PL2908626T3 - Zwierzęta z humanizowaną - Google Patents

Zwierzęta z humanizowaną

Info

Publication number
PL2908626T3
PL2908626T3 PL14790452T PL14790452T PL2908626T3 PL 2908626 T3 PL2908626 T3 PL 2908626T3 PL 14790452 T PL14790452 T PL 14790452T PL 14790452 T PL14790452 T PL 14790452T PL 2908626 T3 PL2908626 T3 PL 2908626T3
Authority
PL
Poland
Prior art keywords
humanized
animals
Prior art date
Application number
PL14790452T
Other languages
English (en)
Inventor
Jose F. Rojas
Ka-Man Venus Lai
Andrew J. Murphy
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of PL2908626T3 publication Critical patent/PL2908626T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Knock-in vertebrates, e.g. humanised vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5443IL-15
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0387Animal model for diseases of the immune system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL14790452T 2013-10-15 2014-10-15 Zwierzęta z humanizowaną PL2908626T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361891013P 2013-10-15 2013-10-15

Publications (1)

Publication Number Publication Date
PL2908626T3 true PL2908626T3 (pl) 2017-05-31

Family

ID=51830649

Family Applications (2)

Application Number Title Priority Date Filing Date
PL14790452T PL2908626T3 (pl) 2013-10-15 2014-10-15 Zwierzęta z humanizowaną
PL16192440T PL3138397T3 (pl) 2013-10-15 2014-10-15 Zwierzęta z humanizowanym IL-15

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL16192440T PL3138397T3 (pl) 2013-10-15 2014-10-15 Zwierzęta z humanizowanym IL-15

Country Status (28)

Country Link
US (5) US9155290B2 (pl)
EP (3) EP3461331A1 (pl)
JP (3) JP6492095B2 (pl)
KR (1) KR102376041B1 (pl)
CN (2) CN105744829B (pl)
AU (2) AU2014337526B2 (pl)
BR (1) BR112016008175A2 (pl)
CA (1) CA2926090C (pl)
CY (2) CY1118675T1 (pl)
DK (2) DK2908626T3 (pl)
ES (2) ES2715949T3 (pl)
HK (1) HK1210659A1 (pl)
HR (2) HRP20170380T1 (pl)
HU (2) HUE033272T2 (pl)
IL (2) IL244525B (pl)
LT (2) LT2908626T (pl)
MX (1) MX2016004781A (pl)
NZ (1) NZ718655A (pl)
PL (2) PL2908626T3 (pl)
PT (2) PT3138397T (pl)
RS (2) RS55472B1 (pl)
RU (1) RU2674910C2 (pl)
SG (2) SG10201607768YA (pl)
SI (2) SI2908626T1 (pl)
SM (1) SMT201700024B (pl)
TR (1) TR201904342T4 (pl)
WO (1) WO2015057758A1 (pl)
ZA (1) ZA201601676B (pl)

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ES2591107T3 (es) 2009-10-06 2016-11-24 Regeneron Pharmaceuticals, Inc. Ratones modificados genéticamente e injerto
KR102061143B1 (ko) 2011-02-15 2019-12-31 리제너론 파마슈티칼스 인코포레이티드 인간화된 m-csf 마우스
CN113897398A (zh) 2012-09-07 2022-01-07 再生元制药公司 经遗传修饰的非人动物及其使用方法
DK3939423T3 (da) 2012-11-05 2024-05-06 Regeneron Pharma Genetisk modificerede ikke-humane dyr og fremgangsmåder til anvendelse deraf
RS55472B1 (sr) 2013-10-15 2017-04-28 Regeneron Pharma Životinje sa humanizovanim il-15
ES2968749T3 (es) 2014-05-05 2024-05-13 Regeneron Pharma Animales con C5 y C3 humanizados
NO2785538T3 (pl) 2014-05-07 2018-08-04
DK3145307T3 (en) 2014-05-19 2019-04-15 Regeneron Pharma RE-MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO
FI3850946T3 (fi) 2014-12-05 2023-12-28 Regeneron Pharma Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni
ES2950399T3 (es) 2015-04-13 2023-10-09 Regeneron Pharma Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos
SG11201806176PA (en) 2016-02-04 2018-08-30 Regeneron Pharma Non-human animals having an engineered angptl8 gene
SG10202001578RA (en) 2016-02-29 2020-04-29 Regeneron Pharma Rodents having a humanized tmprss gene
DK3476865T3 (da) 2016-06-28 2023-12-18 Biocytogen Pharmaceuticals Beijing Co Ltd Fremgangsmåde til konstruktion af pd-1-gen-modificeret humaniseret dyremodel og anvendelse deraf
CN107815468B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
WO2018041120A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tigit
WO2018041118A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric pd-l1
WO2018041121A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric ctla-4
CN107815467B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
WO2018086594A1 (en) 2016-11-11 2018-05-17 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tim-3
CN108070613B (zh) 2016-11-11 2020-03-13 百奥赛图江苏基因生物技术有限公司 人源化基因改造动物模型的制备方法及应用
CN108239659B (zh) 2016-12-23 2020-03-03 百奥赛图江苏基因生物技术有限公司 人源化基因改造动物模型的制备方法及应用
CN108424928B (zh) 2016-12-30 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
CN108467873B (zh) 2017-03-17 2020-03-13 百奥赛图江苏基因生物技术有限公司 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用
WO2018177441A1 (en) 2017-03-31 2018-10-04 Beijing Biocytogen Co., Ltd GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
CN108588126B (zh) 2017-03-31 2020-04-10 北京百奥赛图基因生物技术有限公司 Cd47基因人源化改造动物模型的制备方法及应用
CN109136275B (zh) 2017-06-19 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化gitr基因改造动物模型的制备方法及应用
CN109136274B (zh) 2017-06-19 2021-04-23 百奥赛图江苏基因生物技术有限公司 人源化cd40基因改造动物模型的制备方法及应用
CN109136261B (zh) 2017-06-19 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化cd28基因改造动物模型的制备方法及应用
KR20200135274A (ko) * 2017-08-09 2020-12-02 더 잭슨 래보라토리 인간 인터류킨 15를 발현하는 면역결핍 마우스
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CN109913493B (zh) 2017-12-12 2021-03-16 百奥赛图江苏基因生物技术有限公司 人源化cd3基因改造动物模型的制备方法及应用
CN116200426A (zh) 2018-07-16 2023-06-02 瑞泽恩制药公司 Ditra疾病的非人动物模型及其用途
WO2020074005A1 (en) 2018-10-12 2020-04-16 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric genes
CN111304247B (zh) 2018-12-20 2021-03-16 百奥赛图江苏基因生物技术有限公司 人源化lag-3基因改造动物模型的制备方法及应用
CN111304248B (zh) 2018-12-25 2021-08-24 百奥赛图江苏基因生物技术有限公司 人源化细胞因子il15基因改造非人动物的构建方法及应用
CN114164177A (zh) * 2019-01-17 2022-03-11 百奥赛图(北京)医药科技股份有限公司 人源化转基因动物
ES2966625T3 (es) 2019-04-04 2024-04-23 Regeneron Pharma Roedores que comprenden un locus del factor de coagulación 12 humanizado
CA3137761A1 (en) 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
CA3137764A1 (en) 2019-06-07 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized albumin locus
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RS55472B1 (sr) 2013-10-15 2017-04-28 Regeneron Pharma Životinje sa humanizovanim il-15

Also Published As

Publication number Publication date
RS58465B1 (sr) 2019-04-30
US9155290B2 (en) 2015-10-13
HRP20170380T1 (hr) 2017-05-19
LT3138397T (lt) 2019-04-10
HUE033272T2 (en) 2017-11-28
AU2014337526A1 (en) 2016-04-28
SG11201601828XA (en) 2016-04-28
EP3461331A1 (en) 2019-04-03
MX2016004781A (es) 2016-07-26
US20230189772A1 (en) 2023-06-22
NZ718655A (en) 2022-08-26
IL244525B (en) 2019-10-31
CN105744829A (zh) 2016-07-06
EP2908626A1 (en) 2015-08-26
EP2908626B1 (en) 2016-12-07
PT2908626T (pt) 2017-01-09
IL244525A0 (en) 2016-04-21
AU2014337526B2 (en) 2020-09-10
US20150366175A1 (en) 2015-12-24
HUE043969T2 (hu) 2019-09-30
SI3138397T1 (sl) 2019-04-30
CN109090037B (zh) 2021-05-28
JP2019022518A (ja) 2019-02-14
JP6492095B2 (ja) 2019-03-27
PT3138397T (pt) 2019-03-26
AU2020286186A1 (en) 2021-01-07
HRP20190542T1 (hr) 2019-07-26
ZA201601676B (en) 2019-12-18
SI2908626T1 (sl) 2017-02-28
LT2908626T (lt) 2017-01-25
US10561125B2 (en) 2020-02-18
BR112016008175A2 (pt) 2017-10-03
KR20160068774A (ko) 2016-06-15
CA2926090A1 (en) 2015-04-23
ES2613379T3 (es) 2017-05-24
PL3138397T3 (pl) 2019-06-28
JP2019216750A (ja) 2019-12-26
DK3138397T3 (en) 2019-04-15
US20180116192A1 (en) 2018-05-03
CN105744829B (zh) 2018-08-07
AU2020286186B2 (en) 2024-05-23
RU2016116847A3 (pl) 2018-06-07
CY1118675T1 (el) 2018-03-07
KR102376041B1 (ko) 2022-03-18
CN109090037A (zh) 2018-12-28
JP6600061B2 (ja) 2019-10-30
EP3138397B1 (en) 2018-12-26
JP2016533192A (ja) 2016-10-27
CY1121405T1 (el) 2020-05-29
US20200178508A1 (en) 2020-06-11
SMT201700024B (it) 2017-03-08
SG10201607768YA (en) 2016-11-29
WO2015057758A1 (en) 2015-04-23
TR201904342T4 (tr) 2019-05-21
RS55472B1 (sr) 2017-04-28
EP3138397A1 (en) 2017-03-08
ES2715949T3 (es) 2019-06-07
US11503813B2 (en) 2022-11-22
DK2908626T3 (en) 2017-03-20
HK1210659A1 (en) 2016-05-06
IL269907B (en) 2020-09-30
RU2016116847A (ru) 2017-11-21
US20150106961A1 (en) 2015-04-16
CA2926090C (en) 2022-07-05
RU2674910C2 (ru) 2018-12-13

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