DE69421183T2 - Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe - Google Patents

Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe

Info

Publication number
DE69421183T2
DE69421183T2 DE69421183T DE69421183T DE69421183T2 DE 69421183 T2 DE69421183 T2 DE 69421183T2 DE 69421183 T DE69421183 T DE 69421183T DE 69421183 T DE69421183 T DE 69421183T DE 69421183 T2 DE69421183 T2 DE 69421183T2
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
pct
fluoro
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69421183T
Other languages
English (en)
Other versions
DE69421183D1 (de
Inventor
Akiyoshi Kawai
Rodney Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE69421183D1 publication Critical patent/DE69421183D1/de
Application granted granted Critical
Publication of DE69421183T2 publication Critical patent/DE69421183T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69421183T 1993-07-20 1994-07-05 Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe Expired - Fee Related DE69421183T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17940193 1993-07-20
PCT/JP1994/001093 WO1995003292A1 (en) 1993-07-20 1994-07-05 Heteroaryl cycloalkenyl hydroxyureas

Publications (2)

Publication Number Publication Date
DE69421183D1 DE69421183D1 (de) 1999-11-18
DE69421183T2 true DE69421183T2 (de) 2000-01-20

Family

ID=16065226

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69421183T Expired - Fee Related DE69421183T2 (de) 1993-07-20 1994-07-05 Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe

Country Status (11)

Country Link
US (1) US5665768A (de)
EP (1) EP0710233B1 (de)
JP (1) JPH08511029A (de)
AT (1) ATE185563T1 (de)
CA (1) CA2167715C (de)
DE (1) DE69421183T2 (de)
DK (1) DK0710233T3 (de)
ES (1) ES2139746T3 (de)
FI (1) FI943420A (de)
GR (1) GR3032238T3 (de)
WO (1) WO1995003292A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016054A1 (en) * 1994-11-18 1996-05-30 Pfizer Pharmaceuticals Inc. Cycloalkenyl-n-hydroxyureas
CA2388844A1 (en) * 1999-11-12 2001-05-25 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
CN101134119A (zh) 2002-05-24 2008-03-05 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334975C (en) * 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
GB9025514D0 (en) * 1990-11-23 1991-01-09 Wellcome Found Anti-inflammatory compounds
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
JPH0717612B2 (ja) * 1991-06-28 1995-03-01 ファイザー製薬株式会社 新規なテトラヒドロベンズアゼピン誘導体
JP2989951B2 (ja) * 1991-10-25 1999-12-13 ファイザー製薬株式会社 新規なシクロアルキル尿素誘導体および組成物
US5521212A (en) * 1991-12-13 1996-05-28 Pfizer Inc. Cyclopropyl N-hydroxyurea and N-hydroxyacetamides which inhibit lipoxygenase
US5169854A (en) * 1992-02-26 1992-12-08 Abbott Laboratories N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity
US5187192A (en) * 1992-03-13 1993-02-16 Abbott Laboratories Cyclobutyl derivatives having lipoxygenase inhibitory activity

Also Published As

Publication number Publication date
WO1995003292A1 (en) 1995-02-02
FI943420A (fi) 1995-01-21
EP0710233B1 (de) 1999-10-13
CA2167715C (en) 1998-10-06
CA2167715A1 (en) 1995-02-02
FI943420A0 (fi) 1994-07-19
GR3032238T3 (en) 2000-04-27
DK0710233T3 (da) 2000-01-03
US5665768A (en) 1997-09-09
ATE185563T1 (de) 1999-10-15
ES2139746T3 (es) 2000-02-16
JPH08511029A (ja) 1996-11-19
DE69421183D1 (de) 1999-11-18
EP0710233A1 (de) 1996-05-08

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DE69421183T2 (de) Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe
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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee