ATE215366T1 - 3-benzoylphenylessigsäure-derivate enthaltende topische zusammensetzungen zur behandlung der ophthalmischen entzündungserkrankungen - Google Patents
3-benzoylphenylessigsäure-derivate enthaltende topische zusammensetzungen zur behandlung der ophthalmischen entzündungserkrankungenInfo
- Publication number
- ATE215366T1 ATE215366T1 AT95923733T AT95923733T ATE215366T1 AT E215366 T1 ATE215366 T1 AT E215366T1 AT 95923733 T AT95923733 T AT 95923733T AT 95923733 T AT95923733 T AT 95923733T AT E215366 T1 ATE215366 T1 AT E215366T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- compositions containing
- acid derivatives
- inflammatory diseases
- topical compositions
- Prior art date
Links
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- ALDSXDRDRWDASQ-UHFFFAOYSA-N 2-(3-benzoylphenyl)acetic acid Chemical class OC(=O)CC1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 ALDSXDRDRWDASQ-UHFFFAOYSA-N 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- -1 amide derivatives of 3-benzoylphenylacetic acid Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/254,090 US5475034A (en) | 1994-06-06 | 1994-06-06 | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
| PCT/US1995/007187 WO1995033457A1 (en) | 1994-06-06 | 1995-06-06 | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE215366T1 true ATE215366T1 (de) | 2002-04-15 |
Family
ID=22962892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95923733T ATE215366T1 (de) | 1994-06-06 | 1995-06-06 | 3-benzoylphenylessigsäure-derivate enthaltende topische zusammensetzungen zur behandlung der ophthalmischen entzündungserkrankungen |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5475034A (de) |
| EP (1) | EP0716600B1 (de) |
| JP (1) | JP2866744B2 (de) |
| KR (1) | KR100194242B1 (de) |
| CN (1) | CN1088992C (de) |
| AT (1) | ATE215366T1 (de) |
| CA (1) | CA2167524C (de) |
| DE (1) | DE69526183T2 (de) |
| DK (1) | DK0716600T3 (de) |
| ES (1) | ES2171543T3 (de) |
| MX (1) | MX9600487A (de) |
| PT (1) | PT716600E (de) |
| TW (1) | TW425382B (de) |
| WO (1) | WO1995033457A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| US20030086899A1 (en) * | 2000-03-14 | 2003-05-08 | Jafari Masoud R. | Chondroitin sulfate containing viscoelastics for use in treating joints |
| AR030346A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| WO2002078681A2 (en) * | 2001-04-02 | 2002-10-10 | Alcon, Inc. | Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac |
| US20040132773A1 (en) * | 2001-08-13 | 2004-07-08 | Gamache Daniel A | Method of treating neurodgenerative disorders of the retina and optic nerve head |
| EP1507522A2 (de) * | 2002-05-03 | 2005-02-23 | Alcon, Inc. | Verfahren zur behandlung von durch des wachstumsfaktors der vaskularen endothelzellen (vegf) vermittelten vaskulären krankheiten mit amfenac oder nepafenac |
| ES2301964T3 (es) | 2003-01-21 | 2008-07-01 | Senju Pharmaceutical Co., Ltd. | Preparado liquido acuoso que contiene acido 2-amino-3-(4-bromobenzoil)fenilacetico. |
| US20030187072A1 (en) * | 2003-02-14 | 2003-10-02 | Kapin Michael A. | Method of treating angiogenesis-related disorders |
| MXPA05012696A (es) * | 2003-06-13 | 2006-02-22 | Alcon Inc | Formulaciones de agentes antiinflamatorios no esteroides para tratar angiogenesis ocular patologica. |
| ATE552838T1 (de) * | 2003-11-14 | 2012-04-15 | Senju Pharma Co | Wässrige lösung mit aminoglykosid-antibiotikum und bromfenac |
| US8372814B2 (en) | 2004-06-07 | 2013-02-12 | Ista Pharmaceuticals, Inc. | Ophthalmic formulations and uses thereof |
| US8748402B2 (en) | 2004-06-07 | 2014-06-10 | Bausch & Lomb Pharma Holdings Corp. | Ophthalmic formulations and uses thereof |
| TWI358290B (en) | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| KR20080011311A (ko) * | 2005-05-10 | 2008-02-01 | 알콘, 인코퍼레이티드 | 안과 약제, 폴록사민 및 글리콜 장성―조절제를 포함하는안과 현탁제, 안질환 치료용 의약의 제조를 위한 상기조성물의 용도 |
| DE602006006308D1 (de) * | 2005-05-10 | 2009-05-28 | Alcon Inc | Suspensionsformulierungen mit einem aktiven wirkstoff, einem poloxamer- oder meroxapol-tensid und einem glycol und ihre verwendung zur herstellung eines medikaments zur behandlung von augenkrankheiten |
| US20100130580A1 (en) * | 2006-01-25 | 2010-05-27 | Aciex Therapeutics, Inc. | Formulations and Methods for Treating Dry Eye |
| WO2007087609A2 (en) * | 2006-01-25 | 2007-08-02 | Aciex, Inc. | Formulations and methods for treating dry eye |
| TW200812575A (en) * | 2006-04-28 | 2008-03-16 | Alcon Inc | Formulations containing amide derivatives of carboxylic acid NSAIDs for topical administration to the eye |
| US20080153819A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor |
| US20090105245A1 (en) * | 2006-12-21 | 2009-04-23 | Bingaman David P | Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor |
| US20080153818A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for preventing inflammation during surgery |
