ES2059204T3 - Derivados del acido hidroxamico inhibidores de lipoxigenasa. - Google Patents

Derivados del acido hidroxamico inhibidores de lipoxigenasa.

Info

Publication number
ES2059204T3
ES2059204T3 ES92900468T ES92900468T ES2059204T3 ES 2059204 T3 ES2059204 T3 ES 2059204T3 ES 92900468 T ES92900468 T ES 92900468T ES 92900468 T ES92900468 T ES 92900468T ES 2059204 T3 ES2059204 T3 ES 2059204T3
Authority
ES
Spain
Prior art keywords
hydroxamic acid
derivatives
lipoxigenase inhibitors
lipoxigenase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92900468T
Other languages
English (en)
Inventor
Kazuo Ando
Takafumi Ikeda
Masami Nakane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2059204T3 publication Critical patent/ES2059204T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms

Abstract

CIERTOS NUEVOS DERIVADOS DE ACIDO HIDROXAMICO QUE TIENEN LA ESTRUCTURA (I) INHIBEN LA LIPOXIGENASA DE ENZIMA. ESTOS COMPUESTOS, Y LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS MISMOS, SON UTILES EN EL TRATAMIENTO O ALIVIO DE ENFERMEDADES INFLAMATORIAS, CONDICIONES ALERGICAS Y ENFERMEDADES CARDIOVASCULARES EN MAMIFEROS Y COMO INGREDIENTE ACTIVO EN COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE DICHAS CONDICIONES.
ES92900468T 1990-12-11 1991-10-08 Derivados del acido hidroxamico inhibidores de lipoxigenasa. Expired - Lifetime ES2059204T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2415745A JPH06256285A (ja) 1990-12-11 1990-12-11 ヒドロキサム酸誘導体およびその用途

Publications (1)

Publication Number Publication Date
ES2059204T3 true ES2059204T3 (es) 1994-11-01

Family

ID=18524043

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92900468T Expired - Lifetime ES2059204T3 (es) 1990-12-11 1991-10-08 Derivados del acido hidroxamico inhibidores de lipoxigenasa.

Country Status (11)

Country Link
EP (1) EP0561882B1 (es)
JP (1) JPH06256285A (es)
AT (1) ATE110714T1 (es)
CA (1) CA2094247A1 (es)
DE (1) DE69103773T2 (es)
DK (1) DK0561882T3 (es)
ES (1) ES2059204T3 (es)
FI (1) FI932654A0 (es)
IE (1) IE63704B1 (es)
PT (1) PT99729A (es)
WO (1) WO1992010469A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476873A (en) * 1990-07-25 1995-12-19 Abbott Laboratories Acetylene derivatives having lipoxygenase inhibitory activity
DK0540673T3 (da) * 1990-07-25 1997-03-24 Abbott Lab Acetylen-derivater med lipoxygenaseinhiberende virkning
GB9215921D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Anti-inflammatory compounds
US5288751A (en) * 1992-11-06 1994-02-22 Abbott Laboratories [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis
US5342980A (en) * 1992-12-30 1994-08-30 American Cyanamid Company Fungicidal agents
GB9308652D0 (en) * 1993-04-27 1993-06-09 Wellcome Found Anti-inflammatory compounds
TW448144B (en) * 1993-08-19 2001-08-01 Pfizer Phenoxyphenyl cyclopentenyl hydroxyureas
JP2732504B2 (ja) * 1995-03-08 1998-03-30 農林水産省中国農業試験場長 アラキドン酸代謝活性阻害剤とその製造法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0288553A (ja) * 1988-07-14 1990-03-28 Wellcome Found Ltd:The 抗炎症性アリール誘導体
MC2091A1 (fr) * 1989-02-03 1991-02-15 Wellcome Found Procedes pour la preparation de composes a action anti-inflammatoire et de formulations pharmaceutiques les contenant
EP0588785A1 (en) * 1989-03-30 1994-03-30 Abbott Laboratories Urea based lipoxygenase inhibiting compounds

Also Published As

Publication number Publication date
CA2094247A1 (en) 1992-06-13
IE63704B1 (en) 1995-05-31
JPH06256285A (ja) 1994-09-13
ATE110714T1 (de) 1994-09-15
FI932654A (fi) 1993-06-10
FI932654A0 (fi) 1993-06-10
WO1992010469A1 (en) 1992-06-25
IE914284A1 (en) 1992-06-17
EP0561882B1 (en) 1994-08-31
PT99729A (pt) 1992-11-30
DE69103773T2 (de) 1994-12-15
DK0561882T3 (da) 1994-10-03
DE69103773D1 (de) 1994-10-06
EP0561882A1 (en) 1993-09-29

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