ES2675847T3 - Nuevo anticuerpo anti-DR5 - Google Patents

Nuevo anticuerpo anti-DR5 Download PDF

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ES2675847T3
ES2675847T3 ES15200394.3T ES15200394T ES2675847T3 ES 2675847 T3 ES2675847 T3 ES 2675847T3 ES 15200394 T ES15200394 T ES 15200394T ES 2675847 T3 ES2675847 T3 ES 2675847T3
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amino acid
acid sequence
seq
sequence represented
acid residues
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Toshiaki Ohtsuka
Takeshi Takizawa
Akiko Oguni
Tatsuji Matsuoka
Hiroko Yoshida
Yumi Matsui
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
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    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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Abstract

Un anticuerpo anti-DR5, o un fragmento funcional del mismo, que tiene actividad de unión antigénica, caracterizado porque contiene: (a) una secuencia de región variable de cadena pesada seleccionada del grupo que consiste en las siguientes secuencias de aminoácidos: a1) una secuencia de aminoácidos que comprende los restos de aminoácidos 20 a 141 de la secuencia de aminoácidos representada por SEQ ID NO: 34; a2) una secuencia de aminoácidos que comprende los restos de aminoácidos 20 a 141 de la secuencia de aminoácidos representada por SEQ ID NO: 36; a3) una secuencia de aminoácidos que comprende los restos de aminoácidos 20 a 141 de la secuencia de aminoácidos representada por SEQ ID NO: 38; a4) una secuencia de aminoácidos que comprende los restos de aminoácidos 20 a 141 de la secuencia de aminoácidos representada por SEQ ID NO: 40; a5) una secuencia de aminoácidos que comprende los restos de aminoácidos 20 a 141 de la secuencia de aminoácidos representada por SEQ ID NO: 44; a6) una secuencia de aminoácidos que comprende los restos de aminoácidos 20 a 141 de la secuencia de aminoácidos representada por SEQ ID NO: 46; a7) una secuencia de aminoácidos que comprende los restos de aminoácidos 20 a 141 de la secuencia de aminoácidos representada por SEQ ID NO: 48; a8) una secuencia de aminoácidos que comprende los restos de aminoácidos 20 a 141 de la secuencia de aminoácidos representada por SEQ ID NO: 50; y (b) una secuencia de región variable de cadena ligera seleccionada del grupo que consiste en las siguientes secuencias de aminoácidos: b1) una secuencia de aminoácidos que comprende los restos de aminoácidos 21 a 134 de la secuencia de aminoácidos representada por SEQ ID NO: 28; b2) una secuencia de aminoácidos que comprende los restos de aminoácidos 21 a 134 de la secuencia de aminoácidos representada por SEQ ID NO: 30; b3) una secuencia de aminoácidos que comprende los restos de aminoácidos 21 a 134 de la secuencia de aminoácidos representada por SEQ ID NO: 32; b4) una secuencia de aminoácidos que comprende los restos de aminoácidos 21 a 134 de la secuencia de aminoácidos representada por SEQ ID NO: 52; b5) una secuencia de aminoácidos que comprende los restos de aminoácidos 21 a 134 de la secuencia de aminoácidos representada por SEQ ID NO: 58; b6) una secuencia de aminoácidos que comprende los restos de aminoácidos 21 a 134 de la secuencia de aminoácidos representada por SEQ ID NO: 62; b7) una secuencia de aminoácidos que comprende los restos de aminoácidos 21 a 134 de la secuencia de aminoácidos representada por SEQ ID NO: 66.
ES15200394.3T 2010-10-29 2011-10-27 Nuevo anticuerpo anti-DR5 Active ES2675847T3 (es)

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JP2010243549 2010-10-29
JP2010243549 2010-10-29

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ES2675847T3 true ES2675847T3 (es) 2018-07-13

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US (2) US9127070B2 (es)
EP (2) EP3020812B1 (es)
JP (2) JP5918143B2 (es)
KR (1) KR101814852B1 (es)
CN (2) CN103282495B (es)
AU (2) AU2011321374B2 (es)
BR (1) BR112013010574A2 (es)
CA (2) CA2816291C (es)
CO (1) CO6700893A2 (es)
CY (1) CY1117662T1 (es)
DK (1) DK2636736T3 (es)
ES (2) ES2675847T3 (es)
HR (1) HRP20160584T1 (es)
HU (1) HUE028057T2 (es)
IL (2) IL226023A (es)
MX (1) MX344200B (es)
MY (1) MY158499A (es)
NZ (2) NZ610153A (es)
PH (1) PH12013500845A1 (es)
PL (1) PL2636736T3 (es)
RS (1) RS54846B1 (es)
RU (2) RU2644678C1 (es)
SG (1) SG189456A1 (es)
SI (1) SI2636736T1 (es)
SM (1) SMT201600193B (es)
TW (1) TWI507417B (es)
WO (1) WO2012057288A1 (es)

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Publication number Priority date Publication date Assignee Title
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