PE20191842A1 - Vectores de neoantigeno de alfavirus - Google Patents
Vectores de neoantigeno de alfavirusInfo
- Publication number
- PE20191842A1 PE20191842A1 PE2019002380A PE2019002380A PE20191842A1 PE 20191842 A1 PE20191842 A1 PE 20191842A1 PE 2019002380 A PE2019002380 A PE 2019002380A PE 2019002380 A PE2019002380 A PE 2019002380A PE 20191842 A1 PE20191842 A1 PE 20191842A1
- Authority
- PE
- Peru
- Prior art keywords
- vectors
- alfavirus
- neoantigen
- vaccines
- nucleotides
- Prior art date
Links
- 239000013598 vector Substances 0.000 title abstract 3
- 241000710929 Alphavirus Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001191—Melan-A/MART
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001188—NY-ESO
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/605—MHC molecules or ligands thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
Abstract
Se describen vectores de alfavirus que incluyen secuencias de acidos nucleicos que codifican neoantigenos derivados de un tumor de un sujeto. Tambien se describen nucleotidos, celulas y metodos asociados a los vectores, incluido su uso como vacunas
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762503283P | 2017-05-08 | 2017-05-08 | |
US201762523201P | 2017-06-21 | 2017-06-21 | |
US201762590163P | 2017-11-22 | 2017-11-22 | |
PCT/US2018/031696 WO2018208856A1 (en) | 2017-05-08 | 2018-05-08 | Alphavirus neoantigen vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20191842A1 true PE20191842A1 (es) | 2019-12-31 |
Family
ID=64105513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2019002380A PE20191842A1 (es) | 2017-05-08 | 2018-05-08 | Vectores de neoantigeno de alfavirus |
Country Status (16)
Country | Link |
---|---|
US (3) | US11504421B2 (es) |
EP (1) | EP3634449A4 (es) |
JP (2) | JP2020518648A (es) |
KR (1) | KR20200003390A (es) |
CN (1) | CN110612116A (es) |
AU (2) | AU2018266705B2 (es) |
BR (1) | BR112019023477A2 (es) |
CA (1) | CA3062591A1 (es) |
CO (1) | CO2019013609A2 (es) |
MX (1) | MX2019013259A (es) |
PE (1) | PE20191842A1 (es) |
PH (1) | PH12019502518A1 (es) |
SG (1) | SG11201910101SA (es) |
TW (2) | TW201907937A (es) |
WO (1) | WO2018208856A1 (es) |
ZA (1) | ZA201907461B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20200010849A1 (en) * | 2016-11-23 | 2020-01-09 | Gritstone Oncology, Inc. | Viral delivery of neoantigens |
CN116693695A (zh) | 2017-02-12 | 2023-09-05 | 百欧恩泰美国公司 | 基于hla的方法和组合物及其用途 |
EP3634449A4 (en) | 2017-05-08 | 2021-03-17 | Gritstone Oncology, Inc. | ALPHAVIRAL NEOANTIGENIC VECTORS |
GB201812474D0 (en) | 2018-07-31 | 2018-09-12 | Autolus Ltd | Nucleic acid construct |
CN109536464B (zh) * | 2018-12-10 | 2022-06-10 | 中国科学院武汉病毒研究所 | 一种缺失衣壳蛋白基因的基孔肯雅病毒感染性克隆及构建方法和在制备减毒疫苗中的应用 |
CA3121430A1 (en) * | 2018-12-14 | 2020-06-18 | Glaxosmithkline Biologicals Sa | Heterologous prime boost vaccine compositions and methods |
TW202043256A (zh) | 2019-01-10 | 2020-12-01 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
AU2020282369A1 (en) * | 2019-05-30 | 2022-01-20 | Gritstone Bio, Inc. | Modified adenoviruses |
EP3982980A4 (en) * | 2019-06-12 | 2023-11-29 | BioNTech US Inc. | NEOANTIGEN COMPOSITIONS AND USES THEREOF |
KR20220041844A (ko) * | 2019-07-02 | 2022-04-01 | 그릿스톤 바이오, 인코포레이티드 | Hiv 항원 및 mhc 복합체 |
KR20220047277A (ko) | 2019-07-16 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 백신, 및 이의 제조 및 사용 방법 |
CN110515301B (zh) * | 2019-08-06 | 2021-06-08 | 大连理工大学 | 一种结合dmpc的改进的admm算法 |
MX2022001664A (es) | 2019-08-09 | 2022-07-19 | Nutcracker Therapeutics Inc | Aparato microfluídico y metodos de uso del mismo. |
WO2021092095A1 (en) * | 2019-11-04 | 2021-05-14 | Gritstone Oncology, Inc. | Neoantigen vaccine therapy |
TW202200605A (zh) | 2020-03-09 | 2022-01-01 | 美商亞克圖羅斯醫療公司 | 冠狀病毒疫苗組成物和方法 |
CA3173793A1 (en) * | 2020-04-03 | 2021-10-07 | Andrew Ferguson | Infectious disease antigens and vaccines |
CN111951887A (zh) * | 2020-07-27 | 2020-11-17 | 深圳市新合生物医疗科技有限公司 | 基于深度学习的白细胞抗原与多肽结合亲和力预测方法 |
WO2022032196A2 (en) * | 2020-08-06 | 2022-02-10 | Gritstone Bio, Inc. | Multiepitope vaccine cassettes |
CN114438128A (zh) * | 2020-10-30 | 2022-05-06 | 上海市公共卫生临床中心 | 一种增强型溶瘤腺病毒及其应用 |
US11591544B2 (en) | 2020-11-25 | 2023-02-28 | Akagera Medicines, Inc. | Ionizable cationic lipids |
US20220194999A1 (en) * | 2020-12-23 | 2022-06-23 | Janssen Biotech, Inc. | Neoantigen Peptide Mimics |
CN112553232B (zh) * | 2020-12-29 | 2022-10-21 | 中国科学院武汉病毒研究所 | 多功能自组装纳米颗粒的可控生物合成方法 |
CA3205216A1 (en) * | 2021-01-19 | 2022-07-28 | Sue-Jean HONG | Modified alphavirus vectors |
CN117083071A (zh) | 2021-03-19 | 2023-11-17 | 蒂巴生物技术有限公司 | 人工甲病毒衍生的rna复制子表达系统 |
WO2022229966A1 (en) | 2021-04-29 | 2022-11-03 | Yeda Research And Development Co. Ltd. | T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same |
CN113517030B (zh) * | 2021-07-19 | 2022-09-20 | 中国人民解放军国防科技大学 | 基于病毒传播网络的基因序列表示学习方法 |
CN117794947A (zh) * | 2021-07-22 | 2024-03-29 | 海军秘书处代表的美国政府 | 结合并中和委内瑞拉马脑炎病毒的单结构域抗体 |
US11810644B2 (en) | 2022-03-08 | 2023-11-07 | Avalo, Inc. | System and method for genomic association |
WO2023183827A2 (en) * | 2022-03-21 | 2023-09-28 | Gritstone Bio, Inc. | Low-dose neoantigen vaccine therapy |
WO2024026274A2 (en) * | 2022-07-26 | 2024-02-01 | Yale University | Virus-like vesicles (vlvs) based vaccines and methods of preventing, ameliorating, and/or treating covid-19 and/or hepatocellular carcinoma (hcc) |
Family Cites Families (208)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
GB8311018D0 (en) | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
US6090406A (en) | 1984-04-12 | 2000-07-18 | The Liposome Company, Inc. | Potentiation of immune responses with liposomal adjuvants |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5223427A (en) | 1987-03-31 | 1993-06-29 | The Scripps Research Institute | Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain |
US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
DE69031305T2 (de) | 1989-11-03 | 1998-03-26 | Univ Vanderbilt | Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen |
US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
US6770283B1 (en) | 1990-12-13 | 2004-08-03 | Bioption Ab | DNA expression systems based on alphaviruses |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
US6037135A (en) | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
IL105914A0 (en) | 1992-06-04 | 1993-10-20 | Univ California | Methods and compositions for in vivo gene therapy |
US9340577B2 (en) | 1992-08-07 | 2016-05-17 | Epimmune Inc. | HLA binding motifs and peptides and their uses |
US5662907A (en) | 1992-08-07 | 1997-09-02 | Cytel Corporation | Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes |
US20050271676A1 (en) | 1993-03-05 | 2005-12-08 | Epimmune Inc. | Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions |
JP3926839B2 (ja) | 1993-09-14 | 2007-06-06 | エピミューン,インコーポレイティド | 万能dr−結合性ペプチドを用いる免疫応答の改変 |
US6413935B1 (en) | 1993-09-14 | 2002-07-02 | Epimmune Inc. | Induction of immune response against desired determinants |
US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
JPH09503657A (ja) | 1993-09-15 | 1997-04-15 | チロン ビアジーン インコーポレイティド | 組換えアルファウイルスベクター |
ATE272123T1 (de) | 1993-11-09 | 2004-08-15 | Ohio Med College | Stabile zellinie, die in der lage ist, das replikationsgen des adenoassoziertenvirus zu exprimieren |
US5505947A (en) | 1994-05-27 | 1996-04-09 | The University Of North Carolina At Chapel Hill | Attenuating mutations in Venezuelan Equine Encephalitis virus |
FR2726285B1 (fr) | 1994-10-28 | 1996-11-29 | Centre Nat Rech Scient | Adenovirus depourvus de particules contaminantes viables, preparation et utilisation |
ATE293701T1 (de) | 1994-10-28 | 2005-05-15 | Univ Pennsylvania | Rekombinanter adenovirus und methoden zu dessen verwendung |
US5552350A (en) | 1994-12-12 | 1996-09-03 | Ceramco Inc. | Low-fusing temperature porcelain |
US5792462A (en) | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
US5851796A (en) | 1995-06-07 | 1998-12-22 | Yale University | Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes |
UY24367A1 (es) | 1995-11-23 | 2000-10-31 | Boehringer Ingelheim Int | Vacunas contra tumores y procedimiento para su produccion |
US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
US6451592B1 (en) | 1996-04-05 | 2002-09-17 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
EP0803573A1 (en) | 1996-04-25 | 1997-10-29 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Polycistronic expression construct with cytokines for multivalent vaccines |
US6514731B1 (en) | 1996-05-24 | 2003-02-04 | Chiron Corporation | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
US6610321B2 (en) | 1996-07-03 | 2003-08-26 | University Of Pittsburgh | Emulsion formulations for hydrophilic active agents |
AU4255397A (en) | 1996-09-06 | 1998-03-26 | Trustees Of The University Of Pennsylvania, The | Chimpanzee adenovirus vectors |
US7732129B1 (en) | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
US5849561A (en) | 1997-05-22 | 1998-12-15 | Cornell Research Foundation, Inc. | Method for the production of non-group C adenoviral vectors |
EP1000628A1 (en) | 1998-09-28 | 2000-05-17 | Fondation Mondiale Recherche et Prevention SIDA | Use of antigenic complexes of HIV envelope and HLA class I antigens as HIV vaccine |
US20030072767A1 (en) | 1998-09-30 | 2003-04-17 | Alexander Gaiger | Compositions and methods for WT1 specific immunotherapy |
US20080050393A1 (en) | 1998-12-03 | 2008-02-28 | Tang Y Tom | Novel nucleic acids and polypeptides |
AU771774B2 (en) | 1998-12-07 | 2004-04-01 | U.S. Medical Research Institute Of Infectious Diseases | Live attenuated Venezuelan equine encephalitis vaccine |
JP2002536008A (ja) | 1999-02-11 | 2002-10-29 | ジェンザイム・コーポレーション | 抗原ペプチドコンカテマー |
US7262049B2 (en) | 1999-03-16 | 2007-08-28 | Dana-Farber Cancer Institute, Inc. | Pseudotyped lentiviral vectors and uses thereof |
EP1171617B1 (en) | 1999-04-08 | 2008-02-13 | Novartis Vaccines and Diagnostics, Inc. | Enhancement of the immune response for vaccine and gene therapy applications |
US8647864B2 (en) | 1999-04-14 | 2014-02-11 | Novartis Ag | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
EP2196472A3 (en) | 1999-04-14 | 2011-04-13 | Novartis Vaccines and Diagnostics, Inc. | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
US6365394B1 (en) | 1999-09-29 | 2002-04-02 | The Trustees Of The University Of Pennsylvania | Cell lines and constructs useful in production of E1-deleted adenoviruses in absence of replication competent adenovirus |
EP1244465A4 (en) | 1999-12-21 | 2005-01-12 | Epimmune Inc | INDUCTION OF CELLULAR IMMUNE RESPONSE TO PROSTATE CANCER BY MEANS OF PEPTIDE AND NUCLEIC ACID COMPOUNDS |
US20040248113A1 (en) | 1999-12-28 | 2004-12-09 | Alessandro Sette | Method and system for optimizing multi-epitope nucleic acid constructs and peptides encoded thereby |
US7462354B2 (en) | 1999-12-28 | 2008-12-09 | Pharmexa Inc. | Method and system for optimizing minigenes and peptides encoded thereby |
