SG11201601828XA - Humanized il-15 animals - Google Patents

Humanized il-15 animals

Info

Publication number
SG11201601828XA
SG11201601828XA SG11201601828XA SG11201601828XA SG11201601828XA SG 11201601828X A SG11201601828X A SG 11201601828XA SG 11201601828X A SG11201601828X A SG 11201601828XA SG 11201601828X A SG11201601828X A SG 11201601828XA SG 11201601828X A SG11201601828X A SG 11201601828XA
Authority
SG
Singapore
Prior art keywords
humanized
animals
Prior art date
Application number
SG11201601828XA
Inventor
Jose F Rojas
Ka-Man Venus Lai
Andrew J Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11201601828XA publication Critical patent/SG11201601828XA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027New breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Humanized animals, e.g. knockin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5443IL-15
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0387Animal model for diseases of the immune system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
SG11201601828XA 2013-10-15 2014-10-15 Humanized il-15 animals SG11201601828XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361891013P 2013-10-15 2013-10-15
PCT/US2014/060568 WO2015057758A1 (en) 2013-10-15 2014-10-15 Humanized il-15 animals

Publications (1)

Publication Number Publication Date
SG11201601828XA true SG11201601828XA (en) 2016-04-28

Family

ID=51830649

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201607768YA SG10201607768YA (en) 2013-10-15 2014-10-15 Humanized il-15 animals
SG11201601828XA SG11201601828XA (en) 2013-10-15 2014-10-15 Humanized il-15 animals

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201607768YA SG10201607768YA (en) 2013-10-15 2014-10-15 Humanized il-15 animals

Country Status (28)

Country Link
US (5) US9155290B2 (en)
EP (3) EP2908626B1 (en)
JP (3) JP6492095B2 (en)
KR (1) KR102376041B1 (en)
CN (2) CN109090037B (en)
AU (2) AU2014337526B2 (en)
BR (1) BR112016008175A2 (en)
CA (1) CA2926090C (en)
CY (2) CY1118675T1 (en)
DK (2) DK2908626T3 (en)
ES (2) ES2715949T3 (en)
HK (1) HK1210659A1 (en)
HR (2) HRP20170380T1 (en)
HU (2) HUE043969T2 (en)
IL (2) IL244525B (en)
LT (2) LT2908626T (en)
MX (1) MX2016004781A (en)
NZ (1) NZ718655A (en)
PL (2) PL3138397T3 (en)
PT (2) PT3138397T (en)
RS (2) RS55472B1 (en)
RU (1) RU2674910C2 (en)
SG (2) SG10201607768YA (en)
SI (2) SI3138397T1 (en)
SM (1) SMT201700024B (en)
TR (1) TR201904342T4 (en)
WO (1) WO2015057758A1 (en)
ZA (1) ZA201601676B (en)

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CN104918483B (en) 2012-11-05 2018-05-11 再生元制药公司 Generation and the method using genetically modified non-human animal
EP2908626B1 (en) 2013-10-15 2016-12-07 Regeneron Pharmaceuticals, Inc. Humanized il-15 animals
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CN113045639A (en) 2014-05-19 2021-06-29 再生元制药公司 Genetically modified non-human animals expressing human EPO
CA2967834C (en) 2014-12-05 2024-01-16 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 47 gene
FI3282835T3 (en) * 2015-04-13 2023-07-20 Regeneron Pharma Humanized sirpa-il15 knockin mice and methods of use thereof
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KR20230021759A (en) 2016-02-29 2023-02-14 리제너론 파마슈티칼스 인코포레이티드 Rodents having a humanized tmprss gene
DK3476865T3 (en) 2016-06-28 2023-12-18 Biocytogen Pharmaceuticals Beijing Co Ltd PROCEDURE FOR CONSTRUCTION OF PD-1 GENE-MODIFIED HUMANIZED ANIMAL MODEL AND USE THEREOF
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CN108424928B (en) 2016-12-30 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Preparation method and application of humanized gene modified animal model
CN108467873B (en) 2017-03-17 2020-03-13 百奥赛图江苏基因生物技术有限公司 Preparation method and application of CD132 gene-deleted immunodeficiency animal model
WO2018177441A1 (en) 2017-03-31 2018-10-04 Beijing Biocytogen Co., Ltd GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
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CN109136274B (en) 2017-06-19 2021-04-23 百奥赛图江苏基因生物技术有限公司 Preparation method and application of humanized CD40 gene modified animal model
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CN112118734A (en) * 2017-08-09 2020-12-22 杰克逊实验室 Immunodeficient mice expressing human interleukin 15
WO2019072241A1 (en) 2017-10-13 2019-04-18 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric pd-1
CN109913493B (en) 2017-12-12 2021-03-16 百奥赛图江苏基因生物技术有限公司 Preparation method and application of humanized CD3 gene modified animal model
CN116200426A (en) 2018-07-16 2023-06-02 瑞泽恩制药公司 Non-human animal model of DITRA disease and uses thereof
CN111057721B (en) 2018-10-12 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Preparation method and application of humanized IL-4 and/or IL-4R alpha modified animal model
CN111304247B (en) 2018-12-20 2021-03-16 百奥赛图江苏基因生物技术有限公司 Preparation method and application of humanized LAG-3 gene modified animal model
WO2020135518A1 (en) * 2018-12-25 2020-07-02 Biocytogen Jiangsu Co., Ltd. Genetically modified non-human animal with human or chimeric il15
CN114107385A (en) * 2019-01-17 2022-03-01 百奥赛图(北京)医药科技股份有限公司 Humanized transgenic animal
SG11202108454RA (en) 2019-04-04 2021-09-29 Regeneron Pharma Non-human animals comprising a humanized coagulation factor 12 locus
WO2020247452A1 (en) 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
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Also Published As

Publication number Publication date
ES2715949T3 (en) 2019-06-07
EP3138397B1 (en) 2018-12-26
MX2016004781A (en) 2016-07-26
NZ718655A (en) 2022-08-26
CN105744829B (en) 2018-08-07
LT2908626T (en) 2017-01-25
US20200178508A1 (en) 2020-06-11
PL3138397T3 (en) 2019-06-28
US20150106961A1 (en) 2015-04-16
ES2613379T3 (en) 2017-05-24
JP2016533192A (en) 2016-10-27
JP6600061B2 (en) 2019-10-30
EP3138397A1 (en) 2017-03-08
EP2908626A1 (en) 2015-08-26
WO2015057758A1 (en) 2015-04-23
US20150366175A1 (en) 2015-12-24
DK2908626T3 (en) 2017-03-20
RU2674910C2 (en) 2018-12-13
CA2926090A1 (en) 2015-04-23
EP3461331A1 (en) 2019-04-03
JP2019022518A (en) 2019-02-14
AU2014337526A1 (en) 2016-04-28
AU2014337526B2 (en) 2020-09-10
PL2908626T3 (en) 2017-05-31
EP2908626B1 (en) 2016-12-07
HK1210659A1 (en) 2016-05-06
IL269907B (en) 2020-09-30
CN109090037B (en) 2021-05-28
RS55472B1 (en) 2017-04-28
ZA201601676B (en) 2019-12-18
SI3138397T1 (en) 2019-04-30
HUE043969T2 (en) 2019-09-30
CA2926090C (en) 2022-07-05
RU2016116847A3 (en) 2018-06-07
HUE033272T2 (en) 2017-11-28
SMT201700024B (en) 2017-03-08
IL244525A0 (en) 2016-04-21
HRP20170380T1 (en) 2017-05-19
BR112016008175A2 (en) 2017-10-03
JP2019216750A (en) 2019-12-26
IL244525B (en) 2019-10-31
RU2016116847A (en) 2017-11-21
CY1121405T1 (en) 2020-05-29
PT2908626T (en) 2017-01-09
US9155290B2 (en) 2015-10-13
US10561125B2 (en) 2020-02-18
CN109090037A (en) 2018-12-28
DK3138397T3 (en) 2019-04-15
US20230189772A1 (en) 2023-06-22
CY1118675T1 (en) 2018-03-07
KR20160068774A (en) 2016-06-15
US20180116192A1 (en) 2018-05-03
US11503813B2 (en) 2022-11-22
LT3138397T (en) 2019-04-10
AU2020286186A1 (en) 2021-01-07
HRP20190542T1 (en) 2019-07-26
TR201904342T4 (en) 2019-05-21
RS58465B1 (en) 2019-04-30
PT3138397T (en) 2019-03-26
KR102376041B1 (en) 2022-03-18
JP6492095B2 (en) 2019-03-27
CN105744829A (en) 2016-07-06
SG10201607768YA (en) 2016-11-29
SI2908626T1 (en) 2017-02-28

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