BR112022013589A2 - Tratamento da fibrodisplasia ossificante progressiva - Google Patents

Tratamento da fibrodisplasia ossificante progressiva

Info

Publication number
BR112022013589A2
BR112022013589A2 BR112022013589A BR112022013589A BR112022013589A2 BR 112022013589 A2 BR112022013589 A2 BR 112022013589A2 BR 112022013589 A BR112022013589 A BR 112022013589A BR 112022013589 A BR112022013589 A BR 112022013589A BR 112022013589 A2 BR112022013589 A2 BR 112022013589A2
Authority
BR
Brazil
Prior art keywords
treatment
progressive ossifying
progressive
ossifying fibrodysplasia
fop
Prior art date
Application number
BR112022013589A
Other languages
English (en)
Inventor
Economides Aristides
Forleo Neto Eduardo
Gonzalez Trotter Dinko
Herman Gary
Rankin Andrew
Mellis Scott
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of BR112022013589A2 publication Critical patent/BR112022013589A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

TRATAMENTO DE FIBROPLASIA OSSIFICANTE PROGRESSIVA. A presente invenção refere-se a métodos para o tratamento de fibrodisplasia ossificante progressiva (FOP) em indivíduos humanos. Tais métodos envolvem administrar a um indivíduo com FOP uma quantidade terapeuticamente eficaz de um antagonista da Ativina A, tal como um anticorpo contra a Ativina A.
BR112022013589A 2020-01-08 2021-01-08 Tratamento da fibrodisplasia ossificante progressiva BR112022013589A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202062958448P 2020-01-08 2020-01-08
US202063076691P 2020-09-10 2020-09-10
US202063081428P 2020-09-22 2020-09-22
PCT/US2021/012598 WO2021142191A1 (en) 2020-01-08 2021-01-08 Treatment of fibrodysplasia ossificans progressiva

Publications (1)

Publication Number Publication Date
BR112022013589A2 true BR112022013589A2 (pt) 2022-09-13

Family

ID=74550734

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022013589A BR112022013589A2 (pt) 2020-01-08 2021-01-08 Tratamento da fibrodisplasia ossificante progressiva

Country Status (12)

Country Link
US (1) US20210253685A1 (pt)
EP (1) EP4087652A1 (pt)
JP (1) JP2023510270A (pt)
KR (1) KR20220139886A (pt)
CN (1) CN115243763A (pt)
AU (1) AU2021205929A1 (pt)
BR (1) BR112022013589A2 (pt)
CA (1) CA3164168A1 (pt)
CL (1) CL2022001861A1 (pt)
IL (1) IL294611A (pt)
MX (1) MX2022008494A (pt)
WO (1) WO2021142191A1 (pt)

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Also Published As

Publication number Publication date
JP2023510270A (ja) 2023-03-13
EP4087652A1 (en) 2022-11-16
CN115243763A (zh) 2022-10-25
KR20220139886A (ko) 2022-10-17
AU2021205929A1 (en) 2022-09-01
CL2022001861A1 (es) 2023-02-24
MX2022008494A (es) 2022-10-10
WO2021142191A1 (en) 2021-07-15
IL294611A (en) 2022-09-01
US20210253685A1 (en) 2021-08-19
CA3164168A1 (en) 2021-07-15

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