DE69532820D1 - 7-alkyliden cephalosporansäuren und deren verwendungen - Google Patents

7-alkyliden cephalosporansäuren und deren verwendungen

Info

Publication number
DE69532820D1
DE69532820D1 DE69532820T DE69532820T DE69532820D1 DE 69532820 D1 DE69532820 D1 DE 69532820D1 DE 69532820 T DE69532820 T DE 69532820T DE 69532820 T DE69532820 T DE 69532820T DE 69532820 D1 DE69532820 D1 DE 69532820D1
Authority
DE
Germany
Prior art keywords
cephalosporic
alkylides
acids
alkylidene
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69532820T
Other languages
English (en)
Other versions
DE69532820T2 (de
Inventor
D Buynak
Brian Bachmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Application granted granted Critical
Publication of DE69532820D1 publication Critical patent/DE69532820D1/de
Publication of DE69532820T2 publication Critical patent/DE69532820T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1995632820 1994-12-09 1995-12-11 7-alkyliden cephalosporansäuren und deren verwendungen Expired - Fee Related DE69532820T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/354,850 US5629306A (en) 1994-12-09 1994-12-09 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US354850 1994-12-09
PCT/US1995/015608 WO1996017849A1 (en) 1994-12-09 1995-12-11 7-alkylidene cephalosporanic acid derivatives and methods of using the same

Publications (2)

Publication Number Publication Date
DE69532820D1 true DE69532820D1 (de) 2004-05-06
DE69532820T2 DE69532820T2 (de) 2005-01-13

Family

ID=23395164

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1995632820 Expired - Fee Related DE69532820T2 (de) 1994-12-09 1995-12-11 7-alkyliden cephalosporansäuren und deren verwendungen

Country Status (11)

Country Link
US (3) US5629306A (de)
EP (1) EP0796262B1 (de)
JP (1) JP3241737B2 (de)
AT (1) ATE263173T1 (de)
AU (1) AU4290796A (de)
BR (1) BR9509889A (de)
CA (1) CA2206699C (de)
DE (1) DE69532820T2 (de)
ES (1) ES2218557T3 (de)
PT (1) PT796262E (de)
WO (1) WO1996017849A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629306A (en) * 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US5760027A (en) * 1996-12-06 1998-06-02 Research Corporation Technologies, Inc. Use of 7-alkylidene cephalosporins to inhibit elastase activity
DE69805975T2 (de) 1997-12-29 2002-12-19 Res Corp Technologies Inc 2-beta-substituierte-6-alkylidenpenizillansäure-derivate als beta-laktamase inhibitoren
ATE242250T1 (de) 1997-12-29 2003-06-15 Res Corp Technologies Inc Verfahren zur herstellung von alpha-oxolactamen
JP2002542249A (ja) * 1999-04-15 2002-12-10 リサーチ コーポレイション テクノロジーズ，インコーポレイティド β−ラクタマーゼ阻害化合物
US6407091B1 (en) * 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
EP1359153B1 (de) * 1999-04-15 2006-06-21 Research Corporation Technologies, Inc Beta-Lactamase hemmende Verbindungen
JP2005502687A (ja) * 2001-07-24 2005-01-27 アラムクス エルエルシー β−ラクタマーゼ阻害剤としての７−アルキリデン−３−置換型−３−セフェム−４−カルボキシラート
JP2005525399A (ja) * 2002-04-04 2005-08-25 アラムクス エルエルシー セリンおよびメタロ−β−ラクタマーゼの阻害剤
KR101403164B1 (ko) * 2005-12-07 2014-06-03 바실리어 파마슈티카 아게 베타-락타마아제 저해제 및 모노박탐 항생물질의 유용한조합
AU2012233003B2 (en) * 2005-12-07 2014-12-18 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150156A (en) * 1975-11-21 1979-04-17 Merck & Co., Inc. 7-(Substituted methyl)-3-(substituted thio)-cephalosporins, derivatives and pharmaceutical compositions containing them
EP0041768B1 (de) * 1980-04-24 1987-11-11 Beecham Group Plc Beta-Lactam-Verbindungen, ihre Herstellung und Verwendung
US4459405A (en) * 1982-11-16 1984-07-10 Eli Lilly And Company Desacetylcephalosporin sulfones
EP0120613A1 (de) * 1983-03-02 1984-10-03 Beecham Group Plc Penem-Derivate und Vorstufenverbindungen
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US5132301A (en) * 1983-05-02 1992-07-21 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4637999A (en) 1983-05-02 1987-01-20 Merck & Co., Inc. Substituted cephalosporins as anti-inflammatory and antidegenerative agents
GB8518421D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8808701D0 (en) 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
GB8811388D0 (en) * 1988-05-13 1988-06-15 Erba Carlo Spa 1,1-dioxo-cephem-4-carbothiolic acid derivatives
US5179023A (en) 1989-03-24 1993-01-12 Research Corporation Technologies, Inc. Recombinant α-galactosidase a therapy for Fabry disease
US4992541A (en) 1989-08-01 1991-02-12 Merck & Co., Inc. Process for the preparation of 1,1-dioxo-7-substituted cephems
US5264429A (en) 1989-10-06 1993-11-23 Synphar Laboratories, Inc. 2-spirocyclopropyl cephalosporin sulfone derivatives
GB8928373D0 (en) * 1989-12-15 1990-02-21 Erba Carlo Spa Beta-lactam derivatives
US5126446A (en) * 1991-01-04 1992-06-30 Eli Lilly And Company Process for 3-exomethylenecepham sulfoxide esters
US5258377A (en) 1991-04-08 1993-11-02 Taiho Pharmaceutical Co., Ltd. 2-spirocyclopropyl 4-acylcephems
US5446037A (en) * 1991-12-05 1995-08-29 Synphar Laboratories, Inc. 2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents
US5629306A (en) * 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US5597817A (en) 1994-12-09 1997-01-28 Southern Methodist University 7-vinylidene cephalosporins and methods of using the same

Also Published As

Publication number Publication date
US20020025954A1 (en) 2002-02-28
JP3241737B2 (ja) 2001-12-25
WO1996017849A1 (en) 1996-06-13
EP0796262A4 (de) 1998-03-25
ATE263173T1 (de) 2004-04-15
JPH10510265A (ja) 1998-10-06
US5629306A (en) 1997-05-13
DE69532820T2 (de) 2005-01-13
US6599892B2 (en) 2003-07-29
CA2206699A1 (en) 1996-06-13
EP0796262B1 (de) 2004-03-31
EP0796262A1 (de) 1997-09-24
ES2218557T3 (es) 2004-11-16
BR9509889A (pt) 1997-12-30
PT796262E (pt) 2004-08-31
CA2206699C (en) 2007-03-20
AU4290796A (en) 1996-06-26
US6303592B1 (en) 2001-10-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee