WO1990003170A3 - Prostaglandin-derivatives having antithrombotic activity - Google Patents

Prostaglandin-derivatives having antithrombotic activity Download PDF

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Publication number
WO1990003170A3
WO1990003170A3 PCT/IT1989/000061 IT8900061W WO9003170A3 WO 1990003170 A3 WO1990003170 A3 WO 1990003170A3 IT 8900061 W IT8900061 W IT 8900061W WO 9003170 A3 WO9003170 A3 WO 9003170A3
Authority
WO
WIPO (PCT)
Prior art keywords
branched
linear
prostaglandin
derivatives
antithrombotic activity
Prior art date
Application number
PCT/IT1989/000061
Other languages
French (fr)
Other versions
WO1990003170A2 (en
Inventor
Umberto Valcavi
Original Assignee
Istituto Biochimico Italiano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT8822012A external-priority patent/IT1227129B/en
Priority claimed from IT8920927A external-priority patent/IT1230879B/en
Application filed by Istituto Biochimico Italiano filed Critical Istituto Biochimico Italiano
Publication of WO1990003170A2 publication Critical patent/WO1990003170A2/en
Publication of WO1990003170A3 publication Critical patent/WO1990003170A3/en
Priority to DK124390A priority Critical patent/DK124390A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The compounds of formula (I), wherein: n = 2, 3; m = 4, 5, 6, 7; X = NHR, CH2NHR, NHNH2; R = H, a linear or branched (C1-C4)alkyl, a linear or branched (C1-C4)acyl; Y = CH2NH2, COOH, CONH2 (with the exclusion of the compounds wherein n = 2, m = 5, X = NHR with R = H, a linear or branched (C1-C4)alkyl, a linear or branched (C1-C4)acyl; Y = COOH, CONH2) including all optical and/or geometrical isomers, alone or in admixture, and their salts, which inhibit the platelet aggregation in the blood and which can be prepared for use as antiplatelet, antithrombotic agents.
PCT/IT1989/000061 1988-09-20 1989-09-12 Prostaglandin-derivatives having antithrombotic activity WO1990003170A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK124390A DK124390A (en) 1988-09-20 1990-05-18 PROSTAGLAND INERIVATIVES WITH ANTITHROMOBOTIC EFFECT

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT8822012A IT1227129B (en) 1988-09-20 1988-09-20 New 3-alkyl-cyclopentyl or cyclohexyl prostanoid derivs.
IT22012A/88 1988-09-20
IT20927A/89 1989-06-20
IT8920927A IT1230879B (en) 1989-06-20 1989-06-20 New 3-alkyl-cyclopentyl or cyclohexyl prostanoid derivs.

Publications (2)

Publication Number Publication Date
WO1990003170A2 WO1990003170A2 (en) 1990-04-05
WO1990003170A3 true WO1990003170A3 (en) 1990-05-17

Family

ID=26327704

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT1989/000061 WO1990003170A2 (en) 1988-09-20 1989-09-12 Prostaglandin-derivatives having antithrombotic activity

Country Status (5)

Country Link
EP (1) EP0425584A1 (en)
JP (1) JPH03502103A (en)
AU (1) AU628400B2 (en)
DK (1) DK124390A (en)
WO (1) WO1990003170A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385945A (en) * 1992-10-21 1995-01-31 Allergan, Inc. 7-(5-substituted cyclopentyl) and (5-substituted cyclopentenyl) heptyl alcohols, heptylamines and heptanoic acid amides, and method of lowering intraocular pressure in the eye of a mammal by administration of these novel compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0218953A2 (en) * 1985-10-04 1987-04-22 IBI- Istituto Biochimico Italiano Giovanni Lorenzini S.p.A. Derivatives of 19,20-bis-nor-prostanoic acid with antiulcer and anorectic activity, process for their preparation and pharmaceutical compositions thereof
WO1988010252A1 (en) * 1987-06-25 1988-12-29 Ibi Istituto Biochimico Italiano Giovanni Lorenzin Prostaglandin derivates, their process and pharmaceutical compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0218953A2 (en) * 1985-10-04 1987-04-22 IBI- Istituto Biochimico Italiano Giovanni Lorenzini S.p.A. Derivatives of 19,20-bis-nor-prostanoic acid with antiulcer and anorectic activity, process for their preparation and pharmaceutical compositions thereof
WO1988010252A1 (en) * 1987-06-25 1988-12-29 Ibi Istituto Biochimico Italiano Giovanni Lorenzin Prostaglandin derivates, their process and pharmaceutical compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
The Merck Manual of Diagnosis and Therapy, 15th Edition, 1987, Edited by R. BERKOW et al., publ. by Merck Sharp & Dohme Research Laboratories, (Rahway, N.J. US), pages 2513-2516 *

Also Published As

Publication number Publication date
DK124390D0 (en) 1990-05-18
JPH03502103A (en) 1991-05-16
DK124390A (en) 1990-05-18
EP0425584A1 (en) 1991-05-08
AU4313889A (en) 1990-04-18
AU628400B2 (en) 1992-09-17
WO1990003170A2 (en) 1990-04-05

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