ATE167180T1 - Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren - Google Patents

Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren

Info

Publication number
ATE167180T1
ATE167180T1 AT94910604T AT94910604T ATE167180T1 AT E167180 T1 ATE167180 T1 AT E167180T1 AT 94910604 T AT94910604 T AT 94910604T AT 94910604 T AT94910604 T AT 94910604T AT E167180 T1 ATE167180 T1 AT E167180T1
Authority
AT
Austria
Prior art keywords
pct
chain
date oct
sec
optionally
Prior art date
Application number
AT94910604T
Other languages
English (en)
Inventor
Rodney W Stevens
Takashi Mano
Yoshiyuki Okumura
Masami Nakane
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE167180T1 publication Critical patent/ATE167180T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT94910604T 1993-04-07 1994-04-05 Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren ATE167180T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8095293 1993-04-07

Publications (1)

Publication Number Publication Date
ATE167180T1 true ATE167180T1 (de) 1998-06-15

Family

ID=13732846

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94910604T ATE167180T1 (de) 1993-04-07 1994-04-05 Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren

Country Status (8)

Country Link
US (1) US5681858A (de)
EP (1) EP0693054B1 (de)
AT (1) ATE167180T1 (de)
CA (1) CA2160140C (de)
DE (1) DE69411003T2 (de)
DK (1) DK0693054T3 (de)
ES (1) ES2116591T3 (de)
WO (1) WO1994022814A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3179286B2 (ja) * 1994-05-19 2001-06-25 ファイザー製薬株式会社 Ｎ−ヒドロキシ尿素系抗炎症剤
ATE184272T1 (de) * 1994-11-10 1999-09-15 Pfizer Aryloxycycloalkenyl- und aryloxyiminocycloalkenyl-hydroxyharnstoffe mit 5-lipoxygenase inhibierender wirkung
RU2666530C2 (ru) 2012-01-12 2018-09-11 Йейл Юниверсити Соединения и способы усиления деградации белков-мишеней и других полипептидов с помощью е3 убиквитин лигазы
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
US10071164B2 (en) 2014-08-11 2018-09-11 Yale University Estrogen-related receptor alpha based protac compounds and associated methods of use
BR112018008918A8 (pt) 2015-11-02 2019-02-26 Univ Yale compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
AU647177B2 (en) * 1990-07-25 1994-03-17 Abbott Laboratories Acetylenic urea derivatives having lipoxygenase inhibitory activity
US5476873A (en) * 1990-07-25 1995-12-19 Abbott Laboratories Acetylene derivatives having lipoxygenase inhibitory activity
GB9025514D0 (en) * 1990-11-23 1991-01-09 Wellcome Found Anti-inflammatory compounds
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物

Also Published As

Publication number Publication date
EP0693054B1 (de) 1998-06-10
DE69411003T2 (de) 1998-10-08
EP0693054A1 (de) 1996-01-24
WO1994022814A1 (en) 1994-10-13
CA2160140C (en) 1999-03-16
ES2116591T3 (es) 1998-07-16
CA2160140A1 (en) 1994-10-13
DK0693054T3 (da) 1998-10-19
US5681858A (en) 1997-10-28
DE69411003D1 (de) 1998-07-16

Similar Documents

Publication Publication Date Title
DK0883616T3 (da) Dihydrobenzofuranforbindelser og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler
ATE167180T1 (de) Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren
DE69229637D1 (de) Oxazolidone Derivative als Monoamine-Oxidaseinhibitoren
DE69512208T2 (de) Aminosäurederivate und ihre verwendung als phospholipase-a2-inhibitoren
DE69200665D1 (de) Lipoxygenase inhibierende Hydroxamsäure und N-Hydroxyharnstoff-Derivate.
PE57194A1 (es) Hidroxiurea de fenoxifenil ciclopentenil
IL113706A (en) N-hydroxyurea alkyl phenyl oxazoles and thiazoles uses thereof as anti-inflammatory agents and pharmaceutical compositions containing them
KR950702533A (ko) 리폭시게나제 억제제로서의 인돌리닐 n-하이드록시우레아 및 n-하이드록삼산 유도체(indolinyl n-hydroxyurea and n-hydroxamic acid derivatives as lipoxygenase inhibitors)
DK0710233T3 (da) Heteroarylcycloalkenylhydroxyurinstoffer

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee