PT3456190T - Animal murino transgénico produtor de anticorpo - Google Patents

Animal murino transgénico produtor de anticorpo

Info

Publication number
PT3456190T
PT3456190T PT181839804T PT18183980T PT3456190T PT 3456190 T PT3456190 T PT 3456190T PT 181839804 T PT181839804 T PT 181839804T PT 18183980 T PT18183980 T PT 18183980T PT 3456190 T PT3456190 T PT 3456190T
Authority
PT
Portugal
Prior art keywords
human mammals
antibody producing
producing non
mammals
antibody
Prior art date
Application number
PT181839804T
Other languages
English (en)
Original Assignee
Merus Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41280336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3456190(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merus Nv filed Critical Merus Nv
Publication of PT3456190T publication Critical patent/PT3456190T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT181839804T 2008-06-27 2009-06-29 Animal murino transgénico produtor de anticorpo PT3456190T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL2008050430 2008-06-27

Publications (1)

Publication Number Publication Date
PT3456190T true PT3456190T (pt) 2022-02-15

Family

ID=41280336

Family Applications (3)

Application Number Title Priority Date Filing Date
PT121755441T PT2556747T (pt) 2008-06-27 2009-06-29 Ratinhos transgénicos que produzem anticorpos
PT181839804T PT3456190T (pt) 2008-06-27 2009-06-29 Animal murino transgénico produtor de anticorpo
PT90752791T PT2147594E (pt) 2008-06-27 2009-06-29 Mamíferos não humanos que produzem anticorpos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT121755441T PT2556747T (pt) 2008-06-27 2009-06-29 Ratinhos transgénicos que produzem anticorpos

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT90752791T PT2147594E (pt) 2008-06-27 2009-06-29 Mamíferos não humanos que produzem anticorpos

Country Status (23)

Country Link
EP (6) EP3456190B1 (pt)
JP (6) JP5749161B2 (pt)
KR (5) KR101990228B1 (pt)
CN (3) CN105191863B (pt)
AU (1) AU2009263082C1 (pt)
CA (1) CA2729095C (pt)
CY (2) CY1114830T1 (pt)
DK (3) DK3456190T3 (pt)
ES (3) ES2906344T3 (pt)
HK (1) HK1154463A1 (pt)
HR (2) HRP20220205T1 (pt)
HU (1) HUE057994T2 (pt)
LT (1) LT3456190T (pt)
MX (1) MX2010014542A (pt)
NZ (1) NZ590118A (pt)
PL (2) PL2147594T3 (pt)
PT (3) PT2556747T (pt)
RS (2) RS53146B (pt)
RU (3) RU2731084C2 (pt)
SG (3) SG10201914027VA (pt)
SI (2) SI3456190T1 (pt)
WO (1) WO2009157771A2 (pt)
ZA (1) ZA201009312B (pt)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
CN101537180B (zh) 2002-07-18 2016-02-10 莫鲁斯有限公司 抗体混合物的重组生产
ES2408582T3 (es) 2003-05-30 2013-06-21 Merus B.V. Biblioteca de Fab para la preparación de una mezcla de anticuerpos
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
GB2404382B (en) 2003-07-28 2008-01-30 Oxitec Ltd Pest control
GB2443186A (en) 2006-10-25 2008-04-30 Oxitec Ltd Expression system for mediating alternative splicing
CN105191863B (zh) 2008-06-27 2020-12-22 莫鲁斯股份有限公司 产生抗体的非人哺乳动物
US9346873B2 (en) 2008-09-30 2016-05-24 Ablexis, Llc Non-human mammals for the production of chimeric antibodies
PL2564695T3 (pl) * 2009-07-08 2015-10-30 Kymab Ltd Modele zwierzęce i cząsteczki terapeutyczne
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
US20120204278A1 (en) 2009-07-08 2012-08-09 Kymab Limited Animal models and therapeutic molecules
WO2011158009A1 (en) * 2010-06-17 2011-12-22 Kymab Limited Animal models and therapeutic molecules
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
AU2013204019B2 (en) * 2010-02-08 2014-02-27 Regeneron Pharmaceuticals, Inc. Common light chain mouse
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
ES2603559T5 (es) 2010-02-08 2021-02-22 Regeneron Pharma Cadena ligera común de ratón
US20120021409A1 (en) * 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
EP4345163A2 (en) 2010-03-31 2024-04-03 Ablexis, LLC Genetic engineering of non-human animals for the production of chimeric antibodies
US10793829B2 (en) 2010-07-26 2020-10-06 Trianni, Inc. Transgenic mammals and methods of use thereof
US10662256B2 (en) 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
CN103025884B (zh) 2010-07-26 2015-11-25 特里安尼公司 转基因动物和使用方法
CN113150121A (zh) * 2010-08-02 2021-07-23 瑞泽恩制药公司 制造包含vl结构域的结合蛋白的小鼠
SI3572517T1 (sl) * 2011-08-05 2021-09-30 Regeneron Pharmaceuticals, Inc. Humanizirana miš z univerzalno lahko verigo
CA2846322A1 (en) 2011-09-19 2013-03-28 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
CA2791109C (en) 2011-09-26 2021-02-16 Merus B.V. Generation of binding molecules
EP2761008A1 (en) 2011-09-26 2014-08-06 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
JP2015502165A (ja) 2011-12-22 2015-01-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 発現ベクター構成、新規の産生細胞生成法、およびポリペプチドの組換え産生のためのそれらの使用
HUE046744T2 (hu) * 2012-02-01 2020-03-30 Regeneron Pharma VL doméneket tartalmazó nehézláncokat expresszáló humanizált egér
GB2500113A (en) 2012-03-05 2013-09-11 Oxitec Ltd Arthropod male germline gene expression system
CN107090471A (zh) * 2012-03-06 2017-08-25 瑞泽恩制药公司 共同轻链小鼠
US20140013456A1 (en) 2012-03-16 2014-01-09 Regeneron Pharmaceuticals, Inc. Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
SG10201607727PA (en) 2012-03-16 2016-11-29 Regeneron Pharma Mice that produce antigen-binding proteins with ph-dependent binding characteristics
EP3348140B1 (en) 2012-03-16 2020-12-30 Regeneron Pharmaceuticals, Inc. Histidine engineered light chain antibodies and genetically modified rodents for generating the same
SG10201700360VA (en) * 2012-03-16 2017-03-30 Regeneron Pharma Non-human animals expressing ph-sensitive immunoglobulin sequences
GB2502127A (en) * 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
PT2838918T (pt) 2012-04-20 2019-08-23 Merus Nv Métodos e meios para a produção de moléculas heterrodiméricas do tipo ig
