DK0716600T3 - Topisk indgivelsesbare præparater indeholdende 3-benzoylphenyleddikesyrederivater til behandling af inflammatoriske øjensygdomme - Google Patents
Topisk indgivelsesbare præparater indeholdende 3-benzoylphenyleddikesyrederivater til behandling af inflammatoriske øjensygdommeInfo
- Publication number
- DK0716600T3 DK0716600T3 DK95923733T DK95923733T DK0716600T3 DK 0716600 T3 DK0716600 T3 DK 0716600T3 DK 95923733 T DK95923733 T DK 95923733T DK 95923733 T DK95923733 T DK 95923733T DK 0716600 T3 DK0716600 T3 DK 0716600T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- acid derivatives
- topically administrable
- preparations containing
- eye diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/254,090 US5475034A (en) | 1994-06-06 | 1994-06-06 | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
| PCT/US1995/007187 WO1995033457A1 (en) | 1994-06-06 | 1995-06-06 | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0716600T3 true DK0716600T3 (da) | 2002-06-24 |
Family
ID=22962892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95923733T DK0716600T3 (da) | 1994-06-06 | 1995-06-06 | Topisk indgivelsesbare præparater indeholdende 3-benzoylphenyleddikesyrederivater til behandling af inflammatoriske øjensygdomme |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5475034A (de) |
| EP (1) | EP0716600B1 (de) |
| JP (1) | JP2866744B2 (de) |
| KR (1) | KR100194242B1 (de) |
| CN (1) | CN1088992C (de) |
| AT (1) | ATE215366T1 (de) |
| CA (1) | CA2167524C (de) |
| DE (1) | DE69526183T2 (de) |
| DK (1) | DK0716600T3 (de) |
| ES (1) | ES2171543T3 (de) |
| HK (1) | HK1012554A1 (de) |
| MX (1) | MX9600487A (de) |
| PT (1) | PT716600E (de) |
| TW (1) | TW425382B (de) |
| WO (1) | WO1995033457A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
| US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| US20030086899A1 (en) * | 2000-03-14 | 2003-05-08 | Jafari Masoud R. | Chondroitin sulfate containing viscoelastics for use in treating joints |
| AR030346A1 (es) | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| AU2002247284A1 (en) | 2001-04-02 | 2002-10-15 | Alcon, Inc. | Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac |
| US20040132773A1 (en) * | 2001-08-13 | 2004-07-08 | Gamache Daniel A | Method of treating neurodgenerative disorders of the retina and optic nerve head |
| AU2003231730A1 (en) * | 2002-05-03 | 2003-11-17 | Alcon, Inc. | Method of treating vascular endothelial growth factor mediated vascular disorders using amfenac or nepafenac |
| JP4500261B2 (ja) * | 2003-01-21 | 2010-07-14 | 千寿製薬株式会社 | ２−アミノ−３−（４−ブロモベンゾイル）フェニル酢酸含有水性液剤 |
| US20030187072A1 (en) * | 2003-02-14 | 2003-10-02 | Kapin Michael A. | Method of treating angiogenesis-related disorders |
| JP2007500250A (ja) * | 2003-06-13 | 2007-01-11 | アルコン，インコーポレイテッド | 病的な眼の新脈管形成を処置するための非ステロイド性抗炎症剤の処方物 |
| PL1683526T3 (pl) | 2003-11-14 | 2012-09-28 | Senju Pharma Co | Preparat wodnego roztworu zawierający antybiotyk aminoglikozydowy i bromfenak |
| US8372814B2 (en) | 2004-06-07 | 2013-02-12 | Ista Pharmaceuticals, Inc. | Ophthalmic formulations and uses thereof |
| US8748402B2 (en) | 2004-06-07 | 2014-06-10 | Bausch & Lomb Pharma Holdings Corp. | Ophthalmic formulations and uses thereof |
| TWI358290B (en) | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| KR20080011310A (ko) * | 2005-05-10 | 2008-02-01 | 알콘, 인코퍼레이티드 | 폴록사머 또는 메록사폴 계면활성제 및 글리콜을유효성분으로 함유하는 현탁제, 안질환 치료용 의약의제조를 위한 그의 용도 |
| SI1906916T1 (sl) * | 2005-05-10 | 2009-02-28 | Alcon Inc | Oftalmična suspenzija, ki obsega oftalmično zdravilo, poloksamin in glikolno sredstvo za naravnavo toničnosti, uporaba sestavka za pripravo zdravila za zdravljenje oftalmičnih motenj |
| US20100130580A1 (en) * | 2006-01-25 | 2010-05-27 | Aciex Therapeutics, Inc. | Formulations and Methods for Treating Dry Eye |
| WO2007087609A2 (en) * | 2006-01-25 | 2007-08-02 | Aciex, Inc. | Formulations and methods for treating dry eye |
| TW200812575A (en) * | 2006-04-28 | 2008-03-16 | Alcon Inc | Formulations containing amide derivatives of carboxylic acid NSAIDs for topical administration to the eye |
| US20080153819A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor |
| US20080153818A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for preventing inflammation during surgery |
| US20090105245A1 (en) * | 2006-12-21 | 2009-04-23 | Bingaman David P | Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor |
| UY31058A1 (es) * | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Formulaciones de aminoacido n-halogenado con compuestos antiinflamatorios |
| CA2687717A1 (en) * | 2007-05-24 | 2008-12-18 | Aciex Therapeutics, Inc. | Formulations and methods for treating dry eye |
| CN101889017B (zh) | 2007-10-05 | 2013-11-27 | 奥克塞拉有限公司 | 用于治疗疾病的烷氧基化合物 |
| US20100292289A1 (en) * | 2007-11-30 | 2010-11-18 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with novel amides |
| US20090239909A1 (en) * | 2008-03-24 | 2009-09-24 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with lactams |
| US20100234469A1 (en) * | 2009-03-12 | 2010-09-16 | Medichem, S.A. | New Crystals Of A Benzoylbenzeneacetamide Derivative |
| EP2448569B1 (de) | 2009-07-02 | 2021-10-27 | Acucela, Inc. | Pharmakologie sichtbarer zyklusmodulatoren |
| PL2586426T3 (pl) | 2009-12-03 | 2016-01-29 | Alcon Res Ltd | Zawiesiny zawierające nanocząsteczkowe polimery karboksywinylowe |
| US9630909B2 (en) | 2013-06-27 | 2017-04-25 | Mylan Laboratories Ltd | Process for the preparation of nepafenac |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1226344A (de) * | 1967-07-31 | 1971-03-24 | ||
| SE400966B (sv) * | 1975-08-13 | 1978-04-17 | Robins Co Inc A H | Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror |
| US4318949A (en) * | 1976-09-16 | 1982-03-09 | Toray Industries, Inc. | Composite nap sheet and process for preparing the same |
| US4313949A (en) * | 1979-09-26 | 1982-02-02 | A. H. Robins Company, Inc. | Method of producing an inhibitory effect on blood platelet aggregation |
| US4254146A (en) * | 1979-10-18 | 1981-03-03 | A. H. Robins Company, Inc. | 3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters |
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
| DE3026402A1 (de) * | 1980-07-11 | 1982-02-04 | Syntex Corp., Palo Alto, Calif. | Die verwendung analgetischer und nicht-hormonaler, entzuendungshemmender mittel bei der behandlung von mikrovaskulaeren erkrankungen |
| US4503073A (en) * | 1981-01-07 | 1985-03-05 | A. H. Robins Company, Incorporated | 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids |
| IL64724A0 (en) * | 1981-02-17 | 1982-03-31 | Robins Co Inc A H | 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them |
| US4568695A (en) * | 1983-12-07 | 1986-02-04 | A. H. Robins Company, Incorporated | 2-Amino-3-benzoyl-phenethylalcohols and intermediates therefor |
| US4851443A (en) * | 1985-03-14 | 1989-07-25 | Smith Kline Dauelsberg, Gmbh | Carboxylic acid amides, compositions and medical use thereof |
| DE3668450D1 (de) * | 1985-03-14 | 1990-03-01 | Smithkline Dauelsberg | 5-aminosalicylsaeurederivate von nicht-steroidalen entzuendungshemmenden sauren. |
| US4683242A (en) * | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
| US4910225A (en) * | 1988-01-27 | 1990-03-20 | Senju Pharmaceutical Co., Ltd. | Locally administrable therapeutic composition for inflammatory disease |
-
1994
- 1994-06-06 US US08/254,090 patent/US5475034A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 KR KR1019960700563A patent/KR100194242B1/ko not_active IP Right Cessation
- 1995-06-06 MX MX9600487A patent/MX9600487A/es unknown
- 1995-06-06 WO PCT/US1995/007187 patent/WO1995033457A1/en active IP Right Grant
- 1995-06-06 AT AT95923733T patent/ATE215366T1/de active
- 1995-06-06 DK DK95923733T patent/DK0716600T3/da active
- 1995-06-06 TW TW084105686A patent/TW425382B/zh not_active IP Right Cessation
- 1995-06-06 JP JP8501284A patent/JP2866744B2/ja not_active Expired - Lifetime
- 1995-06-06 CN CN95190521A patent/CN1088992C/zh not_active Expired - Lifetime
- 1995-06-06 DE DE69526183T patent/DE69526183T2/de not_active Expired - Lifetime
- 1995-06-06 PT PT95923733T patent/PT716600E/pt unknown
- 1995-06-06 CA CA002167524A patent/CA2167524C/en not_active Expired - Lifetime
- 1995-06-06 EP EP95923733A patent/EP0716600B1/de not_active Expired - Lifetime
- 1995-06-06 ES ES95923733T patent/ES2171543T3/es not_active Expired - Lifetime
-
1998
- 1998-12-17 HK HK98113825A patent/HK1012554A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0716600B1 (de) | 2002-04-03 |
| ES2171543T3 (es) | 2002-09-16 |
| CN1129397A (zh) | 1996-08-21 |
| PT716600E (pt) | 2002-09-30 |
| US5475034A (en) | 1995-12-12 |
| DE69526183D1 (de) | 2002-05-08 |
| KR960703580A (ko) | 1996-08-31 |
| AU2818495A (en) | 1996-01-04 |
| CA2167524C (en) | 2002-08-13 |
| KR100194242B1 (ko) | 1999-06-15 |
| TW425382B (en) | 2001-03-11 |
| EP0716600A1 (de) | 1996-06-19 |
| CA2167524A1 (en) | 1995-12-14 |
| ATE215366T1 (de) | 2002-04-15 |
| MX9600487A (es) | 1997-06-28 |
| DE69526183T2 (de) | 2002-09-26 |
| CN1088992C (zh) | 2002-08-14 |
| HK1012554A1 (en) | 1999-08-06 |
| AU689277B2 (en) | 1998-03-26 |
| WO1995033457A1 (en) | 1995-12-14 |
| JP2866744B2 (ja) | 1999-03-08 |
| JPH08510479A (ja) | 1996-11-05 |
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