DE69200665D1 - Lipoxygenase inhibierende Hydroxamsäure und N-Hydroxyharnstoff-Derivate. - Google Patents

Lipoxygenase inhibierende Hydroxamsäure und N-Hydroxyharnstoff-Derivate.

Info

Publication number
DE69200665D1
DE69200665D1 DE69200665T DE69200665T DE69200665D1 DE 69200665 D1 DE69200665 D1 DE 69200665D1 DE 69200665 T DE69200665 T DE 69200665T DE 69200665 T DE69200665 T DE 69200665T DE 69200665 D1 DE69200665 D1 DE 69200665D1
Authority
DE
Germany
Prior art keywords
hydrogen
hydroxamic acid
hydroxyurea derivatives
alkenyl
sulfur
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69200665T
Other languages
English (en)
Other versions
DE69200665T2 (de
Inventor
Rodney William Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE69200665D1 publication Critical patent/DE69200665D1/de
Application granted granted Critical
Publication of DE69200665T2 publication Critical patent/DE69200665T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
DE69200665T 1991-02-07 1992-01-08 Lipoxygenase inhibierende Hydroxamsäure und N-Hydroxyharnstoff-Derivate. Expired - Fee Related DE69200665T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3016325A JPH0730061B2 (ja) 1991-02-07 1991-02-07 ヒドロキサム酸誘導体および組成物
PCT/US1992/000027 WO1992013848A1 (en) 1991-02-07 1992-01-08 Lipoxygenase-inhibiting hydroxamic acid and n-hydroxyurea derivatives

Publications (2)

Publication Number Publication Date
DE69200665D1 true DE69200665D1 (de) 1994-12-15
DE69200665T2 DE69200665T2 (de) 1995-04-06

Family

ID=11913313

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69200665T Expired - Fee Related DE69200665T2 (de) 1991-02-07 1992-01-08 Lipoxygenase inhibierende Hydroxamsäure und N-Hydroxyharnstoff-Derivate.

Country Status (21)

Country Link
EP (1) EP0570401B1 (de)
JP (1) JPH0730061B2 (de)
KR (1) KR930703279A (de)
AT (1) ATE113942T1 (de)
AU (1) AU648872B2 (de)
CA (1) CA2101539A1 (de)
DE (1) DE69200665T2 (de)
DK (1) DK0570401T3 (de)
ES (1) ES2063578T3 (de)
FI (1) FI933492A0 (de)
HU (1) HUT65539A (de)
IE (1) IE920392A1 (de)
IL (1) IL100846A0 (de)
MX (1) MX9200519A (de)
MY (1) MY134478A (de)
NO (1) NO932815L (de)
NZ (1) NZ241530A (de)
PT (1) PT100093A (de)
TW (1) TW222627B (de)
WO (1) WO1992013848A1 (de)
ZA (1) ZA92862B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
CA2140034A1 (en) 1992-07-13 1994-01-20 Xiong Cai 2,5-diaryl tetrahydro-thiophenes, -furans and analogs for the treatment of inflammatory and immune disorders
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US6201016B1 (en) * 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
CA2194064C (en) * 1994-06-27 2009-03-17 Xiong Cai Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
MX9701042A (es) * 1996-02-07 1998-05-31 Pfizer Compuestos del acido hidroxamico.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1044308A (en) * 1964-04-28 1966-09-28 Langbein Pfanhauser Werke Ag Electrodeposition of bright copper
US3393209A (en) * 1965-10-04 1968-07-16 Dow Chemical Co Furfuryl and tetrahydrofurfuryl phenyl ureas
JPS5742632B2 (de) * 1972-12-25 1982-09-09
DE3882732T2 (de) * 1987-02-10 1993-12-02 Abbott Lab Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen.
GB2201008B (en) * 1987-02-12 1991-10-23 Stc Plc Optical fibre cables

Also Published As

Publication number Publication date
MY134478A (en) 2007-12-31
AU1173692A (en) 1992-09-07
DE69200665T2 (de) 1995-04-06
JPH04257571A (ja) 1992-09-11
KR930703279A (ko) 1993-11-29
EP0570401A1 (de) 1993-11-24
AU648872B2 (en) 1994-05-05
HU9302283D0 (en) 1993-10-28
ES2063578T3 (es) 1995-01-01
CA2101539A1 (en) 1992-08-08
JPH0730061B2 (ja) 1995-04-05
FI933492A (fi) 1993-08-06
ZA92862B (en) 1993-08-06
DK0570401T3 (da) 1994-12-05
FI933492A0 (fi) 1993-08-06
IE920392A1 (en) 1992-08-12
NZ241530A (en) 1994-06-27
PT100093A (pt) 1993-03-31
IL100846A0 (en) 1992-11-15
NO932815D0 (no) 1993-08-06
ATE113942T1 (de) 1994-11-15
MX9200519A (es) 1992-08-31
HUT65539A (en) 1994-06-28
TW222627B (de) 1994-04-21
WO1992013848A1 (en) 1992-08-20
NO932815L (no) 1993-08-09
EP0570401B1 (de) 1994-11-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee