MX337873B - Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12. - Google Patents

Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12.

Info

Publication number
MX337873B
MX337873B MX2013003419A MX2013003419A MX337873B MX 337873 B MX337873 B MX 337873B MX 2013003419 A MX2013003419 A MX 2013003419A MX 2013003419 A MX2013003419 A MX 2013003419A MX 337873 B MX337873 B MX 337873B
Authority
MX
Mexico
Prior art keywords
chain variable
variable region
cdrs
adc
bind
Prior art date
Application number
MX2013003419A
Other languages
English (en)
Other versions
MX2013003419A (es
Inventor
Aya Jakobovits
Jean Gudas
Robert Kendall Morrison
Karen Jane Meyrick Morrison
Daulet Satpaev
Zili An
Michael Torgov
Original Assignee
Agensys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45871300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX337873(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Agensys Inc filed Critical Agensys Inc
Publication of MX2013003419A publication Critical patent/MX2013003419A/es
Publication of MX337873B publication Critical patent/MX337873B/es

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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

La presente invención se refiere a un anticuerpo anti-191P4D12 o fragmento de enlace de antígeno del mismo, caracterizado porque el anticuerpo o fragmento de enlace de antígeno del mismo comprende una región variable de cadena pesada que comprende regiones de determinación de complementariedad (CDRs) que tienen las secuencias de aminoácido de las CDRs de región variable de cadena pesada expuestas en la SEQ ID NO: 7 y una región variable de cadena ligera que comprende CDRs que tienen las secuencias de aminoácido de las CDRs de región variable de cadena ligera expuestas en la SEQ ID NO: 8.
MX2013003419A 2010-09-29 2011-09-29 Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12. MX337873B (es)

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