ES2171543T3 - Composiciones administrables topicamente que contienen derivados del acido 3-benzoilfenilacetico para el tratamiento de trastornos inflamatorios oftalmicos. - Google Patents
Composiciones administrables topicamente que contienen derivados del acido 3-benzoilfenilacetico para el tratamiento de trastornos inflamatorios oftalmicos.Info
- Publication number
- ES2171543T3 ES2171543T3 ES95923733T ES95923733T ES2171543T3 ES 2171543 T3 ES2171543 T3 ES 2171543T3 ES 95923733 T ES95923733 T ES 95923733T ES 95923733 T ES95923733 T ES 95923733T ES 2171543 T3 ES2171543 T3 ES 2171543T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- inflammatory disorders
- optalmic
- compositions containing
- administrable compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE PRESENTAN NUEVOS DERIVADOS DE ESTER Y AMIDA DE ACIDO 3BENZOILFENILACETICO. TAMBIEN SE PRESENTA EL USO DE ESTOS DERIVADOS NUEVOS Y DE CIERTOS DERIVADOS CONOCIDOS EN COMPOSICIONES DE ADMINISTRACION TOPICA PARA EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS OFTALMICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/254,090 US5475034A (en) | 1994-06-06 | 1994-06-06 | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2171543T3 true ES2171543T3 (es) | 2002-09-16 |
Family
ID=22962892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95923733T Expired - Lifetime ES2171543T3 (es) | 1994-06-06 | 1995-06-06 | Composiciones administrables topicamente que contienen derivados del acido 3-benzoilfenilacetico para el tratamiento de trastornos inflamatorios oftalmicos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5475034A (es) |
EP (1) | EP0716600B1 (es) |
JP (1) | JP2866744B2 (es) |
KR (1) | KR100194242B1 (es) |
CN (1) | CN1088992C (es) |
AT (1) | ATE215366T1 (es) |
CA (1) | CA2167524C (es) |
DE (1) | DE69526183T2 (es) |
DK (1) | DK0716600T3 (es) |
ES (1) | ES2171543T3 (es) |
HK (1) | HK1012554A1 (es) |
MX (1) | MX9600487A (es) |
PT (1) | PT716600E (es) |
TW (1) | TW425382B (es) |
WO (1) | WO1995033457A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
US20030086899A1 (en) * | 2000-03-14 | 2003-05-08 | Jafari Masoud R. | Chondroitin sulfate containing viscoelastics for use in treating joints |
AR030346A1 (es) | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico |
AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
WO2002078681A2 (en) * | 2001-04-02 | 2002-10-10 | Alcon, Inc. | Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac |
US20040132773A1 (en) * | 2001-08-13 | 2004-07-08 | Gamache Daniel A | Method of treating neurodgenerative disorders of the retina and optic nerve head |
CN1649575A (zh) * | 2002-05-03 | 2005-08-03 | 爱尔康公司 | 用氨芬酸或奈帕芬胺治疗血管内皮生长因子介导的血管疾病的方法 |
EP1586316B1 (en) | 2003-01-21 | 2008-04-30 | Senju Pharmaceutical Co., Ltd. | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid |
US20030187072A1 (en) * | 2003-02-14 | 2003-10-02 | Kapin Michael A. | Method of treating angiogenesis-related disorders |
MXPA05012696A (es) * | 2003-06-13 | 2006-02-22 | Alcon Inc | Formulaciones de agentes antiinflamatorios no esteroides para tratar angiogenesis ocular patologica. |
ATE552838T1 (de) | 2003-11-14 | 2012-04-15 | Senju Pharma Co | Wässrige lösung mit aminoglykosid-antibiotikum und bromfenac |
US8372814B2 (en) | 2004-06-07 | 2013-02-12 | Ista Pharmaceuticals, Inc. | Ophthalmic formulations and uses thereof |
US8748402B2 (en) | 2004-06-07 | 2014-06-10 | Bausch & Lomb Pharma Holdings Corp. | Ophthalmic formulations and uses thereof |
TWI358290B (en) | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
PT1885336E (pt) * | 2005-05-10 | 2009-05-07 | Alcon Inc | Formulações de suspensão compreendendo um princípio activo, um tensoactivo poloxâmero ou meroxapol e um glicol, sua utilização no fabrico de um medicamento para tratamento de distúrbios oftálmicos |
CA2607014A1 (en) * | 2005-05-10 | 2006-11-16 | Alcon, Inc. | Suspension formulations of nepafenac and other ophthalmic drugs for topical treatment of ophthalmic disorders |
US20070254841A1 (en) * | 2006-01-25 | 2007-11-01 | Ophthalmic Research Associates, Inc. | Formulations and methods for treating dry eye |
US20100130580A1 (en) * | 2006-01-25 | 2010-05-27 | Aciex Therapeutics, Inc. | Formulations and Methods for Treating Dry Eye |
TW200812575A (en) * | 2006-04-28 | 2008-03-16 | Alcon Inc | Formulations containing amide derivatives of carboxylic acid NSAIDs for topical administration to the eye |
US20080153818A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for preventing inflammation during surgery |
US20090105245A1 (en) * | 2006-12-21 | 2009-04-23 | Bingaman David P | Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor |
WO2008080110A1 (en) * | 2006-12-21 | 2008-07-03 | Alcon, Inc. | Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor |
UY31058A1 (es) * | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Formulaciones de aminoacido n-halogenado con compuestos antiinflamatorios |
EP2160182A1 (en) * | 2007-05-24 | 2010-03-10 | Aciex Therapeutics, Inc. | Formulations and methods for treating dry eye |
MX337100B (es) * | 2007-10-05 | 2016-02-11 | Acucela Inc | Compuestos alcoxi para el tratamiento de enfermedades. |
WO2009073138A2 (en) * | 2007-11-30 | 2009-06-11 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with novel amides |
US20090239909A1 (en) * | 2008-03-24 | 2009-09-24 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with lactams |
CN102438979A (zh) * | 2009-03-12 | 2012-05-02 | 麦迪凯姆股份公司 | 苯甲酰基苯乙酰胺衍生物的新型晶体 |
WO2011003103A2 (en) | 2009-07-02 | 2011-01-06 | Acucela, Inc. | Pharmacology of visual cycle modulators |
DK2506831T3 (da) | 2009-12-03 | 2013-12-16 | Alcon Res Ltd | Carboxyvinylpolymerholdige nanopartikelsuspensioner |
US9630909B2 (en) | 2013-06-27 | 2017-04-25 | Mylan Laboratories Ltd | Process for the preparation of nepafenac |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1226344A (es) * | 1967-07-31 | 1971-03-24 | ||
CH577461A5 (es) * | 1975-08-13 | 1976-07-15 | Robins Co Inc A H | |
US4318949A (en) * | 1976-09-16 | 1982-03-09 | Toray Industries, Inc. | Composite nap sheet and process for preparing the same |
US4313949A (en) * | 1979-09-26 | 1982-02-02 | A. H. Robins Company, Inc. | Method of producing an inhibitory effect on blood platelet aggregation |
US4254146A (en) * | 1979-10-18 | 1981-03-03 | A. H. Robins Company, Inc. | 3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters |
IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
DE3026402A1 (de) * | 1980-07-11 | 1982-02-04 | Syntex Corp., Palo Alto, Calif. | Die verwendung analgetischer und nicht-hormonaler, entzuendungshemmender mittel bei der behandlung von mikrovaskulaeren erkrankungen |
US4503073A (en) * | 1981-01-07 | 1985-03-05 | A. H. Robins Company, Incorporated | 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids |
IL64724A0 (en) * | 1981-02-17 | 1982-03-31 | Robins Co Inc A H | 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them |
US4568695A (en) * | 1983-12-07 | 1986-02-04 | A. H. Robins Company, Incorporated | 2-Amino-3-benzoyl-phenethylalcohols and intermediates therefor |
US4851443A (en) * | 1985-03-14 | 1989-07-25 | Smith Kline Dauelsberg, Gmbh | Carboxylic acid amides, compositions and medical use thereof |
DE3668450D1 (de) * | 1985-03-14 | 1990-03-01 | Smithkline Dauelsberg | 5-aminosalicylsaeurederivate von nicht-steroidalen entzuendungshemmenden sauren. |
US4683242A (en) * | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
CA1325382C (en) * | 1988-01-27 | 1993-12-21 | Takahiro Ogawa | Locally administrable therapeutic composition for inflammatory disease |
-
1994
- 1994-06-06 US US08/254,090 patent/US5475034A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 WO PCT/US1995/007187 patent/WO1995033457A1/en active IP Right Grant
- 1995-06-06 JP JP8501284A patent/JP2866744B2/ja not_active Expired - Lifetime
- 1995-06-06 ES ES95923733T patent/ES2171543T3/es not_active Expired - Lifetime
