DK3421601T3 - Fremstilling og anvendelse af in-vitro-syntetiseret ssRNA til indføring i pattedyrceller med henblik på at inducere en biologisk eller biokemisk effekt - Google Patents
Fremstilling og anvendelse af in-vitro-syntetiseret ssRNA til indføring i pattedyrceller med henblik på at inducere en biologisk eller biokemisk effekt Download PDFInfo
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- DK3421601T3 DK3421601T3 DK18170777.9T DK18170777T DK3421601T3 DK 3421601 T3 DK3421601 T3 DK 3421601T3 DK 18170777 T DK18170777 T DK 18170777T DK 3421601 T3 DK3421601 T3 DK 3421601T3
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- mammalian cells
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161582050P | 2011-12-30 | 2011-12-30 | |
US201161582080P | 2011-12-30 | 2011-12-30 | |
US201261651738P | 2012-05-25 | 2012-05-25 | |
EP16186283.4A EP3144389B1 (en) | 2011-12-30 | 2012-12-31 | Making and using in vitro-synthesized ssrna for introducing into mammalian cells to induce a biological or biochemical effect |
Publications (1)
Publication Number | Publication Date |
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DK3421601T3 true DK3421601T3 (da) | 2020-02-24 |
Family
ID=47559751
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18170777.9T DK3421601T3 (da) | 2011-12-30 | 2012-12-31 | Fremstilling og anvendelse af in-vitro-syntetiseret ssRNA til indføring i pattedyrceller med henblik på at inducere en biologisk eller biokemisk effekt |
DK16186283.4T DK3144389T3 (da) | 2011-12-30 | 2012-12-31 | Fremstilling og anvendelse af in vitro-syntetiseret SSRNA til indføring i pattedyrceller for at inducere en biologisk eller biokemisk effekt |
DK12815983.7T DK2798064T3 (da) | 2011-12-30 | 2012-12-31 | Fremstilling og anvendelse af in vitro-syntetiseret ssrna til indføring i pattedyrceller til induktion af en biologisk eller biokemisk virkning |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16186283.4T DK3144389T3 (da) | 2011-12-30 | 2012-12-31 | Fremstilling og anvendelse af in vitro-syntetiseret SSRNA til indføring i pattedyrceller for at inducere en biologisk eller biokemisk effekt |
DK12815983.7T DK2798064T3 (da) | 2011-12-30 | 2012-12-31 | Fremstilling og anvendelse af in vitro-syntetiseret ssrna til indføring i pattedyrceller til induktion af en biologisk eller biokemisk virkning |
Country Status (13)
Country | Link |
---|---|
US (3) | US10201620B2 (da) |
EP (5) | EP3421601B1 (da) |
AU (3) | AU2012362113B2 (da) |
CA (1) | CA2862377A1 (da) |
DK (3) | DK3421601T3 (da) |
ES (2) | ES2770314T3 (da) |
HK (1) | HK1203559A1 (da) |
HR (1) | HRP20200251T1 (da) |
HU (1) | HUE047947T2 (da) |
LT (2) | LT3421601T (da) |
PL (2) | PL3421601T3 (da) |
SI (1) | SI3421601T1 (da) |
WO (1) | WO2013102203A1 (da) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
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LT2578685T (lt) | 2005-08-23 | 2019-06-10 | The Trustees Of The University Of Pennsylvania | Rnr, apimančios modifikuotus nukleozidus ir jų panaudojimo būdai |
US9012219B2 (en) | 2005-08-23 | 2015-04-21 | The Trustees Of The University Of Pennsylvania | RNA preparations comprising purified modified RNA for reprogramming cells |
PT3338765T (pt) | 2009-12-01 | 2019-03-18 | Translate Bio Inc | Derivado de esteróide adequado para a administração de arnm em doenças genéticas humanas |
DK3287525T3 (da) | 2009-12-07 | 2020-01-20 | Univ Pennsylvania | RNA-præparater omfattende oprenset modificeret RNA til omprogrammering af celler |
EP2600901B1 (en) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
HRP20220796T1 (hr) | 2010-10-01 | 2022-10-14 | ModernaTX, Inc. | Ribonukleinske kiseline koje sadrže n1-metil-pseudouracil i njihove uporabe |
US8853377B2 (en) | 2010-11-30 | 2014-10-07 | Shire Human Genetic Therapies, Inc. | mRNA for use in treatment of human genetic diseases |
CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
AU2012267531B2 (en) | 2011-06-08 | 2017-06-22 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mRNA delivery |
EP2788033B1 (en) | 2011-12-05 | 2017-05-31 | Factor Bioscience Inc. | Methods and products for transfecting cells |
RS63244B1 (sr) | 2011-12-16 | 2022-06-30 | Modernatx Inc | Kompozicije modifikovane mrna |
DK3421601T3 (da) | 2011-12-30 | 2020-02-24 | Cellscript Llc | Fremstilling og anvendelse af in-vitro-syntetiseret ssRNA til indføring i pattedyrceller med henblik på at inducere en biologisk eller biokemisk effekt |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
EP3536787A1 (en) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nuclease resistant polynucleotides and uses thereof |
WO2014028429A2 (en) | 2012-08-14 | 2014-02-20 | Moderna Therapeutics, Inc. | Enzymes and polymerases for the synthesis of rna |
RU2019143431A (ru) | 2012-11-01 | 2020-04-28 | Фэктор Байосайенс Инк. | Способы и продукты для экспрессии белков в клетках |
CA2890529C (en) | 2012-11-09 | 2020-07-28 | Biontech Ag | Method for modification of cellular rna expression comprising interferon (ifn) receptors and signalling |
PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
JP6586075B2 (ja) | 2013-03-14 | 2019-10-02 | トランスレイト バイオ, インコーポレイテッド | メッセンジャーrnaの精製方法 |
WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
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