DK0540673T3 - Acetylen-derivater med lipoxygenaseinhiberende virkning - Google Patents

Acetylen-derivater med lipoxygenaseinhiberende virkning

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Publication number
DK0540673T3
DK0540673T3 DK91915194.4T DK91915194T DK0540673T3 DK 0540673 T3 DK0540673 T3 DK 0540673T3 DK 91915194 T DK91915194 T DK 91915194T DK 0540673 T3 DK0540673 T3 DK 0540673T3
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DK
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Prior art keywords
inhibitory effect
benzol
furyl
thienyl
cycloalkyl
Prior art date
Application number
DK91915194.4T
Other languages
English (en)
Inventor
Dee W Brooks
Andrew O Stewart
Daniel J Kerkman
Pramila A Bhatia
Anwer Basha
Jonathan G Martin
Original Assignee
Abbott Lab
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Publication of DK0540673T3 publication Critical patent/DK0540673T3/da

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
DK91915194.4T 1990-07-25 1991-07-11 Acetylen-derivater med lipoxygenaseinhiberende virkning DK0540673T3 (da)

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JP2737584B2 (ja) * 1991-12-27 1998-04-08 三菱電機株式会社 スクロール型圧縮機
US5169854A (en) * 1992-02-26 1992-12-08 Abbott Laboratories N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity
JPH05294921A (ja) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd 新規なフェニル置換シクロアルキル尿素誘導体および組成物
GB9215921D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Anti-inflammatory compounds
US5288751A (en) * 1992-11-06 1994-02-22 Abbott Laboratories [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis
ATE167180T1 (de) * 1993-04-07 1998-06-15 Pfizer Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren
JP3487858B2 (ja) * 1993-11-05 2004-01-19 アボツト・ラボラトリーズ Ｎ−［４−［（置換フェニル）アルキルチエニル］−及びｎ−４−［（置換フェニル）アルキルフリル］−ブト−３−イン−２−イル］−ｎ−ヒドロキシ尿素化合物の製造方法
JP3179286B2 (ja) * 1994-05-19 2001-06-25 ファイザー製薬株式会社 Ｎ−ヒドロキシ尿素系抗炎症剤
US5516789A (en) * 1995-04-12 1996-05-14 Abbott Laboratories Lipoxygenase and cyclooxygenase inhibiting compounds
DE69635048T2 (de) * 1995-06-12 2006-02-16 G.D. Searle & Co. Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
US5714633A (en) * 1995-09-12 1998-02-03 Abbott Laboratories Process for the preparation of arylalkynyl-N-hydroxyurea derivatives having lipoxygenase inhibitory activity
ES2183140T3 (es) 1996-02-13 2003-03-16 Searle & Co Combinaciones, que tienen efectos inmunosupresores, que contienen un inhibidor de ciclooxigenasa-2 y un inhibidor de leucotrieno a4 hidrolasa.
DK0888127T3 (da) 1996-02-13 2002-04-08 Searle & Co Kombinationer med immunoundertrykkende virkninger indeholdende cyclooxygenase-2-inhibitorer og 5-lipooxygenaseinhibitortorer
WO1998029408A1 (fr) 1996-12-26 1998-07-09 Nikken Chemicals Co., Ltd. Derives de n-hydroxyuree et compositions medicinales a base de ces derives
US6172106B1 (en) 1998-02-09 2001-01-09 R. Armour Forse Sesamol inhibition of Δ-5-desaturase activity and uses therefor
MXPA04007611A (es) * 2002-02-08 2005-05-27 Hoffmann La Roche Metodo para tratar y prevenir perdida osea.

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MX9203676A (es) 1992-09-01
JPH0819069B2 (ja) 1996-02-28
AU663441B2 (en) 1995-10-05
ES2095325T3 (es) 1997-02-16
IE77040B1 (en) 1997-11-19
AU8414291A (en) 1992-02-18
GR3022120T3 (en) 1997-03-31
PT98440B (pt) 1999-01-29
JPH05508861A (ja) 1993-12-09
WO1992001682A1 (en) 1992-02-06
EP0540673A4 (da) 1994-04-27
AU6077494A (en) 1994-07-21
KR960005541B1 (ko) 1996-04-26
EP0540673B1 (en) 1996-10-16
AU647177B2 (en) 1994-03-17
DE69122759T2 (de) 1997-05-15
EP0540673A1 (en) 1993-05-12
CA2087836A1 (en) 1992-01-26
IL98870A (en) 1996-08-04
DE69122759D1 (de) 1996-11-21
IL98870A0 (en) 1992-07-15
ATE144247T1 (de) 1996-11-15
IE912469A1 (en) 1992-01-29
PT98440A (pt) 1992-05-29

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