NO2785538T3 - - Google Patents
Info
- Publication number
- NO2785538T3 NO2785538T3 NO12794266A NO12794266A NO2785538T3 NO 2785538 T3 NO2785538 T3 NO 2785538T3 NO 12794266 A NO12794266 A NO 12794266A NO 12794266 A NO12794266 A NO 12794266A NO 2785538 T3 NO2785538 T3 NO 2785538T3
- Authority
- NO
- Norway
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0368—Animal model for inflammation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Environmental Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461989757P | 2014-05-07 | 2014-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO2785538T3 true NO2785538T3 (pl) | 2018-08-04 |
Family
ID=53284509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO12794266A NO2785538T3 (pl) | 2014-05-07 | 2012-11-22 |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US9565841B2 (pl) |
| EP (3) | EP3281521B1 (pl) |
| JP (4) | JP6640740B2 (pl) |
| KR (2) | KR102473565B1 (pl) |
| CN (2) | CN110269047B (pl) |
| AU (3) | AU2015255977B2 (pl) |
| BR (1) | BR112016025745A2 (pl) |
| CA (2) | CA3207834A1 (pl) |
| CY (2) | CY1119773T1 (pl) |
| DK (2) | DK3281521T3 (pl) |
| ES (2) | ES2656529T3 (pl) |
| HR (2) | HRP20211455T1 (pl) |
| HU (2) | HUE038028T2 (pl) |
| IL (3) | IL248358B2 (pl) |
| LT (2) | LT3027015T (pl) |
| MX (1) | MX370672B (pl) |
| NO (1) | NO2785538T3 (pl) |
| NZ (2) | NZ725615A (pl) |
| PH (1) | PH12016502058A1 (pl) |
| PL (2) | PL3281521T3 (pl) |
| PT (2) | PT3027015T (pl) |
| RS (2) | RS57073B1 (pl) |
| RU (1) | RU2703139C2 (pl) |
| SG (2) | SG11201608570YA (pl) |
| SI (2) | SI3027015T1 (pl) |
| WO (1) | WO2015171861A1 (pl) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2785538T3 (pl) | 2014-05-07 | 2018-08-04 | ||
| WO2015196051A1 (en) | 2014-06-19 | 2015-12-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| EP3212819B1 (en) * | 2014-09-17 | 2023-03-29 | Oerlikon Surface Solutions AG, Pfäffikon | Method for producing a double-layer coated cutting tool with improved wear resistance |
| CN113016720B (zh) | 2014-11-24 | 2023-02-21 | 瑞泽恩制药公司 | 表达人源化cd3复合物的非人类动物 |
| LT3850946T (lt) | 2014-12-05 | 2024-01-10 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, išskyrus žmogų, turintys humanizuotą ląstelės diferenciacijos klasterio 47 geną |
| RU2711729C2 (ru) | 2014-12-09 | 2020-01-21 | Регенерон Фармасьютикалз, Инк. | Не относящиеся к человеку животные, имеющие гуманизированный ген кластера дифференцировки 274 |
| WO2017087780A1 (en) | 2015-11-20 | 2017-05-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized lymphocyte-activation gene 3 |
| WO2017136712A1 (en) | 2016-02-04 | 2017-08-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered angptl8 gene |
| KR102493894B1 (ko) | 2016-02-29 | 2023-01-31 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 tmprss 유전자를 갖는 설치류 |
| TWI784988B (zh) * | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| EP3610041A1 (en) | 2017-04-13 | 2020-02-19 | Regeneron Pharmaceuticals, Inc. | Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1 |
| CA3066918A1 (en) | 2017-06-12 | 2018-12-20 | Bluefin Biomedicine, Inc. | Anti-il1rap antibodies and antibody drug conjugates |
| BR112020003609A2 (pt) | 2017-09-29 | 2020-09-01 | Regeneron Pharmaceuticals, Inc. | sistema e método para formar uma emulsão |
| KR102709884B1 (ko) | 2017-11-30 | 2024-09-26 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 trkb 유전자좌를 포함하는 비인간 동물 |
| JP7328243B2 (ja) | 2018-03-26 | 2023-08-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療薬を試験するためのヒト化げっ歯類 |
| IL277890B2 (en) | 2018-04-11 | 2024-03-01 | Regeneron Pharma | Methods for quantification of IL-33 |
| JP7048051B2 (ja) | 2018-07-11 | 2022-04-05 | 正徳 染井 | 痒みを軽減するアトピー性皮膚炎治療剤 |
| US11589562B2 (en) * | 2018-07-16 | 2023-02-28 | Regeneran Pharmaceuticals, Inc. | Mouse model of DITRA disease and uses thereof |
| CN111057721B (zh) * | 2018-10-12 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用 |
| CN114107385A (zh) * | 2019-01-17 | 2022-03-01 | 百奥赛图(北京)医药科技股份有限公司 | 人源化转基因动物 |
| SG11202108454RA (en) | 2019-04-04 | 2021-09-29 | Regeneron Pharma | Non-human animals comprising a humanized coagulation factor 12 locus |
| JP2022534867A (ja) | 2019-06-04 | 2022-08-04 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法 |
| CN113939595A (zh) | 2019-06-07 | 2022-01-14 | 瑞泽恩制药公司 | 包括人源化白蛋白基因座的非人动物 |
| WO2021018198A1 (en) * | 2019-07-29 | 2021-02-04 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric il33 |
| CN112430621B (zh) * | 2019-08-09 | 2022-09-27 | 百奥赛图(北京)医药科技股份有限公司 | Il2ra基因人源化的非人动物的构建方法及应用 |
| EP4057807A4 (en) * | 2019-11-11 | 2023-12-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES |
| WO2021129766A1 (zh) * | 2019-12-25 | 2021-07-01 | 江苏集萃药康生物科技股份有限公司 | 一种il-15人源化小鼠模型及其用途 |
| EP4096396A1 (en) * | 2020-01-28 | 2022-12-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized pnpla3 locus and methods of use |
| CN111149767B (zh) * | 2020-02-24 | 2021-07-20 | 中南大学湘雅二医院 | 一种人源化皮肤型红斑狼疮小鼠模型的构建方法和应用 |
| CN113527485A (zh) * | 2020-04-17 | 2021-10-22 | 上海麦济生物技术有限公司 | 抗人白细胞介素-4受体α抗体及其制备方法和应用 |
| CN111808882B (zh) * | 2020-09-01 | 2020-12-29 | 北京百奥赛图基因生物技术有限公司 | Il7r基因人源化改造的动物模型的构建方法及其应用 |
| CN111793646B (zh) * | 2020-09-08 | 2021-01-15 | 北京百奥赛图基因生物技术有限公司 | Il1r1基因人源化改造的非人动物的构建方法及其应用 |
| CN111926039B (zh) * | 2020-09-23 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Il-13基因人源化的非人动物的构建方法和应用 |
| US20220192165A1 (en) * | 2020-12-21 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized tslp gene, a humanized tslp receptor gene, and/or a humanized il7ra gene |
| WO2022247936A1 (en) * | 2021-05-28 | 2022-12-01 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric cd36 |
| WO2024067796A1 (zh) * | 2022-09-28 | 2024-04-04 | 百奥赛图(北京)医药科技股份有限公司 | 一种il5和/或il5ra基因人源化修饰的非人动物 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU643427B2 (en) * | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| JP2007252370A (ja) * | 2006-02-22 | 2007-10-04 | Institute Of Physical & Chemical Research | Ｉｌ−４初期発現系トランスジェニック非ヒト動物およびその利用 |
| US20110016543A1 (en) * | 2008-12-04 | 2011-01-20 | Sigma-Aldrich Co. | Genomic editing of genes involved in inflammation |
| SG176118A1 (en) * | 2009-06-29 | 2011-12-29 | Qingfeng Chen | Methods of producing humanized non-human mammals |
| CA2767377A1 (en) * | 2009-07-24 | 2011-01-27 | Sigma-Aldrich Co. Llc | Method for genome editing |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| DK3056082T3 (en) | 2009-10-06 | 2018-12-17 | Regeneron Pharma | RE-MODIFIED MICE AND INPUT |
| ES2948210T3 (es) | 2011-02-15 | 2023-09-06 | Regeneron Pharma | Ratones humanizados con M-CSF y uso de los mismos |
| PL3262932T3 (pl) | 2011-10-28 | 2019-10-31 | Regeneron Pharma | Genetycznie zmodyfikowany główny układ zgodności tkankowej myszy |
| PT2663575E (pt) * | 2011-10-28 | 2014-12-05 | Regeneron Pharma | Il-6 e receptor de il-6 humanizados |
| KR101926442B1 (ko) | 2011-10-28 | 2018-12-12 | 리제너론 파아마슈티컬스, 인크. | 키메라 주요 조직적합성 복합체 （ｍｈｃ） ｉｉ 분자들을 발현하는 유전자 변형된 마우스 |
| US8962913B2 (en) * | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| CN110624107A (zh) * | 2012-08-21 | 2019-12-31 | 赛诺菲生物技术公司 | 通过施用il-4r拮抗剂治疗或预防哮喘的方法 |
| KR20240045263A (ko) | 2012-09-07 | 2024-04-05 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| EP4389764A3 (en) | 2012-11-05 | 2024-08-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals and methods of use thereof |
| KR102313047B1 (ko) | 2013-02-20 | 2021-10-19 | 리제너론 파아마슈티컬스, 인크. | 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스 |
| CN105164154B (zh) | 2013-02-22 | 2019-06-07 | 瑞泽恩制药公司 | 表达人源化主要组织相容性复合物的小鼠 |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| US9193977B2 (en) | 2013-09-23 | 2015-11-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized signal-regulatory protein gene |
| CA2926090C (en) | 2013-10-15 | 2022-07-05 | Regeneron Pharmaceuticals, Inc. | Humanized il-15 animals |
| ES2703549T3 (es) | 2013-11-19 | 2019-03-11 | Regeneron Pharma | Animales no humanos que tienen un gen de un ligando inductor de la proliferación humanizado |
| JP6505689B2 (ja) | 2013-11-19 | 2019-04-24 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化ｂ細胞活性化因子遺伝子を有する非ヒト動物 |
| ES2794942T3 (es) | 2014-04-08 | 2020-11-19 | Regeneron Pharma | Animales no humanos que tienen receptores Fc-gamma humanizados |
| NZ726602A (en) | 2014-05-05 | 2024-05-31 | Regeneron Pharmaceuticals Inc | Humanized c5 and c3 animals |
| NO2785538T3 (pl) | 2014-05-07 | 2018-08-04 |
-
2012
- 2012-11-22 NO NO12794266A patent/NO2785538T3/no unknown
-
2015
- 2015-05-07 JP JP2016566656A patent/JP6640740B2/ja active Active
- 2015-05-07 RS RS20180131A patent/RS57073B1/sr unknown
- 2015-05-07 DK DK17193855.8T patent/DK3281521T3/da active
- 2015-05-07 PL PL17193855T patent/PL3281521T3/pl unknown
- 2015-05-07 CN CN201910691834.4A patent/CN110269047B/zh active Active
- 2015-05-07 HR HRP20211455TT patent/HRP20211455T1/hr unknown
- 2015-05-07 CA CA3207834A patent/CA3207834A1/en active Pending
- 2015-05-07 SI SI201530162T patent/SI3027015T1/en unknown
- 2015-05-07 SI SI201531703T patent/SI3281521T1/sl unknown
- 2015-05-07 LT LTEP15727106.5T patent/LT3027015T/lt unknown
- 2015-05-07 RU RU2016143376A patent/RU2703139C2/ru active
- 2015-05-07 PT PT157271065T patent/PT3027015T/pt unknown
- 2015-05-07 IL IL248358A patent/IL248358B2/en unknown
- 2015-05-07 ES ES15727106.5T patent/ES2656529T3/es active Active
- 2015-05-07 ES ES17193855T patent/ES2887852T3/es active Active
- 2015-05-07 DK DK15727106.5T patent/DK3027015T3/en active
- 2015-05-07 PT PT171938558T patent/PT3281521T/pt unknown
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