HK1200272A1 - Genetically modified major histocompatibility complex mice - Google Patents
Genetically modified major histocompatibility complex miceInfo
- Publication number
- HK1200272A1 HK1200272A1 HK15101011.6A HK15101011A HK1200272A1 HK 1200272 A1 HK1200272 A1 HK 1200272A1 HK 15101011 A HK15101011 A HK 15101011A HK 1200272 A1 HK1200272 A1 HK 1200272A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- genetically modified
- major histocompatibility
- histocompatibility complex
- modified major
- complex mice
- Prior art date
Links
- 108700018351 Major Histocompatibility Complex Proteins 0.000 title 1
- 241000699670 Mus sp. Species 0.000 title 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552582P | 2011-10-28 | 2011-10-28 | |
| US201161552587P | 2011-10-28 | 2011-10-28 | |
| US201261700908P | 2012-09-14 | 2012-09-14 | |
| PCT/US2012/062042 WO2013063346A1 (en) | 2011-10-28 | 2012-10-26 | Genetically modified major histocompatibility complex mice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1200272A1 true HK1200272A1 (en) | 2015-08-07 |
Family
ID=47178940
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15101011.6A HK1200272A1 (en) | 2011-10-28 | 2015-01-29 | Genetically modified major histocompatibility complex mice |
| HK18108466.8A HK1249712B (zh) | 2011-10-28 | 2018-06-29 | 主要組織相容性複合物基因修飾小鼠 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18108466.8A HK1249712B (zh) | 2011-10-28 | 2018-06-29 | 主要組織相容性複合物基因修飾小鼠 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US9615550B2 (sr) |
| EP (4) | EP3262932B1 (sr) |
| JP (4) | JP6154391B2 (sr) |
| KR (3) | KR101921126B1 (sr) |
| CN (3) | CN113564188A (sr) |
| AU (3) | AU2012324016C1 (sr) |
| BR (1) | BR112014009259A2 (sr) |
| CA (2) | CA2850387A1 (sr) |
| CY (2) | CY1119657T1 (sr) |
| DK (2) | DK3262932T3 (sr) |
| ES (3) | ES2741649T3 (sr) |
| HK (2) | HK1200272A1 (sr) |
| HR (2) | HRP20171761T1 (sr) |
| HU (2) | HUE045879T2 (sr) |
| IL (3) | IL232097A (sr) |
| LT (2) | LT3262932T (sr) |
| MX (2) | MX355725B (sr) |
| MY (2) | MY178723A (sr) |
| NZ (1) | NZ734532A (sr) |
| PL (2) | PL3262932T3 (sr) |
| PT (2) | PT3262932T (sr) |
| RS (2) | RS59082B1 (sr) |
| SG (2) | SG10201603188SA (sr) |
| SI (2) | SI2770821T1 (sr) |
| WO (1) | WO2013063346A1 (sr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2818478T3 (en) | 2011-10-28 | 2017-05-22 | Regeneron Pharma | HUMANIZED IL-6 AND IL-6 RECEPTOR |
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| LT2958938T (lt) * | 2013-02-20 | 2019-07-25 | Regeneron Pharmaceuticals, Inc. | Pelės, ekspresuojančios humanizuotus t ląstelių koreceptorius |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| HUE041878T2 (hu) * | 2013-02-22 | 2019-06-28 | Regeneron Pharma | Humanizált fõ hisztokompatibilitási komplexet expresszáló egerek |
| EP2967014B1 (en) * | 2013-03-11 | 2019-10-16 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules |
| CN105592695B (zh) | 2013-09-23 | 2018-04-10 | 瑞泽恩制药公司 | 具有人源化信号调节蛋白基因的非人动物 |
| DK2908626T3 (en) | 2013-10-15 | 2017-03-20 | Regeneron Pharma | Humanized IL-15 animals |
| WO2015056774A1 (ja) * | 2013-10-18 | 2015-04-23 | 大鵬薬品工業株式会社 | Ｈｌａクラスｉ発現非ヒト動物 |
| CN106163273B (zh) | 2014-04-08 | 2020-07-24 | 瑞泽恩制药公司 | 具有人源化FC-γ受体的非人动物 |
| EP3636073B1 (en) | 2014-05-05 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Humanized c5 and c3 animals |
| NO2785538T3 (sr) | 2014-05-07 | 2018-08-04 | ||
| RU2735958C2 (ru) | 2014-06-19 | 2020-11-11 | Регенерон Фармасьютикалз, Инк. | Животные, отличные от человека, имеющие гуманизированный ген 1 запрограммированной гибели клеток |
| WO2016044745A1 (en) | 2014-09-19 | 2016-03-24 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors |
| RU2726446C2 (ru) | 2014-11-24 | 2020-07-14 | Регенерон Фармасьютикалз, Инк. | Не относящиеся к человеку животные, экспрессирующие гуманизированный комплекс cd3 |
| AU2015355328B2 (en) | 2014-12-05 | 2022-03-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 47 gene |
| HUE052606T2 (hu) | 2014-12-09 | 2021-05-28 | Regeneron Pharma | Humanizált differenciációs klaszter 274 génnel rendelkezõ nem humán állatok |
| CA2969847A1 (en) * | 2014-12-10 | 2016-06-16 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| KR20170133498A (ko) | 2015-04-06 | 2017-12-05 | 리제너론 파아마슈티컬스, 인크. | 비인간 동물에서의 인간화 t 세포 매개 면역반응 |
| KR102658190B1 (ko) * | 2015-04-13 | 2024-04-17 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 sirpa-il15 녹인 마우스 및 이의 이용 방법 |
| PT3376857T (pt) | 2015-11-20 | 2021-05-27 | Regeneron Pharma | Animais não humanos com um gene humanizado 3 de ativação de linfócitos |
| JP6980674B2 (ja) | 2016-02-29 | 2021-12-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | ヒト化ｔｍｐｒｓｓ遺伝子を有する齧歯類 |
| SG10201914014XA (en) | 2016-06-03 | 2020-03-30 | Regeneron Pharma | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
| CN109456942A (zh) * | 2017-09-06 | 2019-03-12 | 亘喜生物科技（上海）有限公司 | 通用型嵌合抗原受体t细胞制备技术 |
| CN111386039B (zh) | 2017-09-29 | 2023-02-28 | 瑞泽恩制药公司 | 经基因修饰的啮齿动物基因组 |
| CN116064611A (zh) | 2017-11-30 | 2023-05-05 | 瑞泽恩制药公司 | 包含人源化trkb基因座的非人动物 |
| SG11202008799PA (en) | 2018-03-24 | 2020-10-29 | Regeneron Pharma | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| US11576984B2 (en) | 2018-03-26 | 2023-02-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified mouse with humanized immunoglobulin heavy chain constant region genes and method of using |
| CN112638154B (zh) | 2018-07-16 | 2022-10-18 | 瑞泽恩制药公司 | Ditra疾病的非人动物模型及其用途 |
| CN114206108B (zh) | 2019-04-04 | 2023-09-29 | 瑞泽恩制药公司 | 包括人源化凝血因子12基因座的非人动物 |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| EP3796776A1 (en) | 2019-06-07 | 2021-03-31 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized albumin locus |
| EP4087392A4 (en) * | 2020-01-10 | 2024-02-21 | Biocytogen Pharmaceuticals Beijing Co Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC PROTEIN-MHC COMPLEX |
| WO2022133155A1 (en) * | 2020-12-16 | 2022-06-23 | Xenotherapeutics, Inc. | Humanization of beta2-microglobulin in porcine genome resulting in functional expression of human βeta2-microglobulin within donor cells, tissues, or organs |
| US20240065239A1 (en) | 2020-12-16 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| IL307238A (en) | 2021-03-31 | 2023-11-01 | Regeneron Pharma | Transgenic mice containing human components of the cellular immune system with an enhanced diversity of the TCRB repertoire |
| WO2023240109A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Multispecific molecules for modulating t-cell activity, and uses thereof |
| WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
| US20240099279A1 (en) | 2022-09-22 | 2024-03-28 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing components of human cellular immune system |
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| HUE041878T2 (hu) | 2013-02-22 | 2019-06-28 | Regeneron Pharma | Humanizált fõ hisztokompatibilitási komplexet expresszáló egerek |
| KR20170133498A (ko) | 2015-04-06 | 2017-12-05 | 리제너론 파아마슈티컬스, 인크. | 비인간 동물에서의 인간화 t 세포 매개 면역반응 |
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2012
- 2012-10-26 EP EP17184955.7A patent/EP3262932B1/en active Active
- 2012-10-26 KR KR1020147014476A patent/KR101921126B1/ko active IP Right Grant
- 2012-10-26 CN CN202110831383.7A patent/CN113564188A/zh active Pending
- 2012-10-26 PT PT17184955T patent/PT3262932T/pt unknown
- 2012-10-26 ES ES17184955T patent/ES2741649T3/es active Active
- 2012-10-26 DK DK17184955.7T patent/DK3262932T3/da active
- 2012-10-26 SI SI201231136T patent/SI2770821T1/en unknown
- 2012-10-26 ES ES19167619T patent/ES2962287T3/es active Active
- 2012-10-26 RS RS20190998A patent/RS59082B1/sr unknown
- 2012-10-26 EP EP19167619.6A patent/EP3563680B1/en active Active
- 2012-10-26 WO PCT/US2012/062042 patent/WO2013063346A1/en active Application Filing
- 2012-10-26 BR BR112014009259-1A patent/BR112014009259A2/pt not_active Application Discontinuation
- 2012-10-26 CN CN201280060540.8A patent/CN104039132B9/zh active Active
- 2012-10-26 KR KR1020187033187A patent/KR102074145B1/ko active IP Right Grant
- 2012-10-26 ES ES12787255.4T patent/ES2651517T3/es active Active
- 2012-10-26 PT PT127872554T patent/PT2770821T/pt unknown
- 2012-10-26 NZ NZ734532A patent/NZ734532A/en unknown
- 2012-10-26 CA CA2850387A patent/CA2850387A1/en active Pending
- 2012-10-26 LT LTEP17184955.7T patent/LT3262932T/lt unknown
- 2012-10-26 DK DK12787255.4T patent/DK2770821T3/da active
- 2012-10-26 HU HUE17184955A patent/HUE045879T2/hu unknown
- 2012-10-26 JP JP2014539029A patent/JP6154391B2/ja active Active
- 2012-10-26 LT LTEP12787255.4T patent/LT2770821T/lt unknown
- 2012-10-26 AU AU2012324016A patent/AU2012324016C1/en active Active
- 2012-10-26 US US13/661,159 patent/US9615550B2/en active Active
- 2012-10-26 MY MYPI2017703836A patent/MY178723A/en unknown
- 2012-10-26 MX MX2014004895A patent/MX355725B/es active IP Right Grant
- 2012-10-26 CA CA3074400A patent/CA3074400A1/en active Pending
- 2012-10-26 PL PL17184955T patent/PL3262932T3/pl unknown
- 2012-10-26 PL PL12787255T patent/PL2770821T3/pl unknown
- 2012-10-26 MY MYPI2014000784A patent/MY164836A/en unknown
- 2012-10-26 HU HUE12787255A patent/HUE035652T2/en unknown
- 2012-10-26 RS RS20171195A patent/RS56656B1/sr unknown
- 2012-10-26 CN CN201710347715.8A patent/CN107254480B/zh active Active
- 2012-10-26 SG SG10201603188SA patent/SG10201603188SA/en unknown
- 2012-10-26 SG SG11201400933VA patent/SG11201400933VA/en unknown
- 2012-10-26 KR KR1020207002887A patent/KR102295746B1/ko active IP Right Grant
- 2012-10-26 SI SI201231650T patent/SI3262932T1/sl unknown
- 2012-10-26 MX MX2020010763A patent/MX2020010763A/es unknown
- 2012-10-26 EP EP12787255.4A patent/EP2770821B1/en active Active
- 2012-10-26 EP EP23193595.8A patent/EP4311833A3/en active Pending
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2014
- 2014-04-13 IL IL232097A patent/IL232097A/en active IP Right Grant
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2018
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