SG11201811704SA - Dosage regimens of lingo-1 antagonists and uses for treatment of demyelinating disorders - Google Patents

Dosage regimens of lingo-1 antagonists and uses for treatment of demyelinating disorders

Info

Publication number
SG11201811704SA
SG11201811704SA SG11201811704SA SG11201811704SA SG11201811704SA SG 11201811704S A SG11201811704S A SG 11201811704SA SG 11201811704S A SG11201811704S A SG 11201811704SA SG 11201811704S A SG11201811704S A SG 11201811704SA SG 11201811704S A SG11201811704S A SG 11201811704SA
Authority
SG
Singapore
Prior art keywords
international
biogen
cambridge
rule
binney
Prior art date
Application number
SG11201811704SA
Inventor
Diego Cadavid
Lei Xu
Lin Xu
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of SG11201811704SA publication Critical patent/SG11201811704SA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/285—Demyelinating diseases; Multipel sclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111101111 0 DOI HIM 011101 0 0111111 01110011H111111111111111111111111111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/013714 Al 18 January 2018 (18.01.2018) WI P0 I P C T (51) International Patent Classification: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, A61K 39/395 (2006.01) G01N 33/50 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (21) International Application Number: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, PCT/US2017/041757 KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (22) International Filing Date: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 12 July 2017 (12.07.2017) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 62/362,032 13 July 2016 (13.07.2016) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 62/394,094 13 September 2016 (13.09.2016) US TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 62/412,582 25 October 2016 (25.10.2016) US EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 62/486,217 17 April 2017 (17.04.2017) US MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 62/512,510 30 May 2017 (30.05.2017) US TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (71) Applicant: BIOGEN MA INC. [US/US]; 225 Binney St, Cambridge, MA 02142 (US). Declarations under Rule 4.17: (72) Inventors: CADAVID, Diego; c/o Biogen MA Inc., 225 — as to applicant's entitlement to apply for and be granted a Binney Street, Cambridge, MA 02142 (US). XU, Lei; c/o patent (Rule 4.17(0 Biogen MA Inc., 225 Binney Street, Cambridge, MA 02142 — as to the applicant's entitlement to claim the priority of the (US). XU, Lin; c/o Biogen MA Inc., 225 Binney Street, earlier application (Rule 4.17(iii)) Cambridge, MA 02142 (US). Published: (74) Agent: BRENNAN, Jack et al.; Fish & Richardson P.C., — with international search report (Art. 21(3)) P.O. Box 1022, Minneapolis, MN 55440-1022 (US). — with sequence listing part of description (Rule 5.2(a)) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, Title: DOSAGE REGIMENS OF LINGO-1 ANTAGONISTS AND USES FOR TREATMENT OF DEMYELINATING = (54) DISORDERS End of End of study/ treatment follow-up AON onset Baseline Trragulaggi4 whe visit visit Day-2b Day 1 W4 WS W12 W16 W20 W24 W32 Screen 1 ,--- : (pretreatrn 4 ent) 1-1 cu 0 3-5 days IV 71- steroidsa 1-1 IN C 4 \") 1-1 aFor participants with AON who had not been already treated. 0 --.... ,-, © ei I. I (57) : Dosage regimens, methods, compositions and kits are described herein useful for detecting and/or treating a CNS demyelinating disease.
SG11201811704SA 2016-07-13 2017-07-12 Dosage regimens of lingo-1 antagonists and uses for treatment of demyelinating disorders SG11201811704SA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662362032P 2016-07-13 2016-07-13
US201662394094P 2016-09-13 2016-09-13
US201662412582P 2016-10-25 2016-10-25
US201762486217P 2017-04-17 2017-04-17
US201762512510P 2017-05-30 2017-05-30
PCT/US2017/041757 WO2018013714A1 (en) 2016-07-13 2017-07-12 Dosage regimens of lingo-1 antagonists and uses for treatment of demyelinating disorders

Publications (1)

Publication Number Publication Date
SG11201811704SA true SG11201811704SA (en) 2019-01-30

Family

ID=59388180

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201811704SA SG11201811704SA (en) 2016-07-13 2017-07-12 Dosage regimens of lingo-1 antagonists and uses for treatment of demyelinating disorders

Country Status (16)

Country Link
US (2) US20200031924A1 (en)
EP (1) EP3484512A1 (en)
JP (1) JP7149257B2 (en)
KR (1) KR20190039134A (en)
CN (1) CN109862911A (en)
AU (1) AU2017297404A1 (en)
BR (1) BR112019000630A2 (en)
CA (1) CA3030745A1 (en)
CL (1) CL2019000027A1 (en)
CO (1) CO2019001116A2 (en)
IL (1) IL264139A (en)
MA (1) MA45668A (en)
MX (1) MX2019000327A (en)
PH (1) PH12019500075A1 (en)
SG (1) SG11201811704SA (en)
WO (1) WO2018013714A1 (en)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
TW202103732A (en) * 2019-03-11 2021-02-01 美商百健Ｍａ公司 Pharmaceutical compositions containing anti-lingo-1 antibodies
WO2024196749A2 (en) * 2023-03-17 2024-09-26 Biome-ase Research, LLC Enzymatic methods for treating neurodegenerative disorders
CN116549632B (en) * 2023-03-28 2024-09-10 中国人民解放军军事科学院军事医学研究院 New application of anti-Lingo-1 antibody Opicinumab and medicine for new application
CN116740064B (en) * 2023-08-14 2023-10-20 山东奥洛瑞医疗科技有限公司 Nuclear magnetic resonance tumor region extraction method

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Also Published As

Publication number Publication date
CN109862911A (en) 2019-06-07
MA45668A (en) 2019-05-22
JP2019524731A (en) 2019-09-05
BR112019000630A2 (en) 2019-07-09
WO2018013714A1 (en) 2018-01-18
US20200031924A1 (en) 2020-01-30
EP3484512A1 (en) 2019-05-22
CL2019000027A1 (en) 2019-05-24
IL264139A (en) 2019-02-28
US20210403556A1 (en) 2021-12-30
AU2017297404A1 (en) 2019-01-24
MX2019000327A (en) 2019-04-11
JP7149257B2 (en) 2022-10-06
CO2019001116A2 (en) 2019-02-19
PH12019500075A1 (en) 2019-07-08
CA3030745A1 (en) 2018-01-18
KR20190039134A (en) 2019-04-10

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SG11201811704SA (en) Dosage regimens of lingo-1 antagonists and uses for treatment of demyelinating disorders