RS56656B1 - Miševi sa genetski modifikovanim glavnim kompleksom gena tkivne podudarnosti - Google Patents
Miševi sa genetski modifikovanim glavnim kompleksom gena tkivne podudarnostiInfo
- Publication number
- RS56656B1 RS56656B1 RS20171195A RSP20171195A RS56656B1 RS 56656 B1 RS56656 B1 RS 56656B1 RS 20171195 A RS20171195 A RS 20171195A RS P20171195 A RSP20171195 A RS P20171195A RS 56656 B1 RS56656 B1 RS 56656B1
- Authority
- RS
- Serbia
- Prior art keywords
- genetically modified
- major histocompatibility
- histocompatibility complex
- modified major
- complex mice
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552587P | 2011-10-28 | 2011-10-28 | |
| US201161552582P | 2011-10-28 | 2011-10-28 | |
| US201261700908P | 2012-09-14 | 2012-09-14 | |
| PCT/US2012/062042 WO2013063346A1 (en) | 2011-10-28 | 2012-10-26 | Genetically modified major histocompatibility complex mice |
| EP12787255.4A EP2770821B1 (en) | 2011-10-28 | 2012-10-26 | Genetically modified major histocompatibility complex mice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS56656B1 true RS56656B1 (sr) | 2018-03-30 |
Family
ID=47178940
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20171195A RS56656B1 (sr) | 2011-10-28 | 2012-10-26 | Miševi sa genetski modifikovanim glavnim kompleksom gena tkivne podudarnosti |
| RS20190998A RS59082B1 (sr) | 2011-10-28 | 2012-10-26 | Miševi sa genetski modifikovanim glavnim kompleksom gena tkivne podudarnosti |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20190998A RS59082B1 (sr) | 2011-10-28 | 2012-10-26 | Miševi sa genetski modifikovanim glavnim kompleksom gena tkivne podudarnosti |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US9615550B2 (sr) |
| EP (4) | EP2770821B1 (sr) |
| JP (4) | JP6154391B2 (sr) |
| KR (3) | KR102074145B1 (sr) |
| CN (3) | CN107254480B (sr) |
| AU (3) | AU2012324016C1 (sr) |
| BR (1) | BR112014009259A2 (sr) |
| CA (2) | CA3074400A1 (sr) |
| CY (2) | CY1119657T1 (sr) |
| DK (2) | DK3262932T3 (sr) |
| ES (3) | ES2651517T3 (sr) |
| HK (2) | HK1200272A1 (sr) |
| HR (2) | HRP20171761T1 (sr) |
| HU (2) | HUE035652T2 (sr) |
| IL (3) | IL232097A (sr) |
| LT (2) | LT2770821T (sr) |
| MX (2) | MX355725B (sr) |
| MY (2) | MY164836A (sr) |
| NZ (1) | NZ734532A (sr) |
| PL (2) | PL2770821T3 (sr) |
| PT (2) | PT3262932T (sr) |
| RS (2) | RS56656B1 (sr) |
| SG (2) | SG10201603188SA (sr) |
| SI (2) | SI3262932T1 (sr) |
| WO (1) | WO2013063346A1 (sr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| EP2663575B1 (en) | 2011-10-28 | 2014-10-01 | Regeneron Pharmaceuticals, Inc. | Humanized il-6 and il-6 receptor |
| JP6444895B2 (ja) | 2013-02-20 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化ｔ細胞補助受容体を発現するマウス |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| DK2958937T3 (en) | 2013-02-22 | 2018-11-26 | Regeneron Pharma | Mice expressing humanized major histocompatibility complex |
| ES2764829T3 (es) * | 2013-03-11 | 2020-06-04 | Regeneron Pharma | Ratones transgénicos que expresan moléculas quiméricas del complejo mayor de histocompatibilidad (mhc) de clase I |
| RS64573B1 (sr) | 2013-09-23 | 2023-10-31 | Regeneron Pharma | Ne-humana životinja sa humanizovanim signalno-regulatornim proteinskim genom |
| PL2908626T3 (pl) | 2013-10-15 | 2017-05-31 | Regeneron Pharmaceuticals, Inc. | Zwierzęta z humanizowaną |
| WO2015056774A1 (ja) * | 2013-10-18 | 2015-04-23 | 大鵬薬品工業株式会社 | Ｈｌａクラスｉ発現非ヒト動物 |
| CN106163273B (zh) | 2014-04-08 | 2020-07-24 | 瑞泽恩制药公司 | 具有人源化FC-γ受体的非人动物 |
| JP6598798B2 (ja) | 2014-05-05 | 2019-10-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｃ５およびｃ３動物 |
| NO2785538T3 (sr) | 2014-05-07 | 2018-08-04 | ||
| JP6904707B2 (ja) | 2014-06-19 | 2021-07-21 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化プログラム細胞死１遺伝子を持つ非ヒト動物 |
| EP3193592A1 (en) | 2014-09-19 | 2017-07-26 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors |
| RS63410B1 (sr) | 2014-11-24 | 2022-08-31 | Regeneron Pharma | Ne-humane životinje koje eksprimiraju humanizovani cd3 kompleks |
| SI3850946T1 (sl) | 2014-12-05 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Nehumane živali, ki imajo humaniziran grozd diferenciacije gena 47 |