- 1995-06-06 PT PT95923733T patent/PT716600E/pt unknown
- 1995-06-06 EP EP95923733A patent/EP0716600B1/en not_active Expired - Lifetime
- 1995-06-06 TW TW084105686A patent/TW425382B/zh not_active IP Right Cessation
- 1995-06-06 CA CA002167524A patent/CA2167524C/en not_active Expired - Lifetime
- 1995-06-06 MX MX9600487A patent/MX9600487A/es unknown
- 1995-06-06 DE DE69526183T patent/DE69526183T2/de not_active Expired - Lifetime
- 1995-06-06 CN CN95190521A patent/CN1088992C/zh not_active Expired - Lifetime
- 1995-06-06 KR KR1019960700563A patent/KR100194242B1/ko not_active IP Right Cessation
- 1995-06-06 AT AT95923733T patent/ATE215366T1/de active
- 1995-06-06 DK DK95923733T patent/DK0716600T3/da active
-
1998
- 1998-12-17 HK HK98113825A patent/HK1012554A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0716600A1 (en) | 1996-06-19 |
DE69526183D1 (de) | 2002-05-08 |
DK0716600T3 (da) | 2002-06-24 |
US5475034A (en) | 1995-12-12 |
CA2167524C (en) | 2002-08-13 |
JP2866744B2 (ja) | 1999-03-08 |
KR960703580A (ko) | 1996-08-31 |
JPH08510479A (ja) | 1996-11-05 |
AU2818495A (en) | 1996-01-04 |
WO1995033457A1 (en) | 1995-12-14 |
KR100194242B1 (ko) | 1999-06-15 |
CA2167524A1 (en) | 1995-12-14 |
CN1088992C (zh) | 2002-08-14 |
HK1012554A1 (en) | 1999-08-06 |
PT716600E (pt) | 2002-09-30 |
TW425382B (en) | 2001-03-11 |
MX9600487A (es) | 1997-06-28 |
DE69526183T2 (de) | 2002-09-26 |
CN1129397A (zh) | 1996-08-21 |
EP0716600B1 (en) | 2002-04-03 |
AU689277B2 (en) | 1998-03-26 |
ATE215366T1 (de) | 2002-04-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2171543T3 (es) | Composiciones administrables topicamente que contienen derivados del acido 3-benzoilfenilacetico para el tratamiento de trastornos inflamatorios oftalmicos. | |
NZ331163A (en) | Composition comprising interleukin-1 inhibitor and hydrogel ester (hyaluronan) for treating inflammatory diseases | |
ES2159851T3 (es) | Amidas de acidos aminotiofenocarboxilicos y su empleo como inhibidores de la fosfodiestearasa. | |
ES2069410T3 (es) | Nuevos derivados del acido hidroxamico y n-hidroxiurea y su uso. | |
EE9900565A (et) | Piperasiini derivaadid ja nende kasutamine põletikuvastaste vahenditena | |
ES2150152T3 (es) | Nuevos derivados de esteres de nitrito/nitrato esteroideos utiles como farmacos antiinflamatorios. | |
MC2078A1 (fr) | Emploi d'alezastine comme matiere active contre le psoriasis et des maladies inflammatoires | |
EP0226223A3 (en) | Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity | |
BR9713178A (pt) | Inbidores espirocìclicos da metaloprotease. | |
NO922634L (no) | Azaoksindol-derivater | |
EA199700380A1 (ru) | Бициклические ароматические соединения, фармацевтическая и косметическая композиции на их основе и применение косметической композиции | |
MY133125A (en) | Novel dihydroxyhexanoic acid derivatives | |
DK0869965T3 (da) | Steroidnitritesterderivater anvendelige som antiinflammatoriske lægemidler | |
ES2125356T3 (es) | Empleo de leflunomida para la inhibicion de interleuquina 8. | |
ES2091031T3 (es) | Uso de acido hialuronico para prevenir la reestenosis arterial. | |
ES2059204T3 (es) | Derivados del acido hidroxamico inhibidores de lipoxigenasa. | |
AU2068895A (en) | Dl- di- or tri-hydroxyphenylglycine alkyl esters for the treatment of inflammatory and allergic conditions | |
ATE97812T1 (de) | Therapeutische verwendung des isopropylesterderivates von monosialogangliosiden bei erkrankungen des nervensystems, begleitet von entzuendungen. | |
HUP9902417A2 (hu) | Alfa-ketoészterek, és alfa-ketoamidok acilezett enol-származékai | |
ES2161293T3 (es) | Derivados de enol acilados como profarmacos de inhibidores de la elastasa. | |
NO974551D0 (no) | Bruk av sulbutiamin for å fremskaffe farmasöytiske sammensetninger nyttige i behandling av visse psykomotoriske- og psyko-intellektuelle sykdommer | |
SV1994000023A (es) | Pirroles sustituidos ref. ran 4070/90 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 716600 Country of ref document: ES |