BR112013010574A2 - anticorpo, fragmento funcional do anticorpo, composição farmacêutica, usos de um anticorpo ou um fragmento funcional do mesmo e de pelo menos um membro selecionado do grupo que consiste de paclitaxel, carvoplatina, cpt-11, vinblastina, e 5-fu, polinucleotídeo, vetor, célula hospedeira transformada, e, método de produzir o anticorpo - Google Patents

anticorpo, fragmento funcional do anticorpo, composição farmacêutica, usos de um anticorpo ou um fragmento funcional do mesmo e de pelo menos um membro selecionado do grupo que consiste de paclitaxel, carvoplatina, cpt-11, vinblastina, e 5-fu, polinucleotídeo, vetor, célula hospedeira transformada, e, método de produzir o anticorpo

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Publication number
BR112013010574A2
BR112013010574A2 BR112013010574A BR112013010574A BR112013010574A2 BR 112013010574 A2 BR112013010574 A2 BR 112013010574A2 BR 112013010574 A BR112013010574 A BR 112013010574A BR 112013010574 A BR112013010574 A BR 112013010574A BR 112013010574 A2 BR112013010574 A2 BR 112013010574A2
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BR
Brazil
Prior art keywords
antibody
functional fragment
carvoplatin
cpt
vinblastine
Prior art date
Application number
BR112013010574A
Other languages
English (en)
Inventor
Akiko Oguni
Hiroko Yoshida
Takeshi Takizawa
Tatsuji Matsuoka
Toshiaki Ohtsuka
Yumi Matsui
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of BR112013010574A2 publication Critical patent/BR112013010574A2/pt

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Abstract

anticorpo, fragmento funcional do anticorpo, composição farmacêutica, usos de um anticorpo ou um fragmento funcional do mesmo e de pelo menos um membro selecionado do grupo que consiste de paclitaxel, carvoplatina, cpt-11, vinblastina, e 5-fu, polinucleotídeo, vetor, célula hospedeira transformada, e, método de produzir o anticorpo. a presente invenção diz respeito a um anticorpo que tem um efeito terapêutico sobre o câncer, doençass autoimunes, ou doenças inflamatórias. isto é, a presente invenção diz respeito a um anticorpo que exibe uma atividade citotóxica mediada pela apoptose sobre uma célula que expressa um receptor que contém o domínio de morte. a presente invenção trata o problema de fornecer um medicamento que tem um efeito terapêutico sobre o câncer. a presente invenção esclarece que um novo anticorpo anti-dr5, que é capaz de induzir a apoptose em uma célula, tem atividade citotóxica acentuável comparada com os anticorpos anti-dr5 convencionais.
BR112013010574A 2010-10-29 2011-10-27 anticorpo, fragmento funcional do anticorpo, composição farmacêutica, usos de um anticorpo ou um fragmento funcional do mesmo e de pelo menos um membro selecionado do grupo que consiste de paclitaxel, carvoplatina, cpt-11, vinblastina, e 5-fu, polinucleotídeo, vetor, célula hospedeira transformada, e, método de produzir o anticorpo BR112013010574A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010243549 2010-10-29
PCT/JP2011/074866 WO2012057288A1 (ja) 2010-10-29 2011-10-27 新規抗ｄｒ５抗体

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BR112013010574A2 true BR112013010574A2 (pt) 2016-08-09

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BR112013010574A BR112013010574A2 (pt) 2010-10-29 2011-10-27 anticorpo, fragmento funcional do anticorpo, composição farmacêutica, usos de um anticorpo ou um fragmento funcional do mesmo e de pelo menos um membro selecionado do grupo que consiste de paclitaxel, carvoplatina, cpt-11, vinblastina, e 5-fu, polinucleotídeo, vetor, célula hospedeira transformada, e, método de produzir o anticorpo

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US (2) US9127070B2 (pt)
EP (2) EP2636736B1 (pt)
JP (2) JP5918143B2 (pt)
KR (1) KR101814852B1 (pt)
CN (2) CN107188963A (pt)
AU (2) AU2011321374B2 (pt)
BR (1) BR112013010574A2 (pt)
CA (2) CA2816291C (pt)
CO (1) CO6700893A2 (pt)
CY (1) CY1117662T1 (pt)
DK (1) DK2636736T3 (pt)
ES (2) ES2675847T3 (pt)
HK (1) HK1189622A1 (pt)
HR (1) HRP20160584T1 (pt)
HU (1) HUE028057T2 (pt)
IL (2) IL226023A (pt)
MX (1) MX344200B (pt)
MY (1) MY158499A (pt)
NZ (2) NZ623347A (pt)
PL (1) PL2636736T3 (pt)
RS (1) RS54846B1 (pt)
RU (2) RU2644678C1 (pt)
SG (1) SG189456A1 (pt)
SI (1) SI2636736T1 (pt)
SM (1) SMT201600193B (pt)
TW (1) TWI507417B (pt)
WO (1) WO2012057288A1 (pt)

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