ATE516354T1 - Apo-2-rezeptor - Google Patents
Apo-2-rezeptorInfo
- Publication number
- ATE516354T1 ATE516354T1 AT07002962T AT07002962T ATE516354T1 AT E516354 T1 ATE516354 T1 AT E516354T1 AT 07002962 T AT07002962 T AT 07002962T AT 07002962 T AT07002962 T AT 07002962T AT E516354 T1 ATE516354 T1 AT E516354T1
- Authority
- AT
- Austria
- Prior art keywords
- apo
- receptor
- chimeras
- antibodies
- nucleic acid
- Prior art date
Links
- 102000002259 TNF-Related Apoptosis-Inducing Ligand Receptors Human genes 0.000 title 1
- 108010000449 TNF-Related Apoptosis-Inducing Ligand Receptors Proteins 0.000 title 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85721697A | 1997-05-15 | 1997-05-15 | |
US2074698A | 1998-02-09 | 1998-02-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE516354T1 true ATE516354T1 (de) | 2011-07-15 |
Family
ID=26693808
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98926036T ATE370232T1 (de) | 1997-05-15 | 1998-05-14 | Anti-apo-2 antikörper |
AT07002962T ATE516354T1 (de) | 1997-05-15 | 1998-05-14 | Apo-2-rezeptor |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98926036T ATE370232T1 (de) | 1997-05-15 | 1998-05-14 | Anti-apo-2 antikörper |
Country Status (13)
Country | Link |
---|---|
US (1) | US20030017161A1 (de) |
EP (2) | EP0981618B2 (de) |
JP (3) | JP2001511653A (de) |
AT (2) | ATE370232T1 (de) |
CA (1) | CA2287911C (de) |
CY (1) | CY1106966T1 (de) |
DE (1) | DE69838249T3 (de) |
DK (2) | DK1860187T3 (de) |
ES (1) | ES2293682T5 (de) |
HK (1) | HK1109423A1 (de) |
IL (1) | IL132067A0 (de) |
PT (2) | PT981618E (de) |
WO (1) | WO1998051793A1 (de) |
Families Citing this family (126)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1788086A1 (de) * | 1997-03-17 | 2007-05-23 | Human Genome Sciences, Inc. | Rezeptor 5, der eine für den Zelltod verantwortliche Domäne enthält |
US20050233958A1 (en) * | 1997-03-17 | 2005-10-20 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
CA2285040C (en) * | 1997-03-17 | 2009-01-27 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
US20100152426A1 (en) * | 1997-05-15 | 2010-06-17 | Ashkenazi Avi J | Apo-2 receptor fusion proteins |
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WO1999011791A2 (en) * | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
ES2331901T3 (es) * | 1998-06-12 | 2010-01-19 | Genentech, Inc. | Anticuerpos monoclonales, anticuerpos que reaccionan de forma cruzada y procedimiento para la produccion de los mismos. |
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ATE330972T1 (de) * | 1999-06-09 | 2006-07-15 | Genentech Inc | Apo-2l rezeptor-agonist und cpt-11 synergie- effekt |
KR100674528B1 (ko) | 1999-06-28 | 2007-01-29 | 제넨테크, 인크. | 2가 금속 이온을 사용한 Apo-2 리간드 제조 방법 |
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TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
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WO2003029420A2 (en) | 2001-10-02 | 2003-04-10 | Genentech, Inc. | Apo-2 ligand variants and uses thereof |
WO2003042344A2 (en) | 2001-11-13 | 2003-05-22 | Genentech, Inc. | Apo2 ligand/trail formulations |
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EP4277706A1 (de) | 2021-01-15 | 2023-11-22 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Induktoren der seneszenz in kombination mit einem dr5-agonisten zur verwendung in einem verfahren zur behandlung von krebs |
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ES2293682T3 (es) | 2008-03-16 |
PT1860187E (pt) | 2011-10-04 |
PT981618E (pt) | 2007-11-23 |
EP0981618B2 (de) | 2011-08-24 |
US20030017161A1 (en) | 2003-01-23 |
EP1860187A1 (de) | 2007-11-28 |
WO1998051793A1 (en) | 1998-11-19 |
AU7796398A (en) | 1998-12-08 |
AU740858B2 (en) | 2001-11-15 |
EP0981618A1 (de) | 2000-03-01 |
JP2008148695A (ja) | 2008-07-03 |
DK1860187T3 (da) | 2011-10-31 |
CA2287911C (en) | 2014-05-06 |
CA2287911A1 (en) | 1998-11-19 |
EP0981618B1 (de) | 2007-08-15 |
DE69838249T3 (de) | 2012-01-19 |
DE69838249T2 (de) | 2008-05-15 |
ATE370232T1 (de) | 2007-09-15 |
IL132067A0 (en) | 2001-03-19 |
ES2293682T5 (es) | 2011-11-17 |
JP2010075184A (ja) | 2010-04-08 |
DK0981618T4 (da) | 2011-11-21 |
EP1860187B1 (de) | 2011-07-13 |
CY1106966T1 (el) | 2012-09-26 |
DE69838249D1 (de) | 2007-09-27 |
HK1109423A1 (en) | 2008-06-06 |
JP2001511653A (ja) | 2001-08-14 |
DK0981618T3 (da) | 2007-11-26 |
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