| UY31058A1 (es) * | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Formulaciones de aminoacido n-halogenado con compuestos antiinflamatorios |
| MX2009012645A (es) * | 2007-05-24 | 2010-03-08 | Aciex Therapeutics Inc | Formulaciones y metodos para tratar el ojo seco. |
| AU2008307492B2 (en) | 2007-10-05 | 2013-03-14 | Acucela Inc. | Alkoxy compounds for disease treatment |
| WO2009073138A2 (en) * | 2007-11-30 | 2009-06-11 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with novel amides |
| US20090239909A1 (en) * | 2008-03-24 | 2009-09-24 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with lactams |
| US8778999B2 (en) | 2009-03-05 | 2014-07-15 | Insite Vision Incorporated | Non-steroidal anti-inflammatory ophthalmic compositions |
| CA2755314A1 (en) * | 2009-03-12 | 2010-09-16 | Medichem, S.A. | New crystals of a benzoylbenzeneacetamide derivative |
| EP4000610A1 (de) | 2009-07-02 | 2022-05-25 | Acucela Inc. | Pharmakologie sichtbarer zyklusmodulatoren |
| DK2586426T3 (en) | 2009-12-03 | 2015-11-23 | Alcon Res Ltd | Carboxyvinyl polymer-containing nanopartikelsuspensioner |
| WO2014207769A1 (en) | 2013-06-27 | 2014-12-31 | Mylan Laboratories Ltd | Process for the preparation of nepafenac |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1226344A (de) * | 1967-07-31 | 1971-03-24 | ||
| CH577461A5 (de) * | 1975-08-13 | 1976-07-15 | Robins Co Inc A H | |
| US4318949A (en) * | 1976-09-16 | 1982-03-09 | Toray Industries, Inc. | Composite nap sheet and process for preparing the same |
| US4313949A (en) * | 1979-09-26 | 1982-02-02 | A. H. Robins Company, Inc. | Method of producing an inhibitory effect on blood platelet aggregation |
| US4254146A (en) * | 1979-10-18 | 1981-03-03 | A. H. Robins Company, Inc. | 3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters |
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
| DE3026402A1 (de) * | 1980-07-11 | 1982-02-04 | Syntex Corp., Palo Alto, Calif. | Die verwendung analgetischer und nicht-hormonaler, entzuendungshemmender mittel bei der behandlung von mikrovaskulaeren erkrankungen |
| US4503073A (en) * | 1981-01-07 | 1985-03-05 | A. H. Robins Company, Incorporated | 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids |
| IL64724A0 (en) * | 1981-02-17 | 1982-03-31 | Robins Co Inc A H | 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them |
| US4568695A (en) * | 1983-12-07 | 1986-02-04 | A. H. Robins Company, Incorporated | 2-Amino-3-benzoyl-phenethylalcohols and intermediates therefor |
| EP0195582B1 (de) * | 1985-03-14 | 1990-01-24 | SMITH KLINE DAUELSBERG GmbH | 5-Aminosalicylsäurederivate von nicht-steroidalen entzündungshemmenden Sauren |
| US4851443A (en) * | 1985-03-14 | 1989-07-25 | Smith Kline Dauelsberg, Gmbh | Carboxylic acid amides, compositions and medical use thereof |
| US4683242A (en) * | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
| US4910225A (en) * | 1988-01-27 | 1990-03-20 | Senju Pharmaceutical Co., Ltd. | Locally administrable therapeutic composition for inflammatory disease |
-
1994
- 1994-06-06 US US08/254,090 patent/US5475034A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 ES ES95923733T patent/ES2171543T3/es not_active Expired - Lifetime
- 1995-06-06 DE DE69526183T patent/DE69526183T2/de not_active Expired - Lifetime
- 1995-06-06 EP EP95923733A patent/EP0716600B1/de not_active Expired - Lifetime
- 1995-06-06 CN CN95190521A patent/CN1088992C/zh not_active Expired - Lifetime
- 1995-06-06 MX MX9600487A patent/MX9600487A/es unknown
- 1995-06-06 PT PT95923733T patent/PT716600E/pt unknown
- 1995-06-06 AT AT95923733T patent/ATE215366T1/de active
- 1995-06-06 KR KR1019960700563A patent/KR100194242B1/ko not_active Expired - Lifetime
- 1995-06-06 CA CA002167524A patent/CA2167524C/en not_active Expired - Lifetime
- 1995-06-06 JP JP8501284A patent/JP2866744B2/ja not_active Expired - Lifetime
- 1995-06-06 TW TW084105686A patent/TW425382B/zh not_active IP Right Cessation
- 1995-06-06 WO PCT/US1995/007187 patent/WO1995033457A1/en not_active Ceased
- 1995-06-06 DK DK95923733T patent/DK0716600T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2866744B2 (ja) | 1999-03-08 |
| KR100194242B1 (ko) | 1999-06-15 |
| HK1012554A1 (en) | 1999-08-06 |
| US5475034A (en) | 1995-12-12 |
| AU2818495A (en) | 1996-01-04 |
| CN1129397A (zh) | 1996-08-21 |
| DK0716600T3 (da) | 2002-06-24 |
| CA2167524C (en) | 2002-08-13 |
| AU689277B2 (en) | 1998-03-26 |
| KR960703580A (ko) | 1996-08-31 |
| WO1995033457A1 (en) | 1995-12-14 |
| EP0716600A1 (de) | 1996-06-19 |
| TW425382B (en) | 2001-03-11 |
| DE69526183T2 (de) | 2002-09-26 |
| CA2167524A1 (en) | 1995-12-14 |
| JPH08510479A (ja) | 1996-11-05 |
| CN1088992C (zh) | 2002-08-14 |
| MX9600487A (es) | 1997-06-28 |
| DE69526183D1 (de) | 2002-05-08 |
| ES2171543T3 (es) | 2002-09-16 |
| PT716600E (pt) | 2002-09-30 |
| EP0716600B1 (de) | 2002-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |