SG10201902547SA - Non-human animals having a humanized signal-regulatory protein gene - Google Patents
Non-human animals having a humanized signal-regulatory protein geneInfo
- Publication number
- SG10201902547SA SG10201902547SA SG10201902547SA SG10201902547SA SG10201902547SA SG 10201902547S A SG10201902547S A SG 10201902547SA SG 10201902547S A SG10201902547S A SG 10201902547SA SG 10201902547S A SG10201902547S A SG 10201902547SA SG 10201902547S A SG10201902547S A SG 10201902547SA
- Authority
- SG
- Singapore
- Prior art keywords
- human animals
- regulatory protein
- protein gene
- humanized
- signal
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 2
- 101150036449 SIRPA gene Proteins 0.000 abstract 3
- 241000699670 Mus sp. Species 0.000 abstract 2
- 238000012239 gene modification Methods 0.000 abstract 1
- 230000005017 genetic modification Effects 0.000 abstract 1
- 235000013617 genetically modified food Nutrition 0.000 abstract 1
- 230000006303 immediate early viral mRNA transcription Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K49/00—Preparations for testing in vivo
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- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- A01K2267/0387—Animal model for diseases of the immune system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
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- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
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Abstract
NON-HUMAN ANIMALS HAVING A HUMANIZED SIGNAL-REGULATORY PROTEIN GENE Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRP α gene. Genetically modified mice are described, including mice that express a human or humanized SIRP α protein from an endogenous SIRP α locus. [No Figure]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201361881261P | 2013-09-23 | 2013-09-23 |
Publications (1)
Publication Number | Publication Date |
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SG10201902547SA true SG10201902547SA (en) | 2019-04-29 |
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ID=51663510
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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SG10201902547SA SG10201902547SA (en) | 2013-09-23 | 2014-09-23 | Non-human animals having a humanized signal-regulatory protein gene |
SG11201601184UA SG11201601184UA (en) | 2013-09-23 | 2014-09-23 | Non-human animals having a humanized signal-regulatory protein gene |
SG10201801326PA SG10201801326PA (en) | 2013-09-23 | 2014-09-23 | Non-human animals having a humanized signal-regulatory protein gene |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
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SG11201601184UA SG11201601184UA (en) | 2013-09-23 | 2014-09-23 | Non-human animals having a humanized signal-regulatory protein gene |
SG10201801326PA SG10201801326PA (en) | 2013-09-23 | 2014-09-23 | Non-human animals having a humanized signal-regulatory protein gene |
Country Status (28)
Country | Link |
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US (9) | US9193977B2 (en) |
EP (4) | EP3175706B1 (en) |
JP (4) | JP6453893B2 (en) |
KR (2) | KR102370419B1 (en) |
CN (2) | CN105592695B (en) |
AU (2) | AU2014321187B2 (en) |
CA (1) | CA2925564C (en) |
CY (1) | CY1121410T1 (en) |
DK (3) | DK2922394T3 (en) |
ES (3) | ES2959333T3 (en) |
FI (1) | FI3434101T3 (en) |
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