JP2003523365A (ja) | 2000-01-28 | 2003-08-05 | スタテンズ セーラム インスティテュート | Hiv感染の診断及びコントロールのためのhivペプチド及びそれをエンコードする核酸 |
AU785151B2 (en) | 2000-01-28 | 2006-10-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Novel MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1 |
AU2001252945A1 (en) | 2000-03-24 | 2001-10-08 | Corixa Corporation | Compositions and methods for therapy and diagnosis of colon cancer |
US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
US20040115625A1 (en) | 2000-10-02 | 2004-06-17 | Reinhard Ebner | Cancer gene determination and therapeutic screening using signature gene sets |
US6783939B2 (en) | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
AU2001291162A1 (en) | 2000-09-25 | 2002-04-08 | Regents Of The University Of Michigan | Production of viral vectors |
US20020137081A1 (en) | 2001-01-08 | 2002-09-26 | Olga Bandman | Genes differentially expressed in vascular tissue activation |
US7557200B2 (en) | 2001-02-01 | 2009-07-07 | Johns Hopkins University | Superior molecular vaccine based on self-replicating RNA, suicidal DNA or naked DNA vector, that links antigen with polypeptide that promotes antigen presentation |
US20030232324A1 (en) * | 2001-05-31 | 2003-12-18 | Chiron Corporation | Chimeric alphavirus replicon particles |
ATE472335T1 (de) | 2001-05-31 | 2010-07-15 | Novartis Vaccines & Diagnostic | Chimere alphavirus-replikon-partikel |
ES2375557T3 (es) | 2001-06-22 | 2012-03-02 | The Trustees Of The University Of Pennsylvania | Adenovirus recombinantes que comprenden prote�?nas de adenovirus de simios y usos de los mismos. |
PL208588B1 (pl) | 2002-04-25 | 2011-05-31 | Crucell Holland Bv | Rekombinowane adenowirusy, wyizolowane kwasy nukleinowe, komórki pakujące oraz sposoby zwiększania stabilności i/lub pojemności upakowania rekombinowanego adenowirusa |
DK1497438T3 (da) | 2002-04-25 | 2010-01-04 | Crucell Holland Bv | Midler og fremgangsmåder til fremstilling af adenovirusvektorer |
WO2004023973A2 (en) | 2002-09-12 | 2004-03-25 | Incyte Corporation | Molecules for diagnostics and therapeutics |
JP2006516089A (ja) | 2002-10-02 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
WO2004031210A2 (en) | 2002-10-03 | 2004-04-15 | Epimmune Inc. | Optimized multi-epitope constructs and uses thereof |
DK3246399T3 (da) | 2002-12-13 | 2021-10-04 | Alphavax Inc | Alfavirus-partikler og fremgangsmåder til fremstilling |
CA2509973C (en) | 2002-12-13 | 2013-02-26 | Alphavax, Inc. | Multi-antigenic alphavirus replicon particles and methods |
GB2398300A (en) | 2003-02-17 | 2004-08-18 | Isis Innovation | Method and compositions for boosting immune response |
US7425328B2 (en) | 2003-04-22 | 2008-09-16 | Purdue Pharma L.P. | Tissue factor antibodies and uses thereof |
WO2005033265A2 (en) | 2003-04-25 | 2005-04-14 | Epimmune Inc. | Optimized multi-epitope constructs and uses thereof |
US7605235B2 (en) | 2003-05-30 | 2009-10-20 | Centocor, Inc. | Anti-tissue factor antibodies and compositions |
KR20060017635A (ko) | 2003-06-05 | 2006-02-24 | 와이어쓰 홀딩스 코포레이션 | 베네쥬엘라 말 뇌염 바이러스 레플리콘 벡터 및파라믹소바이러스 단백질 항원을 포함하는 면역원성 조성물 |
US7291498B2 (en) | 2003-06-20 | 2007-11-06 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
PL2163260T3 (pl) | 2004-01-23 | 2017-12-29 | Msd Italia S.R.L. | Szympansie adenowirusowe nośniki szczepionek |
US8119336B2 (en) | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
CA2563500C (en) | 2004-04-28 | 2016-06-28 | The Trustees Of The University Of Pennsylvania | Immunization regimen with e4-deleted adenovirus prime and e1-deleted adenovirus boost |
JP2007535550A (ja) | 2004-04-28 | 2007-12-06 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | アデノウイルスおよびアデノ随伴ウイルス媒介投与を介する免疫原性分子の連続的な送達 |
ES2647491T3 (es) | 2004-05-21 | 2017-12-21 | Novartis Vaccines And Diagnostics, Inc. | Vectores del alfavirus para las vacunas del virus de la gripe |
WO2006076032A2 (en) | 2004-05-25 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Alphavirus replicon packaging constructs |
WO2006007712A1 (en) | 2004-07-19 | 2006-01-26 | Protiva Biotherapeutics, Inc. | Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents |
ES2310848T3 (es) | 2004-10-04 | 2009-01-16 | Biovaxim Limited | Vacunas de virus enteros inactivados correspondientes a un subtipo para tratar pacientes con la infeccion vih. |
US20060198854A1 (en) | 2004-12-28 | 2006-09-07 | Peter Pushko | Vector platforms derived from the alphavirus vaccines |
US7220549B2 (en) | 2004-12-30 | 2007-05-22 | Helicos Biosciences Corporation | Stabilizing a nucleic acid for nucleic acid sequencing |
FR2882557A1 (fr) | 2005-02-25 | 2006-09-01 | Centre Nat Rech Scient | Epitopes de vih et composition pharmaceutique les contenant |
US7283337B2 (en) | 2005-03-04 | 2007-10-16 | Headway Technologies, Inc. | Abutted exchange bias design for sensor stabilization |
CA2609142C (en) * | 2005-05-27 | 2016-02-09 | Fondazione Centro San Raffaele Del Monte Tabor | Therapeutic gene vectors comprising mirna target sequences |
PL2578685T3 (pl) | 2005-08-23 | 2020-01-31 | The Trustees Of The University Of Pennsylvania | Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania |
EP2357000A1 (en) | 2005-10-18 | 2011-08-17 | Novartis Vaccines and Diagnostics, Inc. | Mucosal and systemic immunizations with alphavirus replicon particles |
KR101499750B1 (ko) | 2006-02-27 | 2015-03-06 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 가감염성 플라비바이러스 및 이들의 용도 |
WO2008033966A2 (en) | 2006-09-12 | 2008-03-20 | Alphavax, Inc. | Alphavirus replicon particles matched to protein antigens as immunological adjuvants |
US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
GB0706914D0 (en) | 2007-04-10 | 2007-05-16 | Isis Innovation | Novel adenovirus vectors |
AU2008262490B2 (en) | 2007-05-22 | 2011-11-17 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
US8969542B2 (en) | 2007-05-31 | 2015-03-03 | Genimmune N.V. | HPV polyepitope constructs and uses thereof |
ES2670813T3 (es) | 2007-06-21 | 2018-06-01 | Alphavax, Inc. | Partículas de replicón de alfavirus para uso en vacunación |
US20100015179A1 (en) | 2007-08-16 | 2010-01-21 | Frolov Ilya V | Attenuation of encephalitogenic alphavirus and uses thereof |
EP2201023A2 (en) | 2007-09-14 | 2010-06-30 | GENimmune N.V. | Affinity tag |
US20100285050A1 (en) | 2007-10-05 | 2010-11-11 | Isis Innovation Limited | Compositions and Methods |
GB0719526D0 (en) | 2007-10-05 | 2007-11-14 | Isis Innovation | Compositions and methods |
JP5627464B2 (ja) | 2007-11-26 | 2014-11-19 | ノバルティス アーゲー | アルファウイルス粒子を生成する方法 |
US20110091496A1 (en) | 2008-01-19 | 2011-04-21 | Graham Barney S | Methods and compositions for the delivery of vaccines to disrupted epithelium |
US20090253184A1 (en) | 2008-01-23 | 2009-10-08 | Introgen Therapeutics, Inc. | Compositions and methods related to an adenoviral trans-complementing cell line |
CA2910235C (en) | 2008-01-24 | 2021-07-06 | Scott C. Weaver | Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof |
US20110142880A1 (en) | 2008-03-28 | 2011-06-16 | Franck Yann Lemiale | Lentivirus-based immunogenic vectors |
US20110129498A1 (en) | 2008-06-03 | 2011-06-02 | Okairos Ag | Vaccine for the prevention and therapy of hcv infections |
US8093021B2 (en) * | 2008-06-13 | 2012-01-10 | New York University | Defective sindbis viral vectors |
ES2544702T3 (es) | 2008-07-17 | 2015-09-02 | Medigen, Inc. | Vacunas en forma de ADNi y métodos para utilizarlas |
ES2536465T3 (es) * | 2008-10-01 | 2015-05-25 | Immatics Biotechnologies Gmbh | Composición de péptidos tumor-asociados y relacionados con la vacuna contra el cáncer para el tratamiento de glioblastoma (GBM) y otros cánceres |
US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
US8807362B2 (en) | 2008-10-17 | 2014-08-19 | Jeong-min Lee | Bottle cap |
MY161495A (en) | 2008-11-26 | 2017-04-14 | Government Of The Us Secretary Dept Of Health And Human Services | Virus like particle compositions and methods of use |
ES2525707T3 (es) | 2008-12-01 | 2014-12-29 | Alphavax, Inc. | Uso de microRNAs para el control de ácidos nucleicos colaboradores de virus |
DE102008061522A1 (de) | 2008-12-10 | 2010-06-17 | Biontech Ag | Verwendung von Flt3-Ligand zur Verstärkung von Immunreaktionen bei RNA-Immunisierung |
KR101763093B1 (ko) | 2009-02-02 | 2017-07-28 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 시미안 아데노바이러스 핵산- 및 아미노산-서열, 이를 포함하는 벡터 및 이의 용도 |
CN101579528B (zh) | 2009-06-24 | 2011-06-29 | 中国人民解放军军事医学科学院军事兽医研究所 | 一种hiv复合多表位dna疫苗及其应用 |
GB0918154D0 (en) | 2009-10-16 | 2009-12-02 | Isis Innovation | Mycobacterial vaccines |
WO2011082388A2 (en) | 2009-12-31 | 2011-07-07 | Medigen, Inc . | Infectious dna vaccines against chikungunya virus |
GB201006405D0 (en) | 2010-04-16 | 2010-06-02 | Isis Innovation | Poxvirus expression system |
AU2011252795B2 (en) | 2010-05-14 | 2015-09-03 | Dana-Farber Cancer Institute, Inc. | Compositions and methods of identifying tumor specific neoantigens |
WO2012006369A2 (en) | 2010-07-06 | 2012-01-12 | Novartis Ag | Immunisation of large mammals with low doses of rna |
ES2649896T3 (es) | 2010-07-06 | 2018-01-16 | Glaxosmithkline Biologicals Sa | Emulsiones catiónicas de aceite en agua |
CN103153284B (zh) | 2010-07-06 | 2015-11-25 | 诺华股份有限公司 | 含有其pKa值有利于RNA递送的脂质的脂质体 |
RS63817B1 (sr) | 2010-07-06 | 2023-01-31 | Glaxosmithkline Biologicals Sa | Čestice za isporuku slične virionu za molekule samoreplicirajuće rnk |
US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
DK3243526T3 (da) | 2010-07-06 | 2020-02-17 | Glaxosmithkline Biologicals Sa | Levering af rna til at udløse flere immunsignalveje |
BR112013004879A2 (pt) | 2010-08-31 | 2018-04-24 | Novartis Ag | lipossomas pequenos para entrega de rna que codifica imunogénio |
EP2611420B1 (en) | 2010-08-31 | 2019-03-27 | GlaxoSmithKline Biologicals SA | Lipids suitable for liposomal delivery of protein-coding rna |
HUE058667T2 (hu) | 2010-08-31 | 2022-09-28 | Glaxosmithkline Biologicals Sa | Pegilált liposzómák immunogént kódoló RNS szállítására |
KR20190002733A (ko) | 2010-12-30 | 2019-01-08 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
WO2012106356A2 (en) | 2011-01-31 | 2012-08-09 | GOVERNMENT OF THE USA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES | Virus-like particles and methods of use |
US8722044B2 (en) | 2011-03-15 | 2014-05-13 | Janssen Biotech, Inc. | Human tissue factor antibody and uses thereof |
SG194755A1 (en) | 2011-05-13 | 2013-12-30 | Novartis Ag | Pre-fusion rsv f antigens |
NZ730355A (en) | 2011-05-24 | 2022-10-28 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh | Individualized vaccines for cancer |
GB201108879D0 (en) | 2011-05-25 | 2011-07-06 | Isis Innovation | Vector |
WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
EP2729168A2 (en) | 2011-07-06 | 2014-05-14 | Novartis AG | Immunogenic compositions and uses thereof |
EP4115875A1 (en) | 2011-07-06 | 2023-01-11 | GlaxoSmithKline Biologicals S.A. | Liposomes having useful n:p ratio for delivery of rna molecules |
US11896636B2 (en) | 2011-07-06 | 2024-02-13 | Glaxosmithkline Biologicals Sa | Immunogenic combination compositions and uses thereof |
KR102067760B1 (ko) | 2011-08-16 | 2020-01-17 | 삼성전자주식회사 | 세포 내 전달용 단백질 복합체 및 그의 용도 |
CN103974719A (zh) | 2011-08-31 | 2014-08-06 | 诺华股份有限公司 | 用于递送免疫原编码rna的聚乙二醇化脂质体 |
BR112014008694A2 (pt) | 2011-10-11 | 2017-06-20 | Novartis Ag | moléculas de ácido nucleico policistrônico recombinante |
AR092796A1 (es) | 2012-02-16 | 2015-05-06 | Vlp Therapeutics Llc | Composicion particulada de tipo viral |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US20160289674A1 (en) | 2012-04-02 | 2016-10-06 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of membrane proteins |
WO2013173702A2 (en) | 2012-05-18 | 2013-11-21 | The Trustees Of The University Of Pennsylvania | Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof |
ES2663688T3 (es) | 2012-07-04 | 2018-04-16 | Sirion Biotech Gmbh | Medios y métodos para aumentar la producción de adenovirus |
CN104853770A (zh) | 2012-07-06 | 2015-08-19 | 诺华股份有限公司 | 免疫原性组合物及其应用 |
US8961995B2 (en) | 2012-09-20 | 2015-02-24 | Uab Research Foundation | Methods and compositions for alphavirus replicons |
GB201220119D0 (en) | 2012-11-08 | 2012-12-26 | Univ Cork | Vector |
US9402888B2 (en) | 2013-03-14 | 2016-08-02 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for treating cancer |
EP2983702A2 (en) | 2013-04-07 | 2016-02-17 | The Broad Institute, Inc. | Compositions and methods for personalized neoplasia vaccines |
AP2015008926A0 (en) | 2013-06-03 | 2015-12-31 | Vlp Therapeutics Llc | Malaria vaccine |
BR112016008806A2 (pt) | 2013-11-01 | 2017-10-03 | Pfizer | Vetores para expressão de antígenos associados à próstata |
GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
CN106132432A (zh) | 2013-12-06 | 2016-11-16 | 博德研究所 | 用于瘤形成疫苗的配制品 |
BR112016014410A2 (pt) | 2013-12-20 | 2018-02-20 | The Broad Institute Inc. | terapia de combinação com vacina de neoantígeno |
WO2016036971A1 (en) | 2014-09-03 | 2016-03-10 | Bavarian Nordic A/S | Methods and compositions for enhancing immune responses |
EP3666288B1 (en) | 2014-11-26 | 2023-09-27 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-mutated kras t cell receptors |
EP3234193B1 (en) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Molecular biomarkers for cancer immunotherapy |
US10993997B2 (en) | 2014-12-19 | 2021-05-04 | The Broad Institute, Inc. | Methods for profiling the t cell repertoire |
EP3250233A4 (en) | 2015-01-29 | 2018-07-25 | Agency for Science, Technology and Research | Nanocapsules carrying chikungunya-associated peptides |
DK3253795T3 (da) | 2015-02-06 | 2019-07-29 | Navigo Proteins Gmbh | Hidtil ukendte bindende proteiner, der omfatter et ubiquitin-mutein, og antistoffer eller antistoffragmenter |
WO2016154047A2 (en) | 2015-03-20 | 2016-09-29 | Memorial Sloan-Kettering Cancer Center | Monoclonal antigen-binding proteins to intracellular oncogene products |
US20180086832A1 (en) | 2015-03-23 | 2018-03-29 | The Johns Hopkins University | Hla-restricted epitopes encoded by somatically mutated genes |
MY190974A (en) | 2015-05-20 | 2022-05-25 | Massachusetts Gen Hospital | Shared neoantigens |
WO2017053297A1 (en) | 2015-09-21 | 2017-03-30 | Trilink Biotechnologies, Inc. | Compositions and methods for synthesizing 5'-capped rnas |
JP2018530579A (ja) | 2015-10-12 | 2018-10-18 | ナントミクス,エルエルシー | ウイルス性癌ネオエピトープのための組成物および方法 |
EP4299136A3 (en) | 2015-12-16 | 2024-02-14 | Gritstone bio, Inc. | Neoantigen identification, manufacture, and use |
EP3423828A4 (en) | 2016-02-29 | 2019-11-13 | Foundation Medicine, Inc. | METHODS AND SYSTEMS FOR EVALUATING THE MUTATIONAL CHARGE OF A TUMOR |
KR20180132070A (ko) | 2016-03-03 | 2018-12-11 | 큐 바이오파마, 인크. | T-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법 |
