CY1124845T1 - Μεθοδοι παροχης μονοκλωνου rna - Google Patents

Μεθοδοι παροχης μονοκλωνου rna

Info

Publication number
CY1124845T1
CY1124845T1 CY20211101032T CY211101032T CY1124845T1 CY 1124845 T1 CY1124845 T1 CY 1124845T1 CY 20211101032 T CY20211101032 T CY 20211101032T CY 211101032 T CY211101032 T CY 211101032T CY 1124845 T1 CY1124845 T1 CY 1124845T1
Authority
CY
Cyprus
Prior art keywords
methods
rna
monoclon
delivering
ssrna
Prior art date
Application number
CY20211101032T
Other languages
English (en)
Inventor
Markus BAIERSDÖRFER
Katalin Karikó
Original Assignee
BioNTech SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioNTech SE filed Critical BioNTech SE
Publication of CY1124845T1 publication Critical patent/CY1124845T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με μεθόδους για την παροχή μονόκλωνου RNA (ssRNA). Επιπλέον, η παρούσα εφεύρεση σχετίζεται με το ssRNA, το οποίο μπορεί να ληφθεί με τις μεθόδους της εφεύρεσης και τη χρήση τέτοιου ssRNA στη θεραπεία.
CY20211101032T 2016-04-22 2021-11-26 Μεθοδοι παροχης μονοκλωνου rna CY1124845T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2016059056 2016-04-22
PCT/EP2017/059293 WO2017182524A1 (en) 2016-04-22 2017-04-19 Methods for providing single-stranded rna

Publications (1)

Publication Number Publication Date
CY1124845T1 true CY1124845T1 (el) 2022-11-25

Family

ID=58699087

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211101032T CY1124845T1 (el) 2016-04-22 2021-11-26 Μεθοδοι παροχης μονοκλωνου rna

Country Status (26)

Country Link
US (1) US20190153425A1 (el)
EP (2) EP3445850B1 (el)
JP (2) JP7000343B2 (el)
KR (2) KR102565881B1 (el)
CN (1) CN109072232B (el)
AU (1) AU2017251983B2 (el)
BR (1) BR112018069417A2 (el)
CA (1) CA3020481A1 (el)
CY (1) CY1124845T1 (el)
DK (1) DK3445850T3 (el)
ES (1) ES2900272T3 (el)
HR (1) HRP20211745T1 (el)
HU (1) HUE059314T2 (el)
IL (1) IL262304A (el)
LT (1) LT3445850T (el)
MA (1) MA44732B1 (el)
MD (1) MD3445850T2 (el)
MX (1) MX2018012880A (el)
PL (1) PL3445850T3 (el)
PT (1) PT3445850T (el)
RS (1) RS62612B1 (el)
RU (2) RU2021134269A (el)
SG (2) SG11201807573VA (el)
SI (1) SI3445850T1 (el)
WO (1) WO2017182524A1 (el)
ZA (2) ZA201805949B (el)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3445850T3 (pl) 2016-04-22 2022-01-17 BioNTech SE Sposoby otrzymywania jednoniciowego rna
WO2018188730A1 (en) * 2017-04-11 2018-10-18 Biontech Rna Pharmaceuticals Gmbh Rna for treatment of autoimmune diseases
US11912982B2 (en) 2017-08-18 2024-02-27 Modernatx, Inc. Methods for HPLC analysis
US20210040472A1 (en) * 2019-08-09 2021-02-11 Nutcracker Therapeutics, Inc. Methods and apparatuses for manufacturing for removing material from a therapeutic composition
WO2021160346A1 (en) 2020-02-13 2021-08-19 Institut Pasteur Nucleic acid vaccine against the sars-cov-2 coronavirus
BR112022019769A2 (pt) 2020-03-30 2022-12-13 BioNTech SE Composições de rna que direcionam claudina-18.2
EP3896160A1 (en) * 2020-04-17 2021-10-20 Bia Separations D.O.O. A method of single-stranded rna purification
EP3896159A1 (en) * 2020-04-17 2021-10-20 Bia Separations D.O.O. A method of single strand rna purification employing an anion exchanger
EP3896161A1 (en) * 2020-04-17 2021-10-20 Bia Separations D.O.O. A method of single-stranded rna purification
EP4168544A1 (en) 2020-06-19 2023-04-26 eTheRNA Immunotherapies NV Rna purification method
MX2023005696A (es) 2020-11-16 2023-05-29 BioNTech SE Composiciones de lnp que comprenden arn y metodos para preparar, almacenar y usar las mismas.
WO2022101471A1 (en) 2020-11-16 2022-05-19 BioNTech SE Pharmaceutical compositions comprising lipid nanoparticles and mrna, and methods for preparing and storing the same
WO2022218503A1 (en) 2021-04-12 2022-10-20 BioNTech SE Lnp compositions comprising rna and methods for preparing, storing and using the same
US20240102065A1 (en) 2021-01-27 2024-03-28 CureVac SE Method of reducing the immunostimulatory properties of in vitro transcribed rna
CN115197935A (zh) * 2021-04-08 2022-10-18 上海细胞治疗集团有限公司 纤维素色谱纯化rna的方法
AU2022256732A1 (en) 2021-04-12 2023-10-19 Biontech Delivery Technologies Gmbh Rna compositions comprising a buffer substance and methods for preparing, storing and using the same
EP4330278A1 (en) 2021-04-26 2024-03-06 Institut Pasteur Human neutralizing monoclonal antibodies against sars-cov-2 and uses thereof
US20240218351A1 (en) * 2021-06-14 2024-07-04 2Seventy Bio, Inc. Single stranded rna purification methods
US20240218353A1 (en) * 2021-06-17 2024-07-04 Modernatx, Inc. Alternative rna purification strategies
CN115558664A (zh) * 2021-07-27 2023-01-03 上海兆维科技发展有限公司 一种rna的制备方法、合成蛋白质的方法以及转录反应液
BR112024001180A2 (pt) 2021-07-29 2024-04-30 BioNTech SE Composições e métodos para tratamento do melanoma
WO2023030635A1 (en) 2021-09-02 2023-03-09 BioNTech SE Potency assay for therapeutic potential of coding nucleic acid
CN118265522A (zh) 2021-09-10 2024-06-28 生物技术欧洲股份公司 适用于治疗的基于脂质的rna制剂
WO2023051926A1 (en) 2021-09-30 2023-04-06 BioNTech SE Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists
AU2022374004A1 (en) 2021-10-22 2024-05-02 BioNTech SE Compositions for administration of different doses of rna
EP4422698A1 (en) 2021-10-29 2024-09-04 CureVac SE Improved circular rna for expressing therapeutic proteins
CA3236959A1 (en) * 2021-11-08 2023-05-11 Sue-Jean HONG Self-amplifying rna compositions and methods of use thereof
WO2023083434A1 (en) 2021-11-09 2023-05-19 BioNTech SE Rna encoding peptidoglycan hydrolase and use thereof for treating bacterial infection
WO2023126053A1 (en) 2021-12-28 2023-07-06 BioNTech SE Lipid-based formulations for administration of rna
WO2023147090A1 (en) 2022-01-27 2023-08-03 BioNTech SE Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods
US20230279471A1 (en) * 2022-02-28 2023-09-07 Perkinelmer Health Sciences, Inc. Methods for separating and detecting double-stranded and single-stranded ribonucleic acid (rna)
WO2023165681A1 (en) 2022-03-01 2023-09-07 BioNTech SE Rna lipid nanoparticles (lnps) comprising a polyoxazoline and/or polyoxazine polymer
KR20230142248A (ko) 2022-04-01 2023-10-11 주식회사 엘지에너지솔루션 연성회로기판을 포함하는 파우치형 전지셀
WO2023193892A1 (en) 2022-04-05 2023-10-12 BioNTech SE Nucleic acid compositions comprising an inorganic polyphosphate and methods for preparing, storing and using the same
WO2023218431A1 (en) 2022-05-13 2023-11-16 BioNTech SE Rna compositions targeting hiv
CN114921457B (zh) * 2022-05-16 2023-09-29 硅羿科技（上海）有限公司 一种提取dsRNA的方法
WO2023230295A1 (en) 2022-05-25 2023-11-30 BioNTech SE Rna compositions for delivery of monkeypox antigens and related methods
WO2024017479A1 (en) 2022-07-21 2024-01-25 BioNTech SE Multifunctional cells transiently expressing an immune receptor and one or more cytokines, their use and methods for their production
WO2024028325A1 (en) 2022-08-01 2024-02-08 BioNTech SE Nucleic acid compositions comprising amphiphilic oligo ethylene glycol (oeg)-conjugated compounds and methods of using such compounds and compositions
WO2024027910A1 (en) 2022-08-03 2024-02-08 BioNTech SE Rna for preventing or treating tuberculosis
WO2024028445A1 (en) 2022-08-03 2024-02-08 BioNTech SE Rna for preventing or treating tuberculosis
WO2024064934A1 (en) 2022-09-23 2024-03-28 BioNTech SE Compositions for delivery of plasmodium csp antigens and related methods
WO2024063788A1 (en) 2022-09-23 2024-03-28 BioNTech SE Compositions for delivery of malaria antigens and related methods
WO2024064931A1 (en) 2022-09-23 2024-03-28 BioNTech SE Compositions for delivery of liver stage antigens and related methods
WO2024063789A1 (en) 2022-09-23 2024-03-28 BioNTech SE Compositions for delivery of malaria antigens and related methods
WO2024074634A1 (en) 2022-10-06 2024-04-11 BioNTech SE Rna compositions targeting claudin-18.2
WO2024074211A1 (en) 2022-10-06 2024-04-11 BioNTech SE Rna compositions targeting claudin-18.2
WO2024141955A1 (en) 2022-12-28 2024-07-04 BioNTech SE Rna compositions targeting hiv
WO2024153324A1 (en) 2023-01-18 2024-07-25 BioNTech SE Rna formulations for pharmaceutical use
WO2024180054A1 (en) 2023-02-28 2024-09-06 BioNTech SE Linker sequence potency assays for multiple coding nucleic acids
WO2024180363A1 (en) 2023-02-28 2024-09-06 BioNTech SE Linker sequence potency assays for multiple coding nucleic acids
WO2024184533A1 (en) 2023-03-09 2024-09-12 BioNTech SE Peptidoglycan hydrolases with bactericidal activity
EP4442276A1 (en) 2023-04-07 2024-10-09 Institut Pasteur Combined antibodies against sarbecoviruses and uses thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2936240A1 (de) * 1979-09-07 1981-03-26 Bayer Ag, 51373 Leverkusen Verfahren zur herstellung bekannter und neuer 6-amino-6-desoxy-2,3-0-isopropyliden-(alpha)-l-sorbofuranose-derivate sowie neue zwischenprodukte des verfahrens
US4475196A (en) 1981-03-06 1984-10-02 Zor Clair G Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4486194A (en) 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (es) 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
NL8900725A (nl) * 1989-03-23 1990-10-16 Az Univ Amsterdam Werkwijze en combinatie van middelen voor het isoleren van nucleinezuur.
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
DK1309726T4 (en) 2000-03-30 2019-01-28 Whitehead Inst Biomedical Res RNA Sequence-Specific Mediators of RNA Interference
JP3692395B2 (ja) 2000-09-01 2005-09-07 独立行政法人農業・生物系特定産業技術研究機構 ベクターモノカリオンを用いた紫紋羽病菌に対するゲノムが２本鎖ｒｎａである糸状菌に寄生するウイルスを導入する新規方法
EP1660631B1 (en) * 2003-08-01 2013-04-24 Life Technologies Corporation Compositions and methods for purifying short rna molecules
US9012219B2 (en) * 2005-08-23 2015-04-21 The Trustees Of The University Of Pennsylvania RNA preparations comprising purified modified RNA for reprogramming cells
DE102005046490A1 (de) 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
JP2009528845A (ja) * 2006-03-08 2009-08-13 プロメガ・コーポレーション 低分子量ｒｎａの精製方法
CN101086011B (zh) * 2006-06-08 2010-12-08 河南农业大学 食用菌和植物双链rna病毒检测试剂盒及其应用
DE102006061015A1 (de) 2006-12-22 2008-06-26 Curevac Gmbh Verfahren zur Reinigung von RNA im präparativen Maßstab mittels HPLC
CA2692906C (en) 2007-06-19 2016-01-19 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap
DK3287525T3 (da) 2009-12-07 2020-01-20 Univ Pennsylvania RNA-præparater omfattende oprenset modificeret RNA til omprogrammering af celler
DK3421601T3 (da) 2011-12-30 2020-02-24 Cellscript Llc Fremstilling og anvendelse af in-vitro-syntetiseret ssRNA til indføring i pattedyrceller med henblik på at inducere en biologisk eller biokemisk effekt
PT3303583T (pt) * 2015-05-29 2020-07-07 Curevac Ag Um método para produção e purificação de rna, compreendendendo pelo menos um passo de filtração por fluxo tangencial
PL3445850T3 (pl) 2016-04-22 2022-01-17 BioNTech SE Sposoby otrzymywania jednoniciowego rna

Also Published As

Publication number Publication date
JP7000343B2 (ja) 2022-02-10
DK3445850T3 (da) 2021-11-15
EP3445850A1 (en) 2019-02-27
KR102378404B1 (ko) 2022-03-24
HUE059314T2 (hu) 2022-11-28
CN109072232B (zh) 2022-11-15
ZA201905536B (en) 2023-04-26
PT3445850T (pt) 2021-12-06
MA44732A (fr) 2021-06-02
AU2017251983A1 (en) 2018-09-27
RU2018136601A (ru) 2020-05-22
JP2019517782A (ja) 2019-06-27
RU2021134269A (ru) 2022-03-16
EP4008782A1 (en) 2022-06-08
MX2018012880A (es) 2019-03-28
CN109072232A (zh) 2018-12-21
SG10202010471UA (en) 2020-11-27
MA44732B1 (fr) 2021-11-30
RU2760790C2 (ru) 2021-11-30
BR112018069417A2 (pt) 2019-01-22
AU2017251983B2 (en) 2023-07-20
LT3445850T (lt) 2021-11-25
KR20180135451A (ko) 2018-12-20
KR20220041247A (ko) 2022-03-31
KR102565881B1 (ko) 2023-08-10
MD3445850T2 (ro) 2022-01-31
SG11201807573VA (en) 2018-10-30
JP2022058394A (ja) 2022-04-12
ZA201805949B (en) 2019-12-18
IL262304A (en) 2018-11-29
ES2900272T3 (es) 2022-03-16
PL3445850T3 (pl) 2022-01-17
CA3020481A1 (en) 2017-10-26
HRP20211745T1 (hr) 2022-02-04
RS62612B1 (sr) 2021-12-31
US20190153425A1 (en) 2019-05-23
JP7335313B2 (ja) 2023-08-29
EP3445850B1 (en) 2021-10-27
WO2017182524A1 (en) 2017-10-26
RU2018136601A3 (el) 2020-09-16
SI3445850T1 (sl) 2021-12-31

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