ES2116591T3 - Cicloalquilhidroxiureas y su uso como inhibidores de la lipoxigenasa. - Google Patents

Cicloalquilhidroxiureas y su uso como inhibidores de la lipoxigenasa.

Info

Publication number
ES2116591T3
ES2116591T3 ES94910604T ES94910604T ES2116591T3 ES 2116591 T3 ES2116591 T3 ES 2116591T3 ES 94910604 T ES94910604 T ES 94910604T ES 94910604 T ES94910604 T ES 94910604T ES 2116591 T3 ES2116591 T3 ES 2116591T3
Authority
ES
Spain
Prior art keywords
pct
chain
date oct
sec
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94910604T
Other languages
English (en)
Inventor
Rodney W Stevens
Takashi Mano
Yoshiyuki Okumura
Masami Nakane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2116591T3 publication Critical patent/ES2116591T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SUMINISTRA UN NUEVO COMPUESTO DE N-HIDROXIUREA DE LA FORMULA QUIMICA (I) EN DONDE R1 Y R2 SON CADA UNA INDEPENDIENTEMENTE HIDROGENO O ALQUIL C{SUB, 1-4}; AR ES FENIL O FENIL MONO, DI O TRISUSTITUIDO; A ES UN ENLACE DE VALENCIA O UNA CADENA DE ALQUILENO C{SUB, 1-6}, QUE TIENE OPCIONALMENTE UN ENLACE DOBLE O UN ENLACE TRIPLE EN LA CADENA Y OPCIONALMENTE TIENE UNO O MAS GRUPOS DE ALQUIL C{SUB, 1-4} UNIDOS A LA CADENA; X ES OXIGENO O AZUFRE, N ES UN ENTERO ENTRE 3 Y 6; M ES HIDROGENO, UN CATION FARMACOLOGICAMENTE ACEPTABLE O UN GRUPO METABOLICAMENTE DIVISIBLE; Y X Y A PUEDEN ESTAR UNIDAS EN CUALQUIER POSICION DISPONIBLE SOBRE EL ANILLO. ESTOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO O EL ALIVIO DE ENFERMEDADES INFLAMATORIOS, ALERGIAS Y ENFERMEDADES CARDIOVASCULARES EN MAMIFEROS Y COMO INGREDIENTE ACTIVO EN COMPOSICIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE DICHAS CONDICIONES.
ES94910604T 1993-04-07 1994-04-05 Cicloalquilhidroxiureas y su uso como inhibidores de la lipoxigenasa. Expired - Lifetime ES2116591T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8095293 1993-04-07

Publications (1)

Publication Number Publication Date
ES2116591T3 true ES2116591T3 (es) 1998-07-16

Family

ID=13732846

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94910604T Expired - Lifetime ES2116591T3 (es) 1993-04-07 1994-04-05 Cicloalquilhidroxiureas y su uso como inhibidores de la lipoxigenasa.

Country Status (8)

Country Link
US (1) US5681858A (es)
EP (1) EP0693054B1 (es)
AT (1) ATE167180T1 (es)
CA (1) CA2160140C (es)
DE (1) DE69411003T2 (es)
DK (1) DK0693054T3 (es)
ES (1) ES2116591T3 (es)
WO (1) WO1994022814A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3179286B2 (ja) * 1994-05-19 2001-06-25 ファイザー製薬株式会社 Ｎ−ヒドロキシ尿素系抗炎症剤
WO1996015106A1 (en) * 1994-11-10 1996-05-23 Pfizer Pharmaceuticals Inc. Aryloxycycloalkenyl and aryloxyiminocycloalkenylhydroxyureas as 5-lipoxygenase inhibitors
CN104736569A (zh) 2012-01-12 2015-06-24 耶鲁大学 通过e3泛素连接酶增强靶蛋白质及其他多肽降解的化合物和方法
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
US10071164B2 (en) 2014-08-11 2018-09-11 Yale University Estrogen-related receptor alpha based protac compounds and associated methods of use
BR112018008918A8 (pt) 2015-11-02 2019-02-26 Univ Yale compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
EP0540673B1 (en) * 1990-07-25 1996-10-16 Abbott Laboratories Acetylene derivatives having lipoxygenase inhibitory activity
US5476873A (en) * 1990-07-25 1995-12-19 Abbott Laboratories Acetylene derivatives having lipoxygenase inhibitory activity
GB9025514D0 (en) * 1990-11-23 1991-01-09 Wellcome Found Anti-inflammatory compounds
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物

Also Published As

Publication number Publication date
DE69411003T2 (de) 1998-10-08
EP0693054B1 (en) 1998-06-10
CA2160140C (en) 1999-03-16
ATE167180T1 (de) 1998-06-15
US5681858A (en) 1997-10-28
CA2160140A1 (en) 1994-10-13
DE69411003D1 (de) 1998-07-16
EP0693054A1 (en) 1996-01-24
DK0693054T3 (da) 1998-10-19
WO1994022814A1 (en) 1994-10-13

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