DE69122759D1 - Acetylenderivate mit lipoxygenase inhibitorischer wirkung - Google Patents

Acetylenderivate mit lipoxygenase inhibitorischer wirkung

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Publication number
DE69122759D1
DE69122759D1 DE69122759T DE69122759T DE69122759D1 DE 69122759 D1 DE69122759 D1 DE 69122759D1 DE 69122759 T DE69122759 T DE 69122759T DE 69122759 T DE69122759 T DE 69122759T DE 69122759 D1 DE69122759 D1 DE 69122759D1
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Germany
Prior art keywords
lipoxygenase
inhibitoric
effect
benzol
furyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69122759T
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English (en)
Other versions
DE69122759T2 (de
Inventor
Dee Brooks
Andrew Stewart
Daniel Kerkman
Pramila Bhatia
Anwer Basha
Jonathan Martin
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Abbott Laboratories
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Abbott Laboratories
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Publication of DE69122759D1 publication Critical patent/DE69122759D1/de
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Publication of DE69122759T2 publication Critical patent/DE69122759T2/de
Anticipated expiration legal-status Critical
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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DE69122759T 1990-07-25 1991-07-11 Acetylenderivate mit lipoxygenase inhibitorischer wirkung Expired - Fee Related DE69122759T2 (de)

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US55805090A 1990-07-25 1990-07-25
US68461491A 1991-04-12 1991-04-12
PCT/US1991/004911 WO1992001682A1 (en) 1990-07-25 1991-07-11 Acetylene derivatives having lipoxygenase inhibitory activity

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JP (1) JPH0819069B2 (de)
KR (1) KR960005541B1 (de)
AT (1) ATE144247T1 (de)
AU (2) AU647177B2 (de)
CA (1) CA2087836A1 (de)
DE (1) DE69122759T2 (de)
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GR (1) GR3022120T3 (de)
IE (1) IE77040B1 (de)
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JP2737584B2 (ja) * 1991-12-27 1998-04-08 三菱電機株式会社 スクロール型圧縮機
US5169854A (en) * 1992-02-26 1992-12-08 Abbott Laboratories N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity
JPH05294921A (ja) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd 新規なフェニル置換シクロアルキル尿素誘導体および組成物
GB9215921D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Anti-inflammatory compounds
US5288751A (en) * 1992-11-06 1994-02-22 Abbott Laboratories [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis
DK0693054T3 (da) * 1993-04-07 1998-10-19 Pfizer Cycloalkylhydroxyurinstoffer og deres anvendelse som lipoxygenaseinhibitorer
WO1995012589A1 (en) * 1993-11-05 1995-05-11 Abbott Laboratories Process for the preparation of n-4-[(substituted phenyl)alkylthienyl]-, and n-4-[(substituted phenyl)alkylfuryl]but-3-yn-2-yl]-n-hydroxyurea compounds
JP3179286B2 (ja) * 1994-05-19 2001-06-25 ファイザー製薬株式会社 Ｎ−ヒドロキシ尿素系抗炎症剤
US5516789A (en) * 1995-04-12 1996-05-14 Abbott Laboratories Lipoxygenase and cyclooxygenase inhibiting compounds
WO1996041626A1 (en) * 1995-06-12 1996-12-27 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
US5714633A (en) * 1995-09-12 1998-02-03 Abbott Laboratories Process for the preparation of arylalkynyl-N-hydroxyurea derivatives having lipoxygenase inhibitory activity
ES2169351T3 (es) 1996-02-13 2002-07-01 Searle & Co Combinaciones que tienen efectos inmunosupresores, que contienen inhibidores de ciclooxigenasa-2 y 5-lipoxigenasa.
WO1997029774A1 (en) 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing a cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
CA2276042C (en) 1996-12-26 2002-10-08 Michika Takano N-hydroxyurea derivatives and medicinal compositions containing the same
US6172106B1 (en) 1998-02-09 2001-01-09 R. Armour Forse Sesamol inhibition of Δ-5-desaturase activity and uses therefor
KR100589819B1 (ko) * 2002-02-08 2006-06-14 에프. 호프만-라 로슈 아게 골 손실의 치료 및 예방 방법

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US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
US4608390A (en) * 1985-04-26 1986-08-26 Abbott Laboratories Lipoxygenase inhibiting compounds
US4861798A (en) * 1986-12-29 1989-08-29 Bristol-Myers Company Lipoxygenase inhibitory compounds
EP0279263B1 (de) * 1987-02-10 1993-08-04 Abbott Laboratories Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen
ES2053609T3 (es) * 1987-04-24 1994-08-01 Abbott Lab Derivados de urea inhibidores de lipoxigenasa.
PL154186B1 (en) * 1987-07-15 1991-07-31 Wellcome Found Method for manufacturing arylic derivatives of the hydroxamic acid
CA1334975C (en) * 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
ES2013834A6 (es) * 1989-01-30 1990-06-01 Uriach & Cia Sa J Procedimiento para la obtencion de derivados 4-sustituidos de 2-alcoxitetrahidrofurano.
JPH04504261A (ja) * 1989-03-30 1992-07-30 アボツト・ラボラトリーズ 尿素系リポキシゲナーゼ阻害化合物
JPH06256285A (ja) * 1990-12-11 1994-09-13 Pfizer Pharmaceut Co Ltd ヒドロキサム酸誘導体およびその用途

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JPH05508861A (ja) 1993-12-09
PT98440B (pt) 1999-01-29
AU663441B2 (en) 1995-10-05
GR3022120T3 (en) 1997-03-31
DK0540673T3 (da) 1997-03-24
IL98870A (en) 1996-08-04
ATE144247T1 (de) 1996-11-15
EP0540673A1 (de) 1993-05-12
EP0540673B1 (de) 1996-10-16
EP0540673A4 (de) 1994-04-27
IL98870A0 (en) 1992-07-15
ES2095325T3 (es) 1997-02-16
AU6077494A (en) 1994-07-21
IE912469A1 (en) 1992-01-29
WO1992001682A1 (en) 1992-02-06
MX9203676A (es) 1992-09-01
PT98440A (pt) 1992-05-29
CA2087836A1 (en) 1992-01-26
IE77040B1 (en) 1997-11-19
KR960005541B1 (ko) 1996-04-26
AU647177B2 (en) 1994-03-17
AU8414291A (en) 1992-02-18
DE69122759T2 (de) 1997-05-15
JPH0819069B2 (ja) 1996-02-28

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