MX2009007632A - Precipitacion de polielectrolito y purificacion de proteinas. - Google Patents

Precipitacion de polielectrolito y purificacion de proteinas.

Info

Publication number
MX2009007632A
MX2009007632A MX2009007632A MX2009007632A MX2009007632A MX 2009007632 A MX2009007632 A MX 2009007632A MX 2009007632 A MX2009007632 A MX 2009007632A MX 2009007632 A MX2009007632 A MX 2009007632A MX 2009007632 A MX2009007632 A MX 2009007632A
Authority
MX
Mexico
Prior art keywords
polyelectrolyte
proteins
purification
polyelectrolyte precipitation
complex
Prior art date
Application number
MX2009007632A
Other languages
English (en)
Inventor
Robert L Fahrner
Jayme Franklin
Paul J Mcdonald
Thanmaya Peram
Vikram Sisodiya
Corazon Victa
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2009007632A publication Critical patent/MX2009007632A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Abstract

Se presentan métodos para aislar y purificar anticuerpos, al agregar un polielectrolito a un fluido de cultivo celular, tal como un fluido de cultivo celular acumulado y precipitar un complejo de anticuerpo-polielectrolito o un complejo de impurezas y el polielectrolito.
MX2009007632A 2007-01-22 2008-01-10 Precipitacion de polielectrolito y purificacion de proteinas. MX2009007632A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88606807P 2007-01-22 2007-01-22
US1344607P 2007-12-13 2007-12-13
PCT/US2008/050747 WO2008091740A2 (en) 2007-01-22 2008-01-10 Polyelectrolyte precipitation and purification of antibodies

Publications (1)

Publication Number Publication Date
MX2009007632A true MX2009007632A (es) 2009-07-24

Family

ID=39247681

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007632A MX2009007632A (es) 2007-01-22 2008-01-10 Precipitacion de polielectrolito y purificacion de proteinas.

Country Status (17)

Country Link
US (1) US7947813B2 (es)
EP (2) EP2377527B1 (es)
JP (1) JP5361738B2 (es)
KR (1) KR101431856B1 (es)
CN (1) CN101646431B (es)
AT (1) ATE526017T1 (es)
AU (1) AU2008209404B2 (es)
BR (1) BRPI0806367A2 (es)
CA (1) CA2673851C (es)
ES (2) ES2426158T3 (es)
HK (1) HK1135920A1 (es)
IL (1) IL199550A (es)
MX (1) MX2009007632A (es)
NZ (1) NZ577933A (es)
RU (1) RU2474585C2 (es)
WO (1) WO2008091740A2 (es)
ZA (1) ZA200904482B (es)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
FR2902799B1 (fr) 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
US9375499B2 (en) * 2006-07-14 2016-06-28 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
WO2008079280A1 (en) 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
US8999702B2 (en) 2008-06-11 2015-04-07 Emd Millipore Corporation Stirred tank bioreactor
US8592555B2 (en) 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
CN102171237A (zh) * 2008-08-14 2011-08-31 默沙东公司 使用蛋白a亲和色谱法纯化抗体的方法
US8846877B2 (en) * 2008-09-25 2014-09-30 Jsr Corporation Packing material for affinity chromatography
GB0818228D0 (en) 2008-10-06 2008-11-12 Avecia Biolog Ltd Purification process
CN105037535A (zh) 2008-12-16 2015-11-11 Emd密理博公司 搅拌槽反应器及方法
BRPI0923541A2 (pt) 2008-12-22 2016-01-26 Hoffmann La Roche purificação de imunoglobulina
SG195555A1 (en) 2008-12-24 2013-12-30 Emd Millipore Corp Caustic stable chromatography ligands
WO2010082894A1 (en) * 2009-01-13 2010-07-22 Ge Healthcare Bio-Sciences Ab Precipitation of biomolecules with negatively charged polymers
US9428548B2 (en) * 2009-09-01 2016-08-30 Genentech, Inc. Enhanced protein purification through a modified protein A elution
PL3715356T3 (pl) 2009-12-18 2024-03-11 Csl Limited Sposób oczyszczania polipeptydów
US8377672B2 (en) 2010-02-18 2013-02-19 3M Innovative Properties Company Ligand functionalized polymers
WO2011109151A1 (en) 2010-03-03 2011-09-09 3M Innovative Properties Company Ligand guanidinyl functionalized polymers
EP2571903B1 (en) * 2010-05-17 2019-09-04 EMD Millipore Corporation Stimulus responsive polymers for the purification of biomolecules
US20130289247A1 (en) * 2010-11-01 2013-10-31 Dsm Ip Assets B.V. Single unit ion exchange chromatography antibody purification
EP2691411B1 (en) * 2011-03-29 2020-02-26 GlaxoSmithKline LLC Buffer system for protein purification
IL212911A0 (en) * 2011-05-16 2011-07-31 Omrix Biopharmaceuticals Ltd Immunoglobulin reduced in thrombogenic contaminants and preparation thereof
SG186552A1 (en) 2011-06-08 2013-01-30 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
EP2739641B2 (en) 2011-08-02 2020-04-15 Baxalta GmbH Systems and methods to increase protein yield from recombinant manufacturing processes
EP2744518A2 (en) * 2011-08-19 2014-06-25 EMD Millipore Corporation Use of small molecules in methods for purification of biomolecules
EP2578286A1 (en) 2011-10-04 2013-04-10 Merck Patent GmbH Method and apparatus for chromatographic purification
EP2656892A1 (en) 2012-04-23 2013-10-30 Merck Patent GmbH Chromatography method
JP6268167B2 (ja) 2012-05-31 2018-01-24 エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ タンパク質製剤中の凝集物含量を低減するために混合型多官能表面を使用する方法
JP6297029B2 (ja) 2012-05-31 2018-03-20 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 多様な官能基を有する粒子による免疫グロブリンｇ調製物のクロマトグラフィー精製
SG11201407812SA (en) 2012-05-31 2014-12-30 Agency Science Tech & Res Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by treatment with electropositive organic additives
US20150239956A1 (en) * 2012-06-27 2015-08-27 Asahi Kasei Medical Co., Ltd. High-affinity antibody and method for manufacturing the same
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
LT2890710T (lt) * 2012-08-28 2017-10-25 Novartis Ag Antikūnų gryninimo būdai, panaudojant alifatinius alkoholius
BR112015009969A2 (pt) * 2012-11-05 2017-07-11 Medimmune Llc método de isolamento de synagis® na ausência de benzonase
CN104854123B (zh) * 2012-12-20 2020-04-21 默克专利股份公司 用于蛋白质沉淀的共聚物
WO2014123484A1 (en) 2013-02-06 2014-08-14 Agency For Science, Technology And Research Methods For Reducing Aggregate Content In Protein Preparations
SG10201610955SA (en) * 2013-02-26 2017-02-27 Agency Science Tech & Res Protein purification in the presence of nonionic organic polymers and electropositive surfaces
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
PL3022301T3 (pl) 2013-07-18 2018-12-31 Chr. Hansen A/S Kompozycja ścinającego mleko enzymu proteazy asparaginowej
JP2016531128A (ja) * 2013-08-23 2016-10-06 ベーリンガー インゲルハイム エルツェーファウ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 新規の吸着組成物及びその使用
WO2015035180A1 (en) * 2013-09-05 2015-03-12 Genentech, Inc. Method for chromatography reuse
KR20160055940A (ko) * 2013-09-24 2016-05-18 엘라스타겐 피티와이 리미티드 단백질 추출 방법
GB201318840D0 (en) * 2013-10-24 2013-12-11 Univ Leeds Method and device for protein preparation
EP3071682A1 (en) * 2013-11-20 2016-09-28 CMC Biologics A/S A bioreactor system and method for producing a biopolymer
DK3102935T3 (da) 2014-02-07 2021-04-06 Cmc Biologics As Bioreaktoranordning og fremgangsmåde til fremstilling af en biopolymer
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
RU2710967C9 (ru) 2014-04-16 2020-08-12 Кмк Биологикс А/С Способ отъемно-доливной ферментации с высокой плотностью клеток
SG11201701965VA (en) 2014-11-03 2017-05-30 Merck Patent Gmbh Soluble intein fusion proteins and methods for purifying biomolecules
EP3636749B1 (en) * 2015-03-06 2022-04-27 F. Hoffmann-La Roche AG Ultrapurified dsbc and methods of making and using the same
WO2017022651A1 (ja) 2015-07-31 2017-02-09 中外製薬株式会社 アニオン性ポリマーによる抗体を含有する組成物の精製方法
CN111655722A (zh) * 2018-01-31 2020-09-11 瑞泽恩制药公司 用于表征药物产品杂质的系统和方法
EP3816177A4 (en) * 2018-06-29 2021-12-01 Mitsubishi Chemical Corporation POLYPEPTIDE ISOLATION PROCESS, POLYPEPTIDE PRODUCTION PROCESS AND POLYPEPTIDE PURIFICATION APPARATUS
JP6564539B1 (ja) * 2018-09-14 2019-08-21 長瀬産業株式会社 スルホン酸化合物によるペプチド精製方法
HUP1900112A1 (hu) 2019-04-04 2020-10-28 Richter Gedeon Nyrt Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával
AR119264A1 (es) * 2019-06-05 2021-12-09 Genentech Inc Método para reutilización de cromatografía
KR102612555B1 (ko) * 2020-12-18 2023-12-11 한국세라믹기술원 항체결합단백질 및 칼시퀘스트린 융합단백질을 이용한 면역침강 방법
WO2023068999A1 (en) * 2021-10-21 2023-04-27 Nyctea Technology Ab Device for separating an analyte from other components in an electrolytic solution
CN114574457A (zh) * 2022-01-25 2022-06-03 华东理工大学 一种快速分离纯化蛋白质的方法

