) * 2011-06-27 2012-12-27 University Of Maryland, Baltimore Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof
US20150064273A1 (en) 2012-02-13 2015-03-05 Gamida-Cell Ltd. Mesenchymal Stem Cells Conditioned Medium and Methods of Generating and Using the Same
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CA2344653A1 (en) 2000-04-06
US20050118150A1 (en) 2005-06-02
US20110045589A1 (en) 2011-02-24
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US7429489B2 (en) 2008-09-30
US20050214262A1 (en) 2005-09-29
US7312078B2 (en) 2007-12-25
AU2004201623A1 (en) 2004-05-13
AU2004201623B2 (en) 2006-04-27
AU5299899A (en) 2000-04-17
US8202724B2 (en) 2012-06-19
JP2003523166A (ja) 2003-08-05
IL142094A (en) 2006-07-05
WO2000018885A1 (en) 2000-04-06
US7855075B2 (en) 2010-12-21
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AU770896C (en) 2006-09-07
EP1117762A4 (en) 2004-02-25

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