DE16192152T1 - Verwendung von interleukin-4 rezeptor (il-4r) antikörpern und zusammensetzungen davon - Google Patents

Verwendung von interleukin-4 rezeptor (il-4r) antikörpern und zusammensetzungen davon Download PDF

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DE16192152T1
DE16192152T1 DE16192152.3T DE16192152T DE16192152T1 DE 16192152 T1 DE16192152 T1 DE 16192152T1 DE 16192152 T DE16192152 T DE 16192152T DE 16192152 T1 DE16192152 T1 DE 16192152T1
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monoclonal antibody
human
human monoclonal
antibody
transgenic mouse
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Arvia E Morris
John D. Pluenneke
Richard J Armitage
Jose Carlos Escobar
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Immunex Corp
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Immunex Corp
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Priority claimed from US09/785,934 external-priority patent/US20020002132A1/en
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Publication of DE16192152T1 publication Critical patent/DE16192152T1/de
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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Abstract

Menschlicher monoklonaler Antikörper, der den menschlichen IL-4-Rezeptor (IL-4R) bindet, wobei der Antikörper die Bindung von IL-4 und IL-13 an Zellen blockiert, eine IL-4-induzierte biologische Aktivität hemmen kann und eine IL-13-induzierte biologische Aktivität hemmen kann.

Claims (8)

  1. Menschlicher monoklonaler Antikörper, der den menschlichen IL-4-Rezeptor (IL-4R) bindet, wobei der Antikörper die Bindung von IL-4 und IL-13 an Zellen blockiert, eine IL-4-induzierte biologische Aktivität hemmen kann und eine IL-13-induzierte biologische Aktivität hemmen kann.
  2. Menschlicher monoklonaler Antikörper gemäß Anspruch 1, wobei der Antikörper durch ein Verfahren zur Herstellung eines Antikörpers erhältlich ist, das Schritte umfasst, bei denen man eine transgene Maus mit einem menschlichen IL-4R-Polypeptid immunisiert, wobei die transgene Maus genetisches Material umfasst, das für Ketten menschlicher Immunglobuline kodiert.
  3. Menschlicher monoklonaler Antikörper gemäß Anspruch 2, wobei die transgene Maus durch Einführung genetischen Materials, das für Ketten menschlicher Immunglobuline kodiert, genetisch verändert wurde.
  4. Menschlicher monoklonaler Antikörper gemäß Anspruch 2 oder 3, wobei das menschliche IL-4R-Polypeptid, das zur Immunisierung der transgenen Maus verwendet wurde, SEQ ID NO:2 umfasst.
  5. Menschlicher monoklonaler Antikörper gemäß einem der Ansprüche 2 bis 4, wobei das Verfahren zur Herstellung des Antikörpers ferner einen Schritt umfasst, bei dem der Isotyp oder die Unterklasse des Antikörpers geändert wird.
  6. Menschlicher monoklonaler Antikörper gemäß einem der Ansprüche 1 bis 5, wobei der menschliche monoklonale Antikörper ein IgGl- oder IgG4-Antikörper ist.
  7. Zusammensetzung, umfassend den menschlichen monoklonalen Antikörper gemäß einem der Ansprüche 1 bis 6, die ferner einen physiologisch verträglichen Träger, Exzipienten oder Verdünnungsmittel umfasst.
  8. Zusammensetzung gemäß Anspruch 7 zur Verwendung für die Behandlung eines Patienten, der an einem durch IL-4 induzierten Zustand leidet, wobei der Zustand aus Asthma, allergischer Rhinitis, Dermatitis, atopischer Dermatitis, Dermatitis herpetiformis und Kawasaki-Krankheit ausgewählt wurde.
DE16192152.3T 2000-05-26 2001-05-25 Verwendung von interleukin-4 rezeptor (il-4r) antikörpern und zusammensetzungen davon Pending DE16192152T1 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US57980800A 2000-05-26 2000-05-26
US579808 2000-05-26
US66534300A 2000-09-19 2000-09-19
US665343 2000-09-19
US09/785,934 US20020002132A1 (en) 2000-05-26 2001-02-15 Use of interleukin-4 antagonists and compositions thereof
US785934 2001-02-15
US84781601A 2001-05-01 2001-05-01
US847816 2001-05-01
EP16192152.3A EP3190126A1 (de) 2000-05-26 2001-05-25 Verwendung von interleukin-4 rezeptor (il-4r) antikörpern und zusammensetzungen davon

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DE16192152T1 true DE16192152T1 (de) 2020-08-06

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DE16192152.3T Pending DE16192152T1 (de) 2000-05-26 2001-05-25 Verwendung von interleukin-4 rezeptor (il-4r) antikörpern und zusammensetzungen davon

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US (8) US7186809B2 (de)
EP (4) EP3190126A1 (de)
AT (1) ATE551363T1 (de)
AU (1) AU2001272925A1 (de)
CA (1) CA2409267C (de)
CY (1) CY1118951T1 (de)
DE (1) DE16192152T1 (de)
DK (1) DK2990420T3 (de)
ES (3) ES2549767T3 (de)
MX (1) MXPA02011682A (de)
PT (1) PT2990420T (de)
WO (1) WO2001092340A2 (de)

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