DK2597945T3 - Transgene dyr og fremgangsmåder til anvendelse deraf - Google Patents
Transgene dyr og fremgangsmåder til anvendelse deraf Download PDFInfo
- Publication number
- DK2597945T3 DK2597945T3 DK11815063.0T DK11815063T DK2597945T3 DK 2597945 T3 DK2597945 T3 DK 2597945T3 DK 11815063 T DK11815063 T DK 11815063T DK 2597945 T3 DK2597945 T3 DK 2597945T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- transgenic animals
- transgenic
- animals
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36780910P | 2010-07-26 | 2010-07-26 | |
| PCT/US2011/045333 WO2012018610A2 (en) | 2010-07-26 | 2011-07-26 | Transgenic animals and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2597945T3 true DK2597945T3 (da) | 2020-09-21 |
Family
ID=45559986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11815063.0T DK2597945T3 (da) | 2010-07-26 | 2011-07-26 | Transgene dyr og fremgangsmåder til anvendelse deraf |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10881084B2 (da) |
| EP (1) | EP2597945B1 (da) |
| JP (4) | JP6482757B2 (da) |
| KR (1) | KR20130097156A (da) |
| CN (1) | CN103025884B (da) |
| AU (1) | AU2011286185B2 (da) |
| CA (1) | CA2806233C (da) |
| DK (1) | DK2597945T3 (da) |
| IL (1) | IL224327B (da) |
| RU (1) | RU2580017C2 (da) |
| WO (1) | WO2012018610A2 (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ601171A (en) * | 2010-03-31 | 2014-11-28 | Ablexis Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| CA2806233C (en) * | 2010-07-26 | 2021-12-07 | Trianni, Inc. | Transgenic animals and methods of use |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| WO2017035252A1 (en) * | 2015-08-24 | 2017-03-02 | Trianni, Inc. | Enhanced production of immunoglobulins |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| WO2017136734A1 (en) | 2016-02-04 | 2017-08-10 | Trianni, Inc. | Enhanced production of immunoglobulins |
| CN116458475A (zh) | 2016-06-03 | 2023-07-21 | 瑞泽恩制药公司 | 表达外源末端脱氧核苷酸转移酶的非人动物 |
| GB2561352B (en) * | 2017-04-10 | 2023-01-18 | Genome Res Ltd | Animal models and therapeutic molecules |
| JP6951545B2 (ja) | 2017-07-21 | 2021-10-20 | トリアンニ インコーポレイテッドＴｒｉａｎｎｉ，Ｉｎｃ． | 単鎖ｖｈ及び重鎖抗体 |
| EP3476942B1 (en) * | 2017-10-27 | 2022-01-26 | Trianni, Inc. | Long germline dh genes and long hcdr3 antibodies |
| TW202003564A (zh) | 2018-03-24 | 2020-01-16 | 美商再生元醫藥公司 | 用於產生抗肽-mhc複合物之治療性抗體的經基因修飾的非人類動物、其製法與用途 |
| KR102617284B1 (ko) | 2018-06-14 | 2023-12-27 | 리제너론 파마슈티칼스 인코포레이티드 | 면역글로불린 중쇄 암호화 서열에서 dh-dh 재배열 가능한 비인간 동물 |
| US20200109422A1 (en) * | 2018-10-09 | 2020-04-09 | Regents Of The University Of Minnesota | Methods of full gene replacement and transgenic non-human cells comprising full human genes |
| EP3927832A4 (en) | 2019-02-18 | 2022-11-30 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH A HUMANIZED IMMUNOGLOBULIN LOCUS |
| JPWO2020240876A1 (da) * | 2019-05-27 | 2020-12-03 | ||
| AU2020299569A1 (en) * | 2019-07-01 | 2022-01-20 | Trianni, Inc. | Transgenic mammals and methods of use |
| DK3785536T3 (da) | 2019-08-28 | 2022-03-28 | Trianni Inc | Adam6-knockin-mus |
| WO2021113297A1 (en) | 2019-12-02 | 2021-06-10 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
| AU2020454777A1 (en) * | 2020-06-25 | 2023-02-02 | Humab Co., Ltd. | Heterozygous transgenic animal |
| WO2022023292A2 (en) | 2020-07-31 | 2022-02-03 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Corona virus spike protein-targeting antibodies and use thereof |
| AU2021342159A1 (en) | 2020-09-11 | 2023-03-02 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| IL303529A (en) | 2020-12-09 | 2023-08-01 | Trianni Inc | Heavy chain antibodies only |
| WO2022132943A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| JP2024501286A (ja) | 2020-12-23 | 2024-01-11 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | アンカー改変型抗体をコードする核酸およびその使用 |
| WO2023056430A1 (en) | 2021-10-01 | 2023-04-06 | Abcellera Biologics Inc. | Transgenic rodents for cell line identification and enrichment |
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| JPWO2014021240A1 (ja) | 2012-08-03 | 2016-07-21 | 国立研究開発法人産業技術総合研究所 | プロテインｇの細胞膜外ドメイン変異体のタンデム型多量体から成るタンパク質を含む捕捉剤 |
| EP3096609B1 (en) | 2014-01-24 | 2021-09-22 | Children's Medical Center Corporation | High-throughput mouse model for optimizing antibody affinities |
| EP4166148A1 (en) | 2014-06-06 | 2023-04-19 | Memorial Sloan-Kettering Cancer Center | Mesothelin-targeted chimeric antigen receptors and uses thereof |
| WO2017035252A1 (en) | 2015-08-24 | 2017-03-02 | Trianni, Inc. | Enhanced production of immunoglobulins |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| WO2017136734A1 (en) | 2016-02-04 | 2017-08-10 | Trianni, Inc. | Enhanced production of immunoglobulins |
| GB2561352B (en) | 2017-04-10 | 2023-01-18 | Genome Res Ltd | Animal models and therapeutic molecules |
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2011
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- 2011-07-26 RU RU2013108269/10A patent/RU2580017C2/ru active
- 2011-07-26 US US13/818,184 patent/US10881084B2/en active Active
- 2011-07-26 KR KR1020137003807A patent/KR20130097156A/ko not_active Application Discontinuation
- 2011-07-26 WO PCT/US2011/045333 patent/WO2012018610A2/en active Application Filing
- 2011-07-26 CN CN201180036683.0A patent/CN103025884B/zh active Active
- 2011-07-26 EP EP11815063.0A patent/EP2597945B1/en active Active
- 2011-07-26 DK DK11815063.0T patent/DK2597945T3/da active
- 2011-07-26 AU AU2011286185A patent/AU2011286185B2/en active Active
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2013
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2017
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2020
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2580017C2 (ru) | 2016-04-10 |
| RU2013108269A (ru) | 2014-09-10 |
| JP2017123880A (ja) | 2017-07-20 |
| JP6801030B2 (ja) | 2020-12-16 |
| JP6482757B2 (ja) | 2019-03-13 |
| AU2011286185B2 (en) | 2014-08-14 |
| CA2806233A1 (en) | 2012-02-09 |
| AU2011286185A1 (en) | 2013-02-14 |
| KR20130097156A (ko) | 2013-09-02 |
| EP2597945B1 (en) | 2020-07-22 |
| US20130219535A1 (en) | 2013-08-22 |
| CN103025884A (zh) | 2013-04-03 |
| JP2021027840A (ja) | 2021-02-25 |
| WO2012018610A3 (en) | 2012-05-03 |
| EP2597945A2 (en) | 2013-06-05 |
| US20210037799A1 (en) | 2021-02-11 |
| JP2013535202A (ja) | 2013-09-12 |
| CA2806233C (en) | 2021-12-07 |
| CN103025884B (zh) | 2015-11-25 |
| WO2012018610A2 (en) | 2012-02-09 |
| JP2019083823A (ja) | 2019-06-06 |
| EP2597945A4 (en) | 2014-01-01 |
| US10881084B2 (en) | 2021-01-05 |
| IL224327B (en) | 2018-04-30 |
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