DE60324099D1 - Arzneistoffhaltiger tampon - Google Patents

Arzneistoffhaltiger tampon

Info

Publication number
DE60324099D1
DE60324099D1 DE60324099T DE60324099T DE60324099D1 DE 60324099 D1 DE60324099 D1 DE 60324099D1 DE 60324099 T DE60324099 T DE 60324099T DE 60324099 T DE60324099 T DE 60324099T DE 60324099 D1 DE60324099 D1 DE 60324099D1
Authority
DE
Germany
Prior art keywords
drug
tampon
containing tampon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60324099T
Other languages
English (en)
Inventor
Steven Craig Gehling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kimberly Clark Worldwide Inc
Kimberly Clark Corp
UMD Inc
Original Assignee
Kimberly Clark Worldwide Inc
Kimberly Clark Corp
UMD Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Worldwide Inc, Kimberly Clark Corp, UMD Inc filed Critical Kimberly Clark Worldwide Inc
Priority claimed from PCT/US2003/000491 external-priority patent/WO2003059318A2/en
Application granted granted Critical
Publication of DE60324099D1 publication Critical patent/DE60324099D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20Tampons, e.g. catamenial tampons; Accessories therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20Tampons, e.g. catamenial tampons; Accessories therefor
    • A61F13/2002Tampons, e.g. catamenial tampons; Accessories therefor characterised by the use
    • A61F13/202Catamenial tampons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20Tampons, e.g. catamenial tampons; Accessories therefor
    • A61F13/2051Tampons, e.g. catamenial tampons; Accessories therefor characterised by the material or the structure of the inner absorbing core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20Tampons, e.g. catamenial tampons; Accessories therefor
    • A61F13/2074Tampons, e.g. catamenial tampons; Accessories therefor impregnated with hydrophobic, hydrophilic, skin enhancers, medicinal etc. substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/84Accessories, not otherwise provided for, for absorbent pads
    • A61F13/8405Additives, e.g. for odour, disinfectant or pH control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20Tampons, e.g. catamenial tampons; Accessories therefor
    • A61F13/26Means for inserting tampons, i.e. applicators
    • A61F13/28Means for inserting tampons, i.e. applicators with lubricating means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/84Accessories, not otherwise provided for, for absorbent pads
    • A61F13/8405Additives, e.g. for odour, disinfectant or pH control
    • A61F2013/8408Additives, e.g. for odour, disinfectant or pH control with odour control
    • A61F2013/8414Additives, e.g. for odour, disinfectant or pH control with odour control with anti-microbic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/84Accessories, not otherwise provided for, for absorbent pads
    • A61F13/8405Additives, e.g. for odour, disinfectant or pH control
    • A61F2013/8408Additives, e.g. for odour, disinfectant or pH control with odour control
    • A61F2013/8414Additives, e.g. for odour, disinfectant or pH control with odour control with anti-microbic
    • A61F2013/8417Additives, e.g. for odour, disinfectant or pH control with odour control with anti-microbic being anti-mycosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/02Suppositories; Bougies; Bases therefor; Ovules
    • A61K9/025Suppositories; Bougies; Bases therefor; Ovules characterised by shape or structure, e.g. hollow layered, coated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/14Female reproductive, genital organs
    • A61M2210/1475Vagina
DE60324099T 2002-01-10 2003-01-07 Arzneistoffhaltiger tampon Expired - Lifetime DE60324099D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34771902P 2002-01-10 2002-01-10
US10/335,759 US7341737B2 (en) 1997-06-11 2002-12-31 Medicated tampon
PCT/US2003/000491 WO2003059318A2 (en) 2002-01-10 2003-01-07 Medicated tampon

Publications (1)

Publication Number Publication Date
DE60324099D1 true DE60324099D1 (de) 2008-11-27

Family

ID=27616650

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60324099T Expired - Lifetime DE60324099D1 (de) 2002-01-10 2003-01-07 Arzneistoffhaltiger tampon

Country Status (8)

Country Link
US (1) US7341737B2 (de)
EP (2) EP1474105B1 (de)
JP (1) JP2006515994A (de)
KR (1) KR100978981B1 (de)
BR (1) BR0306513A (de)
CA (1) CA2470529A1 (de)
DE (1) DE60324099D1 (de)
WO (1) WO2003063829A1 (de)

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US7344732B2 (en) * 2002-01-10 2008-03-18 Kimberly-Clark Worldwide, Inc. Medicated tampon
US7744916B2 (en) * 1997-06-11 2010-06-29 Umd, Inc. Coated vaginal device for delivery of anti-migraine and anti-nausea drugs
US7381434B2 (en) * 2003-04-08 2008-06-03 Herbalscience Llc Methods and compositions of Areca catechu
US7947261B2 (en) * 2003-05-23 2011-05-24 Nektar Therapeutics Conjugates formed from polymer derivatives having particular atom arrangements
US20050098255A1 (en) * 2003-11-06 2005-05-12 Lembo Michael J. Insulation product having nonwoven facing and process for making same
US20050138834A1 (en) * 2003-12-03 2005-06-30 Suda David I. Fiberglass insulation curing oven tower and method of curing fiberglass insulation
US7252868B2 (en) * 2004-01-08 2007-08-07 Certainteed Corporation Reinforced fibrous insulation product and method of reinforcing same
US7476427B2 (en) * 2004-03-11 2009-01-13 Certainteed Corporation Faced fiberglass board with improved surface toughness
US7762944B2 (en) * 2004-04-22 2010-07-27 Taipei Veterans General Hospital Detachable porous vaginal mold
US20050244402A1 (en) * 2004-04-30 2005-11-03 Villanueva Julie M Absorption of pain-causing agents
US20060078699A1 (en) * 2004-10-12 2006-04-13 Mankell Kurt O Insulation board with weather and puncture resistant facing and method of manufacturing the same
US7919453B2 (en) * 2005-03-25 2011-04-05 Kimberly-Clark Worldwide, Inc. Dosage cap assembly for an applicator
US7993667B2 (en) * 2005-03-25 2011-08-09 Kimberly-Clark Worldwide, Inc. Methods of manufacturing a medicated tampon assembly
US7527614B2 (en) * 2005-03-25 2009-05-05 Kimberly-Clark Worldwide, Inc. Protective tube for a medicated tampon
US7744556B2 (en) * 2005-03-25 2010-06-29 Kimberly-Clark Worldwide, Inc. Delivery tube assembly for an applicator
US9295289B2 (en) * 2005-04-01 2016-03-29 Leslie Jane James Waist-fastening, hip-encompassing apparel with at least one concealed storage compartment
US7708726B2 (en) * 2005-04-28 2010-05-04 Kimberly-Clark Worldwide, Inc. Dosage form cap for an applicator
CN101180040B (zh) * 2005-05-20 2012-10-10 奥默罗斯公司 环加氧酶抑制剂和钙通道拮抗剂组合物以及供泌尿科操作使用的方法
US20070141118A1 (en) * 2005-12-15 2007-06-21 Damico Joyce A Layered dosage form for a medicated tampon assembly
US20080077107A1 (en) * 2006-09-22 2008-03-27 Ryo Minoguchi Tampon having a finger cover
EP2094217B2 (de) * 2006-11-24 2018-10-10 Essity Hygiene and Health Aktiebolag Tampon
EP1980241B1 (de) * 2007-04-04 2015-10-14 Mibelle AG Feuchttücher zur Intimpflege für Frauen mit Vitex agnus-castus Extrakt
US20100130907A1 (en) * 2008-11-21 2010-05-27 Linkel Stephan M Article of manufacture used in contact with human body surfaces
WO2010071865A1 (en) 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
US20100160351A1 (en) * 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
JP5409067B2 (ja) * 2009-03-23 2014-02-05 ユニ・チャーム株式会社 タンポン
JP5463061B2 (ja) * 2009-03-23 2014-04-09 ユニ・チャーム株式会社 タンポン、タンポンの製造方法、及び、タンポンの製造装置
WO2011032175A1 (en) 2009-09-14 2011-03-17 Nuon Therapeutics, Inc. Combination formulations of tranilast and allopurinol and methods related thereto
GB2502807A (en) * 2012-06-07 2013-12-11 Margaret Imelda Henson Tampon with enlarged proximal end to trap clots
US10058306B2 (en) 2012-06-22 2018-08-28 Preprogen, LLC Method for obtaining fetal cells and fetal cellular components
GB2519055A (en) * 2013-08-01 2015-04-15 Calla Lily Personal Care Ltd Drug delivery device
KR101517112B1 (ko) * 2014-02-03 2015-05-04 순천향대학교 산학협력단 지혈용 패킹 주머니
JP1592719S (de) * 2016-12-21 2017-12-11
US11439542B2 (en) 2017-10-06 2022-09-13 Essity Hygiene And Health Aktiebolag Tampon applicator
CN111065364A (zh) * 2017-10-06 2020-04-24 易希提卫生与保健公司 卫生棉条施加器
EP3691588B1 (de) 2017-10-06 2022-07-27 Essity Hygiene and Health Aktiebolag Tamponapplikator
US11007091B2 (en) 2017-10-06 2021-05-18 Essity Hygiene And Health Aktiebolag Tampon applicator
US10022276B1 (en) * 2017-10-12 2018-07-17 Lacey Janell Lund Self-lubricating tampon applicator
US10799138B2 (en) 2018-04-05 2020-10-13 University Of Maryland, Baltimore Method of administering sotalol IV/switch
LT6697B (lt) * 2018-06-26 2020-02-10 UAB "Avodės" Menstruacinis tamponas
US11696902B2 (en) 2018-08-14 2023-07-11 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11344518B2 (en) 2018-08-14 2022-05-31 AltaThera Pharmaceuticals LLC Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame
US10512620B1 (en) 2018-08-14 2019-12-24 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11610660B1 (en) 2021-08-20 2023-03-21 AltaThera Pharmaceuticals LLC Antiarrhythmic drug dosing methods, medical devices, and systems
US11304894B2 (en) 2020-05-04 2022-04-19 Garrett E. Wdowin Compositions, delivery devices, and methods thereof for feminine health
US11565096B2 (en) 2021-01-14 2023-01-31 Herphoric, Inc. Delivery system for a pharmaceutical, holistic or medicinal component

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US3338992A (en) 1959-12-15 1967-08-29 Du Pont Process for forming non-woven filamentary structures from fiber-forming synthetic organic polymers
US3502763A (en) 1962-02-03 1970-03-24 Freudenberg Carl Kg Process of producing non-woven fabric fleece
US3502538A (en) 1964-08-17 1970-03-24 Du Pont Bonded nonwoven sheets with a defined distribution of bond strengths
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US3542615A (en) 1967-06-16 1970-11-24 Monsanto Co Process for producing a nylon non-woven fabric
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US3595236A (en) 1969-03-17 1971-07-27 Kimberly Clark Co Coating to aid tampon insertion and tampons coated therewith
DE2048006B2 (de) 1969-10-01 1980-10-30 Asahi Kasei Kogyo K.K., Osaka (Japan) Verfahren und Vorrichtung zur Herstellung einer breiten Vliesbahn
DE1950669C3 (de) 1969-10-08 1982-05-13 Metallgesellschaft Ag, 6000 Frankfurt Verfahren zur Vliesherstellung
US3796219A (en) * 1971-03-24 1974-03-12 Kimberly Clark Co Coated tampon
US4317447A (en) 1979-07-19 1982-03-02 Ortho Pharmaceutical Corporation Drug delivery system
US4340563A (en) 1980-05-05 1982-07-20 Kimberly-Clark Corporation Method for forming nonwoven webs
US4318405A (en) 1980-07-24 1982-03-09 Sneider Vincent R Tampon and drug delivery device
DE3204124A1 (de) 1982-02-06 1983-08-18 Bayer Ag, 5090 Leverkusen Antimykotische tampons mit hoher wirkstoff-freisetzung
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Also Published As

Publication number Publication date
JP2006515994A (ja) 2006-06-15
EP1474105A2 (de) 2004-11-10
US20030144639A1 (en) 2003-07-31
BR0306513A (pt) 2006-12-12
US7341737B2 (en) 2008-03-11
EP1474105B1 (de) 2008-10-15
KR100978981B1 (ko) 2010-08-30
WO2003063829A1 (en) 2003-08-07
KR20040111344A (ko) 2004-12-31
CA2470529A1 (en) 2003-07-24
EP1474106A1 (de) 2004-11-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition