CY1121023T1 - Συζευγματα αντισωματος φαρμακου (adc) τα οποια δεσμευονται σε 191p4d12 πρωτεϊνες - Google Patents

Συζευγματα αντισωματος φαρμακου (adc) τα οποια δεσμευονται σε 191p4d12 πρωτεϊνες

Info

Publication number
CY1121023T1
CY1121023T1 CY181100790T CY181100790T CY1121023T1 CY 1121023 T1 CY1121023 T1 CY 1121023T1 CY 181100790 T CY181100790 T CY 181100790T CY 181100790 T CY181100790 T CY 181100790T CY 1121023 T1 CY1121023 T1 CY 1121023T1
Authority
CY
Cyprus
Prior art keywords
adc
proteins
drug antibodies
adcs
tissue
Prior art date
Application number
CY181100790T
Other languages
English (en)
Inventor
Daulet Satpaev
Robert Kendall Morrison
Karen Jane Meyrick Morrison
Jean Gudas
Aya Jakobovits
Michael Torgov
Zili An
Original Assignee
Agensys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45871300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1121023(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Agensys Inc filed Critical Agensys Inc
Publication of CY1121023T1 publication Critical patent/CY1121023T1/el

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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Συζεύγματα αντισώματος φαρμάκου (ADC's) τα οποία δεσμεύονται σε 191P4D12 πρωτεΐνη και παραλλαγές αυτής περιγράφονται στο παρόν. Η 191P4D12 παρουσιάζει ιστο-ειδική έκφραση σε φυσιολογικό ενήλικο ιστό, και εκφράζεται μη-φυσιολογικά στους καρκίνους οι οποίοι παρατίθενται στον Πίνακα I. Κατά συνέπεια, τα ADC's της εφεύρεσης παρέχουν μία θεραπευτική σύνθεση για την αντιμετώπιση καρκίνου.
CY181100790T 2010-09-29 2018-07-31 Συζευγματα αντισωματος φαρμακου (adc) τα οποια δεσμευονται σε 191p4d12 πρωτεϊνες CY1121023T1 (el)

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