ES2063578T3 - Derivados del acido hidroxamico y de n-hidroxiurea inhibidores de la lipoxigenasa. - Google Patents
Derivados del acido hidroxamico y de n-hidroxiurea inhibidores de la lipoxigenasa.Info
- Publication number
- ES2063578T3 ES2063578T3 ES92903377T ES92903377T ES2063578T3 ES 2063578 T3 ES2063578 T3 ES 2063578T3 ES 92903377 T ES92903377 T ES 92903377T ES 92903377 T ES92903377 T ES 92903377T ES 2063578 T3 ES2063578 T3 ES 2063578T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- hydroxamic acid
- hydroxyurea
- derivatives
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Lubricants (AREA)
Abstract
CIERTOS DERIVADOS NUEVOS DEL ACIDO HIDROXAMICO Y DE HIDROXIUREAS QUE TIENEN LA ESTRUCTURA (I), EN DONDE R1 ES HIDROGENO, ALKILO, ALKENILO, AMINO O AMINO SUSTITUIDO, R4 ES HIDROGENO, UN CATION FARMACEUTICAMENTE ACEPTABLE, AROILO O ALCOILO, A ES ALKILENO O ALKENILENO, X ES OXIGENO O AZUFRE, CADA Y ES HIDROGENO, HALO, CIANO, HIDROXI, ALKILO, ALCOXI, ALKILTIO, ALKENILO, ALCOXIALKILO, CICLOALKILO, ARILO, ARILOXI, ARILALKILO, ARILALKENILO, ARILALCOXI O ARILO SUSTITUIDO, Z ES OXIGENO O AZUFRE, M ES 0 O 1, N ES DE 1 A 5 Y P ES DE 2 A 6 INHIBEN LA LIPOXIGENASA DE LA ENZIMA. ESTOS COMPUESTOS, Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, SON UTILES PARA EL TRATAMIENTO O ALIVIO DE ENFERMEDADES INFLAMATORIAS, ESTADOS ALERGICOS Y ENFERMEDADES CARDIOVASCULARES EN MAMIFEROS Y COMO EL INGREDIENTE ACTIVO DE COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE TALES ESTADOS DE SALUD.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3016325A JPH0730061B2 (ja) | 1991-02-07 | 1991-02-07 | ヒドロキサム酸誘導体および組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2063578T3 true ES2063578T3 (es) | 1995-01-01 |
Family
ID=11913313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92903377T Expired - Lifetime ES2063578T3 (es) | 1991-02-07 | 1992-01-08 | Derivados del acido hidroxamico y de n-hidroxiurea inhibidores de la lipoxigenasa. |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0570401B1 (es) |
JP (1) | JPH0730061B2 (es) |
KR (1) | KR930703279A (es) |
AT (1) | ATE113942T1 (es) |
AU (1) | AU648872B2 (es) |
CA (1) | CA2101539A1 (es) |
DE (1) | DE69200665T2 (es) |
DK (1) | DK0570401T3 (es) |
ES (1) | ES2063578T3 (es) |
FI (1) | FI933492A0 (es) |
HU (1) | HUT65539A (es) |
IE (1) | IE920392A1 (es) |
IL (1) | IL100846A0 (es) |
MX (1) | MX9200519A (es) |
MY (1) | MY134478A (es) |
NO (1) | NO932815L (es) |
NZ (1) | NZ241530A (es) |
PT (1) | PT100093A (es) |
TW (1) | TW222627B (es) |
WO (1) | WO1992013848A1 (es) |
ZA (1) | ZA92862B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639782A (en) * | 1992-03-04 | 1997-06-17 | Center For Innovative Technology | Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors |
CA2140034A1 (en) | 1992-07-13 | 1994-01-20 | Xiong Cai | 2,5-diaryl tetrahydro-thiophenes, -furans and analogs for the treatment of inflammatory and immune disorders |
US5434151A (en) * | 1992-08-24 | 1995-07-18 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5463083A (en) * | 1992-07-13 | 1995-10-31 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5750565A (en) * | 1995-05-25 | 1998-05-12 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