| EP3808775B1 (en) * | 2014-12-09 | 2024-04-17 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| KR102656470B1 (ko) | 2014-12-10 | 2024-04-09 | 리전츠 오브 더 유니버스티 오브 미네소타 | 질환을 치료하기 위한 유전적으로 변형된 세포, 조직 및 장기 |
| SI3280257T1 (sl) | 2015-04-06 | 2023-10-30 | Regeneron Pharmaceuticals, Inc., | S humaniziranimi t-celicami posredovani imunski odzivi pri nehumanih živalih |
| US10123518B2 (en) * | 2015-04-13 | 2018-11-13 | Regeneron Pharmaceuticals, Inc | Genetically modified non-human animals and methods of use thereof |
| SI3376857T1 (sl) | 2015-11-20 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Nehumane živali, ki imajo humaniziran gen 3 za aktivacijo limfocitov |
| EP3895529A1 (en) | 2016-02-29 | 2021-10-20 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| IL263160B2 (en) | 2016-06-03 | 2024-01-01 | Regeneron Pharma | Non-human animals expressing exogenous terminal deoxynucleotidyl transferase |
| CN109456942A (zh) * | 2017-09-06 | 2019-03-12 | 亘喜生物科技（上海）有限公司 | 通用型嵌合抗原受体t细胞制备技术 |
| PT3687287T (pt) | 2017-09-29 | 2023-11-03 | Regeneron Pharma | Roedores que expressam complexo c1q humanizado |
| US11419318B2 (en) | 2017-11-30 | 2022-08-23 | Regeneran Pharmaceuticals, Inc. | Genetically modified rat comprising a humanized TRKB locus |
| BR112020019026A2 (pt) | 2018-03-24 | 2020-12-29 | Regeneron Pharmaceuticals, Inc. | Animal não humano geneticamente modificado, métodos para produzir o animal não humano geneticamente modificado, para geração de uma proteína de ligação a antígeno, para obtenção de um ácido nucleico, e, para obtenção de uma célula que expressa um domínio variável de cadeia pesada de imunoglobulina humana e/ou um domínio variável de cadeia leve de imunoglobulina humana, método in vitro de produção de um domínio variável de imunoglobulina humana, ácido nucleico, célula hospedeira, célula isolada, e, domínio variável de cadeia pesada de imunoglobulina humana |
| CN116420679A (zh) | 2018-03-26 | 2023-07-14 | 瑞泽恩制药公司 | 用于测试治疗剂的人源化啮齿动物 |
| AU2019308205A1 (en) | 2018-07-16 | 2020-11-19 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of DITRA disease and uses thereof |
| US11737435B2 (en) | 2019-04-04 | 2023-08-29 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized coagulation factor 12 locus |
| US11891618B2 (en) | 2019-06-04 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| TW202112229A (zh) | 2019-06-07 | 2021-04-01 | 美商雷傑納榮製藥公司 | 包含人化白蛋白基因座之非人的動物 |
| IL294356A (en) * | 2020-01-10 | 2022-08-01 | Biocytogen Pharmaceuticals Beijing Co Ltd | Non-human animals are genetically engineered with a human or chimeric mhc protein complex |
| IL303626A (en) | 2020-12-16 | 2023-08-01 | Regeneron Pharma | Mice expressing human FC alpha receptors |
| WO2022133155A1 (en) * | 2020-12-16 | 2022-06-23 | Xenotherapeutics, Inc. | Humanization of beta2-microglobulin in porcine genome resulting in functional expression of human βeta2-microglobulin within donor cells, tissues, or organs |
| BR112023018874A2 (pt) | 2021-03-31 | 2023-10-03 | Regeneron Pharma | Camundongos geneticamente modificados compreendendo componentes do sistema imunológico celular humanizado com diversidade melhorada do repertório de tcrb |
| WO2023240109A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Multispecific molecules for modulating t-cell activity, and uses thereof |
| WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
| US20240099279A1 (en) | 2022-09-22 | 2024-03-28 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing components of human cellular immune system |
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| US5574205A (en) | 1989-07-25 | 1996-11-12 | Cell Genesys | Homologous recombination for universal donor cells and chimeric mammalian hosts |
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| JP6444895B2 (ja) | 2013-02-20 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化ｔ細胞補助受容体を発現するマウス |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| DK2958937T3 (en) | 2013-02-22 | 2018-11-26 | Regeneron Pharma | Mice expressing humanized major histocompatibility complex |
| SI3280257T1 (sl) | 2015-04-06 | 2023-10-30 | Regeneron Pharmaceuticals, Inc., | S humaniziranimi t-celicami posredovani imunski odzivi pri nehumanih živalih |
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2012
- 2012-10-26 PT PT17184955T patent/PT3262932T/pt unknown
- 2012-10-26 SG SG10201603188SA patent/SG10201603188SA/en unknown
- 2012-10-26 SI SI201231650T patent/SI3262932T1/sl unknown
- 2012-10-26 DK DK17184955.7T patent/DK3262932T3/da active
- 2012-10-26 AU AU2012324016A patent/AU2012324016C1/en active Active
- 2012-10-26 PL PL12787255T patent/PL2770821T3/pl unknown
- 2012-10-26 KR KR1020187033187A patent/KR102074145B1/ko active IP Right Grant
- 2012-10-26 WO PCT/US2012/062042 patent/WO2013063346A1/en active Application Filing
- 2012-10-26 EP EP12787255.4A patent/EP2770821B1/en active Active
- 2012-10-26 SI SI201231136T patent/SI2770821T1/en unknown
- 2012-10-26 MY MYPI2014000784A patent/MY164836A/en unknown
- 2012-10-26 SG SG11201400933VA patent/SG11201400933VA/en unknown
- 2012-10-26 MX MX2014004895A patent/MX355725B/es active IP Right Grant
- 2012-10-26 CN CN201710347715.8A patent/CN107254480B/zh active Active
- 2012-10-26 EP EP19167619.6A patent/EP3563680B1/en active Active
- 2012-10-26 PL PL17184955T patent/PL3262932T3/pl unknown
- 2012-10-26 HU HUE12787255A patent/HUE035652T2/en unknown
- 2012-10-26 CA CA3074400A patent/CA3074400A1/en active Pending
- 2012-10-26 EP EP23193595.8A patent/EP4311833A3/en active Pending
- 2012-10-26 ES ES12787255.4T patent/ES2651517T3/es active Active
- 2012-10-26 LT LTEP12787255.4T patent/LT2770821T/lt unknown
- 2012-10-26 MY MYPI2017703836A patent/MY178723A/en unknown
- 2012-10-26 NZ NZ734532A patent/NZ734532A/en unknown
- 2012-10-26 JP JP2014539029A patent/JP6154391B2/ja active Active
- 2012-10-26 HU HUE17184955A patent/HUE045879T2/hu unknown
- 2012-10-26 LT LTEP17184955.7T patent/LT3262932T/lt unknown
- 2012-10-26 MX MX2020010763A patent/MX2020010763A/es unknown
- 2012-10-26 DK DK12787255.4T patent/DK2770821T3/da active
- 2012-10-26 PT PT127872554T patent/PT2770821T/pt unknown
- 2012-10-26 KR KR1020147014476A patent/KR101921126B1/ko active IP Right Grant
- 2012-10-26 CN CN202110831383.7A patent/CN113564188A/zh active Pending
- 2012-10-26 KR KR1020207002887A patent/KR102295746B1/ko active IP Right Grant
- 2012-10-26 ES ES17184955T patent/ES2741649T3/es active Active
- 2012-10-26 US US13/661,159 patent/US9615550B2/en active Active
- 2012-10-26 RS RS20171195A patent/RS56656B1/sr unknown
- 2012-10-26 ES ES19167619T patent/ES2962287T3/es active Active
- 2012-10-26 BR BR112014009259-1A patent/BR112014009259A2/pt not_active Application Discontinuation
- 2012-10-26 RS RS20190998A patent/RS59082B1/sr unknown
- 2012-10-26 EP EP17184955.7A patent/EP3262932B1/en active Active
- 2012-10-26 CN CN201280060540.8A patent/CN104039132B9/zh active Active
- 2012-10-26 CA CA2850387A patent/CA2850387A1/en active Pending
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2014
- 2014-04-13 IL IL232097A patent/IL232097A/en active IP Right Grant
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2015
- 2015-01-29 HK HK15101011.6A patent/HK1200272A1/xx unknown
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2016
- 2016-04-27 AU AU2016202688A patent/AU2016202688B2/en active Active
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2017
- 2017-02-22 US US15/439,828 patent/US10869466B2/en active Active
- 2017-04-30 IL IL252022A patent/IL252022A0/en active IP Right Grant
- 2017-06-01 JP JP2017109327A patent/JP6574457B2/ja active Active
- 2017-11-15 HR HRP20171761TT patent/HRP20171761T1/hr unknown
- 2017-11-22 CY CY20171101223T patent/CY1119657T1/el unknown
- 2017-12-22 AU AU2017279797A patent/AU2017279797C1/en active Active
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2018
- 2018-06-29 HK HK18108466.8A patent/HK1249712B/zh unknown
- 2018-08-20 IL IL26123918A patent/IL261239B/en active IP Right Grant
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2019
- 2019-02-06 JP JP2019019707A patent/JP6866409B2/ja active Active
- 2019-08-06 HR HRP20191420 patent/HRP20191420T1/hr unknown
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2020
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- 2020-08-12 US US16/991,283 patent/US20200375160A1/en active Pending
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