CY1124605T1 - Ζωα με εξανθρωπισμενα il-4 και il-4r αλφα - Google Patents
Ζωα με εξανθρωπισμενα il-4 και il-4r αλφαInfo
- Publication number
- CY1124605T1 CY1124605T1 CY20211100805T CY211100805T CY1124605T1 CY 1124605 T1 CY1124605 T1 CY 1124605T1 CY 20211100805 T CY20211100805 T CY 20211100805T CY 211100805 T CY211100805 T CY 211100805T CY 1124605 T1 CY1124605 T1 CY 1124605T1
- Authority
- CY
- Cyprus
- Prior art keywords
- human
- gene
- animals
- humanized
- human animals
- Prior art date
Links
- 108090000978 Interleukin-4 Proteins 0.000 title abstract 5
- 241001465754 Metazoa Species 0.000 title abstract 4
- 108040006852 interleukin-4 receptor activity proteins Proteins 0.000 title 1
- 108091026890 Coding region Proteins 0.000 abstract 4
- 101001002709 Homo sapiens Interleukin-4 Proteins 0.000 abstract 3
- 101001033312 Homo sapiens Interleukin-4 receptor subunit alpha Proteins 0.000 abstract 3
- 102000055229 human IL4 Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 101100232919 Homo sapiens IL4 gene Proteins 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 102000004388 Interleukin-4 Human genes 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 241000283984 Rodentia Species 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0368—Animal model for inflammation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
Abstract
Παρέχονται μη ανθρώπινα ζώα που περιλαμβάνουν μια αλληλουχία ανθρώπινου ή εξανθρωπισμένου νουκλεϊκού οξέος IL-4/ή IL-4Rα. Περιγράφονται μη ανθρώπινα ζώα που περιλαμβάνουν μια αντικατάσταση του ενδογενούς γονιδίου IL-4 ή/και γονιδίου IL-4Rα από ένα ανθρώπινο γονίδιο IL-4 ή/και γονίδιο IL-4Rα εν όλω ή εν μέρει καθώς και μέθοδοι δημιουργίας και χρήσης των μη ανθρώπινων ζώων. Παρέχονται, επίσης, μη ανθρώπινα ζώα που αποτελούνται από ένα ανθρώπινο ή εξανθρωπισμένο γονίδιο IL-4 υπό τον έλεγχο των ρυθμιστικών στοιχείων μη ανθρώπινης IL-4, συμπεριλαμβανομένων μη ανθρώπινων ζώων που έχουν μια αντικατάσταση μη ανθρώπινης αλληλουχίας κωδικοποίησης IL-4 από ανθρώπινη αλληλουχία κωδικοποίησης IL-4 σε έναν ενδογενή γονιδιακό τόπο μη ανθρώπινης IL-4. Παρέχονται, επίσης, μη ανθρώπινα ζώα που αποτελούνται από ένα ανθρώπινο ή εξανθρωπισμένο γονίδιο IL-4Rα υπό τον έλεγχο των ρυθμιστικών στοιχείων μη ανθρώπινου IL-4Rα, συμπεριλαμβανομένων μη ανθρώπινων ζώων που έχουν μια αντικατάσταση μη ανθρώπινης αλληλουχίας κωδικοποίησης IL-4Rα από μια ανθρώπινη ή εξανθρωπισμένη αλληλουχία κωδικοποίησης IL-4Rα σε έναν ενδογενή γονιδιακό τόπο μη ανθρώπινου C IL-4Rα. Παρέχονται μη ανθρώπινα ζώα που περιλαμβάνουν ανθρώπινο ή εξανθρωπισμένο γονίδιο IL-4 ή/και αλληλουχίες IL-4Rα, όπου τα μη ανθρώπινα ζώα είναι τρωκτικά, π.χ. ποντικοί ή αρουραίοι.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461989757P | 2014-05-07 | 2014-05-07 | |
PCT/US2015/029638 WO2015171861A1 (en) | 2014-05-07 | 2015-05-07 | Humanized il-4 and il-4r alpha animals |
EP15727106.5A EP3027015B1 (en) | 2014-05-07 | 2015-05-07 | Humanized il-4 and il-4r alpha animals |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124605T1 true CY1124605T1 (el) | 2022-07-22 |
Family
ID=53284509
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100040T CY1119773T1 (el) | 2014-05-07 | 2018-01-15 | Ανθρωποποιημενα il-4 και il-4r αλφα ζωα |
CY20211100805T CY1124605T1 (el) | 2014-05-07 | 2021-09-14 | Ζωα με εξανθρωπισμενα il-4 και il-4r αλφα |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100040T CY1119773T1 (el) | 2014-05-07 | 2018-01-15 | Ανθρωποποιημενα il-4 και il-4r αλφα ζωα |
Country Status (25)
Country | Link |
---|---|
US (7) | US9565841B2 (el) |
EP (3) | EP3906781A1 (el) |
JP (4) | JP6640740B2 (el) |
KR (2) | KR102473565B1 (el) |
CN (2) | CN106470545B (el) |
AU (2) | AU2015255977B2 (el) |
BR (1) | BR112016025745A2 (el) |
CA (2) | CA2947307C (el) |
CY (2) | CY1119773T1 (el) |
DK (2) | DK3027015T3 (el) |
ES (2) | ES2656529T3 (el) |
HR (2) | HRP20211455T1 (el) |
HU (2) | HUE038028T2 (el) |
IL (3) | IL297105B2 (el) |
LT (2) | LT3027015T (el) |
MX (1) | MX370672B (el) |
NO (1) | NO2785538T3 (el) |
PH (1) | PH12016502058A1 (el) |
PL (2) | PL3027015T3 (el) |
PT (2) | PT3027015T (el) |
RS (2) | RS62345B1 (el) |
RU (1) | RU2703139C2 (el) |
SG (2) | SG10201912354PA (el) |
SI (2) | SI3281521T1 (el) |
WO (1) | WO2015171861A1 (el) |
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EP2922394B1 (en) | 2013-09-23 | 2017-02-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized signal-regulatory protein gene |
SI2908626T1 (sl) | 2013-10-15 | 2017-02-28 | Regeneron Pharmaceuticals, Inc. | Humanizirane živali IL-15 |
CN105792646B (zh) | 2013-11-19 | 2018-03-02 | 瑞泽恩制药公司 | 具有人源化的b细胞活化因子基因的非人动物 |
US20150143559A1 (en) | 2013-11-19 | 2015-05-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
PL3129400T3 (pl) | 2014-04-08 | 2020-09-07 | Regeneron Pharmaceuticals, Inc. | Zwierzęta inne niż człowiek mające humanizowane receptory fc-gamma |
ES2779070T3 (es) | 2014-05-05 | 2020-08-13 | Regeneron Pharma | Animales con C5 y C3 humanizadas |
NO2785538T3 (el) * | 2014-05-07 | 2018-08-04 |
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