BR112019000630A2 - regimes de dosagem dos antagonistas de lingo-1 e usos para tratamento de distúrbios desmielinizante - Google Patents
regimes de dosagem dos antagonistas de lingo-1 e usos para tratamento de distúrbios desmielinizanteInfo
- Publication number
- BR112019000630A2 BR112019000630A2 BR112019000630A BR112019000630A BR112019000630A2 BR 112019000630 A2 BR112019000630 A2 BR 112019000630A2 BR 112019000630 A BR112019000630 A BR 112019000630A BR 112019000630 A BR112019000630 A BR 112019000630A BR 112019000630 A2 BR112019000630 A2 BR 112019000630A2
- Authority
- BR
- Brazil
- Prior art keywords
- lingo
- dosage regimens
- demyelinating disorders
- treating demyelinating
- antagonist dosage
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/285—Demyelinating diseases; Multipel sclerosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
Abstract
a presente invenção refere-se a regimes de dosagem, métodos, composições e kits são úteis para detectar e/ou tratar uma doença desmielinizante do snc.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662362032P | 2016-07-13 | 2016-07-13 | |
US201662394094P | 2016-09-13 | 2016-09-13 | |
US201662412582P | 2016-10-25 | 2016-10-25 | |
US201762486217P | 2017-04-17 | 2017-04-17 | |
US201762512510P | 2017-05-30 | 2017-05-30 | |
PCT/US2017/041757 WO2018013714A1 (en) | 2016-07-13 | 2017-07-12 | Dosage regimens of lingo-1 antagonists and uses for treatment of demyelinating disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019000630A2 true BR112019000630A2 (pt) | 2019-07-09 |
Family
ID=59388180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019000630A BR112019000630A2 (pt) | 2016-07-13 | 2017-07-12 | regimes de dosagem dos antagonistas de lingo-1 e usos para tratamento de distúrbios desmielinizante |
Country Status (16)
Country | Link |
---|---|
US (2) | US20200031924A1 (pt) |
EP (1) | EP3484512A1 (pt) |
JP (1) | JP7149257B2 (pt) |
KR (1) | KR20190039134A (pt) |
CN (1) | CN109862911A (pt) |
AU (1) | AU2017297404A1 (pt) |
BR (1) | BR112019000630A2 (pt) |
CA (1) | CA3030745A1 (pt) |
CL (1) | CL2019000027A1 (pt) |
CO (1) | CO2019001116A2 (pt) |
IL (1) | IL264139A (pt) |
MA (1) | MA45668A (pt) |
MX (1) | MX2019000327A (pt) |
PH (1) | PH12019500075A1 (pt) |
SG (1) | SG11201811704SA (pt) |
WO (1) | WO2018013714A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2021010420A (es) * | 2019-03-11 | 2021-11-12 | Biogen Ma Inc | Composiciones farmacéuticas que contienen anticuerpos antilingo-1. |
CN116549632A (zh) * | 2023-03-28 | 2023-08-08 | 中国人民解放军军事科学院军事医学研究院 | 抗Lingo-1抗体Opicinumab的新用途及针对新用途的药物 |
CN116740064B (zh) * | 2023-08-14 | 2023-10-20 | 山东奥洛瑞医疗科技有限公司 | 一种核磁共振肿瘤区域提取方法 |
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JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
GB2183662B (en) | 1985-04-01 | 1989-01-25 | Celltech Ltd | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
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GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
WO1990002809A1 (en) | 1988-09-02 | 1990-03-22 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
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WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
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CA2109602C (en) | 1990-07-10 | 2002-10-01 | Gregory P. Winter | Methods for producing members of specific binding pairs |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
ATE352612T1 (de) | 1990-08-29 | 2007-02-15 | Pharming Intellectual Pty Bv | Homologe rekombination in säugetier-zellen |
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DK2982695T3 (da) | 2008-07-09 | 2019-05-13 | Biogen Ma Inc | Sammensætninger, der omfatter antistoffer mod lingo eller fragmenter deraf |
IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
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EP3750560A3 (en) * | 2012-10-09 | 2021-03-24 | Biogen MA Inc. | Combination therapies and uses for treatment of demyelinating disorders |
AU2016205197B2 (en) * | 2015-01-08 | 2021-10-21 | Biogen Ma Inc. | LINGO-1 antagonists and uses for treatment of demyelinating disorders |
-
2017
- 2017-07-12 AU AU2017297404A patent/AU2017297404A1/en not_active Abandoned
- 2017-07-12 MA MA045668A patent/MA45668A/fr unknown
- 2017-07-12 SG SG11201811704SA patent/SG11201811704SA/en unknown
- 2017-07-12 JP JP2019501624A patent/JP7149257B2/ja active Active
- 2017-07-12 KR KR1020197004209A patent/KR20190039134A/ko not_active Application Discontinuation
- 2017-07-12 BR BR112019000630A patent/BR112019000630A2/pt not_active Application Discontinuation
- 2017-07-12 WO PCT/US2017/041757 patent/WO2018013714A1/en unknown
- 2017-07-12 EP EP17743155.8A patent/EP3484512A1/en not_active Withdrawn
- 2017-07-12 CN CN201780055045.0A patent/CN109862911A/zh active Pending
- 2017-07-12 US US16/316,428 patent/US20200031924A1/en not_active Abandoned
- 2017-07-12 MX MX2019000327A patent/MX2019000327A/es unknown
- 2017-07-12 CA CA3030745A patent/CA3030745A1/en not_active Abandoned
-
2019
- 2019-01-04 CL CL2019000027A patent/CL2019000027A1/es unknown
- 2019-01-08 IL IL264139A patent/IL264139A/en unknown
- 2019-01-11 PH PH12019500075A patent/PH12019500075A1/en unknown
- 2019-02-06 CO CONC2019/0001116A patent/CO2019001116A2/es unknown
-
2021
- 2021-02-12 US US17/174,610 patent/US20210403556A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CO2019001116A2 (es) | 2019-02-19 |
AU2017297404A1 (en) | 2019-01-24 |
US20200031924A1 (en) | 2020-01-30 |
KR20190039134A (ko) | 2019-04-10 |
PH12019500075A1 (en) | 2019-07-08 |
MA45668A (fr) | 2019-05-22 |
JP7149257B2 (ja) | 2022-10-06 |
CL2019000027A1 (es) | 2019-05-24 |
CA3030745A1 (en) | 2018-01-18 |
CN109862911A (zh) | 2019-06-07 |
WO2018013714A1 (en) | 2018-01-18 |
JP2019524731A (ja) | 2019-09-05 |
IL264139A (en) | 2019-02-28 |
SG11201811704SA (en) | 2019-01-30 |
US20210403556A1 (en) | 2021-12-30 |
MX2019000327A (es) | 2019-04-11 |
EP3484512A1 (en) | 2019-05-22 |
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