RS57073B1 - Životinje sa humanizovanom il-4 i il-4r alfa - Google Patents

Životinje sa humanizovanom il-4 i il-4r alfa

Info

Publication number
RS57073B1
RS57073B1 RS20180131A RSP20180131A RS57073B1 RS 57073 B1 RS57073 B1 RS 57073B1 RS 20180131 A RS20180131 A RS 20180131A RS P20180131 A RSP20180131 A RS P20180131A RS 57073 B1 RS57073 B1 RS 57073B1
Authority
RS
Serbia
Prior art keywords
humanized
animals
alpha
alpha animals
Prior art date
Application number
RS20180131A
Other languages
English (en)
Inventor
Li-Hsien Wang
Yingzi Xue
Andrew J Murphy
Sean Stevens
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of RS57073B1 publication Critical patent/RS57073B1/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RS20180131A 2014-05-07 2015-05-07 Životinje sa humanizovanom il-4 i il-4r alfa RS57073B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989757P 2014-05-07 2014-05-07
EP15727106.5A EP3027015B1 (en) 2014-05-07 2015-05-07 Humanized il-4 and il-4r alpha animals
PCT/US2015/029638 WO2015171861A1 (en) 2014-05-07 2015-05-07 Humanized il-4 and il-4r alpha animals

Publications (1)

Publication Number Publication Date
RS57073B1 true RS57073B1 (sr) 2018-06-29

Family

ID=53284509

Family Applications (2)

Application Number Title Priority Date Filing Date
RS20180131A RS57073B1 (sr) 2014-05-07 2015-05-07 Životinje sa humanizovanom il-4 i il-4r alfa
RS20211141A RS62345B1 (sr) 2014-05-07 2015-05-07 Životinje sa humanizovanim il-4 i il-4r alfa

Family Applications After (1)

Application Number Title Priority Date Filing Date
RS20211141A RS62345B1 (sr) 2014-05-07 2015-05-07 Životinje sa humanizovanim il-4 i il-4r alfa

Country Status (26)

Country Link
US (7) US9565841B2 (sr)
EP (3) EP3281521B1 (sr)
JP (4) JP6640740B2 (sr)
KR (2) KR102473565B1 (sr)
CN (2) CN110269047B (sr)
AU (3) AU2015255977B2 (sr)
BR (1) BR112016025745A2 (sr)
CA (2) CA3207834A1 (sr)
CY (2) CY1119773T1 (sr)
DK (2) DK3281521T3 (sr)
ES (2) ES2656529T3 (sr)
HR (2) HRP20211455T1 (sr)
HU (2) HUE038028T2 (sr)
IL (3) IL248358B2 (sr)
LT (2) LT3027015T (sr)
MX (1) MX370672B (sr)
NO (1) NO2785538T3 (sr)
NZ (2) NZ725615A (sr)
PH (1) PH12016502058A1 (sr)
PL (2) PL3281521T3 (sr)
PT (2) PT3027015T (sr)
RS (2) RS57073B1 (sr)
RU (1) RU2703139C2 (sr)
SG (2) SG11201608570YA (sr)
SI (2) SI3027015T1 (sr)
WO (1) WO2015171861A1 (sr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2785538T3 (sr) 2014-05-07 2018-08-04
WO2015196051A1 (en) 2014-06-19 2015-12-23 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized programmed cell death 1 gene
EP3212819B1 (en) * 2014-09-17 2023-03-29 Oerlikon Surface Solutions AG, Pfäffikon Method for producing a double-layer coated cutting tool with improved wear resistance
CN113016720B (zh) 2014-11-24 2023-02-21 瑞泽恩制药公司 表达人源化cd3复合物的非人类动物
LT3850946T (lt) 2014-12-05 2024-01-10 Regeneron Pharmaceuticals, Inc. Gyvūnai, išskyrus žmogų, turintys humanizuotą ląstelės diferenciacijos klasterio 47 geną
RU2711729C2 (ru) 2014-12-09 2020-01-21 Регенерон Фармасьютикалз, Инк. Не относящиеся к человеку животные, имеющие гуманизированный ген кластера дифференцировки 274
WO2017087780A1 (en) 2015-11-20 2017-05-26 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized lymphocyte-activation gene 3
WO2017136712A1 (en) 2016-02-04 2017-08-10 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered angptl8 gene
KR102493894B1 (ko) 2016-02-29 2023-01-31 리제너론 파마슈티칼스 인코포레이티드 인간화 tmprss 유전자를 갖는 설치류
TWI784988B (zh) * 2016-12-01 2022-12-01 美商再生元醫藥公司 治療發炎症狀的方法
EP3610041A1 (en) 2017-04-13 2020-02-19 Regeneron Pharmaceuticals, Inc. Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1
CA3066918A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
BR112020003609A2 (pt) 2017-09-29 2020-09-01 Regeneron Pharmaceuticals, Inc. sistema e método para formar uma emulsão
KR102709884B1 (ko) 2017-11-30 2024-09-26 리제너론 파마슈티칼스 인코포레이티드 인간화된 trkb 유전자좌를 포함하는 비인간 동물
JP7328243B2 (ja) 2018-03-26 2023-08-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 治療薬を試験するためのヒト化げっ歯類
IL277890B2 (en) 2018-04-11 2024-03-01 Regeneron Pharma Methods for quantification of IL-33
JP7048051B2 (ja) 2018-07-11 2022-04-05 正徳 染井 痒みを軽減するアトピー性皮膚炎治療剤
US11589562B2 (en) * 2018-07-16 2023-02-28 Regeneran Pharmaceuticals, Inc. Mouse model of DITRA disease and uses thereof
CN111057721B (zh) * 2018-10-12 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用
CN114107385A (zh) * 2019-01-17 2022-03-01 百奥赛图(北京)医药科技股份有限公司 人源化转基因动物
SG11202108454RA (en) 2019-04-04 2021-09-29 Regeneron Pharma Non-human animals comprising a humanized coagulation factor 12 locus
JP2022534867A (ja) 2019-06-04 2022-08-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法
CN113939595A (zh) 2019-06-07 2022-01-14 瑞泽恩制药公司 包括人源化白蛋白基因座的非人动物
WO2021018198A1 (en) * 2019-07-29 2021-02-04 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric il33
CN112430621B (zh) * 2019-08-09 2022-09-27 百奥赛图(北京)医药科技股份有限公司 Il2ra基因人源化的非人动物的构建方法及应用
EP4057807A4 (en) * 2019-11-11 2023-12-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
WO2021129766A1 (zh) * 2019-12-25 2021-07-01 江苏集萃药康生物科技股份有限公司 一种il-15人源化小鼠模型及其用途
EP4096396A1 (en) * 2020-01-28 2022-12-07 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
CN111149767B (zh) * 2020-02-24 2021-07-20 中南大学湘雅二医院 一种人源化皮肤型红斑狼疮小鼠模型的构建方法和应用
CN113527485A (zh) * 2020-04-17 2021-10-22 上海麦济生物技术有限公司 抗人白细胞介素-4受体α抗体及其制备方法和应用
CN111808882B (zh) * 2020-09-01 2020-12-29 北京百奥赛图基因生物技术有限公司 Il7r基因人源化改造的动物模型的构建方法及其应用
CN111793646B (zh) * 2020-09-08 2021-01-15 北京百奥赛图基因生物技术有限公司 Il1r1基因人源化改造的非人动物的构建方法及其应用
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
US20220192165A1 (en) * 2020-12-21 2022-06-23 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized tslp gene, a humanized tslp receptor gene, and/or a humanized il7ra gene
WO2022247936A1 (en) * 2021-05-28 2022-12-01 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric cd36
WO2024067796A1 (zh) * 2022-09-28 2024-04-04 百奥赛图(北京)医药科技股份有限公司 一种il5和/或il5ra基因人源化修饰的非人动物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643427B2 (en) * 1988-10-31 1993-11-18 Immunex Corporation Interleukin-4 receptors
ES2463476T3 (es) 2004-10-19 2014-05-28 Regeneron Pharmaceuticals, Inc. Método para generar un ratón homocigótico para una modificación genética
JP2007252370A (ja) * 2006-02-22 2007-10-04 Institute Of Physical & Chemical Research Ｉｌ−４初期発現系トランスジェニック非ヒト動物およびその利用
US20110016543A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genomic editing of genes involved in inflammation
SG176118A1 (en) * 2009-06-29 2011-12-29 Qingfeng Chen Methods of producing humanized non-human mammals
CA2767377A1 (en) * 2009-07-24 2011-01-27 Sigma-Aldrich Co. Llc Method for genome editing
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
DK3056082T3 (en) 2009-10-06 2018-12-17 Regeneron Pharma RE-MODIFIED MICE AND INPUT
ES2948210T3 (es) 2011-02-15 2023-09-06 Regeneron Pharma Ratones humanizados con M-CSF y uso de los mismos
PL3262932T3 (pl) 2011-10-28 2019-10-31 Regeneron Pharma Genetycznie zmodyfikowany główny układ zgodności tkankowej myszy
PT2663575E (pt) * 2011-10-28 2014-12-05 Regeneron Pharma Il-6 e receptor de il-6 humanizados
KR101926442B1 (ko) 2011-10-28 2018-12-12 리제너론 파아마슈티컬스, 인크. 키메라 주요 조직적합성 복합체 （ｍｈｃ） ｉｉ 분자들을 발현하는 유전자 변형된 마우스
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
CN110624107A (zh) * 2012-08-21 2019-12-31 赛诺菲生物技术公司 通过施用il-4r拮抗剂治疗或预防哮喘的方法
KR20240045263A (ko) 2012-09-07 2024-04-05 예일 유니버시티 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
EP4389764A3 (en) 2012-11-05 2024-08-14 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals and methods of use thereof
KR102313047B1 (ko) 2013-02-20 2021-10-19 리제너론 파아마슈티컬스, 인크. 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스
CN105164154B (zh) 2013-02-22 2019-06-07 瑞泽恩制药公司 表达人源化主要组织相容性复合物的小鼠
JO3532B1 (ar) 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
US9193977B2 (en) 2013-09-23 2015-11-24 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized signal-regulatory protein gene
CA2926090C (en) 2013-10-15 2022-07-05 Regeneron Pharmaceuticals, Inc. Humanized il-15 animals
ES2703549T3 (es) 2013-11-19 2019-03-11 Regeneron Pharma Animales no humanos que tienen un gen de un ligando inductor de la proliferación humanizado
JP6505689B2 (ja) 2013-11-19 2019-04-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｂ細胞活性化因子遺伝子を有する非ヒト動物
ES2794942T3 (es) 2014-04-08 2020-11-19 Regeneron Pharma Animales no humanos que tienen receptores Fc-gamma humanizados
NZ726602A (en) 2014-05-05 2024-05-31 Regeneron Pharmaceuticals Inc Humanized c5 and c3 animals
NO2785538T3 (sr) 2014-05-07 2018-08-04

Also Published As

Publication number Publication date
HRP20211455T1 (hr) 2022-01-07
EP3027015A1 (en) 2016-06-08
EP3281521A1 (en) 2018-02-14
KR20160150637A (ko) 2016-12-30
AU2015255977A1 (en) 2016-11-17
US9743647B2 (en) 2017-08-29
HRP20180242T1 (hr) 2018-03-09
US9565841B2 (en) 2017-02-14
NO2785538T3 (sr) 2018-08-04
JP7145250B2 (ja) 2022-09-30
AU2024204694A1 (en) 2024-09-05
RU2016143376A3 (sr) 2018-11-22
WO2015171861A1 (en) 2015-11-12
SG11201608570YA (en) 2016-11-29
CN110269047B (zh) 2021-11-02
EP3906781A1 (en) 2021-11-10
IL297105B2 (en) 2024-01-01
US20170311580A1 (en) 2017-11-02
RS62345B1 (sr) 2021-10-29
CN106470545A (zh) 2017-03-01
US11963521B2 (en) 2024-04-23
CN106470545B (zh) 2019-08-20
SG10201912354PA (en) 2020-02-27
CA2947307C (en) 2023-09-26
SI3281521T1 (sl) 2021-11-30
IL297105B1 (en) 2023-09-01
DK3027015T3 (en) 2018-01-22
SI3027015T1 (en) 2018-02-28
CA3207834A1 (en) 2015-11-12
IL248358A0 (en) 2016-11-30
BR112016025745A2 (pt) 2018-01-16
US10588298B2 (en) 2020-03-17
ES2887852T3 (es) 2021-12-28
IL297105A (en) 2022-12-01
RU2019131253A (ru) 2019-12-06
EP3281521B1 (en) 2021-06-30
JP2021087434A (ja) 2021-06-10
RU2703139C2 (ru) 2019-10-15
NZ725615A (en) 2024-05-31
NZ763861A (en) 2024-05-31
ES2656529T3 (es) 2018-02-27
LT3027015T (lt) 2018-01-25
US20150320022A1 (en) 2015-11-12
AU2015255977B2 (en) 2021-09-02
CA2947307A1 (en) 2015-11-12
HUE038028T2 (hu) 2018-09-28
RU2016143376A (ru) 2018-06-09
CY1119773T1 (el) 2018-06-27
JP6640740B2 (ja) 2020-02-05
PL3027015T3 (pl) 2018-04-30
PL3281521T3 (pl) 2022-01-03
US20180000056A1 (en) 2018-01-04
MX2016014563A (es) 2017-02-23
HUE055860T2 (hu) 2021-12-28
US20230027494A1 (en) 2023-01-26
DK3281521T3 (da) 2021-09-20
IL304841A (en) 2023-09-01
EP3027015B1 (en) 2017-11-08
US20150320021A1 (en) 2015-11-12
JP2022171841A (ja) 2022-11-11
LT3281521T (lt) 2021-09-27
PT3281521T (pt) 2021-09-16
JP2020058379A (ja) 2020-04-16
US10477842B2 (en) 2019-11-19
US11109578B2 (en) 2021-09-07
IL248358B (en) 2022-11-01
KR102473565B1 (ko) 2022-12-02
KR102517112B1 (ko) 2023-04-03
MX370672B (es) 2019-12-19
PH12016502058A1 (en) 2017-01-09
JP2017514501A (ja) 2017-06-08
PT3027015T (pt) 2018-02-09
KR20220165814A (ko) 2022-12-15
US20200022344A1 (en) 2020-01-23
JP6838131B2 (ja) 2021-03-03
US20210368753A1 (en) 2021-12-02
AU2021218060B2 (en) 2024-04-11
CN110269047A (zh) 2019-09-24
AU2021218060A1 (en) 2021-09-09
IL248358B2 (en) 2023-03-01
CY1124605T1 (el) 2022-07-22

Similar Documents

Publication Publication Date Title
IL297105B1 (en) Animals with il–4 and il–4r alpha of human origin
IL276946A (en) Antiproliferative compounds and methods of use
IL248481B (en) Animals containing c5 and c3 of human origin
IL252216A0 (en) Difluoromethyl-aminopyridines and difluoromethyl-aminopyrimidines
IL284291A (en) Anti-acth antibodies from humans and their use
GB201401617D0 (en) Novel combination and use
IL247315B (en) Anti-acth antibodies and their uses
HK1243950A1 (zh) 新型組合物和用途
HK1243077A1 (zh) 呱啶基吡唑並嘧啶酮及其用途
GB201420805D0 (en) Ligatures and use thereof
PL3229772T3 (pl) 6-arylo-9-glikozylopuryny i ich zastosowanie