WO2013184761A1 (en) * 2012-06-05 2013-12-12 Regeneron Pharmaceuticals, Inc. Methods for making fully human bispecific antibodies using a common light chain
BR112015000167B1 (pt) 2012-07-06 2021-11-23 Genmab B.V. Proteína dimérica, proteína, composição, kit de partes e seus usos, bem como método para aumentar a oligomerização em solução de uma proteína dimérica compreendendo um primeiro e segundo polipeptídeo, cada um compreendendo pelo menos as regiões ch2 e ch3 de uma cadeia pesada de igg1 humana e proteína dimérica variante
CN103571872B (zh) * 2012-08-09 2016-11-23 山东国际生物科技园发展有限公司 一种能够表达人抗体的转基因动物的制备方法
SI2900694T1 (sl) 2012-09-27 2018-12-31 Merus N.V. Bispecifična IGG protitelesa kot vključitelji T-celic
GB201303932D0 (en) 2013-03-05 2013-04-17 Oxitec Ltd Muscle actin promoter
EP3501272B1 (en) * 2013-03-13 2023-03-01 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
PL2968440T3 (pl) 2013-03-15 2019-12-31 Zymeworks Inc. Związki cytotoksyczne i antymitotyczne oraz sposoby ich stosowania
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
CA2925723A1 (en) 2013-10-01 2015-04-09 Kymab Limited Animal models and therapeutic molecules
PL2908626T3 (pl) * 2013-10-15 2017-05-31 Regeneron Pharmaceuticals, Inc. Zwierzęta z humanizowaną
EP3086815B1 (en) 2013-12-27 2022-02-09 Zymeworks Inc. Sulfonamide-containing linkage systems for drug conjugates
CA2941030A1 (en) 2014-02-28 2015-09-03 Merus N.V. Antibodies that bind egfr and erbb3
CN106459212B (zh) 2014-02-28 2021-07-13 美勒斯公司 结合erbb-2和erbb-3的抗体
CA2942697A1 (en) 2014-03-21 2015-09-24 Lynn Macdonald Non-human animals that make single domain binding proteins
CA2941514A1 (en) 2014-03-21 2015-09-24 Regeneron Pharmaceuticals, Inc. Vl antigen binding proteins exhibiting distinct binding characteristics
GB2526867A (en) * 2014-06-05 2015-12-09 Oxitec Ltd Gene expression system
RS62860B1 (sr) 2014-09-17 2022-02-28 Zymeworks Inc Citotoksična i antimitotička jedinjenja, i postupci upotrebe istih
EP3271403A1 (en) 2015-03-19 2018-01-24 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
ES2812303T3 (es) 2015-07-10 2021-03-16 Merus Nv Anticuerpo que se une a CD3 humano
CA2995717A1 (en) 2015-08-24 2017-03-02 Trianni, Inc. Enhanced production of immunoglobulins
HUE055222T2 (hu) 2015-10-23 2021-11-29 Merus Nv Megkötõ molekulák, amelyek gátolják a rák növekedését
WO2017095939A1 (en) 2015-12-03 2017-06-08 Trianni, Inc. Enhanced immunoglobulin diversity
KR20180104149A (ko) 2016-02-04 2018-09-19 트리아니, 인코포레이티드 면역글로불린의 증대된 생성
AU2017272337C1 (en) 2016-06-03 2024-02-29 Regeneron Pharmaceuticals, Inc. Non-human animals expressing exogenous terminal deoxynucleotidyltransferase
WO2018029534A1 (en) 2016-08-12 2018-02-15 Oxitec Ltd. A self-limiting, sex-specific gene and methods of using
NZ751956A (en) 2016-09-23 2022-01-28 Merus Nv Binding molecules that modulate a biological activity expressed by a cell
CN110637083A (zh) * 2017-03-20 2019-12-31 华盛顿大学 细胞及其使用和制备方法
MX2019011660A (es) 2017-03-31 2019-11-18 Merus Nv Anticuerpos biespecificos que se unen al receptor 2 del factor de crecimiento humano (erbb-2) y receptor 3 del factor de crecimiento humano (erbb3) para usarse en el tratamiento de celulas que tienen un gen de fusion de neuregulina-1 (nrg1).
BR112019020507A2 (pt) 2017-03-31 2020-08-04 Merus N.V. agente de alvejamento de erbb-2 e um anticorpo bispecífico com locais de ligação de antígenos que ligam um epítopo em uma parte extracelular de erbb-2 e erbb-3 para tratamento de um indivíduo com um tumor positivo erbb-2, erbb-2 / erbb-3
ES2951864T3 (es) 2017-05-17 2023-10-25 Merus Nv Combinación de un anticuerpo biespecífico ERBB-2/ERBB-3 con terapia endocrina para el cáncer de mama
US11753470B2 (en) 2017-07-06 2023-09-12 Merus N.V. Bispecific anti PD1-anti TIM3 antibodies
JP2020525533A (ja) 2017-07-06 2020-08-27 メルス ナムローゼ フェンノートシャップ 細胞により発現される生物学的活性を調節する抗体
WO2019009726A1 (en) 2017-07-06 2019-01-10 Merus N.V. BINDING MOLECULES FOR MODULATING THE BIOLOGICAL ACTIVITY EXPRESSED BY A CELL
GB201710984D0 (en) * 2017-07-07 2017-08-23 Kymab Ltd Cells, vertebrates, populations & methods
CN111094351A (zh) 2017-08-09 2020-05-01 美勒斯公司 结合EGFR和cMET的抗体
CN111432838A (zh) 2017-12-01 2020-07-17 美勒斯公司 使用双特异性抗体和il-15进行联合治疗
CN111432635B (zh) * 2017-12-05 2022-10-21 瑞泽恩制药公司 具有经工程改造的免疫球蛋白λ轻链的非人动物以及所述非人动物的用途
TWI804572B (zh) 2018-02-09 2023-06-11 日商小野藥品工業股份有限公司 雙特異性抗體
CN116874591A (zh) 2018-03-24 2023-10-13 瑞泽恩制药公司 用于产生针对肽-mhc复合物的治疗性抗体的经过基因修饰的非人动物、其制造方法和用途
CA3094318A1 (en) 2018-03-30 2019-10-03 Merus N.V. Multivalent antibody
CN108624622A (zh) * 2018-05-16 2018-10-09 湖南艾佳生物科技股份有限公司 一种基于CRISPR-Cas9系统构建的能分泌小鼠白细胞介素-6的基因工程细胞株
EP3801010A4 (en) * 2018-06-08 2022-02-23 Crystal Bioscience Inc. TRANSGENIC ANIMAL TO PRODUCE DIVERSIFIED ANTIBODIES WITH THE SAME LIGHT CHAIN I
US20190380316A1 (en) 2018-06-14 2019-12-19 Regeneron Pharmaceuticals, Inc. Non-human animals capable of engineered dh-dh rearrangement and uses thereof
JP2022521036A (ja) 2018-12-20 2022-04-05 メルス ナムローゼ フェンノートシャップ ＣＬＥＣ１２ＡｘＣＤ３二重特異性抗体及び疾患の治療方法
EP3897117A1 (en) 2018-12-21 2021-10-27 Compass Therapeutics LLC Transgenic mouse expressing common human light chain
KR20210111767A (ko) 2018-12-31 2021-09-13 메뤼스 엔.페. 절단된 다가 다량체
JP7443376B2 (ja) * 2018-12-31 2024-03-05 メルス ナムローゼ フェンノートシャップ 混合結合ドメイン
BR112021014106A2 (pt) 2019-01-22 2021-10-13 Bristol-Myers Squibb Company Anticorpos contra subunidade alfa de il-7r e usos dos mesmos
BR112021016094A2 (pt) 2019-02-14 2021-10-26 Merus N.V. Combinações de porções de ligação que se ligam ao egfr, her2 e her3
MX2021009769A (es) 2019-02-14 2021-09-08 Merus Nv Produccion de composiciones que comprenden dos o mas anticuerpos.
TW202039578A (zh) 2019-03-29 2020-11-01 荷蘭商美勒斯公司 Cd3結合分子
TW202102544A (zh) * 2019-04-04 2021-01-16 日商小野藥品工業股份有限公司 雙特異性抗體
JP2022534674A (ja) 2019-05-09 2022-08-03 メルス ナムローゼ フェンノートシャップ タンパク質を多量体化する変異体ドメイン及びその分離
WO2021003149A1 (en) * 2019-07-01 2021-01-07 Trianni, Inc. Transgenic mammals and methods of use
WO2021006199A1 (ja) 2019-07-05 2021-01-14 小野薬品工業株式会社 Ｐｄ－１／ｃｄ３二重特異性タンパク質による血液がん治療
TW202118790A (zh) 2019-07-30 2021-05-16 日商小野藥品工業股份有限公司 雙特異性抗體
EP3772518A1 (en) 2019-08-07 2021-02-10 Merus N.V. Modified human variable domains
AU2020331879A1 (en) 2019-08-19 2022-02-24 Merus N.V. Treatment of cancer with a combination of an antibody that binds LGR5 and EGFR and a topoisomerase I inhibitor.
GB201912008D0 (en) 2019-08-21 2019-10-02 Cambridge Entpr Ltd Antibody
EP4069722A1 (en) 2019-12-02 2022-10-12 Regeneron Pharmaceuticals, Inc. Peptide-mhc ii protein constructs and uses thereof
KR20220117267A (ko) 2019-12-24 2022-08-23 메뤼스 엔.페. Tgf-베타-rii 결합 단백질
JP7480307B2 (ja) 2020-01-29 2024-05-09 メルス ナムローゼ フェンノートシャップ 免疫細胞関与効果を調節するための手段および方法
AU2021261681A1 (en) 2020-04-24 2022-12-08 Merus N.V. Treatment of cancers with an antibody that binds LGR5 and EGFR
IL301137A (en) 2020-09-11 2023-05-01 Regeneron Pharma Identification and production of antigen-specific antibodies
TW202237656A (zh) 2020-12-15 2022-10-01 荷蘭商美勒斯公司 利用結合ｌｇｒ５與ｅｇｆｒ之抗體治療癌症
KR20230147048A (ko) 2020-12-16 2023-10-20 리제너론 파마슈티칼스 인코포레이티드 인간화 Fc 알파 수용체를 발현하는 마우스
JP2023554422A (ja) 2020-12-16 2023-12-27 メルス ナムローゼ フェンノートシャップ がんの治療のための多重特異性抗体
EP4262867A1 (en) 2020-12-18 2023-10-25 Merus N.V. Antibody composition
EP4051700A1 (en) 2020-12-23 2022-09-07 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding anchor modified antibodies and uses thereof
TW202321309A (zh) 2021-10-06 2023-06-01 荷蘭商美勒斯公司 使用至少結合ｅｇｆｒ之抗體治療免疫檢查點抑制劑治療之具高ｅｇｆｒ表現的癌症
WO2023146394A1 (en) 2022-01-25 2023-08-03 Merus N.V. Combination therapy for the treatment of cancer
WO2023172133A1 (en) 2022-03-07 2023-09-14 Merus N.V. Combination therapy including antibodies that bind egfr and cmet
WO2023172134A1 (en) 2022-03-07 2023-09-14 Merus N.V. Treatment with an antibody that binds egfr and cmet.
GB202216503D0 (en) 2022-11-05 2022-12-21 Quadrucept Bio Ltd Non-human vertebrates & cells

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4531078A (en) 1983-10-27 1985-07-23 Polaroid Corporation Control circuit for electronic flash
GB8909218D0 (en) 1989-04-22 1989-06-07 Medical Res Council Improvements in or relating to enhancers
EP0814159B1 (en) * 1990-08-29 2005-07-27 GenPharm International, Inc. Transgenic mice capable of producing heterologous antibodies
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1993012227A1 (en) * 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US7041871B1 (en) * 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
JPH08140528A (ja) * 1993-12-03 1996-06-04 Genpharm Internatl Inc 異種抗体を産生することができるトランスジェニック非ヒト動物
US5885827A (en) * 1996-01-23 1999-03-23 The Regents Of The Universtiy Of California Eukaryotic high rate mutagenesis system
WO1998050431A2 (en) 1997-05-02 1998-11-12 Genentech, Inc. A method for making multispecific antibodies having heteromultimeric and common components
ES2258817T3 (es) 1997-05-21 2006-09-01 Biovation Limited Metodo para la produccion de proteinas no inmunogenas.
RU2236127C2 (ru) * 1998-03-30 2004-09-20 Рисерч Дивелопмент Фаундейшн Способ получения трансгенной мыши, не содержащей функциональный рецептор-1 рилизинг-фактора кортикотропина, способ идентификации агониста или антагониста рилизинг-фактора кортикотропина, урокортина или лиганда семейства рилизинг-фактора кортикотропина и способ скрининга соединений, которые являются аналогами или агонистами кортикостерона или кортикотропина, с использованием такой мыши
US20020028488A1 (en) 2000-06-19 2002-03-07 Sujay Singh Transgenic avian species for making human and chimeric antibodies
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
CN101537180B (zh) * 2002-07-18 2016-02-10 莫鲁斯有限公司 抗体混合物的重组生产
EP1439234A1 (en) * 2003-01-08 2004-07-21 ARTEMIS Pharmaceuticals GmbH Targeted transgenesis using the rosa26 locus
ES2408582T3 (es) 2003-05-30 2013-06-21 Merus B.V. Biblioteca de Fab para la preparación de una mezcla de anticuerpos
DK1737971T3 (da) 2004-01-20 2017-11-13 Merus Nv Blandinger af bindingsproteiner
JP4487068B2 (ja) * 2004-10-12 2010-06-23 国立大学法人 岡山大学 細胞の遺伝子変異機能の制御による変異タンパク質の作製方法
AU2006242854A1 (en) * 2005-04-29 2006-11-09 Inserm (Institut National De La Sante Et De La Recherche Medicale) Transgenic animals and methods of making recombinant antibodies
EP2505058A1 (en) * 2006-03-31 2012-10-03 Medarex, Inc. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
ES2398076T3 (es) 2006-06-02 2013-03-13 Regeneron Pharmaceuticals, Inc. Anticuerpos de alta afinidad contra el receptor de IL-6 humano
LT2769992T (lt) 2006-10-02 2021-04-12 Regeneron Pharmaceuticals, Inc. Didelio afiniškumo žmogaus antikūnai, atpažįstantys žmogaus il-4 receptorių
RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
CN105191863B (zh) * 2008-06-27 2020-12-22 莫鲁斯股份有限公司 产生抗体的非人哺乳动物
ES2603559T5 (es) * 2010-02-08 2021-02-22 Regeneron Pharma Cadena ligera común de ratón

Also Published As

Publication number Publication date
DK2147594T3 (da) 2014-02-10
HRP20140139T1 (hr) 2014-03-14
JP7439201B2 (ja) 2024-02-27
HRP20220205T1 (hr) 2022-05-27
JP6824807B2 (ja) 2021-02-03
RU2020127564A3 (pt) 2022-02-21
SG10201408500RA (en) 2015-01-29
DK2556747T3 (da) 2021-02-15
AU2009263082B9 (en) 2014-07-17
LT3456190T (lt) 2022-03-10
DK3456190T3 (da) 2022-02-14
SI2147594T1 (sl) 2014-02-28
ES2906344T3 (es) 2022-04-18
NZ590118A (en) 2012-10-26
CA2729095C (en) 2018-12-04
JP2022188085A (ja) 2022-12-20
KR102306491B1 (ko) 2021-09-29
EP2556747A3 (en) 2016-08-03
CA2729095A1 (en) 2009-12-30
CN105191863A (zh) 2015-12-30
EP3456190A1 (en) 2019-03-20
CN112481300A (zh) 2021-03-12
RU2020127564A (ru) 2022-02-21
PT2147594E (pt) 2014-02-17
KR101990228B1 (ko) 2019-06-17
SG10201914019YA (en) 2020-03-30
JP5749161B2 (ja) 2015-07-15
KR20140127914A (ko) 2014-11-04
RU2731084C2 (ru) 2020-08-28
PT2556747T (pt) 2021-02-15
JP2015156871A (ja) 2015-09-03
RU2015119670A (ru) 2015-12-10
EP3456191A1 (en) 2019-03-20
PL3456190T3 (pl) 2022-06-06
EP2556747A2 (en) 2013-02-13
KR20170066688A (ko) 2017-06-14
AU2009263082B2 (en) 2014-03-20
HUE057994T2 (hu) 2022-06-28
JP2017121256A (ja) 2017-07-13
KR102261586B1 (ko) 2021-06-08
JP7242611B2 (ja) 2023-03-20
MX2010014542A (es) 2011-04-05
HK1154463A1 (zh) 2012-04-27
ES2853226T3 (es) 2021-09-15
KR102112655B1 (ko) 2020-05-19
EP3456190B1 (en) 2021-11-24
ZA201009312B (en) 2011-08-31
EP2556747B1 (en) 2020-12-02
EP3456192A1 (en) 2019-03-20
CY1125119T1 (el) 2023-06-09
RU2015119670A3 (pt) 2019-01-22
AU2009263082A1 (en) 2009-12-30
SI3456190T1 (sl) 2022-06-30
EP2147594B1 (en) 2013-11-13
ES2445193T3 (es) 2014-02-28
WO2009157771A2 (en) 2009-12-30
RU2559524C2 (ru) 2015-08-10
EP2147594A1 (en) 2010-01-27
RS62925B1 (sr) 2022-03-31
CN105191863B (zh) 2020-12-22
WO2009157771A3 (en) 2010-02-18
JP2020191882A (ja) 2020-12-03
KR20200057093A (ko) 2020-05-25
CY1114830T1 (el) 2016-12-14
KR20110029156A (ko) 2011-03-22
AU2009263082C1 (en) 2018-11-01
SG10201914027VA (en) 2020-03-30
EP3456193A1 (en) 2019-03-20
JP2011525808A (ja) 2011-09-29
RU2011102962A (ru) 2012-08-10
RS53146B (en) 2014-06-30
PL2147594T3 (pl) 2014-04-30
KR20190025068A (ko) 2019-03-08
JP2024063038A (ja) 2024-05-10
CN102123582B (zh) 2015-09-30
CN102123582A (zh) 2011-07-13

Similar Documents

Publication Publication Date Title
HK1154463A1 (zh) 產生抗體的非人哺乳動物
EP2346994A4 (en) NON-HUMAN MAMMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
ZA201102119B (en) Improved antibody libraies
EP2241578A4 (en) ANTI-CLDN6 ANTIBODIES
IL212701A0 (en) Improved anti-cd19 antibodies
HK1158229A1 (en) C-met antibodies c-met
SG10201403703XA (en) Methods of producing humanized non-human mammals
PL2262831T3 (pl) Przeciwciała przeciwko properdynie
GB0821100D0 (en) Antibodies
EP2337798A4 (en) BSA-SPECIFIC ANTIBODIES
EP2412808A4 (en) BISPECIFIC ANTIBODY TYPE LH
ZA201006099B (en) Anti-tyrp1 antibodies
ZA201007976B (en) Anti-pirb antibodies
GB0818356D0 (en) Antibodies
GB0911770D0 (en) Antibody
FI20085308A0 (fi) Heparanaasittomia ihmiskuntaan kuulumattomia nisäkkäitä
GB0815963D0 (en) Antibody production
GB0820307D0 (en) Antibody production
PL384301A1 (pl) Urządzenie do produkcji biopaliwa
GB0819113D0 (en) An antibody
GB0817622D0 (en) Antibody
GB0817621D0 (en) Antibody
GB0804684D0 (en) Humanized antibody
GB0804686D0 (en) Humanized antibody
GB0804687D0 (en) Humanized antibody