MX347954B - Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12. - Google Patents

Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12.

Info

Publication number
MX347954B
MX347954B MX2016003743A MX2016003743A MX347954B MX 347954 B MX347954 B MX 347954B MX 2016003743 A MX2016003743 A MX 2016003743A MX 2016003743 A MX2016003743 A MX 2016003743A MX 347954 B MX347954 B MX 347954B
Authority
MX
Mexico
Prior art keywords
adc
bind
drug conjugates
antibody drug
proteins
Prior art date
Application number
MX2016003743A
Other languages
English (en)
Inventor
Torgov Michael
Kendall Morrison Robert
An Zili
Jane Meyrick Morrison Karen
Satpaev Daulet
Gudas Jean
Jakobovits Aya
Original Assignee
Agensys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45871300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX347954(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Agensys Inc filed Critical Agensys Inc
Publication of MX347954B publication Critical patent/MX347954B/es

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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La presente invención se refiere a un polinucleotido aislado que comprende una secuencia que codifica una región variable de cadena pesada que comprende regiones determinantes complementarias (CDRs) que tienen las secuencias de aminoácidos de los CDRs en la secuencia de región variable de cadena pesada mostrada en SEQ ID NO: 7 y una región variable de cadena ligera que comprende CDRs que tienen las secuencias de aminoácidos de los CDRs en la secuencia de región variable de cadena ligera mostrada en SEQ ID NO: 8 de un anticuerpo o fragmento de enlace de antígeno del mismo que enlaza a una proteína 191P4D12.
MX2016003743A 2010-09-29 2011-09-29 Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12. MX347954B (es)

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