CY1121023T1 - Συζευγματα αντισωματος φαρμακου (adc) τα οποια δεσμευονται σε 191p4d12 πρωτεϊνες - Google Patents

Συζευγματα αντισωματος φαρμακου (adc) τα οποια δεσμευονται σε 191p4d12 πρωτεϊνες

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Publication number
CY1121023T1
CY1121023T1 CY181100790T CY181100790T CY1121023T1 CY 1121023 T1 CY1121023 T1 CY 1121023T1 CY 181100790 T CY181100790 T CY 181100790T CY 181100790 T CY181100790 T CY 181100790T CY 1121023 T1 CY1121023 T1 CY 1121023T1
Authority
CY
Cyprus
Prior art keywords
adc
proteins
drug antibodies
adcs
tissue
Prior art date
Application number
CY181100790T
Other languages
English (en)
Inventor
Daulet Satpaev
Robert Kendall Morrison
Karen Jane Meyrick Morrison
Jean Gudas
Aya Jakobovits
Michael Torgov
Zili An
Original Assignee
Agensys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45871300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1121023(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Agensys Inc filed Critical Agensys Inc
Publication of CY1121023T1 publication Critical patent/CY1121023T1/el

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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Συζεύγματα αντισώματος φαρμάκου (ADC's) τα οποία δεσμεύονται σε 191P4D12 πρωτεΐνη και παραλλαγές αυτής περιγράφονται στο παρόν. Η 191P4D12 παρουσιάζει ιστο-ειδική έκφραση σε φυσιολογικό ενήλικο ιστό, και εκφράζεται μη-φυσιολογικά στους καρκίνους οι οποίοι παρατίθενται στον Πίνακα I. Κατά συνέπεια, τα ADC's της εφεύρεσης παρέχουν μία θεραπευτική σύνθεση για την αντιμετώπιση καρκίνου.
CY181100790T 2010-09-29 2018-07-31 Συζευγματα αντισωματος φαρμακου (adc) τα οποια δεσμευονται σε 191p4d12 πρωτεϊνες CY1121023T1 (el)

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PCT/US2011/054054 WO2012047724A1 (en) 2010-09-29 2011-09-29 Antibody drug conjugates (adc) that bind to 191p4d12 proteins

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CY20211100429T CY1124166T1 (el) 2010-09-29 2021-05-18 Συζευγματα αντισωματος φαρμακου (adc) τα οποια δεσμευονται σε 191p4d12 πρωτεϊνες

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