FR2827302B1 - Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations - Google Patents

Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations

Info

Publication number
FR2827302B1
FR2827302B1 FR0109352A FR0109352A FR2827302B1 FR 2827302 B1 FR2827302 B1 FR 2827302B1 FR 0109352 A FR0109352 A FR 0109352A FR 0109352 A FR0109352 A FR 0109352A FR 2827302 B1 FR2827302 B1 FR 2827302B1
Authority
FR
France
Prior art keywords
transgenic cell
modeling human
animal modeling
antigenic presentation
human antigenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0109352A
Other languages
English (en)
Other versions
FR2827302A1 (fr
Inventor
Kader Thiam
Frederique Rattis
Fabien Bertaux
Alexandre Fraichard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genoway SA
Original Assignee
Genoway SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genoway SA filed Critical Genoway SA
Priority to FR0109352A priority Critical patent/FR2827302B1/fr
Priority to PCT/FR2002/002475 priority patent/WO2003006639A1/fr
Priority to EP02784869A priority patent/EP1414949A1/fr
Priority to CA002453928A priority patent/CA2453928A1/fr
Priority to US10/483,569 priority patent/US20050066375A1/en
Publication of FR2827302A1 publication Critical patent/FR2827302A1/fr
Application granted granted Critical
Publication of FR2827302B1 publication Critical patent/FR2827302B1/fr
Priority to US11/709,838 priority patent/US20070209083A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
FR0109352A 2001-07-13 2001-07-13 Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations Expired - Fee Related FR2827302B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR0109352A FR2827302B1 (fr) 2001-07-13 2001-07-13 Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
PCT/FR2002/002475 WO2003006639A1 (fr) 2001-07-13 2002-07-12 Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
EP02784869A EP1414949A1 (fr) 2001-07-13 2002-07-12 Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
CA002453928A CA2453928A1 (fr) 2001-07-13 2002-07-12 Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
US10/483,569 US20050066375A1 (en) 2001-07-13 2002-07-12 Cell and transgenic animal modelling human antigenic presentation and their uses
US11/709,838 US20070209083A1 (en) 2001-07-13 2007-02-23 Cell and transgenic animal modelling human antigenic presentation and their uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0109352A FR2827302B1 (fr) 2001-07-13 2001-07-13 Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations

Publications (2)

Publication Number Publication Date
FR2827302A1 FR2827302A1 (fr) 2003-01-17
FR2827302B1 true FR2827302B1 (fr) 2003-10-10

Family

ID=8865469

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0109352A Expired - Fee Related FR2827302B1 (fr) 2001-07-13 2001-07-13 Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations

Country Status (5)

Country Link
US (2) US20050066375A1 (fr)
EP (1) EP1414949A1 (fr)
CA (1) CA2453928A1 (fr)
FR (1) FR2827302B1 (fr)
WO (1) WO2003006639A1 (fr)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5478003B2 (ja) * 2003-07-10 2014-04-23 アンスティチュ パストゥール ヒトの主要組織適合複合体（ｍｈｃ）の表現型を有するトランスジェニックマウス、その実験のための使用および応用方法
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
GB0425713D0 (en) * 2004-11-23 2004-12-22 Baker Matthew Immunogencity testing and antibody selection methods
FR2882628B1 (fr) * 2005-03-04 2011-03-18 Centre Nat Rech Scient Souris transgeniques et leurs applications comme modele experimental
EP1743904A3 (fr) * 2005-07-13 2007-02-14 F. Hoffmann-La Roche Ag Chymase du cobaye
US20090328240A1 (en) * 2008-06-24 2009-12-31 Sing George L Genetically modified mice as predictors of immune response
NZ592308A (en) * 2008-09-30 2012-11-30 Ablexis Llc Non-human mammals for the production of chimeric antibodies
EP2421980A2 (fr) * 2009-04-23 2012-02-29 Transposagen Biopharmaceuticals, Inc. Rats génétiquement modifiés comme modèles de cancer
WO2011002988A1 (fr) 2009-07-01 2011-01-06 Transposagen Biopharmaceuticals, Inc. Modèles de rats génétiquement modifiés pour l'immunodéficience combinée sévère
EP2564695B1 (fr) 2009-07-08 2015-04-15 Kymab Limited Modèles animaux et molécules thérapeutiques
US20120204278A1 (en) 2009-07-08 2012-08-09 Kymab Limited Animal models and therapeutic molecules
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
EP2456876A2 (fr) 2009-07-24 2012-05-30 Transposagen Biopharmaceuticals, Inc. Modèles rats génétiquement modifiös pour les voies de signalisation cytokine-cytokine
WO2011014721A2 (fr) 2009-07-30 2011-02-03 Transposagen Biopharmaceuticals, Inc. Modèles de rat génétiquement modifiés pour pharmacocinétique
US20110035816A1 (en) * 2009-08-05 2011-02-10 Ostertag Eric M Genetically Modified Rat Models for Drug Metabolism
EP2467013A2 (fr) 2009-08-20 2012-06-27 Transposagen Biopharmaceuticals, Inc. Modèles de rat génétiquement modifié pour l'analyse de la douleur
NZ601171A (en) 2010-03-31 2014-11-28 Ablexis Llc Genetic engineering of non-human animals for the production of chimeric antibodies
US20120020938A1 (en) * 2010-07-26 2012-01-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware MHC- less cells
US20120020885A1 (en) * 2010-07-26 2012-01-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware MHC-Less cells
NZ707327A (en) * 2010-08-02 2017-01-27 Regeneron Pharma Mice that make binding proteins comprising vl domains
US20130291134A1 (en) * 2010-09-24 2013-10-31 Sofia A. Casares Humanized transgenic mouse model
WO2012039779A1 (fr) * 2010-09-24 2012-03-29 The United States Of America As Represented By The Secretary Of The Navy Modèle de souris transgénique humanisée
CN105950654B (zh) * 2010-11-27 2020-03-20 朱坚 一种人源化的转基因动物
WO2012129198A1 (fr) 2011-03-23 2012-09-27 Transposagen Biopharmaceuticals, Inc. Modèles de rat génétiquement modifiés pour l'étude de l'obésité et du diabète
WO2013017545A1 (fr) * 2011-07-29 2013-02-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Souris transgéniques humanisées hla-a2 / hla-dp4 et leurs utilisations en tant que modèle expérimental pour la recherche biomédicale et le développement biomédical
WO2013041844A2 (fr) 2011-09-19 2013-03-28 Kymab Limited Anticorps, domaines variables & chaînes adaptées pour une utilisation humaine
WO2013045916A1 (fr) 2011-09-26 2013-04-04 Kymab Limited Chaînes légères substituts (cls) chimères comprenant vpreb humain
GB201116721D0 (en) 2011-09-28 2011-11-09 Glaxo Group Ltd Novel device
US9043996B2 (en) 2011-10-28 2015-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
LT3590332T (lt) 2011-10-28 2022-08-10 Regeneron Pharmaceuticals, Inc. Genetiškai modifikuotos pelės, ekspresuojančios chimerines pagrindinio audinių dermės komplekso (mhc) ii molekules
RU2653433C2 (ru) * 2011-10-28 2018-05-08 Регенерон Фармасьютикалс, Инк. Генетически модифицированные в отношении главного комплекса гистосовместимости мыши
US9591835B2 (en) 2011-10-28 2017-03-14 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
SI2771357T1 (sl) * 2011-10-28 2018-11-30 Regeneron Pharmaceuticals, Inc. Genetsko T-celično receptorsko modificirane miši
CN107254480B (zh) * 2011-10-28 2021-08-10 瑞泽恩制药公司 制备主要组织相容性复合物基因修饰小鼠的方法
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
SI2958938T1 (sl) 2013-02-20 2019-08-30 Regeneron Pharmaceuticals, Inc. Miši, ki izražajo humanizirane koreceptorje za celice T
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
CN105164154B (zh) * 2013-02-22 2019-06-07 瑞泽恩制药公司 表达人源化主要组织相容性复合物的小鼠
CN105208855B (zh) * 2013-03-11 2018-04-27 瑞泽恩制药公司 表达嵌合的主要组织相容性复合物(mhc)ii类分子的转基因小鼠
WO2014164640A1 (fr) * 2013-03-11 2014-10-09 Regeneron Pharmaceuticals, Inc. Souris transgéniques exprimant des molécules chimériques du complexe majeur d'histocompatibilité (cmh) de classe i
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
DE112014004537T5 (de) 2013-10-01 2016-07-21 Kymab Limited Tiermodelle und therapeutische Moleküle
WO2015056774A1 (fr) * 2013-10-18 2015-04-23 大鵬薬品工業株式会社 Animal non humain exprimant une molécule hla classe i
SG11201607015VA (en) 2014-03-21 2016-09-29 Regeneron Pharma V<sb>L</sb> ANTIGEN BINDING PROTEINS EXHIBITING DISTINCT BINDING CHARACTERISTICS
SG11201607203XA (en) 2014-03-21 2016-09-29 Regeneron Pharma Non-human animals that make single domain binding proteins
AU2015353705C9 (en) * 2014-11-24 2022-09-01 Regeneron Pharmaceuticals, Inc. Non-human animals expressing humanized CD3 complex
AU2016220324B2 (en) 2015-02-16 2020-07-02 The Trustees Of The University Of Pennsylvania A fully-human T cell receptor specific for the 369-377 epitope derived from the HER2/Neu (ERBB2) receptor protein
CA2979702A1 (fr) 2015-03-19 2016-09-22 Regeneron Pharmaceuticals, Inc. Animaux non humains qui selectionnent des regions variables de chaines legeres qui se lient a l'antigene
BR112017021250A2 (pt) 2015-04-06 2018-06-26 Regeneron Pharma respostas imunes mediadas por células t humanizadas em animais não humanos
US11612149B2 (en) 2015-07-10 2023-03-28 Chugai Seiyaku Kabushiki Kaisha Non-human animal having human CD3 gene substituted for endogenous CD3 gene
WO2017150763A1 (fr) * 2016-02-29 2017-09-08 (주)메디톡스 Modèle animal exprimant cd3 humain et son utilisation
JP7125347B2 (ja) 2016-08-22 2022-08-24 中外製薬株式会社 ヒトｇｐｃ３ポリペプチドを発現する遺伝子改変非ヒト動物
EP4144213A1 (fr) 2017-05-12 2023-03-08 The Jackson Laboratory Souris nsg dépourvues de mhc de classe i et de classe ii
CN109136261B (zh) 2017-06-19 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化cd28基因改造动物模型的制备方法及应用
US11712026B2 (en) * 2017-10-18 2023-08-01 The Jackson Laboratory Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489742A (en) * 1990-10-23 1996-02-06 Board Of Regents, The University Of Texas System Transgenic rats and animal models of inflammatory disease
WO1993005817A1 (fr) * 1991-09-19 1993-04-01 President And Fellows Of Harvard College Mammiferes transgeniques depourvus des antigenes des classes mhc i et ii
WO1995014377A2 (fr) * 1993-11-29 1995-06-01 Amgen Canada Inc. Modele pour maladies infectieuses
US5965787A (en) * 1995-08-31 1999-10-12 Mayo Foundation For Medical Education And Research HLA-DRBI peptides with specific binding affinity for HLA-DQ molecules: prevention and treatment of rheumatoid arthritis
WO1997032978A1 (fr) * 1996-03-06 1997-09-12 The Uab Research Foundation Production d'hemoglobine humaine dans des animaux transgeniques
WO1998008943A1 (fr) * 1996-08-30 1998-03-05 Mayo Foundation For Medical Education And Research Peptides de hla-drb1 ayant une affinite de liaison specifique pour les molecules de hla-dq et utiles dans la prevention et le traitement de la polyarthrite rhumatoide
US6255555B1 (en) * 1997-04-17 2001-07-03 Japan Science And Technology Corporation Transgenic mouse expressing human fusin and human CD4
US6833268B1 (en) * 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions

Also Published As

Publication number Publication date
US20070209083A1 (en) 2007-09-06
CA2453928A1 (fr) 2003-01-23
US20050066375A1 (en) 2005-03-24
WO2003006639A1 (fr) 2003-01-23
FR2827302A1 (fr) 2003-01-17
EP1414949A1 (fr) 2004-05-06

Similar Documents

Publication Publication Date Title
FR2827302B1 (fr) Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
FR16C1012I2 (fr) Utilisation therapeutique d&#39;anticorps anti-cs1
MA30684B1 (fr) Anticorps anti-mn et leurs procedes d&#39;utilisation.
DE60324099D1 (de) Arzneistoffhaltiger tampon
FR2888850B1 (fr) Nouveaux anticorps anti-igf-ir et leurs applications
CY2011003I2 (el) Φαρμακευτικα προϊοντα σε διαλυμα που περιεχουν αντισωμα
FR09C0062I2 (fr) Anticorps de la il-1 beta humaine
DE60324178D1 (de) THIAZOLIDIN-4-ONES UM hYAK3 PROTEINEN ZU HEMMEN
DE60221143D1 (de) Brusteinlage enthaltend hautpflegemittel
DK1713544T3 (da) Sammensætninger og fremgangsmåder til oral og personlig pleje
NO20004907L (no) Vandig emulsjon og fremstilling derav
DE60139763D1 (de) Lanzen und -tieren
DE50213460D1 (de) Spirocyclische 3-phenyl-3-substituierte-4-ketolaktame und -laktone
DK1589938T3 (da) Mundplejesammensætninger og fremgangsmåder hertil
FR2834991B1 (fr) Nouveaux anticorps anti-igf-ir et leurs applications
FR2848826B1 (fr) Compositions cosmetiques et cartes de contraste permettant de les caracteriser
FR2834900B1 (fr) Nouvelles compositions a activite anti-igf-ir et anti-egfr et leurs applications
FR2822161B1 (fr) Cellule et animal transgenique modelisant les reponses humaines allergiques mediees par les ige, et leurs utilisations
DE60217668D1 (de) Pflanzenfettemulsion enthaltend haferprotein
FR2864535B1 (fr) Derives acides de quinoline et leurs applications en therapeutique
FR2850969B1 (fr) Aminopropanediols acyles et analogues et leurs utilisations therapeutiques
IT1316921B1 (it) Organo bioartificiale per ospitare cellule animali e/o umane.
FR2862995B1 (fr) Poutre souple autocontrainte et portiques souples parasismiques
NO20042416L (no) Farmasoytisk sammensetning for induksjon av en immunrespons i et menneske eller dyr
FR2846967B1 (fr) Nouveaux composes lipophiles et leurs utilisations

Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20150331