EP0770064B1 (en) * | 1994-06-27 | 2003-11-05 | Millenium Pharmaceuticals, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US6201016B1 (en) * | 1994-06-27 | 2001-03-13 | Cytomed Incorporated | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5703093A (en) * | 1995-05-31 | 1997-12-30 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5792776A (en) * | 1994-06-27 | 1998-08-11 | Cytomed, Inc., | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
MX9701042A (es) * | 1996-02-07 | 1998-05-31 | Pfizer | Compuestos del acido hidroxamico. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1044308A (en) * | 1964-04-28 | 1966-09-28 | Langbein Pfanhauser Werke Ag | Electrodeposition of bright copper |
US3393209A (en) * | 1965-10-04 | 1968-07-16 | Dow Chemical Co | Furfuryl and tetrahydrofurfuryl phenyl ureas |
JPS5742632B2 (es) * | 1972-12-25 | 1982-09-09 | ||
EP0279263B1 (en) * | 1987-02-10 | 1993-08-04 | Abbott Laboratories | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds |
GB2201008B (en) * | 1987-02-12 | 1991-10-23 | Stc Plc | Optical fibre cables |
-
1991
- 1991-02-07 JP JP3016325A patent/JPH0730061B2/ja not_active Expired - Fee Related
-
1992
- 1992-01-08 WO PCT/US1992/000027 patent/WO1992013848A1/en active IP Right Grant
- 1992-01-08 HU HU9302283A patent/HUT65539A/hu unknown
- 1992-01-08 DE DE69200665T patent/DE69200665T2/de not_active Expired - Fee Related
- 1992-01-08 CA CA002101539A patent/CA2101539A1/en not_active Abandoned
- 1992-01-08 AT AT92903377T patent/ATE113942T1/de not_active IP Right Cessation
- 1992-01-08 EP EP92903377A patent/EP0570401B1/en not_active Expired - Lifetime
- 1992-01-08 DK DK92903377.7T patent/DK0570401T3/da active
- 1992-01-08 ES ES92903377T patent/ES2063578T3/es not_active Expired - Lifetime
- 1992-01-08 AU AU11736/92A patent/AU648872B2/en not_active Ceased
- 1992-01-08 KR KR1019930702342A patent/KR930703279A/ko not_active Application Discontinuation
- 1992-01-23 TW TW081100484A patent/TW222627B/zh active
- 1992-02-02 IL IL100846A patent/IL100846A0/xx unknown
- 1992-02-05 PT PT100093A patent/PT100093A/pt not_active Application Discontinuation
- 1992-02-05 NZ NZ241530A patent/NZ241530A/xx unknown
- 1992-02-06 IE IE039292A patent/IE920392A1/en not_active Application Discontinuation
- 1992-02-06 ZA ZA92862A patent/ZA92862B/xx unknown
- 1992-02-06 MX MX9200519A patent/MX9200519A/es unknown
- 1992-02-07 MY MYPI92000189A patent/MY134478A/en unknown
-
1993
- 1993-08-06 NO NO93932815A patent/NO932815L/no unknown
- 1993-08-06 FI FI933492A patent/FI933492A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ241530A (en) | 1994-06-27 |
TW222627B (es) | 1994-04-21 |
NO932815L (no) | 1993-08-09 |
HUT65539A (en) | 1994-06-28 |
ZA92862B (en) | 1993-08-06 |
IL100846A0 (en) | 1992-11-15 |
DE69200665T2 (de) | 1995-04-06 |
MX9200519A (es) | 1992-08-31 |
JPH0730061B2 (ja) | 1995-04-05 |
CA2101539A1 (en) | 1992-08-08 |
AU648872B2 (en) | 1994-05-05 |
EP0570401A1 (en) | 1993-11-24 |
MY134478A (en) | 2007-12-31 |
KR930703279A (ko) | 1993-11-29 |
HU9302283D0 (en) | 1993-10-28 |
ATE113942T1 (de) | 1994-11-15 |
PT100093A (pt) | 1993-03-31 |
DK0570401T3 (da) | 1994-12-05 |
FI933492A (fi) | 1993-08-06 |
DE69200665D1 (de) | 1994-12-15 |
FI933492A0 (fi) | 1993-08-06 |
NO932815D0 (no) | 1993-08-06 |
AU1173692A (en) | 1992-09-07 |
IE920392A1 (en) | 1992-08-12 |
WO1992013848A1 (en) | 1992-08-20 |
JPH04257571A (ja) | 1992-09-11 |
EP0570401B1 (en) | 1994-11-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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