ES2056854T3 - Tiadiazinonas. - Google Patents
Tiadiazinonas.Info
- Publication number
- ES2056854T3 ES2056854T3 ES88108308T ES88108308T ES2056854T3 ES 2056854 T3 ES2056854 T3 ES 2056854T3 ES 88108308 T ES88108308 T ES 88108308T ES 88108308 T ES88108308 T ES 88108308T ES 2056854 T3 ES2056854 T3 ES 2056854T3
- Authority
- ES
- Spain
- Prior art keywords
- tiadiazinonas
- tiadiazinones
- formula
- treatment
- cardiovascular diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
LAS TIADIAZINONAS DE FORMULA (I) DONDE A, R1 A R6 Y Z TIENEN EL SIGNIFICADO QUE SE INDICA EN LA REIVINDICACION DE PATENTE I, POSEEN ACTIVIDADES POSITIVAS Y RESULTAN ADECUADAS PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873719031 DE3719031A1 (de) | 1987-06-06 | 1987-06-06 | 5-(1,2,3,4-tetrahydrochinolyl)-3,6-dihydro-1,3,4-thiadiazin-2-one |
DE19873744149 DE3744149A1 (de) | 1987-12-24 | 1987-12-24 | 5-(2,3,4,5-tetrahydro-1h-1-benzazepinyl) -3,6-dihydro-1,3,4-thiadiazin-2-one |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2056854T3 true ES2056854T3 (es) | 1994-10-16 |
Family
ID=25856391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88108308T Expired - Lifetime ES2056854T3 (es) | 1987-06-06 | 1988-05-25 | Tiadiazinonas. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4916128A (es) |
EP (1) | EP0294647B1 (es) |
JP (1) | JP2694535B2 (es) |
KR (1) | KR970000953B1 (es) |
AU (1) | AU614965B2 (es) |
CA (1) | CA1340362C (es) |
DE (1) | DE3882444D1 (es) |
ES (1) | ES2056854T3 (es) |
HK (1) | HK43096A (es) |
HU (1) | HU207068B (es) |
IE (1) | IE62113B1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8901836D0 (en) * | 1989-01-27 | 1989-03-15 | Sobio Lab | Compounds |
DE4041074A1 (de) * | 1990-12-21 | 1992-06-25 | Merck Patent Gmbh | Thiadiazinonderivate |
DE4129062A1 (de) * | 1991-09-02 | 1993-03-04 | Merck Patent Gmbh | Verfahren zur enantiomerentrennung von 5-hetaryl-1,3,4-thiadiazinonen |
DE4134893A1 (de) * | 1991-10-23 | 1993-04-29 | Merck Patent Gmbh | Thiadiazinone |
TW218875B (es) * | 1992-03-09 | 1994-01-11 | Takeda Pharm Industry Co Ltd | |
US5462934A (en) * | 1992-03-09 | 1995-10-31 | Takeda Chemical Industries | Condensed heterocyclic ketone derivatives and their use |
DE4223537A1 (de) * | 1992-07-17 | 1994-01-20 | Merck Patent Gmbh | Thiadiazinone |
ES2199251T3 (es) | 1994-06-15 | 2004-02-16 | Otsuka Pharmaceutical Company, Limited | Derivados benzoheterociclicos utilizables como moduladores de vasopresina o de oxitocina. |
DE19500558A1 (de) * | 1995-01-11 | 1996-07-18 | Merck Patent Gmbh | 3-Alkoxycarbonyl-thiadiazinone |
DE19502699A1 (de) * | 1995-01-28 | 1996-08-01 | Merck Patent Gmbh | Arylalkyl-thiadiazinone |
DE19533975A1 (de) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
US6498154B1 (en) | 1999-05-04 | 2002-12-24 | Wyeth | Cyclic regimens using quinazolinone and benzoxazine derivatives |
US6358948B1 (en) * | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
US6417214B1 (en) | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
DE19929785A1 (de) * | 1999-06-29 | 2001-01-04 | Bayer Ag | Tetrahydrochinolinyl-6-methyldihydrothiadiazinon-Derivate und ihre Verwendung |
US20030153585A1 (en) * | 2000-01-13 | 2003-08-14 | Sven-Alexander Schreder | Pharmaceutical preparations containing 2-pyrrolidone as the dissolving intermediary |
WO2003060078A2 (en) * | 2001-12-21 | 2003-07-24 | X-Ceptor Therapeutics, Inc. | Heterocyclic modulators of nuclear receptors |
GB0224557D0 (en) * | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US7323455B2 (en) | 2004-03-24 | 2008-01-29 | Wyeth | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators |
US7741317B2 (en) * | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
CA2628570A1 (en) | 2005-11-09 | 2007-05-18 | Combinatorx, Incorporated | Methods, compositions, and kits for the treatment of medical conditions |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
EP2058308A1 (fr) * | 2007-11-12 | 2009-05-13 | Merck Sante | Dérivés de benzimidazoledihydrothiadiazinone comme inhibiteurs de fructose-1,6-biphosphatase et compositions pharmaceutiques les contenant. |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
JP6251038B2 (ja) | 2011-03-01 | 2017-12-20 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcアゴニストの調製方法 |
WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
AU2014218599C1 (en) | 2013-02-25 | 2018-09-06 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for use in colonic cleansing |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス,インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3172252D1 (en) * | 1980-11-14 | 1985-10-17 | Ici Plc | Heterocyclic compounds |
CA1199027A (en) * | 1981-11-12 | 1986-01-07 | Stuart D. Mills | Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone |
JPS61106574A (ja) * | 1984-10-29 | 1986-05-24 | Yoshitomi Pharmaceut Ind Ltd | オキサ(またはチア)ジアジン誘導体 |
EP0303418A3 (en) * | 1987-08-11 | 1990-11-07 | Smithkline Beecham Laboratoires Pharmaceutiques | Substituted indolones, useful in the treatment of heart or asthmatic diseases |
GB8816944D0 (en) * | 1988-07-15 | 1988-08-17 | Sobio Lab | Compounds |
-
1988
- 1988-05-20 AU AU16646/88A patent/AU614965B2/en not_active Expired
- 1988-05-25 DE DE8888108308T patent/DE3882444D1/de not_active Expired - Lifetime
- 1988-05-25 ES ES88108308T patent/ES2056854T3/es not_active Expired - Lifetime
- 1988-05-25 EP EP88108308A patent/EP0294647B1/de not_active Expired - Lifetime
- 1988-06-03 CA CA000568660A patent/CA1340362C/en not_active Expired - Fee Related
- 1988-06-03 HU HU882904A patent/HU207068B/hu not_active IP Right Cessation
- 1988-06-03 IE IE167788A patent/IE62113B1/en not_active IP Right Cessation
- 1988-06-04 KR KR1019880006762A patent/KR970000953B1/ko not_active IP Right Cessation
- 1988-06-06 US US07/202,294 patent/US4916128A/en not_active Expired - Lifetime
- 1988-06-06 JP JP63138265A patent/JP2694535B2/ja not_active Expired - Lifetime
-
1996
- 1996-03-14 HK HK43096A patent/HK43096A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0294647B1 (de) | 1993-07-21 |
EP0294647A3 (en) | 1989-07-05 |
IE881677L (en) | 1988-12-06 |
AU614965B2 (en) | 1991-09-19 |
KR890000475A (ko) | 1989-03-14 |
US4916128A (en) | 1990-04-10 |
JPS63310886A (ja) | 1988-12-19 |
EP0294647A2 (de) | 1988-12-14 |
HU207068B (en) | 1993-03-01 |
JP2694535B2 (ja) | 1997-12-24 |
AU1664688A (en) | 1988-12-08 |
HK43096A (en) | 1996-03-22 |
DE3882444D1 (de) | 1993-08-26 |
CA1340362C (en) | 1999-02-02 |
KR970000953B1 (ko) | 1997-01-21 |
IE62113B1 (en) | 1994-12-14 |
HUT51272A (en) | 1990-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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