DE69103773D1 - Derivate von hydroxaminsäure die lipoxygenase hemmen. - Google Patents

Derivate von hydroxaminsäure die lipoxygenase hemmen.

Info

Publication number
DE69103773D1
DE69103773D1 DE69103773T DE69103773T DE69103773D1 DE 69103773 D1 DE69103773 D1 DE 69103773D1 DE 69103773 T DE69103773 T DE 69103773T DE 69103773 T DE69103773 T DE 69103773T DE 69103773 D1 DE69103773 D1 DE 69103773D1
Authority
DE
Germany
Prior art keywords
hydroxamic acid
lipoxygenase
derivatives
inhibit
acid inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69103773T
Other languages
English (en)
Other versions
DE69103773T2 (de
Inventor
Kazuo Ando
Takafumi Ikeda
Masami Nakane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE69103773D1 publication Critical patent/DE69103773D1/de
Publication of DE69103773T2 publication Critical patent/DE69103773T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
DE69103773T 1990-12-11 1991-10-08 Derivate von hydroxaminsäure die lipoxygenase hemmen. Expired - Fee Related DE69103773T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2415745A JPH06256285A (ja) 1990-12-11 1990-12-11 ヒドロキサム酸誘導体およびその用途
PCT/US1991/007193 WO1992010469A1 (en) 1990-12-11 1991-10-08 Hydroxamic acid derivatives which inhibit lipoxygenase

Publications (2)

Publication Number Publication Date
DE69103773D1 true DE69103773D1 (de) 1994-10-06
DE69103773T2 DE69103773T2 (de) 1994-12-15

Family

ID=18524043

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69103773T Expired - Fee Related DE69103773T2 (de) 1990-12-11 1991-10-08 Derivate von hydroxaminsäure die lipoxygenase hemmen.

Country Status (11)

Country Link
EP (1) EP0561882B1 (de)
JP (1) JPH06256285A (de)
AT (1) ATE110714T1 (de)
CA (1) CA2094247A1 (de)
DE (1) DE69103773T2 (de)
DK (1) DK0561882T3 (de)
ES (1) ES2059204T3 (de)
FI (1) FI932654A (de)
IE (1) IE63704B1 (de)
PT (1) PT99729A (de)
WO (1) WO1992010469A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU647177B2 (en) * 1990-07-25 1994-03-17 Abbott Laboratories Acetylenic urea derivatives having lipoxygenase inhibitory activity
US5476873A (en) * 1990-07-25 1995-12-19 Abbott Laboratories Acetylene derivatives having lipoxygenase inhibitory activity
GB9215921D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Anti-inflammatory compounds
US5288751A (en) * 1992-11-06 1994-02-22 Abbott Laboratories [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis
US5342980A (en) * 1992-12-30 1994-08-30 American Cyanamid Company Fungicidal agents
GB9308652D0 (en) * 1993-04-27 1993-06-09 Wellcome Found Anti-inflammatory compounds
TW418089B (en) * 1993-08-19 2001-01-11 Pfizer Pharmaceutical composition comprising phenoxyphenyl cyclopentenyl hydroxyureas (the dextrorotary isomers)
JP2732504B2 (ja) * 1995-03-08 1998-03-30 農林水産省中国農業試験場長 アラキドン酸代謝活性阻害剤とその製造法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0288553A (ja) * 1988-07-14 1990-03-28 Wellcome Found Ltd:The 抗炎症性アリール誘導体
NZ232350A (en) * 1989-02-03 1992-04-28 Wellcome Found N-(1-methyl-3-((halophenoxy)phenyl)prop-2-en-1-yl)-n-hydroxyurea derivatives and pharmaceutical compositions
WO1990012008A1 (en) * 1989-03-30 1990-10-18 Abbott Laboratories Urea based lipoxygenase inhibiting compounds

Also Published As

Publication number Publication date
DE69103773T2 (de) 1994-12-15
IE914284A1 (en) 1992-06-17
DK0561882T3 (da) 1994-10-03
ATE110714T1 (de) 1994-09-15
CA2094247A1 (en) 1992-06-13
PT99729A (pt) 1992-11-30
IE63704B1 (en) 1995-05-31
EP0561882B1 (de) 1994-08-31
JPH06256285A (ja) 1994-09-13
WO1992010469A1 (en) 1992-06-25
FI932654A0 (fi) 1993-06-10
ES2059204T3 (es) 1994-11-01
EP0561882A1 (de) 1993-09-29
FI932654A (fi) 1993-06-10

Similar Documents

Publication Publication Date Title
TW262461B (de)
RU93004907A (ru) Производные гидроксамовой кислоты и n-гидроксимочевины. способ их получения фармацевтическая композиция и способ лечения
SE7903186L (sv) Cerebralverksamt medel
DE69939720D1 (de) Fulvinsäure und deren Verwendung in der Behandlung von viralen Infektionen
DE69103773D1 (de) Derivate von hydroxaminsäure die lipoxygenase hemmen.
EE200100188A (et) Optiliselt aktiivne püridüül-4H-1,2,4-oksadiasiini derivaat ja selle kasutamine vaskulaarsete haiguste ravis
NO975726L (no) N-Hydroksyurea-derivater som anti-inflammatoriske midler

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee