CY1114830T1 - Θηλαστικα διαφορετικα απο ανθρωπο που παραγουν αντισωματα - Google Patents
Θηλαστικα διαφορετικα απο ανθρωπο που παραγουν αντισωματαInfo
- Publication number
- CY1114830T1 CY1114830T1 CY20141100105T CY141100105T CY1114830T1 CY 1114830 T1 CY1114830 T1 CY 1114830T1 CY 20141100105 T CY20141100105 T CY 20141100105T CY 141100105 T CY141100105 T CY 141100105T CY 1114830 T1 CY1114830 T1 CY 1114830T1
- Authority
- CY
- Cyprus
- Prior art keywords
- human
- nucleic acid
- cells
- transgenically
- light chain
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 abstract 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 206010069754 Acquired gene mutation Diseases 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 210000003519 mature b lymphocyte Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
- 230000037439 somatic mutation Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Η εφεύρεση παρέχει διαγονιδιακά διαφορετικά από άνθρωπο ζώα περιλαμβάνοντα νουκλεϊκό οξύ κωδικεύον ελαφριά αλυσίδα ανοσοσφαιρίνης, όπου η ελαφριά αλυσίδα ανοσοσφαιρίνης είναι ανθρώπινη, ανθρωποειδής, ή εξανθρωπισμένη. Το νουκλεϊκό οξύ είναι εφοδιασμένο με τεχνικό μέσο που έχει την ιδιότητα να το καθιστά ανθεκτικό έναντι DNA αναδιατάξεων και/ή σωματικών υπερμεταλλάξεων. Σε μία εφαρμογή, το νουκλεϊκό οξύ περιλαμβάνει κασέτα έκφρασης για την έκφραση επιλεχθέντος μορίου εντός κυττάρων κατά τη διάρκεια ορισμένου σταδίου ανάπτυξης σε κύτταρα αναπτυσσόμενα σε ώριμα Β κύτταρα. Η εφεύρεση περαιτέρω παρέχει μεθόδους για παραγωγή ανοσοσφαιρίνης από το διαγονιδιακά διαφορετικό από άνθρωπο, ζώο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL2008050430 | 2008-06-27 | ||
EP09075279.1A EP2147594B1 (en) | 2008-06-27 | 2009-06-29 | Antibody producing non-human mammals |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114830T1 true CY1114830T1 (el) | 2016-12-14 |
Family
ID=41280336
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100105T CY1114830T1 (el) | 2008-06-27 | 2014-02-12 | Θηλαστικα διαφορετικα απο ανθρωπο που παραγουν αντισωματα |
CY20221100149T CY1125119T1 (el) | 2008-06-27 | 2022-02-22 | Διαγονιδιακο ζωο ποντικος που παραγει αντισωματα |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20221100149T CY1125119T1 (el) | 2008-06-27 | 2022-02-22 | Διαγονιδιακο ζωο ποντικος που παραγει αντισωματα |
Country Status (23)
Country | Link |
---|---|
EP (6) | EP3456190B1 (el) |
JP (6) | JP5749161B2 (el) |
KR (5) | KR101990228B1 (el) |
CN (3) | CN105191863B (el) |
AU (1) | AU2009263082C1 (el) |
CA (1) | CA2729095C (el) |
CY (2) | CY1114830T1 (el) |
DK (3) | DK3456190T3 (el) |
ES (3) | ES2906344T3 (el) |
HK (1) | HK1154463A1 (el) |
HR (2) | HRP20220205T1 (el) |
HU (1) | HUE057994T2 (el) |
LT (1) | LT3456190T (el) |
MX (1) | MX2010014542A (el) |
NZ (1) | NZ590118A (el) |
PL (2) | PL2147594T3 (el) |
PT (3) | PT2556747T (el) |
RS (2) | RS53146B (el) |
RU (3) | RU2731084C2 (el) |
SG (3) | SG10201914027VA (el) |
SI (2) | SI3456190T1 (el) |
WO (1) | WO2009157771A2 (el) |
ZA (1) | ZA201009312B (el) |
Families Citing this family (115)
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USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
CN101537180B (zh) | 2002-07-18 | 2016-02-10 | 莫鲁斯有限公司 | 抗体混合物的重组生产 |
ES2408582T3 (es) | 2003-05-30 | 2013-06-21 | Merus B.V. | Biblioteca de Fab para la preparación de una mezcla de anticuerpos |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
GB2404382B (en) | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
GB2443186A (en) | 2006-10-25 | 2008-04-30 | Oxitec Ltd | Expression system for mediating alternative splicing |
CN105191863B (zh) | 2008-06-27 | 2020-12-22 | 莫鲁斯股份有限公司 | 产生抗体的非人哺乳动物 |
US9346873B2 (en) | 2008-09-30 | 2016-05-24 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
PL2564695T3 (pl) * | 2009-07-08 | 2015-10-30 | Kymab Ltd | Modele zwierzęce i cząsteczki terapeutyczne |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
WO2011158009A1 (en) * | 2010-06-17 | 2011-12-22 | Kymab Limited | Animal models and therapeutic molecules |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
AU2013204019B2 (en) * | 2010-02-08 | 2014-02-27 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
ES2603559T5 (es) | 2010-02-08 | 2021-02-22 | Regeneron Pharma | Cadena ligera común de ratón |
US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
EP4345163A2 (en) | 2010-03-31 | 2024-04-03 | Ablexis, LLC | Genetic engineering of non-human animals for the production of chimeric antibodies |
US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
CN103025884B (zh) | 2010-07-26 | 2015-11-25 | 特里安尼公司 | 转基因动物和使用方法 |
CN113150121A (zh) * | 2010-08-02 | 2021-07-23 | 瑞泽恩制药公司 | 制造包含vl结构域的结合蛋白的小鼠 |
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KR20180104149A (ko) | 2016-02-04 | 2018-09-19 | 트리아니, 인코포레이티드 | 면역글로불린의 증대된 생성 |
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