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3252961A (en) * 1961-04-03 1966-05-24 Foremost Dairies Inc Whey process and product
US3737377A (en) * 1971-01-27 1973-06-05 Miles Lab Purification of lactase
US4055469A (en) * 1976-12-10 1977-10-25 Eastman Kodak Company Purification of microbial enzyme extracts using synthetic polyelectrolytes
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
GB2036891B (en) 1978-12-05 1983-05-05 Windsor Smith C Change speed gear
US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
ES8504461A1 (es) 1982-04-12 1985-04-16 Hybritech Inc Un procedimiento para obtener un polidoma.
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4533496A (en) * 1984-05-08 1985-08-06 Monsanto Company Method of isolating monoclonal antibodies from hybridoma cultures
US5672347A (en) 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
CA1282069C (en) 1985-09-12 1991-03-26 Damon L. Meyer Antibody complexes of hapten-modified diagnostic or therapeutic agents
AU606320B2 (en) 1985-11-01 1991-02-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
DE68919361T2 (de) 1988-06-21 1995-05-24 Genentech Inc Therapeutische zusammensetzungen für die behandlung von myocard-infarkten.
DE68925971T2 (de) 1988-09-23 1996-09-05 Cetus Oncology Corp Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
ES2246502T3 (es) 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
CA2113813C (en) 1991-08-14 2005-04-12 Paula M. Jardieu Immunoglobulin variants for specific fc epsilon receptors
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5525519A (en) * 1992-01-07 1996-06-11 Middlesex Sciences, Inc. Method for isolating biomolecules from a biological sample with linear polymers
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
MX9305070A (es) 1992-08-21 1994-04-29 Genentech Inc Compocicion farmaceutica que contiene un antagonista de lfa-1 para el tratamiento de transtornos o desordenes mediados por el lfa-1
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
WO1995016203A2 (en) 1993-12-10 1995-06-15 Genentech, Inc. Methods for diagnosis of allergy and screening of anti-allergy therapeutics
DK0739214T3 (da) 1994-01-18 1998-10-07 Genentech Inc Fremgangsmåde til behandling af parasitinfektionerunder anvendelse af IgE antagonister
WO1995023865A1 (en) 1994-03-03 1995-09-08 Genentech, Inc. Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders
US5922531A (en) * 1994-06-21 1999-07-13 Advanced Research And Technology Polyelectrolyte treated glass for enzyme immobilization and protein purification
ATE306930T1 (de) 1994-08-12 2005-11-15 Immunomedics Inc Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper
DE69530670T2 (de) * 1994-09-21 2004-03-18 Kanegafuchi Kagaku Kogyo K.K. Verfahren zur absorption von interleukine
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
US5641870A (en) * 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
CA2222231A1 (en) 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
EP1297847A3 (en) 1996-01-23 2003-05-07 Genentech, Inc. Anti-CD18 antibodies in stroke
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
IL130143A0 (en) 1996-11-27 2000-06-01 Genentech Inc Humanized anti-CD11a antibodies
EP1864999B1 (en) 1996-11-27 2009-03-18 Genentech, Inc. Affinity purification of polypeptide on protein a matrix
US6872568B1 (en) 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
EP0973804B1 (en) 1997-04-07 2006-12-27 Genentech, Inc. Anti-vegf antibodies
PT1860187E (pt) 1997-05-15 2011-10-04 Genentech Inc Receptor apo-2
US6265542B1 (en) * 1997-10-24 2001-07-24 Genentech, Inc. Purification of molecules
US6087448A (en) 1997-11-19 2000-07-11 Amcol International Corporation Solid superabsorbent material containing a poly(vinylguanidine) and an acidic water-absorbing resin
ATE321066T1 (de) * 1998-05-06 2006-04-15 Genentech Inc Anti-her2 antikörperzusammensetzung
US6217926B1 (en) * 1998-06-30 2001-04-17 Michael Foods, Inc. Aqueous extraction process to selectively remove phospholipid from egg yolks
WO2000005261A1 (en) * 1998-07-21 2000-02-03 Monsanto Company Clarification of protein precipitate suspensions using anionic polymeric flocculants
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
IL149116A0 (en) 1999-10-29 2002-11-10 Genentech Inc Anti-prostate stem cell antigen (psca) antibody compositions and methods of use
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
CA2467048C (en) * 2001-11-16 2013-02-19 Norgen Biotek Corporation Method of protein purification
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
AU2003210802B2 (en) 2002-02-05 2009-09-10 Genentech Inc. Protein purification
CA2476166C (en) 2002-02-14 2011-11-15 Immunomedics, Inc. Anti-cd20 antibodies and fusion proteins thereof and methods of use
WO2004014942A1 (en) 2002-08-09 2004-02-19 Selborne Biological Services (Australia) Pty Limited A method for preparing lipoprotein from a blood source
SI1558648T1 (sl) 2002-10-17 2012-05-31 Genmab As Človeška monoklonalna protitelesa proti CD
DE60332957D1 (de) 2002-12-16 2010-07-22 Genentech Inc Immunoglobulinvarianten und deren verwendungen
US20040121339A1 (en) * 2002-12-19 2004-06-24 Jizhong Zhou Special film-coated substrate for bio-microarray fabrication and use thereof
EP1581644B1 (en) * 2003-01-09 2007-06-06 Genentech, Inc. Purification of polypeptides
WO2005000901A2 (en) 2003-05-09 2005-01-06 Duke University Cd20-specific antibodies and methods of employing same
AR044388A1 (es) 2003-05-20 2005-09-07 Applied Molecular Evolution Moleculas de union a cd20
ES2786568T3 (es) * 2003-07-28 2020-10-13 Genentech Inc Reducción de la lixiviación de la proteína A durante la cromatografía de afinidad con proteína A
AU2004263538B2 (en) 2003-08-08 2009-09-17 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
US8147832B2 (en) 2003-08-14 2012-04-03 Merck Patent Gmbh CD20-binding polypeptide compositions and methods
EA036531B1 (ru) 2003-11-05 2020-11-19 Роше Гликарт Аг Гуманизированное антитело типа ii к cd20 (варианты), фармацевтическая композиция, содержащая эти варианты антитела, и их применение
US20050147581A1 (en) * 2003-11-19 2005-07-07 The Board Of Trustees Of The University Of Illinois Macromolecular drug complexes having improved stability and therapeutic use of the same
DE602005015542D1 (de) 2004-01-12 2009-09-03 Applied Molecular Evolution Varianten der fc-region
JP5848861B2 (ja) 2004-04-20 2016-01-27 ジェンマブ エー／エスＧｅｎｍａｂ Ａ／Ｓ Ｃｄ２０に対するヒトモノクローナル抗体
US7673757B2 (en) 2006-02-17 2010-03-09 Millipore Corporation Adsorbent filter media for removal of biological contaminants in process liquids
WO2008079280A1 (en) * 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins

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CA2673851C (en) 2016-05-03
RU2009131765A (ru) 2011-02-27
KR101431856B1 (ko) 2014-08-27
CA2673851A1 (en) 2008-07-31
NZ577933A (en) 2011-12-22
WO2008091740A2 (en) 2008-07-31
RU2474585C2 (ru) 2013-02-10
AU2008209404B2 (en) 2012-08-16
ES2426158T3 (es) 2013-10-21
CN101646431A (zh) 2010-02-10
US7947813B2 (en) 2011-05-24
AU2008209404A1 (en) 2008-07-31
JP5361738B2 (ja) 2013-12-04
ES2374330T3 (es) 2012-02-15
BRPI0806367A2 (pt) 2011-09-06
US20080193981A1 (en) 2008-08-14
ATE526017T1 (de) 2011-10-15
CN101646431B (zh) 2012-06-27
EP2120915A2 (en) 2009-11-25
ZA200904482B (en) 2010-09-29
EP2120915B1 (en) 2011-09-28
WO2008091740A3 (en) 2008-11-20
EP2377527B1 (en) 2013-07-17
IL199550A (en) 2015-04-30
KR20090113264A (ko) 2009-10-29
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HK1135920A1 (en) 2010-06-18
JP2010516773A (ja) 2010-05-20

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