BR112018070183A2 (pt) | 2016-03-31 | 2019-04-16 | Neon Therapeutics, Inc. | neoantígenos e métodos de seu uso |
AU2017254477A1 (en) | 2016-04-18 | 2018-11-01 | Jennifer G. ABELIN | Improved HLA epitope prediction |
JP7033549B2 (ja) | 2016-05-04 | 2022-03-10 | フレッド ハッチンソン キャンサー リサーチ センター | 細胞に基づくネオ抗原ワクチンおよびその使用 |
EP3463445A1 (en) | 2016-06-02 | 2019-04-10 | GlaxoSmithKline Biologicals SA | Zika viral antigen constructs |
JP7115803B2 (ja) | 2016-06-20 | 2022-08-09 | アイエスエー ファーマシューティカルズ ビー.ヴイ. | ペプチドワクチン製剤 |
CN107698593A (zh) | 2016-08-09 | 2018-02-16 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
WO2018039131A1 (en) | 2016-08-22 | 2018-03-01 | Protiva Biotherapeutics, Inc. | Anti-pd-1 antibodies, or fragments thereof, for treating hepatitis b |
US20200010849A1 (en) | 2016-11-23 | 2020-01-09 | Gritstone Oncology, Inc. | Viral delivery of neoantigens |
WO2018102585A1 (en) | 2016-11-30 | 2018-06-07 | Advaxis, Inc. | Personalized immunotherapy in combination with immunotherapy targeting recurrent cancer mutations |
GB201620968D0 (en) | 2016-12-09 | 2017-01-25 | Glaxosmithkline Biologicals Sa | Adenovirus polynucleotides and polypeptides |
GB201621732D0 (en) | 2016-12-20 | 2017-02-01 | Agricultural Research Council | A multi-epitope dna vaccine for heartwater |
CA3047326A1 (en) | 2016-12-21 | 2018-06-28 | Arbutus Biopharma Corporation | Methods for ameliorating infusion reactions |
US20230241207A1 (en) | 2017-04-03 | 2023-08-03 | Neon Therapeutics, Inc. | Protein antigens and uses thereof |
EP3634449A4 (en) | 2017-05-08 | 2021-03-17 | Gritstone Oncology, Inc. | ALPHAVIRAL NEOANTIGENIC VECTORS |
WO2018227030A1 (en) | 2017-06-09 | 2018-12-13 | Gritstone Oncology, Inc. | Neoantigen identification, manufacture, and use |
WO2018232330A1 (en) | 2017-06-16 | 2018-12-20 | Arbutus Biopharma Corporation | Therapeutic compositions and methods for treating hepatitis b |
KR20200093518A (ko) | 2017-07-21 | 2020-08-05 | 제넨테크, 인크. | 암에 대한 치료 및 진단 방법 |
CA3072195A1 (en) | 2017-08-07 | 2019-04-04 | The Johns Hopkins University | Methods and materials for assessing and treating cancer |
CA3079253A1 (en) | 2017-11-03 | 2019-05-09 | Guardant Health, Inc. | Normalizing tumor mutation burden |
US20200402613A1 (en) | 2018-03-06 | 2020-12-24 | Cancer Research Technology Limited | Improvements in variant detection |
AU2019275072A1 (en) | 2018-05-23 | 2021-01-21 | Gritstone Bio, Inc. | Shared antigens |
KR20210013589A (ko) | 2018-05-23 | 2021-02-04 | 그릿스톤 온콜로지, 인코포레이티드 | 면역 체크포인트 억제제 공동-발현 벡터 |
CA3119752A1 (en) | 2018-11-07 | 2020-05-14 | Gritstone Oncology, Inc. | Alphavirus neoantigen vectors and interferon inhibitors |
AU2020282369A1 (en) | 2019-05-30 | 2022-01-20 | Gritstone Bio, Inc. | Modified adenoviruses |
KR20220041844A (ko) | 2019-07-02 | 2022-04-01 | 그릿스톤 바이오, 인코포레이티드 | Hiv 항원 및 mhc 복합체 |
WO2021092095A1 (en) | 2019-11-04 | 2021-05-14 | Gritstone Oncology, Inc. | Neoantigen vaccine therapy |
WO2021119545A1 (en) | 2019-12-11 | 2021-06-17 | Gritstone Bio, Inc. | Durable vaccination |
WO2021142437A1 (en) | 2020-01-10 | 2021-07-15 | Gritstone Bio, Inc. | Cell-free dna monitoring |
EP4138890A2 (en) | 2020-04-21 | 2023-03-01 | Gritstone bio, Inc. | Antigen-encoding cassettes |
WO2022032196A2 (en) | 2020-08-06 | 2022-02-10 | Gritstone Bio, Inc. | Multiepitope vaccine cassettes |
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TW201907937A (zh) | 2019-03-01 |
BR112019023477A2 (pt) | 2020-06-30 |
RU2019138741A (ru) | 2021-06-09 |
US20200197500A1 (en) | 2020-06-25 |
KR20200003390A (ko) | 2020-01-09 |
PH12019502518A1 (en) | 2020-07-20 |
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