DE69411003D1 - Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren - Google Patents
Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitorenInfo
- Publication number
- DE69411003D1 DE69411003D1 DE69411003T DE69411003T DE69411003D1 DE 69411003 D1 DE69411003 D1 DE 69411003D1 DE 69411003 T DE69411003 T DE 69411003T DE 69411003 T DE69411003 T DE 69411003T DE 69411003 D1 DE69411003 D1 DE 69411003D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- chain
- date oct
- sec
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8095293 | 1993-04-07 | ||
PCT/JP1994/000567 WO1994022814A1 (en) | 1993-04-07 | 1994-04-05 | Cycloalkylhydroxyureas and their use as lipoxygenase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69411003D1 true DE69411003D1 (de) | 1998-07-16 |
DE69411003T2 DE69411003T2 (de) | 1998-10-08 |
Family
ID=13732846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69411003T Expired - Fee Related DE69411003T2 (de) | 1993-04-07 | 1994-04-05 | Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren |
Country Status (8)
Country | Link |
---|---|
US (1) | US5681858A (de) |
EP (1) | EP0693054B1 (de) |
AT (1) | ATE167180T1 (de) |
CA (1) | CA2160140C (de) |
DE (1) | DE69411003T2 (de) |
DK (1) | DK0693054T3 (de) |
ES (1) | ES2116591T3 (de) |
WO (1) | WO1994022814A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3179286B2 (ja) * | 1994-05-19 | 2001-06-25 | ファイザー製薬株式会社 | N−ヒドロキシ尿素系抗炎症剤 |
US5798383A (en) * | 1994-11-10 | 1998-08-25 | Pfizer Inc. | Aryloxycycloalkenyl and aryloxyiminocycloalkenylhydroxyureas |
KR102668696B1 (ko) | 2012-01-12 | 2024-05-29 | 예일 유니버시티 | E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법 |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
US10071164B2 (en) | 2014-08-11 | 2018-09-11 | Yale University | Estrogen-related receptor alpha based protac compounds and associated methods of use |
BR112018008918A8 (pt) | 2015-11-02 | 2019-02-26 | Univ Yale | compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5120752A (en) * | 1989-12-28 | 1992-06-09 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
ATE144247T1 (de) * | 1990-07-25 | 1996-11-15 | Abbott Lab | Acetylenderivate mit lipoxygenase inhibitorischer wirkung |
US5476873A (en) * | 1990-07-25 | 1995-12-19 | Abbott Laboratories | Acetylene derivatives having lipoxygenase inhibitory activity |
GB9025514D0 (en) * | 1990-11-23 | 1991-01-09 | Wellcome Found | Anti-inflammatory compounds |
JP3007138B2 (ja) * | 1990-11-27 | 2000-02-07 | ファイザー製薬株式会社 | 新規なヒドロキサム酸とn―ヒドロキシ尿素誘導体およびそれらの組成物 |
-
1994
- 1994-04-05 DK DK94910604T patent/DK0693054T3/da active
- 1994-04-05 EP EP94910604A patent/EP0693054B1/de not_active Expired - Lifetime
- 1994-04-05 DE DE69411003T patent/DE69411003T2/de not_active Expired - Fee Related
- 1994-04-05 ES ES94910604T patent/ES2116591T3/es not_active Expired - Lifetime
- 1994-04-05 CA CA002160140A patent/CA2160140C/en not_active Expired - Fee Related
- 1994-04-05 AT AT94910604T patent/ATE167180T1/de not_active IP Right Cessation
- 1994-04-05 US US08/525,748 patent/US5681858A/en not_active Expired - Fee Related
- 1994-04-05 WO PCT/JP1994/000567 patent/WO1994022814A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0693054B1 (de) | 1998-06-10 |
CA2160140C (en) | 1999-03-16 |
EP0693054A1 (de) | 1996-01-24 |
DE69411003T2 (de) | 1998-10-08 |
ATE167180T1 (de) | 1998-06-15 |
US5681858A (en) | 1997-10-28 |
ES2116591T3 (es) | 1998-07-16 |
CA2160140A1 (en) | 1994-10-13 |
WO1994022814A1 (en) | 1994-10-13 |
DK0693054T3 (da) | 1998-10-19 |
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MY110226A (en) | Therapeutic heterocyclic compounds. | |
DE69411003T2 (de) | Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren | |
FI941863A0 (fi) | Oksatsolidonijohdannainen | |
ATE113942T1 (de) | Lipoxygenase inhibierende hydroxamsäure und n- hydroxyharnstoff-derivate. | |
IL113706A (en) | N-hydroxyurea alkyl phenyl oxazoles and thiazoles uses thereof as anti-inflammatory agents and pharmaceutical compositions containing them | |
PE57194A1 (es) | Hidroxiurea de fenoxifenil ciclopentenil | |
BR9306762A (pt) | Derivados indolinila anti-inflamatórios da n-hidroxiuréia e do ácido n-hidroxámico | |
DE69421183T2 (de) | Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe | |
MY107993A (en) | Orally active antiviral compounds. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |